Andrew J Murphy (A J Murphy, Andrew Murphy)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 49

Top Topics

High Fat Diet Induced

Immune Response

Renal Cell Carcinoma

Top Venues

Communications biology

Science translational medicine

Nature communications

Science immunology

This page only lists publications with an associated author ORCID identifier.

Publications

Andrea Vecchione, Joseph C Devlin, Carley Tasker, Venkat Raman Ramnarayan, Paul Haase, Eva Conde, Devin Srivastava, Gurinder S Atwal, Pierre Bruhns, Andrew J Murphy, Matthew A Sleeman, Andre Limnander, Wei Keat Lim, Seblewongel Asrat, Jamie M Orengo
IgE plasma cells are transcriptionally and functionally distinct from other isotypes. Science immunology 9 (99) (2024)
Michael E Dunn, Aaron Kithcart, Jee Hae Kim, Andre Jo-Hao Ho, Matthew C Franklin, Annabel Romero Hernandez, Jan de Hoon, Wouter Botermans, Jonathan Meyer, Ximei Jin, Dongqin Zhang, Justin Torello, Daniel Jasewicz, Vishal Kamat, Elena Garnova, Nina Liu, Michael Rosconi, Hao Pan, Satyajit Karnik, Michael E Burczynski, Wenjun Zheng, Ashique Rafique, Jonas B Nielsen, Tanima De, Niek Verweij, Anita Pandit, Adam E Locke, Naga Chalasani, Olle Melander, Tae-Hwi Schwantes-An, null null, Aris Baras, Luca A Lotta, Bret J Musser, Jason Mastaitis, Kishor B Devalaraja-Narashimha, Andrew J Rankin, Tammy Huang, Gary Herman, William Olson, Andrew J Murphy, George D Yancopoulos, Benjamin A Olenchock, Lori Morton
Agonist antibody to guanylate cyclase receptor NPR1 regulates vascular tone. Nature (2024)
Yi Zhou, Panayiotis E Stevis, Jing Cao, Kei Saotome, Jiaxi Wu, Arielle Glatman Zaretsky, Sokol Haxhinasto, George D Yancopoulos, Andrew J Murphy, Mark W Sleeman, William C Olson, Matthew C Franklin
Structural insights into the assembly of gp130 family cytokine signaling complexes. Science advances 9 (11) (2023)
Wen Lin, Varan Singh, Raynel Springer, Gabrielle Choonoo, Namita Gupta, Aditi Patel, Davor Frleta, Jun Zhong, Tomasz Owczarek, Corinne Decker, Lynn Macdonald, Andrew J Murphy, Gavin Thurston, Markus Mohrs, Ella Ioffe, Yi-Fen Lu
Human CD4 cytotoxic T lymphocytes mediate potent tumor control in humanized immune system mice. Communications biology 6 (1) (2023)
Andre Limnander, Navneet Kaur, Seblewongel Asrat, Carley Tasker, Anita Boyapati, Li-Hong Ben, John Janczy, Paulina Pedraza, Pablo Abreu, Wen-Chi Chen, Stephen Godin, Benjamin J Daniel, Harvey Chin, Michelle DeVeaux, Karen Rodriguez Lorenc, Andres Sirulnik, Olivier Harari, Neil Stahl, Matthew A Sleeman, Andrew J Murphy, George D Yancopoulos, Jamie M Orengo
A therapeutic strategy to target distinct sources of IgE and durably reverse allergy. Science translational medicine 15 (726) (2023)
Wen Lin, Varan Singh, Raynel Springer, Gabrielle Choonoo, Namita Gupta, Aditi Patel, Davor Frleta, Jun Zhong, Tomasz Owczarek, Corinne Decker, Lynn Macdonald, Andrew J Murphy, Gavin Thurston, Markus Mohrs, Ella Ioffe, Yi-Fen Lu
Human CD4 cytotoxic T lymphocytes mediate potent tumor control in humanized immune system mice. Communications biology 6 (1) (2023)
