Science translational medicine

Keyphrases

Publications

volume 15, number 718, 2023

Camila Farias Amorim, Victoria M Lovins, Tej Pratap Singh, Fernanda O Novais, Jordan C Harris, Alexsandro S Lago, Lucas P Carvalho, Edgar Marcelino de Carvalho, Daniel P Beiting, Phillip Scott, Elizabeth A Grice
Multiomic profiling of cutaneous leishmaniasis infections reveals microbiota-driven mechanisms underlying disease severity. Science translational medicine 15 (718) (2023)
Sukanya Narasimhan, Durland Fish, Joao H F Pedra, Utpal Pal, Erol Fikrig
A ticking time bomb hidden in plain sight. Science translational medicine 15 (718) (2023)
David M Morens, Jaekeun Park, Jeffery K Taubenberger
Many potential pathways to future pandemic influenza. Science translational medicine 15 (718) (2023)
Rafael Kroon Campos, Shannan L Rossi, Robert B Tesh, Scott C Weaver
Zoonotic mosquito-borne arboviruses: Spillover, spillback, and realistic mitigation strategies. Science translational medicine 15 (718) (2023)
Anthony S Fauci
What keeps me up at night. Science translational medicine 15 (718) (2023)
Christabel N Hikaambo, Natalia Shakela, John G Woodland, Kathryn J Wicht, Kelly Chibale
Drug discovery in Africa tackles zoonotic and related infections. Science translational medicine 15 (718) (2023)
Amandine Gamble, Ximena A Olarte-Castillo, Gary R Whittaker
Backyard zoonoses: The roles of companion animals and peri-domestic wildlife. Science translational medicine 15 (718) (2023)
Megan B Diamond, Elizabeth Yee, Manisha Bhinge, Samuel V Scarpino
Wastewater surveillance facilitates climate change-resilient pathogen monitoring. Science translational medicine 15 (718) (2023)

volume 15, number 719, 2023

Scott M Norberg, Ke Bai, Cem Sievers, Yvette Robbins, Jay Friedman, Xinping Yang, Meg Kenyon, Elizabeth Ward, Jeffrey Schlom, James L Gulley, Amy Lankford, Roshanak Semnani, Helen Sabzevari, Douglas E Brough, Clint T Allen
The tumor microenvironment state associates with response to HPV therapeutic vaccination in patients with respiratory papillomatosis. Science translational medicine 15 (719) (2023)
Michael Wichroski, Joseph L Benci, Si-Qi Liu, Louis Chupak, Jie Fang, Carolyn Cao, Cindy Wang, Joelle Onorato, Hongchen Qiu, Yongli Shan, Dana Banas, Ryan Powles, Gregory Locke, Abigail Witt, Caitlyn Stromko, Huilin Qi, Xiaofan Zheng, Scott Martin, Min Ding, Robert Gentles, Nicholas A Meanwell, Upender Velaparthi, Richard Olson, Susan Wee, Daniel J Tenney, Christopher G Parker, Benjamin F Cravatt, Michael Lawrence, Robert Borzilleri, Emma Lees
DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity. Science translational medicine 15 (719) (2023)
Wilfried A A Saron, Keerthana Shanmugam, Chi-Ching Tung, Ranjit Kumar Patmanathan, Abhay P S Rathore, Danielle E Anderson, Ashley Lauren St John
Exacerbated Zika virus-induced neuropathology and microcephaly in fetuses of dengue-immune nonhuman primates. Science translational medicine 15 (719) (2023)
Toru Nakata, Chenhao Li, Toufic Mayassi, Helen Lin, Koushik Ghosh, Åsa Segerstolpe, Emma L Diamond, Paula Herbst, Tommaso Biancalani, Shreya Gaddam, Saurabh Parkar, Ziqing Lu, Alok Jaiswal, Bihua Li, Elizabeth A Creasey, Ariel Lefkovith, Mark J Daly, Daniel B Graham, Ramnik J Xavier
Genetic vulnerability to Crohn's disease reveals a spatially resolved epithelial restitution program. Science translational medicine 15 (719) (2023)
Gilda Moadab, Florent Pittet, Jeffrey L Bennett, Christopher L Taylor, Olivia Fiske, Anil Singapuri, Lark L Coffey, Koen K A Van Rompay, Eliza Bliss-Moreau
Prenatal Zika virus infection has sex-specific effects on infant physical development and mother-infant social interactions. Science translational medicine 15 (719) (2023)
Quin Yuhui Xie, Sean Oh, Anthony Wong, Christopher Yau, Kevan C Herold, Jayne S Danska
Immune responses to gut bacteria associated with time to diagnosis and clinical response to T cell-directed therapy for type 1 diabetes prevention. Science translational medicine 15 (719) (2023)

