Molecular therapy. Nucleic acids

Keyphrases

Publications

volume 34, 2023

Chandran Sivasankar, Chamith Hewawaduge, Pandiyan Muthuramalingam, John Hwa Lee
Tumor-targeted delivery of lnc antisense RNA against RCAS1 by live-attenuated tryptophan-auxotrophic Salmonella inhibited 4T1 breast tumors and metastasis in mice. Molecular therapy. Nucleic acids 34 (2023)
Ignacio Prieto, María Kavanagh, Luna Jimenez-Castilla, Marisa Pardines, Iolanda Lazaro, Isabel Herrero Del Real, Monica Flores-Muñoz, Jesus Egido, Oscar Lopez-Franco, Carmen Gomez-Guerrero
A mutual regulatory loop between miR-155 and SOCS1 influences renal inflammation and diabetic kidney disease. Molecular therapy. Nucleic acids 34 (2023)
Yaoyao Lu, Kelly Godbout, Gabriel Lamothe, Jacques P Tremblay
CRISPR-Cas9 delivery strategies with engineered extracellular vesicles. Molecular therapy. Nucleic acids 34 (2023)
Lucyna Budzko, Karolina Hoffa-Sobiech, Paulina Jackowiak, Marek Figlerowicz
Engineered deaminases as a key component of DNA and RNA editing tools. Molecular therapy. Nucleic acids 34 (2023)
Kang Li, Min Qiang, Yungang Xu
Cell-type-specific alternative polyadenylation as a therapeutic biomarker in lung cancer progression. Molecular therapy. Nucleic acids 34 (2023)
Hai Xiao, Odmaa Amarsaikhan, Yunwang Zhao, Xiang Yu, Xin Hu, Shuqin Han, null Chaolumen, Huricha Baigude
Astrocyte-targeted siRNA delivery by adenosine-functionalized LNP in mouse TBI model. Molecular therapy. Nucleic acids 34 (2023)
Zhenzhen Chu, Baohuan Zhang, Xuxuan Zhou, Hui Yuan, Chongqing Gao, Lihao Liu, Yang Xiao, Jichun Zhang, Jian Hong, Junjie Liang, Dong Chen, Nan Yao
A DNA/RNA heteroduplex oligonucleotide coupling asparagine depletion restricts FGFR2 fusion-driven intrahepatic cholangiocarcinoma. Molecular therapy. Nucleic acids 34 (2023)
Chunshen Long, Hanshuang Li, Pengfei Liang, Lemuge Chao, Yan Hong, Junping Zhang, Qilemuge Xi, Yongchun Zuo
Deciphering the decisive factors driving fate bifurcations in somatic cell reprogramming. Molecular therapy. Nucleic acids 34 (2023)
Mi-Gyeong Gwon, Jaechan Leem, Hyun-Jin An, Hyemin Gu, Seongjae Bae, Jong Hyun Kim, Kwan-Kyu Park
The decoy oligodeoxynucleotide against HIF-1α and STAT5 ameliorates atopic dermatitis-like mouse model. Molecular therapy. Nucleic acids 34 (2023)
Matteo Rossi, Mikhail Steklov, Fanny Huberty, Thuy Nguyen, Jérôme Marijsse, Céline Jacques-Hespel, Paul Najm, Caroline Lonez, Eytan Breman
Efficient shRNA-based knockdown of multiple target genes for cell therapy using a chimeric miRNA cluster platform. Molecular therapy. Nucleic acids 34 (2023)
Roberto Giambruno, Elsa Zacco, Camilla Ugolini, Andrea Vandelli, Logan Mulroney, Manfredi D'Onghia, Bianca Giuliani, Elena Criscuolo, Matteo Castelli, Nicola Clementi, Massimo Clementi, Nicasio Mancini, Tiziana Bonaldi, Stefano Gustincich, Tommaso Leonardi, Gian Gaetano Tartaglia, Francesco Nicassio
Unveiling the role of PUS7-mediated pseudouridylation in host protein interactions specific for the SARS-CoV-2 RNA genome. Molecular therapy. Nucleic acids 34 (2023)