Marisa Carbonaro, Kehui Wang, Hui Huang, Davor Frleta, Aditi Patel, Alexander Pennington, Mathieu Desclaux, Sven Moller-Tank, Justin Grindley, Judith Altarejos, Jun Zhong, Greg Polites, William T Poueymirou, Stephen Jaspers, Christos A Kyratsous, Brian Zambrowicz, Andrew J Murphy, John C Lin, Lynn E Macdonald, Christopher Daly, Mark W Sleeman, Gavin Thurston, Zhe Li
IL-6-GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models. Science advances 9 (15) (2023)
Kei Saotome, Drew Dudgeon, Kiersten Colotti, Michael J Moore, Jennifer Jones, Yi Zhou, Ashique Rafique, George D Yancopoulos, Andrew J Murphy, John C Lin, William C Olson, Matthew C Franklin
Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM. Nature communications 14 (1) (2023)
Yi Zhou, Panayiotis E Stevis, Jing Cao, Kei Saotome, Jiaxi Wu, Arielle Glatman Zaretsky, Sokol Haxhinasto, George D Yancopoulos, Andrew J Murphy, Mark W Sleeman, William C Olson, Matthew C Franklin
Structural insights into the assembly of gp130 family cytokine signaling complexes. Science advances 9 (11) (2023)
A K Patel, Ankur Dhanik, Wei Keat Lim, Christina Adler, Min Ni, Yi Wei, Maggie Zhong, Cindy Nguyen, Jun Zhong, Yi-Fen Lu, Gavin Thurston, Lynn Macdonald, Andrew J Murphy, Cagan Gurer, Davor Frleta
Spontaneous tumor regression mediated by human T cells in a humanized immune system mouse model. Communications biology 6 (1) (2023)
A K Patel, Ankur Dhanik, Wei Keat Lim, Christina Adler, Min Ni, Yi Wei, Maggie Zhong, Cindy Nguyen, Jun Zhong, Yi-Fen Lu, Gavin Thurston, Lynn Macdonald, Andrew J Murphy, Cagan Gurer, Davor Frleta
Spontaneous tumor regression mediated by human T cells in a humanized immune system mouse model. Communications biology 6 (1) (2023)
A K Patel, Ankur Dhanik, Wei Keat Lim, Christina Adler, Min Ni, Yi Wei, Maggie Zhong, Cindy Nguyen, Jun Zhong, Yi-Fen Lu, Gavin Thurston, Lynn Macdonald, Andrew J Murphy, Cagan Gurer, Davor Frleta
Spontaneous tumor regression mediated by human T cells in a humanized immune system mouse model. Communications biology 6 (1) (2023)
A K Patel, Ankur Dhanik, Wei Keat Lim, Christina Adler, Min Ni, Yi Wei, Maggie Zhong, Cindy Nguyen, Jun Zhong, Yi-Fen Lu, Gavin Thurston, Lynn Macdonald, Andrew J Murphy, Cagan Gurer, Davor Frleta
Spontaneous tumor regression mediated by human T cells in a humanized immune system mouse model. Communications biology 6 (1) (2023)
Kei Saotome, Drew Dudgeon, Kiersten Colotti, Michael J Moore, Jennifer Jones, Yi Zhou, Ashique Rafique, George D Yancopoulos, Andrew J Murphy, John C Lin, William C Olson, Matthew C Franklin
Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM. Nature communications 14 (1) (2023)
Yi Zhou, Panayiotis E Stevis, Jing Cao, Kei Saotome, Jiaxi Wu, Arielle Glatman Zaretsky, Sokol Haxhinasto, George D Yancopoulos, Andrew J Murphy, Mark W Sleeman, William C Olson, Matthew C Franklin
Structural insights into the assembly of gp130 family cytokine signaling complexes. Science advances 9 (11) (2023)
Audrey Le Floc'h, Kirsten Nagashima, Dylan Birchard, George Scott, Li-Hong Ben, Dharani K Ajithdoss, Kaitlyn M Gayvert, Annabel Romero Hernandez, Olivier Herbin, Amanda Tay, Pamela Farrales, Chandrashekhar K Korgaonkar, Hao Pan, Sweta Shah, Vishal Kamat, Ishita Chatterjee, Jon Popke, Adelekan Oyejide, Wei Keat Lim, Jee H Kim, Tammy Huang, Matthew C Franklin, William C Olson, Thomas Norton, Lorah Perlee, George D Yancopoulos, Andrew J Murphy, Matthew A Sleeman, Jamie M Orengo
