Arun K Ghosh

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 43

Top Topics

Mass Spectrometry

Structure Activity Relationship

Top Venues

The Journal of organic chemistry

Journal of medicinal chemistry

Organic & biomolecular chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Arun K Ghosh, Daniel Lee, Ashish Sharma, Megan E Johnson, Ajay K Ghosh, Yuan-Fang Wang, Johnson Agniswamy, Masayuki Amano, Shin-Ichiro Hattori, Irene T Weber, Hiroaki Mitsuya
Design of substituted tetrahydrofuran derivatives for HIV-1 protease inhibitors: synthesis, biological evaluation, and X-ray structural studies. Organic & biomolecular chemistry (2024)
Arun K Ghosh, John P Gulliver
Total Syntheses of Strasseriolide A and Strasseriolide B, Potent Antimalarial Agents. The Journal of organic chemistry (2024)
Arun K Ghosh, Marc Harper, William L Robinson
Total Synthesis of Neuroprotective Agents, (+)-Lycibarbarine A and (-)-Lycibarbarine B. The Journal of organic chemistry (2023)
Arun K Ghosh, Monika Yadav
Synthesis of optically active SARS-CoV-2 Mpro inhibitor drug nirmatrelvir (Paxlovid): an approved treatment of COVID-19. Organic & biomolecular chemistry (2023)
Arun K Ghosh, William L Robinson, John Gulliver, Hannah M Simpson
Convergent synthesis of (+)-carambolaflavone A, an antidiabetic agent using a bismuth triflate-catalyzed C -aryl glycosylation. Organic & biomolecular chemistry 20 (14) (2022)
Arun K Ghosh, Amartyo J Basu, Che-Sheng Hsu, Monika Yadav
Asymmetric 1,2-Carbamoyl Rearrangement of Lithiated Chiral Oxazolidine Carbamates and Diastereoselective Synthesis of α-Hydroxy Amides. Chemistry (Weinheim an der Bergstrasse, Germany) 28 (43) (2022)
Arun K Ghosh, Jennifer L Mishevich, Andrew Mesecar, Hiroaki Mitsuya
Recent Drug Development and Medicinal Chemistry Approaches for the Treatment of SARS-CoV-2 Infection and COVID-19. ChemMedChem 17 (22) (2022)
Arun K Ghosh, Hao Yuan
Total Syntheses of the Proposed Structure of Iriomoteolide-1a, -1b and Synthesis of Three Derivatives for Structural Studies. Marine drugs 20 (10) (2022)
Arun K Ghosh, Irene T Weber, Hiroaki Mitsuya
Beyond darunavir: recent development of next generation HIV-1 protease inhibitors to combat drug resistance. Chemical communications (Cambridge, England) 58 (84) (2022)
Arun K Ghosh, Satish Kovela, Ashish Sharma, Dana Shahabi, Ajay K Ghosh, Denver R Hopkins, Monika Yadav, Megan E Johnson, Johnson Agniswamy, Yuan-Fang Wang, Shin-Ichiro Hattori, Nobuyo Higashi-Kuwata, Manabu Aoki, Masayuki Amano, Irene T Weber, Hiroaki Mitsuya
Design, Synthesis and X-Ray Structural Studies of Potent HIV-1 Protease Inhibitors Containing C-4 Substituted Tricyclic Hexahydro-Furofuran Derivatives as P2 Ligands. ChemMedChem 17 (9) (2022)
Arun K Ghosh, Che-Sheng Hsu
Enantioselective Total Synthesis of (+)-EBC-23, a Potent Anticancer Agent from the Australian Rainforest. The Journal of organic chemistry 86 (9) (2021)
Arun K Ghosh, Srinivasa Rao Allu, Guddeti Chandrashekar Reddy, Adriana Gamboa Lopez, Patricia Mendez, Melissa S Jurica
Design and synthesis of herboxidiene derivatives that potently inhibit in vitro splicing. Organic & biomolecular chemistry 19 (6) (2021)
Arun K Ghosh, Jennifer L Mishevich, Melissa S Jurica
Spliceostatins and Derivatives: Chemical Syntheses and Biological Properties of Potent Splicing Inhibitors. Journal of natural products 84 (5) (2021)
Arun K Ghosh, Jakka Raghavaiah, Dana Shahabi, Monika Yadav, Brandon J Anson, Emma K Lendy, Shin-Ichiro Hattori, Nobuyo Higashi-Kuwata, Hiroaki Mitsuya, Andrew D Mesecar
Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies. Journal of medicinal chemistry 64 (19) (2021)
