Jan Steyaert (J Steyaert)

ResearcherID Loop profile Scopus Author ID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 48

Top Venues

Nature communications

eLife

Nature structural & molecular biology

Proceedings of the National Academy of Sciences of the United States of America

Vlaams Instituut voor Biotechnologie

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Vlaams Instituut voor Biotechnologie Jan 01 2017

Belgium

Scientific Director :: VIB-VUB center for Structural Biology

Vrije Universiteit Brussel Jan 01 1995

Belgium

Full professor :: Structural Biology Brussels

Publications

Baptiste Fischer, Tomasz Uchański, Aidana Sheryazdanova, Simon Gonzalez, Alexander N Volkov, Elke Brosens, Thomas Zögg, Valentina Kalichuk, Steven Ballet, Wim Versées, Anna A Sablina, Els Pardon, Alexandre Wohlkönig, Jan Steyaert
Allosteric nanobodies to study the interactions between SOS1 and RAS. Nature communications 15 (1) (2024)
Parameswaran Hariharan, Yuqi Shi, Satoshi Katsube, Katleen Willibal, Nathan D Burrows, Patrick G Mitchell, Amirhossein Bakhtiiari, Samantha Stanfield, Els Pardon, H Ronald Kaback, Ruibin Liang, Jan Steyaert, Rosa Viner, Lan Guan
Mobile barrier mechanisms for Na + -coupled symport in an MFS sugar transporter. eLife 12 (2024)
James Hillier, Yuguang Zhao, Loic Carrique, Tomas Malinauskas, Reinis R Ruza, Tao-Hsin Chang, Gangshun Yi, Helen M E Duyvesteyn, Jing Yu, Weixian Lu, Els Pardon, Jan Steyaert, Yanan Zhu, Tao Ni, Edith Yvonne Jones
Structural insights into Frizzled3 through nanobody modulators. Nature communications 15 (1) (2024)
Baptiste Fischer, Tomasz Uchański, Aidana Sheryazdanova, Simon Gonzalez, Alexander N Volkov, Elke Brosens, Thomas Zögg, Valentina Kalichuk, Steven Ballet, Wim Versées, Anna A Sablina, Els Pardon, Alexandre Wohlkönig, Jan Steyaert
Allosteric nanobodies to study the interactions between SOS1 and RAS. Nature communications 15 (1) (2024)
Shashank Khare, Miryam I Villalba, Juan C Canul-Tec, Arantza Balsebre Cajiao, Anand Kumar, Marija Backovic, Felix A Rey, Els Pardon, Jan Steyaert, Camilo Perez, Nicolas Reyes
Receptor-recognition and antiviral mechanisms of retrovirus-derived human proteins. Nature structural & molecular biology (2024)
Parameswaran Hariharan, Yuqi Shi, Satoshi Katsube, Katleen Willibal, Nathan D Burrows, Patrick G Mitchell, Amirhossein Bakhtiiari, Samantha Stanfield, Els Pardon, H Ronald Kaback, Ruibin Liang, Jan Steyaert, Rosa Viner, Lan Guan
Mobile barrier mechanisms for Na + -coupled symport in an MFS sugar transporter. eLife 12 (2024)
James Hillier, Yuguang Zhao, Loic Carrique, Tomas Malinauskas, Reinis R Ruza, Tao-Hsin Chang, Gangshun Yi, Helen M E Duyvesteyn, Jing Yu, Weixian Lu, Els Pardon, Jan Steyaert, Yanan Zhu, Tao Ni, Edith Yvonne Jones
Structural insights into Frizzled3 through nanobody modulators. Nature communications 15 (1) (2024)
Parameswaran Hariharan, Yuqi Shi, Satoshi Katsube, Katleen Willibal, Nathan D Burrows, Patrick G Mitchell, Amirhossein Bakhtiiari, Samantha Stanfield, Els Pardon, H Ronald Kaback, Ruibin Liang, Jan Steyaert, Rosa Viner, Lan Guan
