Alfred C O Vertegaal

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 24

Top Venues

Nature communications

Cells

Proceedings of the National Academy of Sciences of the United States of America

Science signaling

Leiden University

Universiteit Leiden (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Leiden University Feb 01 2019

Netherlands

Professor :: Cell and Chemical Biology

Universiteit Leiden - Jan 31 2019

Netherlands

Associate Professor :: Molecular Cell Biology

Universiteit Leiden

Netherlands

Assistant Professor :: Molecular Cell Biology

Universiteit Leiden

Netherlands

Senior Scientist :: Molecular Cell Biology

Wellcome Trust Biocentre

United Kingdom

Postdoctoral Fellow

Education History

Universiteit Leiden

Netherlands

PHD

Publications

Daniel Salas-Lloret, Néstor García-Rodríguez, Emily Soto-Hidalgo, Lourdes González-Vinceiro, Carmen Espejo-Serrano, Lisanne Giebel, María Luisa Mateos-Martín, Arnoud H de Ru, Peter A van Veelen, Pablo Huertas, Alfred C O Vertegaal, Román González-Prieto
BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis. Nature communications 15 (1) (2024)
Daniel Salas-Lloret, Néstor García-Rodríguez, Emily Soto-Hidalgo, Lourdes González-Vinceiro, Carmen Espejo-Serrano, Lisanne Giebel, María Luisa Mateos-Martín, Arnoud H de Ru, Peter A van Veelen, Pablo Huertas, Alfred C O Vertegaal, Román González-Prieto
BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis. Nature communications 15 (1) (2024)
Daniel Salas-Lloret, Néstor García-Rodríguez, Emily Soto-Hidalgo, Lourdes González-Vinceiro, Carmen Espejo-Serrano, Lisanne Giebel, María Luisa Mateos-Martín, Arnoud H de Ru, Peter A van Veelen, Pablo Huertas, Alfred C O Vertegaal, Román González-Prieto
BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis. Nature communications 15 (1) (2024)
Daniel Salas-Lloret, Néstor García-Rodríguez, Emily Soto-Hidalgo, Lourdes González-Vinceiro, Carmen Espejo-Serrano, Lisanne Giebel, María Luisa Mateos-Martín, Arnoud H de Ru, Peter A van Veelen, Pablo Huertas, Alfred C O Vertegaal, Román González-Prieto
BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis. Nature communications 15 (1) (2024)
Daniel Salas-Lloret, Nicolette S Jansen, Easa Nagamalleswari, Coen van der Meulen, Ekaterina Gracheva, Arnoud H de Ru, H Anne Marie Otte, Peter A van Veelen, Andrea Pichler, Joachim Goedhart, Alfred C O Vertegaal, Román González-Prieto
SUMO-activated target traps (SATTs) enable the identification of a comprehensive E3-specific SUMO proteome. Science advances 9 (31) (2023)
Diana van den Heuvel, Mihyun Kim, Annelotte P Wondergem, Paula J van der Meer, Myrèse Witkamp, Ferdy Lambregtse, Hyun-Suk Kim, Folkert Kan, Katja Apelt, Angela Kragten, Román González-Prieto, Alfred C O Vertegaal, Jung-Eun Yeo, Byung-Gyu Kim, Remco van Doorn, Orlando D Schärer, Martijn S Luijsterburg
A disease-associated XPA allele interferes with TFIIH binding and primarily affects transcription-coupled nucleotide excision repair. Proceedings of the National Academy of Sciences of the United States of America 120 (11) (2023)
Chuannan Fan, Román González-Prieto, Thomas B Kuipers, Alfred C O Vertegaal, Peter A van Veelen, Hailiang Mei, Peter Ten Dijke
The lncRNA LETS1 promotes TGF-β-induced EMT and cancer cell migration by transcriptionally activating a TβR1-stabilizing mechanism. Science signaling 16 (790) (2023)
Nadra Samra, Nicolette S Jansen, Ilham Morani, Reli Rachel Kakun, Rinat Zaid, Tamar Paperna, Mario Garcia-Dominguez, Yuri Viner, Hilel Frankenthal, Eric S Shinwell, Igor Portnov, Doua Bakry, Adel Shalata, Mika Shapira Rootman, Dvora Kidron, Laura A Claessens, Ron A Wevers, Hanna Mandel, Alfred C O Vertegaal, Karin Weiss
Exome sequencing links the SUMO protease SENP7 with fatal arthrogryposis multiplex congenita, early respiratory failure and neutropenia. Journal of medical genetics (2023)
Laura A Claessens, Matty Verlaan-de Vries, Ilona J de Graaf, Alfred C O Vertegaal
SENP6 regulates localization and nuclear condensation of DNA damage response proteins by group deSUMOylation. Nature communications 14 (1) (2023)
Diana van den Heuvel, Mihyun Kim, Annelotte P Wondergem, Paula J van der Meer, Myrèse Witkamp, Ferdy Lambregtse, Hyun-Suk Kim, Folkert Kan, Katja Apelt, Angela Kragten, Román González-Prieto, Alfred C O Vertegaal, Jung-Eun Yeo, Byung-Gyu Kim, Remco van Doorn, Orlando D Schärer, Martijn S Luijsterburg