Blocking common γ chain cytokine signaling ameliorates T cell-mediated pathogenesis in disease models. Science translational medicine 15 (678) (2023)
A K Patel, Ankur Dhanik, Wei Keat Lim, Christina Adler, Min Ni, Yi Wei, Maggie Zhong, Cindy Nguyen, Jun Zhong, Yi-Fen Lu, Gavin Thurston, Lynn Macdonald, Andrew J Murphy, Cagan Gurer, Davor Frleta
Spontaneous tumor regression mediated by human T cells in a humanized immune system mouse model. Communications biology 6 (1) (2023)
A K Patel, Ankur Dhanik, Wei Keat Lim, Christina Adler, Min Ni, Yi Wei, Maggie Zhong, Cindy Nguyen, Jun Zhong, Yi-Fen Lu, Gavin Thurston, Lynn Macdonald, Andrew J Murphy, Cagan Gurer, Davor Frleta
Spontaneous tumor regression mediated by human T cells in a humanized immune system mouse model. Communications biology 6 (1) (2023)
Kei Saotome, Drew Dudgeon, Kiersten Colotti, Michael J Moore, Jennifer Jones, Yi Zhou, Ashique Rafique, George D Yancopoulos, Andrew J Murphy, John C Lin, William C Olson, Matthew C Franklin
Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM. Nature communications 14 (1) (2023)
Audrey Le Floc'h, Kirsten Nagashima, Dylan Birchard, George Scott, Li-Hong Ben, Dharani K Ajithdoss, Kaitlyn M Gayvert, Annabel Romero Hernandez, Olivier Herbin, Amanda Tay, Pamela Farrales, Chandrashekhar K Korgaonkar, Hao Pan, Sweta Shah, Vishal Kamat, Ishita Chatterjee, Jon Popke, Adelekan Oyejide, Wei Keat Lim, Jee H Kim, Tammy Huang, Matthew C Franklin, William C Olson, Thomas Norton, Lorah Perlee, George D Yancopoulos, Andrew J Murphy, Matthew A Sleeman, Jamie M Orengo
Blocking common γ chain cytokine signaling ameliorates T cell-mediated pathogenesis in disease models. Science translational medicine 15 (678) (2023)
Judith Y Altarejos, Jeffrey Pangilinan, Simona Podgrabinska, Barış Akıncı, Maria Cristina Foss de Freitas, Adam H Neidert, Yonaton Ray, Wenjun Zheng, Steven Kim, Vishal Kamat, Meilin Huang, Soo Min, Jason Mastaitis, Giselle Dominguez-Gutierrez, Jee-Hae Kim, Panayiotis Stevis, Tammy Huang, Brian Zambrowicz, William C Olson, Stephen Godin, Elizabeth Bradley, Andrew D Gewitz, Mark Baker, Rita Hench, Matthew S Davenport, Thomas L Chenevert, Frank DiPaola, George D Yancopoulos, Andrew J Murphy, Gary A Herman, Bret J Musser, Hayes Dansky, Joyce Harp, Jesper Gromada, Mark W Sleeman, Elif Arioglu Oral, Benjamin A Olenchock
Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency. Science translational medicine 15 (723) (2023)
Audrey Le Floc'h, Kirsten Nagashima, Dylan Birchard, George Scott, Li-Hong Ben, Dharani K Ajithdoss, Kaitlyn M Gayvert, Annabel Romero Hernandez, Olivier Herbin, Amanda Tay, Pamela Farrales, Chandrashekhar K Korgaonkar, Hao Pan, Sweta Shah, Vishal Kamat, Ishita Chatterjee, Jon Popke, Adelekan Oyejide, Wei Keat Lim, Jee H Kim, Tammy Huang, Matthew C Franklin, William C Olson, Thomas Norton, Lorah Perlee, George D Yancopoulos, Andrew J Murphy, Matthew A Sleeman, Jamie M Orengo
