Ben Lehner

ResearcherID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 42

Top Topics

Dna Methylation

Gene Expression

Top Venues

Nature communications

bioRxiv : the preprint server for biology

This page only lists publications with an associated author ORCID identifier.

Publications

Mike Thompson, Mariano Martín, Trinidad Sanmartín Olmo, Chandana Rajesh, Peter K Koo, Benedetta Bolognesi, Ben Lehner
Interpretably deep learning amyloid nucleation by massive experimental quantification of random sequences. bioRxiv : the preprint server for biology (2024)
Mike Thompson, Mariano Martín, Trinidad Sanmartín Olmo, Chandana Rajesh, Peter K Koo, Benedetta Bolognesi, Ben Lehner
Interpretably deep learning amyloid nucleation by massive experimental quantification of random sequences. bioRxiv : the preprint server for biology (2024)
Anna Arutyunyan, Mireia Seuma, Andre J Faure, Benedetta Bolognesi, Ben Lehner
Energetic portrait of the amyloid beta nucleation transition state. bioRxiv : the preprint server for biology (2024)
Ignasi Toledano, Fran Supek, Ben Lehner
Genome-scale quantification and prediction of pathogenic stop codon readthrough by small molecules. Nature genetics (2024)
Anna Arutyunyan, Mireia Seuma, Andre J Faure, Benedetta Bolognesi, Ben Lehner
Energetic portrait of the amyloid beta nucleation transition state. bioRxiv : the preprint server for biology (2024)
Taraneh Zarin, Ben Lehner
A complete map of specificity encoding for a partially fuzzy protein interaction. bioRxiv : the preprint server for biology (2024)
Andre J Faure, Ben Lehner, Verónica Miró Pina, Claudia Serrano Colome, Shamil R Sunyaev
An extension of the Walsh-Hadamard transform to calculate and model epistasis in genetic landscapes of arbitrary shape and complexity. PLoS computational biology 20 (5) (2024)
Taraneh Zarin, Ben Lehner
A complete map of specificity encoding for a partially fuzzy protein interaction. bioRxiv : the preprint server for biology (2024)
Andre J Faure, Ben Lehner, Verónica Miró Pina, Claudia Serrano Colome, Shamil R Sunyaev
An extension of the Walsh-Hadamard transform to calculate and model epistasis in genetic landscapes of arbitrary shape and complexity. PLoS computational biology 20 (5) (2024)
Chenchun Weng, Andre J Faure, Albert Escobedo, Ben Lehner
The energetic and allosteric landscape for KRAS inhibition. Nature 626 (7999) (2023)
Chenchun Weng, Andre J Faure, Albert Escobedo, Ben Lehner
The energetic and allosteric landscape for KRAS inhibition. Nature 626 (7999) (2023)
Taylor L Mighell, Ignasi Toledano, Ben Lehner
SUNi mutagenesis: Scalable and uniform nicking for efficient generation of variant libraries. PloS one 18 (7) (2023)
Chenchun Weng, Andre J Faure, Albert Escobedo, Ben Lehner
The energetic and allosteric landscape for KRAS inhibition. Nature (2023)
Chenchun Weng, Andre J Faure, Albert Escobedo, Ben Lehner
The energetic and allosteric landscape for KRAS inhibition. Nature 626 (7999) (2023)
Xuan Xie, Xia Sun, Yuheng Wang, Ben Lehner, Xianghua Li
Dominance vs epistasis: the biophysical origins and plasticity of genetic interactions within and between alleles. Nature communications 14 (1) (2023)
Mischan Vali-Pour, Solip Park, Jose Espinosa-Carrasco, Daniel Ortiz-Martínez, Ben Lehner, Fran Supek
Author Correction: The impact of rare germline variants on human somatic mutation processes. Nature communications 14 (1) (2023)
Chenchun Weng, Andre J Faure, Albert Escobedo, Ben Lehner
The energetic and allosteric landscape for KRAS inhibition. Nature (2023)
Chenchun Weng, Andre J Faure, Albert Escobedo, Ben Lehner
The energetic and allosteric landscape for KRAS inhibition. Nature 626 (7999) (2023)
Chenchun Weng, Andre J Faure, Albert Escobedo, Ben Lehner
The energetic and allosteric landscape for KRAS inhibition. Nature 626 (7999) (2023)
Mischan Vali-Pour, Ben Lehner, Fran Supek
The impact of rare germline variants on human somatic mutation processes. Nature communications 13 (1) (2022)