Arun K Ghosh, Dana Shahabi, Monika Yadav, Satish Kovela, Brandon J Anson, Emma K Lendy, Connie Bonham, Devika Sirohi, Carlos A Brito-Sierra, Shin-Ichiro Hattori, Richard Kuhn, Hiroaki Mitsuya, Andrew D Mesecar
Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors. Molecules (Basel, Switzerland) 26 (19) (2021)
Yu-Chen Yen, Annalissa M Kammeyer, Jagannadharao Tirlangi, Arun K Ghosh, Andrew D Mesecar
A Structure-Based Discovery Platform for BACE2 and the Development of Selective BACE Inhibitors. ACS chemical neuroscience 12 (4) (2021)
Adriana Gamboa Lopez, Srinivasa Rao Allu, Patricia Mendez, Guddeti Chandrashekar Reddy, Hannah M Maul-Newby, Arun K Ghosh, Melissa S Jurica
Herboxidiene Features That Mediate Conformation-Dependent SF3B1 Interactions to Inhibit Splicing. ACS chemical biology 16 (3) (2021)
Arun K Ghosh, Monika Yadav
Highly Diastereoselective Intramolecular Asymmetric Oxidopyrylium-olefin [5 + 2] Cycloaddition and Synthesis of 8-Oxabicyclo[3.2.1]oct-3-enone Containing Ring Systems. The Journal of organic chemistry 86 (12) (2021)
Arun K Ghosh, Miranda R Belcher
Lewis Acid-Catalyzed Vinyl Acetal Rearrangement of 4,5-Dihydro-1,3-dioxepines: Stereoselective Synthesis of cis- and trans-2,3-Disubstituted Tetrahydrofurans. The Journal of organic chemistry 85 (16) (2020)
Arun K Ghosh, Shivaji B Markad, William L Robinson
The Chiron Approach to (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol, a Key Subunit of HIV-1 Protease Inhibitor Drug, Darunavir. The Journal of organic chemistry 86 (1) (2020)
Arun K Ghosh, Joshua R Born, Anne M Veitschegger, Melissa S Jurica
Copper-Catalyzed Stille Cross-Coupling Reaction and Application in the Synthesis of the Spliceostatin Core Structure. The Journal of organic chemistry 85 (12) (2020)
Arun K Ghosh, Satish Kovela, Heather L Osswald, Masayuki Amano, Manabu Aoki, Johnson Agniswamy, Yuan-Fang Wang, Irene T Weber, Hiroaki Mitsuya
Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies. Journal of medicinal chemistry 63 (9) (2020)
Kedar Puvar, Aya M Saleh, Ryan W Curtis, Yiyang Zhou, Prasanth R Nyalapatla, Jiaqi Fu, Alexander R Rovira, Yitzhak Tor, Zhao-Qing Luo, Arun K Ghosh, Mary J Wirth, Jean Chmielewski, Tamara L Kinzer-Ursem, Chittaranjan Das
Fluorescent Probes for Monitoring Serine Ubiquitination. Biochemistry 59 (13) (2020)
Arun K Ghosh, Margherita Brindisi, Dana Shahabi, Mackenzie E Chapman, Andrew D Mesecar
Drug Development and Medicinal Chemistry Efforts toward SARS-Coronavirus and Covid-19 Therapeutics. ChemMedChem 15 (11) (2020)
Arun K Ghosh, Zilei Xia, Satish Kovela, William L Robinson, Megan E Johnson, Daniel W Kneller, Yuan-Fang Wang, Manabu Aoki, Yuki Takamatsu, Irene T Weber, Hiroaki Mitsuya
Potent HIV-1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein-Ligand X-ray Structural Studies. ChemMedChem 14 (21) (2019)
Arun K Ghosh, Margherita Brindisi, Yu-Chen Yen, Emma K Lendy, Satish Kovela, Emilio Leal Cárdenas, Bhavanam Sekhara Reddy, Kalapala Venketeswara Rao, Deborah Downs, Xiangping Huang, Jordan Tang, Andrew D Mesecar
Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies. ChemMedChem 14 (5) (2019)
Arun K Ghosh, Margherita Brindisi
Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. Journal of medicinal chemistry 63 (6) (2019)
Yu-Chen Yen, Annalissa M Kammeyer, Katherine C Jensen, Jagannadharao Tirlangi, Arun K Ghosh, Andrew D Mesecar
Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors. Biochemistry 58 (44) (2019)
Arun K Ghosh, Joshua R Born, Luke A Kassekert
Enantioselective Total Syntheses of (+)-Fendleridine and (+)-Acetylaspidoalbidine. The Journal of organic chemistry 84 (9) (2019)
Arun K Ghosh, Daniel S Lee