A disease-associated XPA allele interferes with TFIIH binding and primarily affects transcription-coupled nucleotide excision repair. Proceedings of the National Academy of Sciences of the United States of America 120 (11) (2023)
Jessie S Kroonen, Ilona J de Graaf, Sumit Kumar, Dennis F G Remst, Anne K Wouters, Mirjam H M Heemskerk, Alfred C O Vertegaal
Inhibition of SUMOylation enhances DNA hypomethylating drug efficacy to reduce outgrowth of hematopoietic malignancies. Leukemia (2023)
Bharath Sampadi, Sylvia Vermeulen, Branislav Mišovic, Jan J Boei, Tanveer S Batth, Jer-Gung Chang, Michelle T Paulsen, Brian Magnuson, Joost Schimmel, Hanneke Kool, Cyriel Sebastiaan Olie, Bart Everts, Alfred C O Vertegaal, Jesper V Olsen, Mats Ljungman, Penelope A Jeggo, Leon H F Mullenders, Harry Vrieling
Divergent Molecular and Cellular Responses to Low and High-Dose Ionizing Radiation. Cells 11 (23) (2022)
Alfred C O Vertegaal
Signalling mechanisms and cellular functions of SUMO. Nature reviews. Molecular cell biology 23 (11) (2022)
Sumit Kumar, Mark J A Schoonderwoerd, Jessie S Kroonen, Ilona J de Graaf, Marjolein Sluijter, Dina Ruano, Román González-Prieto, Matty Verlaan-de Vries, Jasper Rip, Ramon Arens, Noel F C C de Miranda, Lukas J A C Hawinkels, Thorbald van Hall, Alfred C O Vertegaal
Targeting pancreatic cancer by TAK-981: a SUMOylation inhibitor that activates the immune system and blocks cancer cell cycle progression in a preclinical model. Gut 71 (11) (2022)
Bharath Sampadi, Sylvia Vermeulen, Branislav Mišovic, Jan J Boei, Tanveer S Batth, Jer-Gung Chang, Michelle T Paulsen, Brian Magnuson, Joost Schimmel, Hanneke Kool, Cyriel Sebastiaan Olie, Bart Everts, Alfred C O Vertegaal, Jesper V Olsen, Mats Ljungman, Penelope A Jeggo, Leon H F Mullenders, Harry Vrieling
Divergent Molecular and Cellular Responses to Low and High-Dose Ionizing Radiation. Cells 11 (23) (2022)
Fredrik Trulsson, Vyacheslav Akimov, Mihaela Robu, Nila van Overbeek, David Aureliano Pérez Berrocal, Rashmi G Shah, Juergen Cox, Girish M Shah, Blagoy Blagoev, Alfred C O Vertegaal
Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates. Nature communications 13 (1) (2022)
Bharath Sampadi, Sylvia Vermeulen, Branislav Mišovic, Jan J Boei, Tanveer S Batth, Jer-Gung Chang, Michelle T Paulsen, Brian Magnuson, Joost Schimmel, Hanneke Kool, Cyriel Sebastiaan Olie, Bart Everts, Alfred C O Vertegaal, Jesper V Olsen, Mats Ljungman, Penelope A Jeggo, Leon H F Mullenders, Harry Vrieling
Divergent Molecular and Cellular Responses to Low and High-Dose Ionizing Radiation. Cells 11 (23) (2022)
Bharath Sampadi, Sylvia Vermeulen, Branislav Mišovic, Jan J Boei, Tanveer S Batth, Jer-Gung Chang, Michelle T Paulsen, Brian Magnuson, Joost Schimmel, Hanneke Kool, Cyriel Sebastiaan Olie, Bart Everts, Alfred C O Vertegaal, Jesper V Olsen, Mats Ljungman, Penelope A Jeggo, Leon H F Mullenders, Harry Vrieling
Divergent Molecular and Cellular Responses to Low and High-Dose Ionizing Radiation. Cells 11 (23) (2022)
Jessie S Kroonen, Alwine B Kruisselbrink, Inge H Briaire-de Bruijn, Olaejirinde O Olaofe, Judith V M G Bovée, Alfred C O Vertegaal
SUMOylation Is Associated with Aggressive Behavior in Chondrosarcoma of Bone. Cancers 13 (15) (2021)
Sabine A G Cuijpers, Edwin Willemstein, Jan G Ruppert, Daphne M van Elsland, William C Earnshaw, Alfred C O Vertegaal
Chromokinesin KIF4A teams up with stathmin 1 to regulate abscission in a SUMO-dependent manner. Journal of cell science 133 (14) (2020)
Frauke Liebelt, Nicolette S Jansen, Sumit Kumar, Ekaterina Gracheva, Laura A Claessens, Matty Verlaan-de Vries, Edwin Willemstein, Alfred C O Vertegaal
The poly-SUMO2/3 protease SENP6 enables assembly of the constitutive centromere-associated network by group deSUMOylation. Nature communications 10 (1) (2019)
Karolin Eifler, Sabine A G Cuijpers, Edwin Willemstein, Jonne A Raaijmakers, Dris El Atmioui, Huib Ovaa, René H Medema, Alfred C O Vertegaal
SUMO targets the APC/C to regulate transition from metaphase to anaphase. Nature communications 9 (1) (2018)
Ramesh Kumar, Román González-Prieto, Zhenyu Xiao, Matty Verlaan-de Vries, Alfred C O Vertegaal
The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Nature communications 8 (1) (2017)
Ivo A Hendriks, Alfred C O Vertegaal
A high-yield double-purification proteomics strategy for the identification of SUMO sites. Nature protocols 11 (9) (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Alfred C O Vertegaal