Blocking common γ chain cytokine signaling ameliorates T cell-mediated pathogenesis in disease models. Science translational medicine 15 (678) (2023)
A K Patel, Ankur Dhanik, Wei Keat Lim, Christina Adler, Min Ni, Yi Wei, Maggie Zhong, Cindy Nguyen, Jun Zhong, Yi-Fen Lu, Gavin Thurston, Lynn Macdonald, Andrew J Murphy, Cagan Gurer, Davor Frleta
Spontaneous tumor regression mediated by human T cells in a humanized immune system mouse model. Communications biology 6 (1) (2023)
Yi Zhou, Panayiotis E Stevis, Jing Cao, Kei Saotome, Jiaxi Wu, Arielle Glatman Zaretsky, Sokol Haxhinasto, George D Yancopoulos, Andrew J Murphy, Mark W Sleeman, William C Olson, Matthew C Franklin
Structural insights into the assembly of gp130 family cytokine signaling complexes. Science advances 9 (11) (2023)
Audrey Le Floc'h, Kirsten Nagashima, Dylan Birchard, George Scott, Li-Hong Ben, Dharani K Ajithdoss, Kaitlyn M Gayvert, Annabel Romero Hernandez, Olivier Herbin, Amanda Tay, Pamela Farrales, Chandrashekhar K Korgaonkar, Hao Pan, Sweta Shah, Vishal Kamat, Ishita Chatterjee, Jon Popke, Adelekan Oyejide, Wei Keat Lim, Jee H Kim, Tammy Huang, Matthew C Franklin, William C Olson, Thomas Norton, Lorah Perlee, George D Yancopoulos, Andrew J Murphy, Matthew A Sleeman, Jamie M Orengo
Blocking common γ chain cytokine signaling ameliorates T cell-mediated pathogenesis in disease models. Science translational medicine 15 (678) (2023)
Parsa Akbari, Olukayode A Sosina, Jonas Bovijn, Karl Landheer, Jonas B Nielsen, Minhee Kim, Senem Aykul, Tanima De, Mary E Haas, George Hindy, Nan Lin, Ian R Dinsmore, Jonathan Z Luo, Stefanie Hectors, Benjamin Geraghty, Mary Germino, Lampros Panagis, Prodromos Parasoglou, Johnathon R Walls, Gabor Halasz, Gurinder S Atwal, null null, null null, Marcus Jones, Michelle G LeBlanc, Christopher D Still, David J Carey, Alice Giontella, Marju Orho-Melander, Jaime Berumen-Campos, Pablo Kuri-Morales, Jesus Alegre, Jason M Torres, Jonathan R Emberson, Rory Collins, Daniel James Rader, Brian Zambrowicz, Andrew J Murphy, Suganthi Balasubramanian, John D Overton, Jeffrey G Reid, Alan R Shuldiner, Michael Cantor, Gonçalo R Abecasis, Manuel A R Ferreira, Mark W Sleeman, Viktoria Gusarova, Judith Altarejos, Charles Harris, Aris N Economides, Vincent Idone, Katia Karalis, Giusy Della Gatta, Tooraj Mirshahi, George D Yancopoulos, Olle Melander, Jonathan Marchini, Roberto Tapia-Conyer, Adam E Locke, Aris Baras, Niek Verweij, Luca A Lotta
Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes. Nature communications 13 (1) (2022)
Joyce Wei, Welby Montalvo-Ortiz, Lola Yu, Amanda Krasco, Sarah Ebstein, Czrina Cortez, Israel Lowy, Andrew J Murphy, Matthew A Sleeman, Dimitris Skokos
Sequence of αPD-1 relative to local tumor irradiation determines the induction of abscopal antitumor immune responses. Science immunology 6 (58) (2022)
Richard Tavaré, Makenzie Danton, Jason T Giurleo, Sosina Makonnen, Carlos Hickey, Tomas C Arnold, Marcus P Kelly, Fanny Fredriksson, Karina Bruestle, Aynur Hermann, Erica Ullman, Kurt H Edelmann, Terra Potocky, Drew Dudgeon, Nikunj B Bhatt, Mikhail Doubrovin, Thomas Barry, Christos A Kyratsous, Cagan Gurer, Naxin Tu, Hans Gartner, Andrew J Murphy, Lynn E Macdonald, Jon Popke, Akiva Mintz, Adam Griesemer, William C Olson, Gavin Thurston, Dangshe Ma, Jessica R Kirshner