Xiangmei Li, Yalan He, Ying Jiang, Bingyue Pan, Jiashuo Wu, Xilong Zhao, Junling Huang, Qian Wang, Liang Cheng, Junwei Han
PathwayTMB: A pathway-based tumor mutational burden analysis method for predicting the clinical outcome of cancer immunotherapy. Molecular therapy. Nucleic acids 34 (2023)
Danushka K Wijesundara, Arthur Yeow, Christopher L D McMillan, Jovin J Y Choo, Aleksandra Todorovic, Zelalem A Mekonnen, Makutiro G Masavuli, Paul R Young, Eric J Gowans, Branka Grubor-Bauk, David A Muller
Superior efficacy of a skin-applied microprojection device for delivering a novel Zika DNA vaccine. Molecular therapy. Nucleic acids 34 (2023)
Jiaqi Yin, Na Ding, Jiaxin Yu, Zishan Wang, Limei Fu, Yongsheng Li, Xia Li, Juan Xu
Systematic analysis of DNA methylation-mediated TF dysregulation on lncRNAs reveals critical roles in tumor immunity. Molecular therapy. Nucleic acids 34 (2023)
Rebecca L Wallings, Julian R Mark, Hannah A Staley, Drew A Gillett, Noelle Neighbarger, Holly Kordasiewicz, Warren D Hirst, Malú Gámez Tansey
ASO-mediated knockdown or kinase inhibition of G2019S -Lrrk2 modulates lysosomal tubule-associated antigen presentation in macrophages. Molecular therapy. Nucleic acids 34 (2023)
Jeong Pil Han, Yeji Lee, Jeong Hyeon Lee, Hye Yoon Chung, Geon Seong Lee, Yu Ri Nam, Myeongjin Choi, Kyoung-Sik Moon, Haeshin Lee, Hyukjin Lee, Su Cheong Yeom
In vivo genome editing using 244- cis LNPs and low-dose AAV achieves therapeutic threshold in hemophilia A mice. Molecular therapy. Nucleic acids 34 (2023)
Ziyin Wang, Egon J Jacobus, David C Stirling, Stefanie Krumm, Katie E Flight, Robert F Cunliffe, Jonathan Mottl, Charanjit Singh, Lucy G Mosscrop, Leticia Aragão Santiago, Annette B Vogel, Katalin Kariko, Ugur Sahin, Stephanie Erbar, John S Tregoning
Reducing cell intrinsic immunity to mRNA vaccine alters adaptive immune responses in mice. Molecular therapy. Nucleic acids 34 (2023)
Naoki Watanabe, Yuichiro Tone, Tetsuya Nagata, Satoru Masuda, Takashi Saito, Norio Motohashi, Kazuchika Takagaki, Yoshitsugu Aoki, Shin'ichi Takeda
Exon 44 skipping in Duchenne muscular dystrophy: NS-089/NCNP-02, a dual-targeting antisense oligonucleotide. Molecular therapy. Nucleic acids 34 (2023)
Shukkwan K Chen, Zachary C E Hawley, Maria I Zavodszky, Sam Hana, Daniel Ferretti, Branka Grubor, Michael Hawes, Shanqin Xu, Stefan Hamann, Galina Marsh, Patrick Cullen, Ravi Challa, Thomas M Carlile, Hang Zhang, Wan-Hung Lee, Andrea Peralta, Pete Clarner, Cong Wei, Kathryn Koszka, Feng Gao, Shih-Ching Lo
Efficacy and safety of a SOD1-targeting artificial miRNA delivered by AAV9 in mice are impacted by miRNA scaffold selection. Molecular therapy. Nucleic acids 34 (2023)
Longxiang Xie, Shengnan Wu, Xiangqian Guo
An important resource and analytic platform for human and mouse cardiovascular-related cis -regulatory elements. Molecular therapy. Nucleic acids 34 (2023)