volume 15, number 720, 2023

Francesco Trepiccione, Anna Iervolino, Mariavittoria D'Acierno, Sabrina Siccardi, Vincenzo Costanzo, Donato Sardella, Luigi R De La Motte, Luciano D'Apolito, Antonio Miele, Alessandra Fortunata Perna, Giovanna Capolongo, Miriam Zacchia, Sebastian Frische, Rikke Nielsen, Leopoldo Staiano, Irene Sambri, Rossella De Cegli, Robert Unwin, Dominique Eladari, Giovambattista Capasso
The SGLT2 inhibitor dapagliflozin improves kidney function in glycogen storage disease XI. Science translational medicine 15 (720) (2023)
Ismail Cimen, Lucia Natarelli, Zahra Abedi Kichi, James M Henderson, Floriana Maria Farina, Eva Briem, Maria Aslani, Remco T A Megens, Yvonne Jansen, Elizabeth Mann-Fallenbuchel, Selin Gencer, Johan Duchene, Maliheh Nazari-Jahantigh, Emiel P C van der Vorst, Wolfgang Enard, Yvonne Döring, Andreas Schober, Donato Santovito, Christian Weber
Targeting a cell-specific microRNA repressor of CXCR4 ameliorates atherosclerosis in mice. Science translational medicine 15 (720) (2023)
Michael H Woodworth, Roth E Conrad, Marina Haldopoulos, Stephanie Marie Pouch, Ahmed Babiker, Aneesh K Mehta, Kaitlin L Sitchenko, Charlotte H Wang, Amanda Strudwick, Jessica M Ingersoll, Cécile Philippe, Sarah Lohsen, Kumru Kocaman, Blake G Lindner, Janet K Hatt, Rheinallt M Jones, Candace Miller, Andrew S Neish, Rachel Friedman-Moraco, Geeta M Karadkhele, Ken H Liu, Dean P Jones, Cyra Christina Mehta, Thomas R Ziegler, David S Weiss, Christian P Larsen, Konstantinos T Konstantinidis, Colleen S Kraft
Fecal microbiota transplantation promotes reduction of antimicrobial resistance by strain replacement. Science translational medicine 15 (720) (2023)
Jingbo Li, Jiao Liu, Zhuan Zhou, Runliu Wu, Xin Chen, Chunhua Yu, Brent R Stockwell, Guido Kroemer, Rui Kang, Daolin Tang
Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer. Science translational medicine 15 (720) (2023)
Minsoo Khang, Ju-Hyun Lee, Teresa Lee, Hee Won Suh, Supum Lee, Alessandra Cavaliere, Amy Rushing, Luiz Henrique Medeiros Geraldo, Erika Belitzky, Samantha Rossano, Henk M De Feyter, Kwangsoo Shin, Anita Huttner, Martine F Roussel, Jean-Léon Thomas, Richard E Carson, Bernadette Marquez-Nostra, Ranjit S Bindra, W Mark Saltzman
Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma. Science translational medicine 15 (720) (2023)

