Christopher D Lima

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 27

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Organic letters

Nature

eLife

Howard Hughes Medical Institute

Northwestern University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Howard Hughes Medical Institute

United States

Investigator :: Structural Biology

Sloan-Kettering Institute Structural Biology Program

United States

Member :: Structural Biology

Sloan-Kettering Institute Structural Biology Program

United States

Associate Member :: Structural Biology

Weill Cornell Medical College

United States

Associate Professor :: Biochemistry

Weill Cornell Medical College

United States

Assistant Professor :: Biochemistry

Education History

Northwestern University

United States

PHD :: Biochemistry, Molecular Biology and Cell Biology

Publications

Tomasz Kochańczyk, Zachary S Hann, Michaelyn C Lux, Avelyn Mae V Delos Reyes, Cheng Ji, Derek S Tan, Christopher D Lima
Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature (2024)
Avelyn Mae V Delos Reyes, Michaelyn C Lux, Zachary S Hann, Cheng Ji, Tomasz Kochańczyk, Mikaela DiBello, Christopher D Lima, Derek S Tan
Design and Semisynthesis of Biselectrophile-Functionalized Ubiquitin Probes To Investigate Transthioesterification Reactions. Organic letters (2024)
Avelyn Mae V Delos Reyes, Michaelyn C Lux, Zachary S Hann, Cheng Ji, Tomasz Kochańczyk, Mikaela DiBello, Christopher D Lima, Derek S Tan
Design and Semisynthesis of Biselectrophile-Functionalized Ubiquitin Probes To Investigate Transthioesterification Reactions. Organic letters (2024)
Tomasz Kochańczyk, Zachary S Hann, Michaelyn C Lux, Avelyn Mae V Delos Reyes, Cheng Ji, Derek S Tan, Christopher D Lima
Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature (2024)
Avelyn Mae V Delos Reyes, Michaelyn C Lux, Zachary S Hann, Cheng Ji, Tomasz Kochańczyk, Mikaela DiBello, Christopher D Lima, Derek S Tan
Design and Semisynthesis of Biselectrophile-Functionalized Ubiquitin Probes To Investigate Transthioesterification Reactions. Organic letters 26 (22) (2024)
Avelyn Mae V Delos Reyes, Michaelyn C Lux, Zachary S Hann, Cheng Ji, Tomasz Kochańczyk, Mikaela DiBello, Christopher D Lima, Derek S Tan
Design and Semisynthesis of Biselectrophile-Functionalized Ubiquitin Probes To Investigate Transthioesterification Reactions. Organic letters 26 (22) (2024)
Avelyn Mae V Delos Reyes, Michaelyn C Lux, Zachary S Hann, Cheng Ji, Tomasz Kochańczyk, Mikaela DiBello, Christopher D Lima, Derek S Tan
Design and Semisynthesis of Biselectrophile-Functionalized Ubiquitin Probes To Investigate Transthioesterification Reactions. Organic letters 26 (22) (2024)
Tomasz Kochańczyk, Zachary S Hann, Michaelyn C Lux, Avelyn Mae V Delos Reyes, Cheng Ji, Derek S Tan, Christopher D Lima
Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature (2024)
Avelyn Mae V Delos Reyes, Michaelyn C Lux, Zachary S Hann, Cheng Ji, Tomasz Kochańczyk, Mikaela DiBello, Christopher D Lima, Derek S Tan
Design and Semisynthesis of Biselectrophile-Functionalized Ubiquitin Probes To Investigate Transthioesterification Reactions. Organic letters (2024)
Hyein G Lee, Abigail A Lemmon, Christopher D Lima
SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Hyein G Lee, Abigail A Lemmon, Christopher D Lima
SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Hyein G Lee, Abigail A Lemmon, Christopher D Lima
SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Hyein G Lee, Abigail A Lemmon, Christopher D Lima
SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Yuhki Saito, Ben R Hawley, M Rhyan Puno, Shreya N Sarathy, Christopher D Lima, Samie R Jaffrey, Robert B Darnell, Scott Keeney, Devanshi Jain
YTHDC2 control of gametogenesis requires helicase activity but not m 6 A binding. Genes & development 36 (3-4) (2022)
Hyein G Lee, Abigail A Lemmon, Christopher D Lima
SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Laurent Cappadocia, Tomasz Kochańczyk, Christopher D Lima
DNA asymmetry promotes SUMO modification of the single-stranded DNA-binding protein RPA. The EMBO journal 40 (22) (2021)
John Ginn, Xiuju Jiang, Shan Sun, Mayako Michino, David J Huggins, Zodwa Mbambo, Robert Jansen, Kyu Y Rhee, Nancy Arango, Christopher D Lima, Nigel Liverton, Toshihiro Imaeda, Rei Okamoto, Takanobu Kuroita, Kazuyoshi Aso, Andrew Stamford, Michael Foley, Peter T Meinke, Carl Nathan, Ruslana Bryk
Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions. ACS infectious diseases 7 (2) (2021)
Mom Das, Dimitrios Zattas, John C Zinder, Elizabeth V Wasmuth, Julien Henri, Christopher D Lima
Substrate discrimination and quality control require each catalytic activity of TRAMP and the nuclear RNA exosome. Proceedings of the National Academy of Sciences of the United States of America 118 (14) (2021)
Armend Axhemi, Elizabeth V Wasmuth, Christopher D Lima, Eckhard Jankowsky
Substrate selectivity by the exonuclease Rrp6p. Proceedings of the National Academy of Sciences of the United States of America 117 (2) (2019)
Zachary S Hann, Meredith B Metzger, Allan M Weissman, Christopher D Lima
Crystal structure of the Schizosaccharomyces pombe U7BR E2-binding region in complex with Ubc7. Acta crystallographica. Section F, Structural biology communications 75 (Pt 8) (2019)
Zachary S Hann, Cheng Ji, Shaun K Olsen, Xuequan Lu, Michaelyn C Lux, Derek S Tan, Christopher D Lima
Structural basis for adenylation and thioester bond formation in the ubiquitin E1. Proceedings of the National Academy of Sciences of the United States of America 116 (31) (2019)
Yue-Ting K Lau, Vladimir Baytshtok, Tessa A Howard, Brooke M Fiala, JayLee M Johnson, Lauren P Carter, David Baker, Christopher D Lima, Christopher D Bahl
Discovery and engineering of enhanced SUMO protease enzymes. The Journal of biological chemistry 293 (34) (2018)
M Rhyan Puno, Christopher D Lima
Structural basis for MTR4-ZCCHC8 interactions that stimulate the MTR4 helicase in the nuclear exosome-targeting complex. Proceedings of the National Academy of Sciences of the United States of America 115 (24) (2018)
Devanshi Jain, M Rhyan Puno, Cem Meydan, Nathalie Lailler, Christopher E Mason, Christopher D Lima, Kathryn V Anderson, Scott Keeney
ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2. eLife 7 (2018)
Laurent Cappadocia, Christopher D Lima
Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism. Chemical reviews 118 (3) (2017)
Elizabeth V Wasmuth, John C Zinder, Dimitrios Zattas, Mom Das, Christopher D Lima
Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase. eLife 6 (2017)
John C Zinder, Christopher D Lima
Targeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactors. Genes & development 31 (2) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Christopher D Lima