Weikai Ge, Xiaozhu Zhao, Shixue Gou, Qin Jin, Fangbing Chen, Zhen Ouyang, Chengdan Lai, Tao Cui, Baoyi Mai, Sijia Lu, Kexin Zhong, Yanhui Liang, Tao Chen, Han Wu, Nan Li, Yinghua Ye, Liangxue Lai, Kepin Wang
Evaluation of guide-free Cas9-induced genomic damage and transcriptome changes in pig embryos. Molecular therapy. Nucleic acids 34 (2023)
Priyanka Mohapatra, Swati Madhulika, Somalisa Behera, Priya Singh, Pratikshya Sa, Punit Prasad, Rajeeb Kumar Swain, Sanjeeb Kumar Sahoo
Nimbolide-based nanomedicine inhibits breast cancer stem-like cells by epigenetic reprogramming of DNMTs-SFRP1-Wnt/β-catenin signaling axis. Molecular therapy. Nucleic acids 34 (2023)
Hong-Yu Ma, Yang Li, Hui-Zi Yin, Hang Yin, Yuan-Yuan Qu, Qing-Yong Xu
Retraction Notice to: TNFAIP8 Promotes Cisplatin Chemoresistance in Triple-Negative Breast Cancer by Repressing p53-Mediated miR-205-5p Expression. Molecular therapy. Nucleic acids 34 (2023)
Michela Simbula, Maria Francesca Manchinu, Maura Mingoia, Mauro Pala, Isadora Asunis, Cristian Antonio Caria, Lucia Perseu, Manan Shah, Merlin Crossley, Paolo Moi, Maria Serafina Ristaldi
miR-365-3p mediates BCL11A and SOX6 erythroid-specific coregulation: A new player in HbF activation. Molecular therapy. Nucleic acids 34 (2023)
Irene González-Martínez, Estefanía Cerro-Herreros, Nerea Moreno, Andrea García-Rey, Jorge Espinosa-Espinosa, Marc Carrascosa-Sàez, Diego Piqueras-Losilla, Andrey Arzumanov, David Seoane-Miraz, Yahya Jad, Richard Raz, Matthew J Wood, Miguel A Varela, Beatriz Llamusí, Rubén Artero
Peptide-conjugated antimiRs improve myotonic dystrophy type 1 phenotypes by promoting endogenous MBNL1 expression. Molecular therapy. Nucleic acids 34 (2023)
Yiming Cheng, Xiaochen Wang, Shuyu Huang, Liang Zhang, Bei Lan, Xuanyuan Li, Hao Chen, Zhenfeng Liu, Yijie Su, Lishan Xi, Shengyun Feng, Yanxuan Guo, Jun Zhou, Yingmei Wang, Chenghao Xuan
A CRISPR-Cas9 library screening identifies CARM1 as a critical inhibitor of ferroptosis in hepatocellular carcinoma cells. Molecular therapy. Nucleic acids 34 (2023)
Jerry F Harb, Chloe L Christensen, Shih-Hsin Kan, Allisandra K Rha, Perla Andrade-Heckman, Laura Pollard, Richard Steet, Jeffrey Y Huang, Raymond Y Wang
Base editing corrects the common Salla disease SLC17A5 c.115C>T variant. Molecular therapy. Nucleic acids 34 (2023)
Alison Generotti, Ryne Contreras, Brenden Zounes, Eric Schade, Andrea Kemme, Yatish Rane, Xinggang Liu, Dustin Elwood, Katherine Schultheis, Jeremy Marston, Jay McCoy, Kate Broderick, Paul Fisher
Intradermal DNA vaccine delivery using vacuum-controlled, needle-free electroporation. Molecular therapy. Nucleic acids 34 (2023)
Li Zeng, Hailun Jiang, Ghulam Md Ashraf, Jianghong Liu, Linlin Wang, Kaiyue Zhao, Mimin Liu, Zhuorong Li, Rui Liu
Erratum: Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer's disease. Molecular therapy. Nucleic acids 34 (2023)
Benjamin C Crawford, Bertha C Elias, John T Benjamin
