David N Sheppard

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 21

Top Topics

Pseudomonas Aeruginosa

Cystic Fibrosis

Top Venues

The Journal of physiology

Chemical science

American journal of physiology. Lung cellular and molecular physiology

Respiratory research

This page only lists publications with an associated author ORCID identifier.

Publications

Hongyu Li, Mayuree Rodrat, Majid K Al Salmani, Diana-Florentina Veselu, Sangwoo T Han, Karen S Raraigh, Garry R Cutting, David N Sheppard
Two rare variants that affect the same amino acid in CFTR have distinct responses to ivacaftor. The Journal of physiology 602 (2) (2024)
Marta Vila-Gonzalez, Laetitia Pinte, Ricardo Fradique, Erika Causa, Heleen Kool, Mayuree Rodrat, Carola Maria Morell, Maha Al-Thani, Linsey Porter, Wenrui Guo, Ruhina Maeshima, Stephen L Hart, Frank McCaughan, Alessandra Granata, David N Sheppard, R Andres Floto, Emma L Rawlins, Pietro Cicuta, Ludovic Vallier
In vitro platform to model the function of ionocytes in the human airway epithelium. Respiratory research 25 (1) (2024)
Hongyu Li, Mayuree Rodrat, Majid K Al Salmani, Diana-Florentina Veselu, Sangwoo T Han, Karen S Raraigh, Garry R Cutting, David N Sheppard
Two rare variants that affect the same amino acid in CFTR have distinct responses to ivacaftor. The Journal of physiology 602 (2) (2024)
Hongyu Li, Mayuree Rodrat, Majid K Al Salmani, Diana-Florentina Veselu, Sangwoo T Han, Karen S Raraigh, Garry R Cutting, David N Sheppard
Two rare variants that affect the same amino acid in CFTR have distinct responses to ivacaftor. The Journal of physiology (2024)
Hongyu Li, Mayuree Rodrat, Majid K Al Salmani, Diana-Florentina Veselu, Sangwoo T Han, Karen S Raraigh, Garry R Cutting, David N Sheppard
Two rare variants that affect the same amino acid in CFTR have distinct responses to ivacaftor. The Journal of physiology 602 (2) (2024)
Marta Vila-Gonzalez, Laetitia Pinte, Ricardo Fradique, Erika Causa, Heleen Kool, Mayuree Rodrat, Carola Maria Morell, Maha Al-Thani, Linsey Porter, Wenrui Guo, Ruhina Maeshima, Stephen L Hart, Frank McCaughan, Alessandra Granata, David N Sheppard, R Andres Floto, Emma L Rawlins, Pietro Cicuta, Ludovic Vallier
In vitro platform to model the function of ionocytes in the human airway epithelium. Respiratory research 25 (1) (2024)
Marta Vila-Gonzalez, Laetitia Pinte, Ricardo Fradique, Erika Causa, Heleen Kool, Mayuree Rodrat, Carola Maria Morell, Maha Al-Thani, Linsey Porter, Wenrui Guo, Ruhina Maeshima, Stephen L Hart, Frank McCaughan, Alessandra Granata, David N Sheppard, R Andres Floto, Emma L Rawlins, Pietro Cicuta, Ludovic Vallier
In vitro platform to model the function of ionocytes in the human airway epithelium. Respiratory research 25 (1) (2024)
Hongyu Li, Mayuree Rodrat, Majid K Al Salmani, Diana-Florentina Veselu, Sangwoo T Han, Karen S Raraigh, Garry R Cutting, David N Sheppard
Two rare variants that affect the same amino acid in CFTR have distinct responses to ivacaftor. The Journal of physiology 602 (2) (2024)
Alicja Urbaniak, Kenneth E Thummel, Ayoade N Alade, Allan E Rettie, Bhagwat Prasad, Amedeo De Nicolò, Jennifer H Martin, David N Sheppard, Michael F Jarvis
Experimental pharmacology in precision medicine. Pharmacology research & perspectives 11 (6) (2023)
Sabrina Noel, Nathalie Servel, Aurélie Hatton, Anita Golec, Mayuree Rodrat, Demi R S Ng, Hongyu Li, Iwona Pranke, Alexandre Hinzpeter, Aleksander Edelman, David N Sheppard, Isabelle Sermet-Gaudelus