Immuno-PET Monitoring of Lymphocytes Using the CD8-Specific Antibody REGN5054. Cancer immunology research 10 (10) (2022)
Nikos Kourtis, Qingqing Wang, Bei Wang, Erin Oswald, Christina Adler, Samvitha Cherravuru, Evangelia Malahias, Lance Zhang, Jacquelynn Golubov, Qiaozhi Wei, Samantha Lemus, Min Ni, Yueming Ding, Yi Wei, Gurinder S Atwal, Gavin Thurston, Lynn E Macdonald, Andrew J Murphy, Ankur Dhanik, Matthew A Sleeman, Scott S Tykodi, Dimitris Skokos
A single-cell map of dynamic chromatin landscapes of immune cells in renal cell carcinoma. Nature cancer 3 (7) (2022)
Joyce Wei, Welby Montalvo-Ortiz, Lola Yu, Amanda Krasco, Kara Olson, Sahar Rizvi, Nathalie Fiaschi, Sandra Coetzee, Fang Wang, Erica Ullman, Hassan Shakil Ahmed, Evan Herlihy, Ken-Wing Lee, Lauren Havel, Terra Potocky, Sarah Ebstein, Davor Frleta, Aditi Patel, Stephen Godin, Sara Hamon, Jurriaan Brouwer-Visser, Travis Gorenc, Douglas MacDonald, Aynur Hermann, Aafia Chaudhry, Andres Sirulnik, William C Olson, John Lin, Gavin Thurston, Israel Lowy, Andrew J Murphy, Eric Smith, Vladimir Jankovic, Matthew A Sleeman, Dimitris Skokos
CD22-targeted CD28 bispecific antibody enhances antitumor efficacy of odronextamab in refractory diffuse large B cell lymphoma models. Science translational medicine 14 (670) (2022)
Zaruhi Hovhannisyan, Nengyin Liu, Sara Khalil-Aguero, Casandra Panea, Jeffrey VanValkenburgh, Ruoyu Zhang, Wei Keat Lim, Yu Bai, Wen Fury, Tammy Huang, Elena Garnova, Jeanette Fairhurst, Jee Kim, Smita Aryal, Dharani K Ajithdoss, Adelekan Oyejide, Maria Del Pilar Molina-Portela, Hock E, William T Poueymirou, Nicole Stokes Oristian, Susannah Brydges, Xia Liu, William C Olson, George Yancopoulos, Andrew J Murphy, Matthew A Sleeman, Sokol Haxhinasto
Enhanced IL-36R signaling promotes barrier impairment and inflammation in skin and intestine. Science immunology 5 (54) (2021)
Michael J Moore, Maggie Zhong, Johanna Hansen, Hans Gartner, Craig Grant, Mei Huang, Faith M Harris, Naxin Tu, Natalie A Bowerman, Kurt H Edelmann, Thomas Barry, Olivier Herbin, Chin-Siean Tay, David J DiLillo, Corinne E Decker, Natasha Levenkova, James Shevchuk, Ankur Dhanik, Karoline A Meagher, Amanda Tay, Jan Roos, Wen-Yi Lee, David Suh, Mark Eckersdorff, T Craig Meagher, Matthew Koss, Lakeisha Esau, Matthew A Sleeman, Robert Babb, Gang Chen, Christos A Kyratsous, William T Poueymirou, John R McWhirter, Vera A Voronina, Chunguang Guo, Cagan Gurer, George D Yancopoulos, Andrew J Murphy, Lynn E Macdonald
Humanization of T cell-mediated immunity in mice. Science immunology 6 (66) (2021)
Janelle C Waite, Bei Wang, Lauric Haber, Aynur Hermann, Erica Ullman, Xuan Ye, Drew Dudgeon, Rabih Slim, Dharani K Ajithdoss, Stephen J Godin, Ilyssa Ramos, Qi Wu, Erin Oswald, Patrick Poon, Jacquelynn Golubov, Devon Grote, Jennifer Stella, Arpita Pawashe, Jennifer Finney, Evan Herlihy, Hassan Shakil Ahmed, Vishal Kamat, Amanda Dorvilliers, Elizabeth Navarro, Jenny Xiao, Julie Kim, Shao Ning Yang, Jacqueline Warsaw, Clarissa Lett, Lauren Canova, Teresa Schulenburg, Randi Foster, Pamela Krueger, Elena Garnova, Ashique Rafique, Robert Babb, Gang Chen, Nicole Stokes Oristian, Chia-Jen Siao, Christopher Daly, Cagan Gurer, Joel Martin, Lynn E Macdonald, Douglas MacDonald, William T Poueymirou, Eric Smith, Israel Lowy, Gavin Thurston, William C Olson, John C Lin, Matthew A Sleeman, George D Yancopoulos, Andrew J Murphy, Dimitris Skokos