Future of biotherapeutics: Harnessing mRNA to enhance elastin expression. Molecular therapy. Nucleic acids 34 (2023)
Yue Wang, Yi-Li Feng, Qian Liu, Jing-Jing Xiao, Si-Cheng Liu, Zhi-Cheng Huang, An-Yong Xie
TREX2 enables efficient genome disruption mediated by paired CRISPR-Cas9 nickases that generate 3'-overhanging ends. Molecular therapy. Nucleic acids 34 (2023)
Yutong Hou, Sihao Lin, Jia Xia, Yu Zhang, Yanan Yin, Masha Huang, Yingjie Xu, Wen Yang, Yingjian Zhu
Alleviation of ischemia-reperfusion induced renal injury by chemically modified SOD2 mRNA delivered via lipid nanoparticles. Molecular therapy. Nucleic acids 34 (2023)
Naoko Shiba, Xiao Yang, Mitsuto Sato, Shin Kadota, Yota Suzuki, Masahiro Agata, Kohei Nagamine, Masaki Izumi, Yusuke Honda, Tomoya Koganehira, Hideki Kobayashi, Hajime Ichimura, Shinichiro Chuma, Junichi Nakai, Shugo Tohyama, Keiichi Fukuda, Daigo Miyazaki, Akinori Nakamura, Yuji Shiba
Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1. Molecular therapy. Nucleic acids 34 (2023)
Katrin Radloff, Birgitt Gutbier, Charlotte Maeve Dunne, Hanieh Moradian, Marko Schwestka, Manfred Gossen, Katharina Ahrens, Laura Kneller, Yadong Wang, Akanksha Moga, Leonidas Gkionis, Oliver Keil, Volker Fehring, Daniel Tondera, Klaus Giese, Ansgar Santel, Jörg Kaufmann, Martin Witzenrath
Cationic LNP-formulated mRNA expressing Tie2-agonist in the lung endothelium prevents pulmonary vascular leakage. Molecular therapy. Nucleic acids 34 (2023)
Andrew H Coles
siRNA goes after diseases of the bone. Molecular therapy. Nucleic acids 34 (2023)
Chun-Yu Chen, Amber Vander Kooi, Alex Cavedon, Xiaohe Cai, Jonathan Hoggatt, Paolo G V Martini, Carol H Miao
Induction of long-term tolerance to a specific antigen using anti-CD3 lipid nanoparticles following gene therapy. Molecular therapy. Nucleic acids 34 (2023)
Zhi-Ming Zheng
RNA therapy is shining for genetic diseases. Molecular therapy. Nucleic acids 34 (2023)
Justin S Antony, Pascale Birrer, Claudia Bohnert, Sina Zimmerli, Petra Hillmann, Hervé Schaffhauser, Christine Hoeflich, Andreas Hoeflich, Ramzi Khairallah, Andreas T Satoh, Isabelle Kappeler, Isabel Ferreira, Klaas P Zuideveld, Friedrich Metzger
Local application of engineered insulin-like growth factor I mRNA demonstrates regenerative therapeutic potential in vivo . Molecular therapy. Nucleic acids 34 (2023)
Brian J Thomas, Caitlyn Guldenpfennig, Yue Guan, Calvin Winkler, Margaret Beecher, Michaela Beedy, Ashley F Berendzen, Lixin Ma, Mark A Daniels, Donald H Burke, David Porciani
Targeting lung cancer with clinically relevant EGFR mutations using anti-EGFR RNA aptamer. Molecular therapy. Nucleic acids 34 (2023)
Ida Autiero, Luigi Vitagliano
Enhanced molecular dynamic simulation studies unravel long-range effects caused by sequence variations and partner binding in RNA aptamers. Molecular therapy. Nucleic acids 34 (2023)
Viggo G Blomquist, Jacqueline Niu, Papiya Choudhury, Ahmad Al Saneh, Henry M Colecraft, Christopher A Ahern