Enantioselective Total Synthesis of (+)-Monocerin, a Dihydroisocoumarin Derivative with Potent Antimalarial Properties. The Journal of organic chemistry 84 (10) (2019)
Arun K Ghosh, William L Robinson
A Photochemical Route to Optically Active Hexahydro-4H-furopyranol, a High-Affinity P2 Ligand for HIV-1 Protease Inhibitors. The Journal of organic chemistry 84 (15) (2019)
Arun K Ghosh, Guddeti Chandrashekar Reddy, Satish Kovela, Nicola Relitti, Veronica K Urabe, Beth E Prichard, Melissa S Jurica
Enantioselective Synthesis of a Cyclopropane Derivative of Spliceostatin A and Evaluation of Bioactivity. Organic letters 20 (22) (2018)
Arun K Ghosh, Anne M Veitschegger, Shenyou Nie, Nicola Relitti, Andrew J MacRae, Melissa S Jurica
Enantioselective Synthesis of Thailanstatin A Methyl Ester and Evaluation of in Vitro Splicing Inhibition. The Journal of organic chemistry 83 (9) (2018)
Arun K Ghosh, Prasanth R Nyalapatla, Satish Kovela, Kalapala Venkateswara Rao, Margherita Brindisi, Heather L Osswald, Masayuki Amano, Manabu Aoki, Johnson Agniswamy, Yuan-Fang Wang, Irene T Weber, Hiroaki Mitsuya
Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis. Journal of medicinal chemistry 61 (10) (2018)
Arun K Ghosh, Jacqueline N Williams, Rachel Y Ho, Hannah M Simpson, Shin-Ichiro Hattori, Hironori Hayashi, Johnson Agniswamy, Yuan-Fang Wang, Irene T Weber, Hiroaki Mitsuya
Design and Synthesis of Potent HIV-1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure-Activity Studies and Biological and X-ray Structural Studies. Journal of medicinal chemistry 61 (21) (2018)
Arun K Ghosh, Anindya Sarkar, Margherita Brindisi
The Curtius rearrangement: mechanistic insight and recent applications in natural product syntheses. Organic & biomolecular chemistry 16 (12) (2018)
Arun K Ghosh, Kalapala Venkateswara Rao, Prasanth R Nyalapatla, Satish Kovela, Margherita Brindisi, Heather L Osswald, Bhavanam Sekhara Reddy, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Shin-Ichiro Hattori, Irene T Weber, Hiroaki Mitsuya
Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants. ChemMedChem 13 (8) (2018)
Arun K Ghosh, Margherita Brindisi, Anindya Sarkar
The Curtius Rearrangement: Applications in Modern Drug Discovery and Medicinal Chemistry. ChemMedChem 13 (22) (2018)
John Y Kong, Zaikuan Yu, Mckay W Easton, Edouard Niyonsaba, Xin Ma, Ravikiran Yerabolu, Huaming Sheng, Tiffany M Jarrell, Zhoupeng Zhang, Arun K Ghosh, Hilkka I Kenttämaa
Differentiating Isomeric Deprotonated Glucuronide Drug Metabolites via Ion/Molecule Reactions in Tandem Mass Spectrometry. Analytical chemistry 90 (15) (2018)
Arun K Ghosh, W Sean Fyvie, Margherita Brindisi, Melinda Steffey, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Masayuki Amano, Irene T Weber, Hiroaki Mitsuya
Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2' Ligands of Darunavir. ChemMedChem 12 (23) (2017)
Arun K Ghosh, Guddeti Chandrashekar Reddy, Andrew J MacRae, Melissa S Jurica
Enantioselective Synthesis of Spliceostatin G and Evaluation of Bioactivity of Spliceostatin G and Its Methyl Ester. Organic letters 20 (1) (2017)
Arun K Ghosh, Kalapala Venkateswara Rao, Prasanth R Nyalapatla, Heather L Osswald, Cuthbert D Martyr, Manabu Aoki, Hironori Hayashi, Johnson Agniswamy, Yuan-Fang Wang, Haydar Bulut, Debananda Das, Irene T Weber, Hiroaki Mitsuya
Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants. Journal of medicinal chemistry 60 (10) (2017)
Ning Yang, James S Gibbs, Heather D Hickman, Glennys V Reynoso, Arun K Ghosh, Jack R Bennink, Jonathan W Yewdell
Defining Viral Defective Ribosomal Products: Standard and Alternative Translation Initiation Events Generate a Common Peptide from Influenza A Virus M2 and M1 mRNAs. Journal of immunology (Baltimore, Md. : 1950) 196 (9) (2016)