Tumor-targeted CD28 bispecific antibodies enhance the antitumor efficacy of PD-1 immunotherapy. Science translational medicine 12 (549) (2021)
Parsa Akbari, Ankit Gilani, Olukayode A Sosina, Jack A Kosmicki, Lori Khrimian, Yi-Ya Fang, Trikaldarshi Persaud, Victor Garcia, Dylan Sun, Alexander H Li, Joelle Mbatchou, Adam E Locke, Christian Benner, Niek Verweij, Nan Lin, Sakib Hossain, Kevin Agostinucci, Jonathan V Pascale, Ercument Dirice, Michael Dunn, null null, null null, William E Kraus, Svati H Shah, Yii-Der I Chen, Jerome I Rotter, Daniel James Rader, Olle Melander, Christopher D Still, Tooraj Mirshahi, David J Carey, Jaime Berumen-Campos, Pablo Kuri-Morales, Jesus Alegre, Jason M Torres, Jonathan R Emberson, Rory Collins, Suganthi Balasubramanian, Alicia Hawes, Marcus Jones, Brian Zambrowicz, Andrew J Murphy, Charles Paulding, Giovanni Coppola, John D Overton, Jeffrey G Reid, Alan R Shuldiner, Michael Cantor, Hyun-Min Kang, Goncalo R Abecasis, Katia Karalis, Aris N Economides, Jonathan Marchini, George D Yancopoulos, Mark W Sleeman, Judith Altarejos, Giusy Della Gatta, Roberto Tapia-Conyer, Michal L Schwartzman, Aris Baras, Manuel A R Ferreira, Luca A Lotta
Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity. Science (New York, N.Y.) 373 (6550) (2021)
Dimitris Skokos, Janelle C Waite, Lauric Haber, Alison Crawford, Aynur Hermann, Erica Ullman, Rabih Slim, Stephen Godin, Dharani Ajithdoss, Xuan Ye, Bei Wang, Qi Wu, Ilyssa Ramos, Arpita Pawashe, Lauren Canova, Kristin Vazzana, Priyanka Ram, Evan Herlihy, Hassan Shakil Ahmed, Erin Oswald, Jacquelynn Golubov, Patrick Poon, Lauren Havel, Danica Chiu, Miguel Lazo, Kathleen Provoncha, Kevin Yu, Julie Kim, Jacqueline J Warsaw, Nicole Stokes Oristian, Chia-Jen Siao, Drew Dudgeon, Tammy Huang, Terra Potocky, Joel Martin, Douglas MacDonald, Adelekan Oyejide, Ashique Rafique, William T Poueymirou, Jessica R Kirshner, Eric Smith, William C Olson, John Lin, Gavin Thurston, Matthew A Sleeman, Andrew J Murphy, George D Yancopoulos
A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies. Science translational medicine 12 (525) (2021)
Casandra Panea, Ruoyu Zhang, Jeffrey VanValkenburgh, Min Ni, Christina Adler, Yi Wei, Francisca Ochoa, Jennifer Schmahl, Yajun Tang, Chia-Jen Siao, William Poueymirou, Jennifer Espert, Wei Keat Lim, Gurinder S Atwal, Andrew J Murphy, Matthew A Sleeman, Zaruhi Hovhannisyan, Sokol Haxhinasto
Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes. Communications biology 4 (1) (2021)