Transfer RNA-mediated restoration of potassium current and electrical correction in premature termination long-QT syndrome hERG mutants. Molecular therapy. Nucleic acids 34 (2023)
Alessia Cavazza, Ayal Hendel, Rasmus O Bak, Paula Rio, Marc Güell, Duško Lainšček, Virginia Arechavala-Gomeza, Ling Peng, Fatma Zehra Hapil, Joshua Harvey, Francisco G Ortega, Coral Gonzalez-Martinez, Carsten W Lederer, Kasper Mikkelsen, Giedrius Gasiunas, Nechama Kalter, Manuel A F V Gonçalves, Julie Petersen, Alejandro Garanto, Lluis Montoliu, Marcello Maresca, Stefan E Seemann, Jan Gorodkin, Loubna Mazini, Rosario Sanchez, Juan R Rodriguez-Madoz, Noelia Maldonado-Pérez, Torella Laura, Michael Schmueck-Henneresse, Cristina Maccalli, Julian Grünewald, Gloria Carmona, Neli Kachamakova-Trojanowska, Annarita Miccio, Francisco Martin, Giandomenico Turchiano, Toni Cathomen, Yonglun Luo, Shengdar Q Tsai, Karim Benabdellah, null null
Progress and harmonization of gene editing to treat human diseases: Proceeding of COST Action CA21113 GenE-HumDi. Molecular therapy. Nucleic acids 34 (2023)
Yilin Guo, Shiqi Yan, Wenling Zhang
Translatomics to explore dynamic differences in immunocytes in the tumor microenvironment. Molecular therapy. Nucleic acids 34 (2023)
Hongbo Zhang, Hongdan Wang, Youcai An, Ze Chen
Construction and application of adenoviral vectors. Molecular therapy. Nucleic acids 34 (2023)
Rohin Ramchandani, Nike Bharucha, Ioannis Karakikes
Precision unleashed: tackling DNA mismatch repair for enhanced prime editing. Molecular therapy. Nucleic acids 34 (2023)
Anna Jeong, Yongwoon Lim, Taewon Kook, Duk-Hwa Kwon, Young Kuk Cho, Juhee Ryu, Yun-Gyeong Lee, Sera Shin, Nakwon Choe, Yong Sook Kim, Hye Jung Cho, Jeong Chul Kim, Yoonjoo Choi, Su-Jin Lee, Hyung-Seok Kim, Hae Jin Kee, Kwang-Il Nam, Youngkeun Ahn, Myung Ho Jeong, Woo Jin Park, Young-Kook Kim, Hyun Kook
Circular RNA circSMAD4 regulates cardiac fibrosis by targeting miR-671-5p and FGFR2 in cardiac fibroblasts. Molecular therapy. Nucleic acids 34 (2023)
Cheng Cheng, Yan Wu, Tian Xiao, Junchao Xue, Jing Sun, Haibo Xia, Huimin Ma, Lu Lu, Junjie Li, Aimin Shi, Tao Bian, Qizhan Liu
Retraction Notice to: METTL3-mediated m 6 A modification of ZBTB4 mRNA is involved in the smoking-induced EMT in cancer of the lung. Molecular therapy. Nucleic acids 34 (2023)
Sadia Mohsin, Hong Wang, Mohsin Khan
Inflammation attenuating lncRNAs in diabetic cardiomyopathy. Molecular therapy. Nucleic acids 34 (2023)
Kai Cheng, Cao Li, Jiachuan Jin, Xuezhen Qian, Jiayin Guo, Limini Shen, YiChen Dai, Xue Zhang, Zhanwei Li, Yichun Guan, Fei Zhou, Jin Tang, Jun Zhang, Bin Shen, Xin Lou
Engineering RsDddA as mitochondrial base editor with wide target compatibility and enhanced activity. Molecular therapy. Nucleic acids 34 (2023)
Beilei Lei, Linda B Liu, Lauren Stokes, Paloma H Giangrande, Francis J Miller, Saami K Yazdani
Smooth muscle cell-targeted RNA ligand promotes accelerated reendothelialization in a swine peripheral injury model. Molecular therapy. Nucleic acids 34 (2023)