Mobile barrier mechanisms for Na + -coupled symport in an MFS sugar transporter. eLife 12 (2024)
Parameswaran Hariharan, Yuqi Shi, Satoshi Katsube, Katleen Willibal, Nathan D Burrows, Patrick G Mitchell, Amirhossein Bakhtiiari, Samantha Stanfield, Els Pardon, H Ronald Kaback, Ruibin Liang, Jan Steyaert, Rosa Viner, Lan Guan
Mobile barrier mechanisms for Na + -coupled symport in an MFS sugar transporter. eLife 12 (2024)
Parameswaran Hariharan, Yuqi Shi, Satoshi Katsube, Katleen Willibal, Nathan D Burrows, Patrick G Mitchell, Amirhossein Bakhtiiari, Samantha Stanfield, Els Pardon, H Ronald Kaback, Ruibin Liang, Jan Steyaert, Rosa Viner, Lan Guan
Mobile barrier mechanisms for Na + -coupled symport in an MFS sugar transporter. eLife 12 (2024)
Karin E J Rödström, Alexander Cloake, Janina Sörmann, Agnese Baronina, Kathryn H M Smith, Ashley C W Pike, Jackie Ang, Peter Proks, Marcus Schewe, Ingelise Holland-Kaye, Simon R Bushell, Jenna Elliott, Els Pardon, Thomas Baukrowitz, Raymond J Owens, Simon Newstead, Jan Steyaert, Elisabeth P Carpenter, Stephen J Tucker
Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nature communications 15 (1) (2024)
James Hillier, Yuguang Zhao, Loic Carrique, Tomas Malinauskas, Reinis R Ruza, Tao-Hsin Chang, Gangshun Yi, Helen M E Duyvesteyn, Jing Yu, Weixian Lu, Els Pardon, Jan Steyaert, Yanan Zhu, Tao Ni, Edith Yvonne Jones
Structural insights into Frizzled3 through nanobody modulators. Nature communications 15 (1) (2024)
Karin E J Rödström, Alexander Cloake, Janina Sörmann, Agnese Baronina, Kathryn H M Smith, Ashley C W Pike, Jackie Ang, Peter Proks, Marcus Schewe, Ingelise Holland-Kaye, Simon R Bushell, Jenna Elliott, Els Pardon, Thomas Baukrowitz, Raymond J Owens, Simon Newstead, Jan Steyaert, Elisabeth P Carpenter, Stephen J Tucker
Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nature communications 15 (1) (2024)
Karin E J Rödström, Alexander Cloake, Janina Sörmann, Agnese Baronina, Kathryn H M Smith, Ashley C W Pike, Jackie Ang, Peter Proks, Marcus Schewe, Ingelise Holland-Kaye, Simon R Bushell, Jenna Elliott, Els Pardon, Thomas Baukrowitz, Raymond J Owens, Simon Newstead, Jan Steyaert, Elisabeth P Carpenter, Stephen J Tucker
Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nature communications 15 (1) (2024)
Baptiste Fischer, Tomasz Uchański, Aidana Sheryazdanova, Simon Gonzalez, Alexander N Volkov, Elke Brosens, Thomas Zögg, Valentina Kalichuk, Steven Ballet, Wim Versées, Anna A Sablina, Els Pardon, Alexandre Wohlkönig, Jan Steyaert
Allosteric nanobodies to study the interactions between SOS1 and RAS. Nature communications 15 (1) (2024)
Parameswaran Hariharan, Yuqi Shi, Satoshi Katsube, Katleen Willibal, Nathan D Burrows, Patrick G Mitchell, Amirhossein Bakhtiiari, Samantha Stanfield, Els Pardon, H Ronald Kaback, Ruibin Liang, Jan Steyaert, Rosa Viner, Lan Guan
Mobile barrier mechanisms for Na + -coupled symport in an MFS sugar transporter. eLife 12 (2024)
Baptiste Fischer, Tomasz Uchański, Aidana Sheryazdanova, Simon Gonzalez, Alexander N Volkov, Elke Brosens, Thomas Zögg, Valentina Kalichuk, Steven Ballet, Wim Versées, Anna A Sablina, Els Pardon, Alexandre Wohlkönig, Jan Steyaert