volume 15, number 721, 2023

volume 15, number 722, 2023

Zibo Meng, Aaron Rodriguez Ehrenfried, Chin Leng Tan, Laura K Steffens, Hannes Kehm, Stefan Zens, Claudia Lauenstein, Alina Paul, Marius Schwab, Jonas D Förster, Mogjiborahman Salek, Angelika Beate Riemer, Heshui Wu, Christoph Eckert, Carl-Stephan Leonhardt, Oliver Strobel, Michael Volkmar, Isabel C Poschke, Rienk Offringa
Transcriptome-based identification of tumor-reactive and bystander CD8 + T cell receptor clonotypes in human pancreatic cancer. Science translational medicine 15 (722) (2023)
Yasutaka Yamada, Varadha Balaji Venkadakrishnan, Kei Mizuno, Martin K Bakht, Sheng Yu Ku, Maria Mica Garcia, Himisha Beltran
Targeting DNA methylation and B7-H3 in RB1-deficient and neuroendocrine prostate cancer. Science translational medicine 15 (722) (2023)
Ana P Peredo, Robert L Mauck, Chet S Friday, Brianna S Orozco, Bijan Dehghani, Austin C Jenk, Edward D Bonnevie, Rachel L Hilliard, Hannah M Zlotnick, George R Dodge, Daeyeon Lee, Julie B Engiles, Michael W Hast, Thomas P Schaer, Harvey E Smith, Robert Leon Mauck
Tension-activated nanofiber patches delivering an anti-inflammatory drug improve repair in a goat intervertebral disc herniation model. Science translational medicine 15 (722) (2023)
Rosemary A Aogo, Jose Victor Zambrana, Nery Sanchez, Sergio Ojeda, Guillermina Kuan, Angel Balmaseda, Aubree Gordon, Eva Harris, Leah C Katzelnick
Effects of boosting and waning in highly exposed populations on dengue epidemic dynamics. Science translational medicine 15 (722) (2023)
Shuaiya Ma, Ye Tian, Jiali Peng, Chaojia Chen, Xueqi Peng, Fabao Zhao, Zhenyu Li, Mengzhen Li, Fangcheng Zhao, Xue Sheng, Runzhe Zong, Yiquan Li, Jiwei Zhang, Mingyan Yu, Qingfen Zhu, Xiaoyu Tian, Yuyang Li, Markus R Neckenig, Huiqing Liu, Peng Zhan, Xuetian Yue, Zhuanchang Wu, Lifen Gao, Xiaohong Liang, Xinyong Liu, Chunyang Li, Chunhong Ma
Identification of a small-molecule Tim-3 inhibitor to potentiate T cell-mediated antitumor immunotherapy in preclinical mouse models. Science translational medicine 15 (722) (2023)
Zemin Ling, Janet L Crane, Hao Hu, Yan Chen, Mei Wan, Shuangfei Ni, Shadpour Demehri, Bahram Mohajer, Xinsheng Peng, Xuenong Zou, Guangzhi Ning
Parathyroid hormone treatment partially reverses endplate remodeling and attenuates low back pain in animal models of spine degeneration. Science translational medicine 15 (722) (2023)

volume 15, number 723, 2023

Matthias H Tschöp, Jeffrey M Friedman
Seeking satiety: From signals to solutions. Science translational medicine 15 (723) (2023)
Judith Y Altarejos, Jeffrey Pangilinan, Simona Podgrabinska, Barış Akıncı, Maria Cristina Foss de Freitas, Adam H Neidert, Yonaton Ray, Wenjun Zheng, Steven Kim, Vishal Kamat, Meilin Huang, Soo Min, Jason Mastaitis, Giselle Dominguez-Gutierrez, Jee-Hae Kim, Panayiotis Stevis, Tammy Huang, Brian Zambrowicz, William C Olson, Stephen Godin, Elizabeth Bradley, Andrew D Gewitz, Mark Baker, Rita Hench, Matthew S Davenport, Thomas L Chenevert, Frank DiPaola, George D Yancopoulos, Andrew J Murphy, Gary A Herman, Bret J Musser, Hayes Dansky, Joyce Harp, Jesper Gromada, Mark W Sleeman, Elif Arioglu Oral, Benjamin A Olenchock
Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency. Science translational medicine 15 (723) (2023)
Shangang Zhao, Qian Lin, Wei Xiong, Li Li, Leon Straub, Dinghong Zhang, Rizaldy C Zapata, Qingzhang Zhu, Xue-Nan Sun, Zhuzhen Zhang, Jan-Bernd Funcke, Chao Li, Shiuhwei Chen, Yi Zhu, Nisi Jiang, Guannan Li, Ziying Xu, Steven C Wyler, May-Yun Wang, Juli Bai, Xianlin Han, Christine M Kusminski, Ningyan Zhang, Zhiqiang An, Joel K Elmquist, Olivia Osborn, Chen Liu, Jan-Bernd Funcke
Hyperleptinemia contributes to antipsychotic drug-associated obesity and metabolic disorders. Science translational medicine 15 (723) (2023)
Stanley Ulijaszek
Translating models of obesity to tackle common obesity. Science translational medicine 15 (723) (2023)
Alberto Díaz-Ruiz, Nathan L Price, Luigi Ferruci, Rafael de Cabo
Obesity and lifespan, a complex tango. Science translational medicine 15 (723) (2023)
Douwe F de Wit, Nordin M J Hanssen, Koen Wortelboer, Hilde J Herrema, Elena Rampanelli, Max Nieuwdorp
Evidence for the contribution of the gut microbiome to obesity and its reversal. Science translational medicine 15 (723) (2023)
Michael W Schleh, Heather L Caslin, Jamie N Garcia, Mona Mashayekhi, Gitanjali Srivastava, Anna B Bradley, Alyssa H Hasty
Metaflammation in obesity and its therapeutic targeting. Science translational medicine 15 (723) (2023)