Johanna Hansen, Alina Baum, Kristen E Pascal, Vincenzo Russo, Stephanie Giordano, Elzbieta Wloga, Benjamin O Fulton, Ying Yan, Katrina Koon, Krunal Patel, Kyung Min Chung, Aynur Hermann, Erica Ullman, Jonathan Cruz, Ashique Rafique, Tammy Huang, Jeanette Fairhurst, Christen Libertiny, Marine Malbec, Wen-Yi Lee, Richard Welsh, Glen Farr, Seth Pennington, Dipali Deshpande, Jemmie Cheng, Anke Watty, Pascal Bouffard, Robert Babb, Natasha Levenkova, Calvin Chen, Bojie Zhang, Annabel Romero Hernandez, Kei Saotome, Yi Zhou, Matthew C Franklin, Sumathi Sivapalasingam, David Chien Lye, Stuart M Weston, James P Logue, Robert E Haupt, Matthew Frieman, Gang Chen, William C Olson, Andrew J Murphy, Neil Stahl, George D Yancopoulos, Christos A Kyratsous
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail. Science (New York, N.Y.) 369 (6506) (2020)
Seblewongel Asrat, Navneet Kaur, Xia Liu, Li-Hong Ben, Daisuke Kajimura, Andrew J Murphy, Matthew A Sleeman, Andre Limnander, Jamie M Orengo
Chronic allergen exposure drives accumulation of long-lived IgE plasma cells in the bone marrow, giving rise to serological memory. Science immunology 5 (43) (2020)
Senem Aykul, Richard A Corpina, Erich J Goebel, Camille J Cunanan, Alexandra Dimitriou, Hyon Jong Kim, Qian Zhang, Ashique Rafique, Raymond Leidich, Xin Wang, Joyce McClain, Johanna Jimenez, Kalyan C Nannuru, Nyanza J Rothman, John B Lees-Shepard, Erik Martinez-Hackert, Andrew J Murphy, Thomas B Thompson, Aris N Economides, Vincent Idone
Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop. eLife 9 (2020)
Alina Baum, Dharani K Ajithdoss, Richard Copin, Anbo Zhou, Kathryn Lanza, Nicole Negron, Min Ni, Yi Wei, Kusha A Mohammadi, Bret J Musser, Gurinder S Atwal, Adelekan Oyejide, Yenny Goez-Gazi, John W Dutton, Elizabeth A Clemmons, Hilary M Staples, Carmen Bartley, Benjamin Klaffke, Kendra J Alfson, Michal Gazi, Olga Gonzalez, Edward J Dick, Ricardo Carrion, Laurent Pessiant, Maciel Porto, Anthony Cook, Renita Brown, Vaneesha Ali, Jack Greenhouse, Tammy Taylor, Hanne A Elyard, Mark G Lewis, Neil Stahl, Andrew J Murphy, George D Yancopoulos, Christos A Kyratsous
REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters. Science (New York, N.Y.) 370 (6520) (2020)
Asiel A Benitez, Sara Khalil-Agüero, Anjali Nandakumar, Namita T Gupta, Wen Zhang, Gurinder S Atwal, Andrew J Murphy, Matthew A Sleeman, Sokol Haxhinasto
Absence of central tolerance in Aire-deficient mice synergizes with immune-checkpoint inhibition to enhance antitumor responses. Communications biology 3 (1) (2020)
Alina Baum, Benjamin O Fulton, Elzbieta Wloga, Richard Copin, Kristen E Pascal, Vincenzo Russo, Stephanie Giordano, Kathryn Lanza, Nicole Negron, Min Ni, Yi Wei, Gurinder S Atwal, Andrew J Murphy, Neil Stahl, George D Yancopoulos, Christos A Kyratsous
Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies. Science (New York, N.Y.) 369 (6506) (2020)
Héloïse Beutier, Béatrice Hechler, Ophélie Godon, Yu Wang, Caitlin M Gillis, Luc de Chaisemartin, Aurélie Gouel-Chéron, Stéphanie Magnenat, Lynn E Macdonald, Andrew J Murphy, null null, Sylvie Chollet-Martin, Dan Longrois, Christian Gachet, Pierre Bruhns, Friederike Jönsson
Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis. Science immunology 3 (22) (2019)
Jonathan W Cruz, Ermelinda Damko, Bhavika Modi, Naxin Tu, Karoline Meagher, Vera A Voronina, Hans Gartner, George Ehrlich, Ashique Rafique, Robert Babb, Priya Aneja, Terra B Potocky, Amanda D' Orvilliers, Alida Coppi, Sook Yen E, Haibo Qiu, Courtney M Williams, Brandy L Bennett, Gang Chen, Lynn Macdonald, William Olson, John C Lin, Neil Stahl, Andrew J Murphy, Christos A Kyratsous, Brinda C Prasad