Allosteric nanobodies to study the interactions between SOS1 and RAS. Nature communications 15 (1) (2024)
Karin E J Rödström, Alexander Cloake, Janina Sörmann, Agnese Baronina, Kathryn H M Smith, Ashley C W Pike, Jackie Ang, Peter Proks, Marcus Schewe, Ingelise Holland-Kaye, Simon R Bushell, Jenna Elliott, Els Pardon, Thomas Baukrowitz, Raymond J Owens, Simon Newstead, Jan Steyaert, Elisabeth P Carpenter, Stephen J Tucker
Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nature communications 15 (1) (2024)
Romany Abskharon, Hope Pan, Michael R Sawaya, Paul Matthew Seidler, Eileen J Olivares, Yu Chen, Kevin A Murray, Jeffrey Zhang, Carter Lantz, Megan Bentzel, David R Boyer, Duilio Cascio, Binh A Nguyen, Ke Hou, Xinyi Cheng, Els Pardon, Christopher K Williams, Alissa L Nana, Harry V Vinters, Salvatore Spina, Lea Tenenholz Grinberg, William W Seeley, Jan Steyaert, Charles G Glabe, Rachel R Ogorzalek Loo, Joseph A Loo, David S Eisenberg
Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proceedings of the National Academy of Sciences of the United States of America 120 (41) (2023)
A Breine, Kevin Van Holsbeeck, C Martin, S Gonzalez, Morgane Mannes, E Pardon, Jan Steyaert, H Remaut, Steven Ballet, Charles Van der Henst
Bypassing the Need for Cell Permeabilization: Nanobody CDR3 Peptide Improves Binding on Living Bacteria. Bioconjugate chemistry (2023)
Adrià Sogues, Antonella Fioravanti, Wim Jonckheere, Els Pardon, Jan Steyaert, Han K Remaut
Structure and function of the EA1 surface layer of Bacillus anthracis. Nature communications 14 (1) (2023)
Scott A Jones, Prerana Gogoi, Jonathan J Ruprecht, Martin S King, Yang Lee, Thomas Zögg, Els Pardon, Deepak Chand, Stefan Steimle, Danielle M Copeman, Camila A Cotrim, Jan Steyaert, Paul G Crichton, Vera Y Moiseenkova-Bell, Edmund R S Kunji
Structural basis of purine nucleotide inhibition of human uncoupling protein 1. Science advances 9 (22) (2023)
Arum Wu, David Salom, John D Hong, Aleksander Tworak, Kohei Watanabe, Els Pardon, Jan Steyaert, Hideki Kandori, Kota Katayama, Philip D Kiser, Krzysztof Palczewski
Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nature communications 14 (1) (2023)
Kapil Goutam, Francesco S Ielasi, Els Pardon, Jan Steyaert, Nicolas Reyes
Structural basis of sodium-dependent bile salt uptake into the liver. Nature 606 (7916) (2022)
John J Kelly, Dale Tranter, Els Pardon, Gamma Chi, Holger B Kramer, Lotta J Happonen, Kelly M Knee, Jay M Janz, Jan Steyaert, Christine Bulawa, Ville O Paavilainen, Juha T Huiskonen, Wyatt W Yue
Snapshots of actin and tubulin folding inside the TRiC chaperonin. Nature structural & molecular biology 29 (5) (2022)
Ranjan Kumar Singh, Ahmed Soliman, Giambattista Guaitoli, Eliza Störmer, Felix von Zweydorf, Thomas Dal Maso, Asmaa Oun, Laura Van Rillaer, Sven H Schmidt, Deep Chatterjee, Joshua A David, Els Pardon, Thomas U Schwartz, Stefan Knapp, Eileen J Kennedy, Jan Steyaert, Friedrich W Herberg, Arjan Kortholt, Christian Johannes Gloeckner, Wim Versées
Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2. Proceedings of the National Academy of Sciences of the United States of America 119 (9) (2022)
Finn P Maloney, Jeremi Kuklewicz, Robin A Corey, Yunchen Bi, Ruoya Ho, Łukasz Mateusiak, Els Pardon, Jan Steyaert, Phillip J Stansfeld, Jochen Zimmer
Structure, substrate recognition and initiation of hyaluronan synthase. Nature 604 (7904) (2022)
Jeremy Russell Keown, Zihan Zhu, Loïc Carrique, Haitian Fan, Alexander P Walker, Itziar Serna Martin, Els Pardon, Jan Steyaert, Ervin Fodor, Jonathan M Grimes
Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Nature communications 13 (1) (2022)
Manoj K Rathinaswamy, Udit Dalwadi, Kaelin D Fleming, Carson Adams, Jordan T B Stariha, Els Pardon, Minkyung Baek, Oscar Vadas, Frank Dimaio, Jan Steyaert, Scott D Hansen, Calvin K Yip, John E Burke
Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation. Science advances 7 (35) (2021)
Pieter De Bruyn, Maruša Prolič-Kalinšek, Alexandra Vandervelde, Milan Malfait, Yann G J Sterckx, Frank Sobott, San Hadži, Els Pardon, Jan Steyaert, Remy Loris
Nanobody-aided crystallization of the transcription regulator PaaR2 from Escherichia coli O157:H7. Acta crystallographica. Section F, Structural biology communications 77 (Pt 10) (2021)
Linda Truebestein, Harald Hornegger, Dorothea Anrather, Markus Hartl, Kaelin D Fleming, Jordan T B Stariha, Els Pardon, Jan Steyaert, John E Burke, Thomas A Leonard
Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation. Proceedings of the National Academy of Sciences of the United States of America 118 (33) (2021)
Daniel Scholl, Maud Sigoillot, Marie Overtus, Rafael Colomer Martinez, Chloé Martens, Yiting Wang, Els Pardon, Toon Laeremans, Abel Garcia-Pino, Jan Steyaert, David N Sheppard, Jelle Hendrix, Cédric Govaerts
A topological switch in CFTR modulates channel activity and sensitivity to unfolding. Nature chemical biology 17 (9) (2021)
Tomasz Uchański, Simonas Masiulis, Baptiste Fischer, Valentina Kalichuk, Uriel López-Sánchez, Eleftherios Zarkadas, Miriam Weckener, Andrija Sente, Philip N Ward, Alexandre Wohlkönig, Thomas Zögg, Han K Remaut, James H Naismith, Hugues Nury, Wim F Vranken, A Radu Aricescu, Els Pardon, Jan Steyaert
Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM. Nature methods 18 (1) (2021)
Inda Setyawati, Weronika K Stanek, Maria Majsnerowska, Lotteke J Y M Swier, Els Pardon, Jan Steyaert, Albert Guskov, Dirk Jan Slotboom
In vitro reconstitution of dynamically interacting integral membrane subunits of energy-coupling factor transporters. eLife 9 (2020)
Levi J McClelland, Kaiming Zhang, Tung-Chung Mou, Jake Johnston, Cindee Yates-Hansen, Shanshan Li, Celestine J Thomas, Tzanko I Doukov, Sarah Triest, Alexandre Wohlkonig, Gregory G Tall, Jan Steyaert, Wah Chiu, Stephen R Sprang
Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1. Nature communications 11 (1) (2020)
Tao Che, Justin G English, Brian E Krumm, Kuglae Kim, Els Pardon, Reid H J Olsen, Sheng Wang, Shicheng Zhang, Jeffrey F Diberto, Noah Sciaky, F Ivy Carroll, Jan Steyaert, Daniel Wacker, Bryan L Roth