volume 15, number 724, 2023

Reza Zonozi, Lucy C Walters, Aaron Shulkin, Vivek Naranbhai, Pravarut Nithagon, Gabriel Sauvage, Clarety Kaeske, Katherine Cosgrove, Anusha Nathan, Rhoda Tano-Menka, Alton C Gayton, Matthew A Getz, Fernando Senjobe, Daniel P Worrall, A John Iafrate, Caroline Fromson, Sydney B Montesi, Deepak A Rao, Jeffrey A Sparks, Zachary Scott Wallace, Jocelyn R Farmer, Bruce D Walker, Richelle C Charles, Karen Laliberte, John L Niles, Gaurav D Gaiha
T cell responses to SARS-CoV-2 infection and vaccination are elevated in B cell deficiency and reduce risk of severe COVID-19. Science translational medicine 15 (724) (2023)
Jonathan Hsu, Renee N Donahue, Madan Katragadda, Jessica Lowry, Wei Huang, Karunya Srinivasan, Gurkan Guntas, Jian Tang, Roya Servattalab, Jacques Moisan, Yo-Ting Tsai, Allart Stoop, Sangeetha Palakurthi, Raj Chopra, Ke Liu, E John Wherry, Zhen Su, James L Gulley, Andrew Bayliffe, Jeffrey Schlom
A T cell receptor β chain-directed antibody fusion molecule activates and expands subsets of T cells to promote antitumor activity. Science translational medicine 15 (724) (2023)
Wendi Guo, Jiaul Hoque, Carolina J Garcia Garcia, Kassandra V Spiller, Abigail P Leinroth, Vijitha Puviindran, Cahil K Potnis, Kiana A Gunn, Hunter Newman, Koji Ishikawa, Tara N Fujimoto, Denae W Neill, Abagail M Delahoussaye, Nerissa T Williams, David G Kirsch, Matthew J Hilton, Shyni Varghese, Cullen M Taniguchi, Colleen Wu
Radiation-induced bone loss in mice is ameliorated by inhibition of HIF-2α in skeletal progenitor cells. Science translational medicine 15 (724) (2023)
Mohammed Repon Khan, Xiling Yin, Sung-Ung Kang, Jaba Mitra, Hu Wang, Taekyung Ryu, Saurav Brahmachari, Senthilkumar S Karuppagounder, Yasuyoshi Kimura, Aanishaa Jhaldiyal, Hyun Hee Kim, Hao Gu, Rong Chen, Javier Redding-Ochoa, Juan Troncoso, Chan Hyun Na, Taekjip Ha, Valina L Dawson, Ted M Dawson
Enhanced mTORC1 signaling and protein synthesis in pathologic α-synuclein cellular and animal models of Parkinson's disease. Science translational medicine 15 (724) (2023)
Kavita Agarwal, Biswa Choudhury, Lloyd S Robinson, Sydney R Morrill, Yasmine Bouchibiti, Daisy Chilin-Fuentes, Sara Brin Rosenthal, Kathleen M Fisch, Jeffrey F Peipert, Carlito B Lebrilla, Jenifer E Allsworth, Amanda L Lewis, Warren G Lewis
Resident microbes shape the vaginal epithelial glycan landscape. Science translational medicine 15 (724) (2023)