Correlating genotype with phenotype using CFTR-mediated whole-cell Cl- currents in human nasal epithelial cells. The Journal of physiology (2021)
Daniel Scholl, Maud Sigoillot, Marie Overtus, Rafael Colomer Martinez, Chloé Martens, Yiting Wang, Els Pardon, Toon Laeremans, Abel Garcia-Pino, Jan Steyaert, David N Sheppard, Jelle Hendrix, Cédric Govaerts
A topological switch in CFTR modulates channel activity and sensitivity to unfolding. Nature chemical biology 17 (9) (2021)
Jia Liu, Allison P Berg, Yiting Wang, Walailak Jantarajit, Katy J Sutcliffe, Edward B Stevens, Lishuang Cao, Marko J Pregel, David N Sheppard
A small molecule CFTR potentiator restores ATP-dependent channel gating to the cystic fibrosis mutant G551D-CFTR. British journal of pharmacology (2021)
Mayuree Rodrat, Walailak Jantarajit, Demi R S Ng, Bartholomew S J Harvey, Jia Liu, William J Wilkinson, Narattaphol Charoenphandhu, David N Sheppard
Carbon monoxide-releasing molecules inhibit the cystic fibrosis transmembrane conductance regulator Cl- channel. American journal of physiology. Lung cellular and molecular physiology 319 (6) (2020)
Alexandre Hinzpeter, Isabelle Sermet-Gaudelus, David N Sheppard
Suppressing 'nonsense' in cystic fibrosis. The Journal of physiology 598 (3) (2020)
Hongyu Li, Hennie Valkenier, Abigail G Thorne, Christopher M Dias, James A Cooper, Marion Kieffer, Nathalie Busschaert, Philip A Gale, David N Sheppard, Anthony P Davis
Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs. Chemical science 10 (42) (2019)
Samuel J Bose, Marcel J C Bijvelds, Yiting Wang, Jia Liu, Zhiwei Cai, Alice G M Bot, Hugo R de Jonge, David N Sheppard
Differential thermostability and response to cystic fibrosis transmembrane conductance regulator potentiators of human and mouse F508del-CFTR. American journal of physiology. Lung cellular and molecular physiology 317 (1) (2019)
Jia Liu, Hermann Bihler, Carlos M Farinha, Nikhil T Awatade, Ana M Romão, Dayna Mercadante, Yi Cheng, Isaac Musisi, Walailak Jantarajit, Yiting Wang, Zhiwei Cai, Margarida Duarte Amaral, Martin Mense, David N Sheppard
Partial rescue of F508del-cystic fibrosis transmembrane conductance regulator channel gating with modest improvement of protein processing, but not stability, by a dual-acting small molecule. British journal of pharmacology 175 (7) (2018)
Michael J Spooner, Hongyu Li, Igor Marques, Pedro M R Costa, Xin Wu, Ethan N W Howe, Nathalie Busschaert, Stephen J Moore, Mark E Light, David N Sheppard, Vítor Félix, Philip A Gale
Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transport. Chemical science 10 (7) (2018)
Yiting Wang, Zhiwei Cai, Martin Gosling, David N Sheppard
Potentiation of the cystic fibrosis transmembrane conductance regulator Cl- channel by ivacaftor is temperature independent. American journal of physiology. Lung cellular and molecular physiology 315 (5) (2018)
Jeng-Haur Chen, Weiyi Xu, David N Sheppard
Altering intracellular pH reveals the kinetic basis of intraburst gating in the CFTR Cl- channel. The Journal of physiology 595 (4) (2017)
Nestor Lopez Mora, Azadeh Bahreman, Hennie Valkenier, Hongyu Li, Thomas H Sharp, David N Sheppard, Anthony P Davis, Alexander Kros
Targeted anion transporter delivery by coiled-coil driven membrane fusion. Chemical science 7 (3) (2016)