Andre J Faure, Júlia Domingo, Jörn M Schmiedel, Cristina Hidalgo-Carcedo, Guillaume Diss, Ben Lehner
Mapping the energetic and allosteric landscapes of protein binding domains. Nature 604 (7904) (2022)
Mireia Seuma, Ben Lehner, Benedetta Bolognesi
An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation. Nature communications 13 (1) (2022)
Mireia Seuma, Andre J Faure, Marta Badia, Ben Lehner, Benedetta Bolognesi
The genetic landscape for amyloid beta fibril nucleation accurately discriminates familial Alzheimer's disease mutations. eLife 10 (2021)
Solip Park, Fran Supek, Ben Lehner
Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers. Nature communications 12 (1) (2021)
Pablo Baeza-Centurion, Belén Miñana, Juan Valcárcel, Ben Lehner
Mutations primarily alter the inclusion of alternatively spliced exons. eLife 9 (2020)
Xianghua Li, Ben Lehner
Biophysical ambiguities prevent accurate genetic prediction. Nature communications 11 (1) (2020)
Andre J Faure, Jörn M Schmiedel, Pablo Baeza-Centurion, Ben Lehner
DiMSum: an error model and pipeline for analyzing deep mutational scanning data and diagnosing common experimental pathologies. Genome biology 21 (1) (2020)
Benedetta Bolognesi, Andre J Faure, Mireia Seuma, Jörn M Schmiedel, Gian Gaetano Tartaglia, Ben Lehner
The mutational landscape of a prion-like domain. Nature communications 10 (1) (2019)
Xianghua Li, Jasna Lalić, Pablo Baeza-Centurion, Riddhiman Dhar, Ben Lehner
Author Correction: Changes in gene expression predictably shift and switch genetic interactions. Nature communications 10 (1) (2019)
Aaron M New, Ben Lehner
Harmonious genetic combinations rewire regulatory networks and flip gene essentiality. Nature communications 10 (1) (2019)
Riddhiman Dhar, Alsu M Missarova, Ben Lehner, Lucas B Carey
Single cell functional genomics reveals the importance of mitochondria in cell-to-cell phenotypic variation. eLife 8 (2019)
Jörn M Schmiedel, Ben Lehner
Determining protein structures using deep mutagenesis. Nature genetics 51 (7) (2019)
Mirko Francesconi, Bruno Di Stefano, Clara Berenguer, Luisa de Andrés-Aguayo, Marcos Plana-Carmona, Maria Mendez-Lago, Amy Guillaumet-Adkins, Gustavo Rodriguez-Esteban, Marta Gut, Ivo Glynne Gut, Holger Heyn, Ben Lehner, Thomas Graf
Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming. eLife 8 (2019)
Xianghua Li, Jasna Lalić, Pablo Baeza-Centurion, Riddhiman Dhar, Ben Lehner
Changes in gene expression predictably shift and switch genetic interactions. Nature communications 10 (1) (2019)
Jörn M Schmiedel, Lucas B Carey, Ben Lehner
Empirical mean-noise fitness landscapes reveal the fitness impact of gene expression noise. Nature communications 10 (1) (2019)
Rik G H Lindeboom, Michiel Vermeulen, Ben Lehner, Fran Supek
The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy. Nature genetics 51 (11) (2019)
Alexandra Avgustinova, Aikaterini Symeonidi, Andrés Castellanos, Uxue Urdiroz-Urricelqui, Llorenç Solé-Boldo, Mercè Martín, Ivan Pérez-Rodríguez, Neus Prats, Ben Lehner, Fran Supek, Salvador Aznar Benitah
Loss of G9a preserves mutation patterns but increases chromatin accessibility, genomic instability and aggressiveness in skin tumours. Nature cell biology 20 (12) (2018)
Guillaume Diss, Ben Lehner
The genetic landscape of a physical interaction. eLife 7 (2018)
Benedetta Bolognesi, Ben Lehner
Reaching the limit. eLife 7 (2018)
Solip Park, Fran Supek, Ben Lehner
Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits. Nature communications 9 (1) (2018)
Adam Klosin, Kadri Reis, Cristina Hidalgo-Carcedo, Eduard Casas, Tanya Vavouri, Ben Lehner
Impaired DNA replication derepresses chromatin and generates a transgenerationally inherited epigenetic memory. Science advances 3 (8) (2017)
Adam Klosin, Eduard Casas, Cristina Hidalgo-Carcedo, Tanya Vavouri, Ben Lehner
Transgenerational transmission of environmental information in C. elegans. Science (New York, N.Y.) 356 (6335) (2017)