volume 15, number 725, 2023

Wensen Jiang, Juliane D Glaeser, Giselle Kaneda, Julia Sheyn, Jacob T Wechsler, Stephen Stephan, Khosrowdad Salehi, Julie L Chan, Wafa Tawackoli, Pablo Avalos, Christopher Johnson, Chloe Castaneda, Linda E A Kanim, Teerachat Tanasansomboon, Joshua E Burda, Oksana Shelest, Haneen Yameen, Tiffany G Perry, Michael Kropf, Jason M Cuellar, Dror Seliktar, Hyun W Bae, Laura S Stone, Dmitriy Sheyn
Intervertebral disc human nucleus pulposus cells associated with back pain trigger neurite outgrowth in vitro and pain behaviors in rats. Science translational medicine 15 (725) (2023)
Lara Paracchini, Laura Mannarino, Chiara Romualdi, Riccardo Zadro, Luca Beltrame, Ilaria Fuso Nerini, Paolo Zola, Maria E Laudani, Eva Pagano, Livia Giordano, Robert Fruscio, Fabio Landoni, Silvia Franceschi, Maria L Dalessandro, Vincenzo Canzonieri, Luca Bocciolone, Domenica Lorusso, Cristina Bosetti, Francesco Raspagliesi, Isabella M G Garassino, null null, Maurizio D'Incalci, Sergio Marchini
Genomic instability analysis in DNA from Papanicolaou test provides proof-of-principle early diagnosis of high-grade serous ovarian cancer. Science translational medicine 15 (725) (2023)
Elena Roselletti, Eva Pericolini, Alexandre Nore, Peter Takacs, Bence Kozma, Arianna Sala, Francesco De Seta, Manola Comar, Jane Usher, Gordon D Brown, Duncan Wilson
Zinc prevents vaginal candidiasis by inhibiting expression of an inflammatory fungal protein. Science translational medicine 15 (725) (2023)
Niklas J Lang, Janine Gote-Schniering, Diana Porras-Gonzalez, Lin Yang, Laurens J De Sadeleer, R Christoph Jentzsch, Vladimir A Shitov, Shuhong Zhou, Meshal Ansari, Ahmed Agami, Christoph H Mayr, Baharak Hooshiar Kashani, Yuexin Chen, Lukas Heumos, Jeanine C Pestoni, Eszter Sarolta Molnar, Emiel Geeraerts, Vincent Anquetil, Laurent Saniere, Melanie Wögrath, Michael Gerckens, Mareike Lehmann, Ali Oender Yildirim, Rudolf Hatz, Nikolaus Kneidinger, Juergen Behr, Wim A Wuyts, Mircea-Gabriel Stoleriu, Malte Daniel Luecken, Fabian Joachim Theis, Gerald Burgstaller, Herbert B Schiller
Ex vivo tissue perturbations coupled to single-cell RNA-seq reveal multilineage cell circuit dynamics in human lung fibrogenesis. Science translational medicine 15 (725) (2023)
Fabin Dang, Lei Bai, Jiazhen Dong, Xiaoping Hu, Jingchao Wang, Joao A Paulo, Yan Xiong, Xiaowei Liang, Yishuang Sun, Yuncai Chen, Ming Guo, Xin Wang, Zhixiang Huang, Hiroyuki Inuzuka, Li Chen, Chen Chu, Jianping Liu, Tao Zhang, Abdol-Hossein Rezaeian, Jing Liu, Husnu Ümit Kaniskan, Bo Zhong, Jinfang Zhang, Michael Letko, Jian Jin, Ke Lan, Wenyi Wei
USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice. Science translational medicine 15 (725) (2023)
Björn Corleis, Constantine N Tzouanas, Marc H Wadsworth, Josalyn L Cho, Alice H Linder, Abigail E Schiff, Björn Zessin, Fabian Stei, Anca Dorhoi, Amy K Dickey, Benjamin D Medoff, Alex K Shalek, Douglas S Kwon
Tobacco smoke exposure recruits inflammatory airspace monocytes that establish permissive lung niches for Mycobacterium tuberculosis . Science translational medicine 15 (725) (2023)