A novel bispecific antibody platform to direct complement activity for efficient lysis of target cells. Scientific reports 9 (1) (2019)
Bei Wang, Wen Zhang, Vladimir Jankovic, Jacquelynn Golubov, Patrick Poon, Erin M Oswald, Cagan Gurer, Joyce Wei, Ilyssa Ramos, Qi Wu, Janelle C Waite, Min Ni, Christina Adler, Yi Wei, Lynn Macdonald, Tracey Rowlands, Susannah Brydges, Jean Siao, William Poueymirou, Douglas MacDonald, George D Yancopoulos, Matthew A Sleeman, Andrew J Murphy, Dimitris Skokos
Combination cancer immunotherapy targeting PD-1 and GITR can rescue CD8+ T cell dysfunction and maintain memory phenotype. Science immunology 3 (29) (2019)
Chang-Han Lee, Tae Hyun Kang, Ophélie Godon, Makiko Watanabe, George Delidakis, Caitlin M Gillis, Delphine Sterlin, David Hardy, Michel Cogné, Lynn E Macdonald, Andrew J Murphy, Naxin Tu, Jiwon Lee, Jonathan R McDaniel, Emily Makowski, Peter M Tessier, Aaron S Meyer, Pierre Bruhns, George Georgiou
An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence. Nature communications 10 (1) (2019)
Chang-Han Lee, Tae Hyun Kang, Ophélie Godon, Makiko Watanabe, George Delidakis, Caitlin M Gillis, Delphine Sterlin, David Hardy, Michel Cogné, Lynn E Macdonald, Andrew J Murphy, Naxin Tu, Jiwon Lee, Jonathan R McDaniel, Emily Makowski, Peter M Tessier, Aaron S Meyer, Pierre Bruhns, George Georgiou
Publisher Correction: An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence. Nature communications 10 (1) (2019)
Viktoria Gusarova, Colm O'Dushlaine, Tanya M Teslovich, Peter N Benotti, Tooraj Mirshahi, Omri Gottesman, Cristopher V Van Hout, Michael F Murray, Anubha Mahajan, Jonas Bille Nielsen, Lars G Fritsche, Anders Berg Wulff, Daníel F Guðbjartsson, Marketa Sjögren, Connor A Emdin, Robert A Scott, Wen-Jane Lee, Aeron Small, Lydia C Kwee, Om Prakash Dwivedi, Rashmi B Prasad, Shannon E Bruse, Alexander E Lopez, John Penn, Anthony Marcketta, Joseph B Leader, Christopher D Still, H Lester Kirchner, Uyenlinh L Mirshahi, Amr H Wardeh, Cassandra M Hartle, Lukas Habegger, Samantha N Fetterolf, Teresa Tusie-Luna, Andrew P Morris, Hilma Holm, Valgerdur Steinthorsdottir, Patrick Sulem, Unnur Thorsteinsdottir, Jerome I Rotter, Lee-Ming Chuang, Scott Damrauer, David Birtwell, Chad M Brummett, Amit V Khera, Pradeep Natarajan, Marju Orho-Melander, Jason Flannick, Luca A Lotta, Cristen J Willer, Oddgeir L Holmen, Marylyn DeRiggi Ritchie, David H Ledbetter, Andrew J Murphy, Ingrid B Borecki, Jeffrey G Reid, John D Overton, Ola Hansson, Leif C Groop, Svati H Shah, William E Kraus, Daniel J Rader, Yii-Der I Chen, Kristian Hveem, Nicholas J Wareham, Sekar Kathiresan, Olle Melander, Kari Stefansson, Børge Grønne Nordestgaard, Anne Tybjærg-Hansen, Goncalo R Abecasis, David Altshuler, Jose C Florez, Michael Boehnke, Mark I McCarthy, George D Yancopoulos, David J Carey, Alan R Shuldiner, Aris Baras, Frederick E Dewey, Jesper Gromada
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes. Nature communications 9 (1) (2018)
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