Nanobody-enabled monitoring of kappa opioid receptor states. Nature communications 11 (1) (2020)
Marijke Brams, Cedric Govaerts, Kumiko Kambara, Kerry L Price, Radovan Spurny, Anant Gharpure, Els Pardon, Genevieve L Evans, Daniel Bertrand, Sarah Cr Lummis, Ryan E Hibbs, Jan Steyaert, Chris Ulens
Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site. eLife 9 (2020)
Hemant Kumar, Janet Finer-Moore, Irina Smirnova, Vladimir Kasho, Els Pardon, Jan Steyaert, H Ronald Kaback, Robert M Stroud
Diversity in kinetics correlated with structure in nano body-stabilized LacY. PloS one 15 (5) (2020)
Jone Paesmans, Ella Martin, Babette Deckers, Marjolijn Berghmans, Ritika Sethi, Yannick Loeys, Els Pardon, Jan Steyaert, Patrik Verstreken, Christian Galicia, Wim Versées
A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations. eLife 9 (2020)
Tomasz Uchański, Thomas Zögg, Jie Yin, Daopeng Yuan, Alexandre Wohlkönig, Baptiste Fischer, Daniel M Rosenbaum, Brian K Kobilka, Els Pardon, Jan Steyaert
An improved yeast surface display platform for the screening of nanobody immune libraries. Scientific reports 9 (1) (2019)
Maud Sigoillot, Marie Overtus, Magdalena Grodecka, Daniel Scholl, Abel Garcia-Pino, Toon Laeremans, Lihua He, Els Pardon, Ellen Hildebrandt, Ina Urbatsch, Jan Steyaert, John R Riordan, Cedric Govaerts
Domain-interface dynamics of CFTR revealed by stabilizing nanobodies. Nature communications 10 (1) (2019)
Camille M Hénault, Cedric Govaerts, Radovan Spurny, Marijke Brams, Argel Estrada-Mondragon, Joseph W Lynch, Daniel Bertrand, Els Pardon, Genevieve L Evans, Kristen Woods, Benjamin W Elberson, Luis G Cuello, Grace Brannigan, Hugues Nury, Jan Steyaert, John E Baenziger, Chris Ulens
A lipid site shapes the agonist response of a pentameric ligand-gated ion channel. Nature chemical biology 15 (12) (2019)
Ekaitz Errasti-Murugarren, Joana Fort, Paola Bartoccioni, Lucía Díaz, Els Pardon, Xavier Carpena, Meritxell Espino-Guarch, Antonio Zorzano, Christine Ziegler, Jan Steyaert, Juan Fernández-Recio, Ignacio Fita, Manuel Palacín
L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction. Nature communications 10 (1) (2019)
Sahil Gulati, Hui Jin, Ikuo Masuho, Tivadar Orban, Yuan Cai, Els Pardon, Kirill A Martemyanov, Philip D Kiser, Phoebe L Stewart, Christopher P Ford, Jan Steyaert, Krzysztof Palczewski
Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nature communications 9 (1) (2018)
Els Pardon, Cecilia Betti, Toon Laeremans, Florent Chevillard, Karel Guillemyn, Peter Kolb, Steven Ballet, Jan Steyaert
Nanobody-Enabled Reverse Pharmacology on G-Protein-Coupled Receptors. Angewandte Chemie (International ed. in English) 57 (19) (2018)
Didier Monté, Bernard Clantin, Frédérique Dewitte, Zoé Lens, Prakash Rucktooa, Els Pardon, Jan Steyaert, Alexis Verger, Vincent Villeret
Crystal structure of human Mediator subunit MED23. Nature communications 9 (1) (2018)
Bart van Beusekom, Tatjana Heidebrecht, Athanassios Adamopoulos, Alexander Fish, Els Pardon, Jan Steyaert, Robbie P Joosten, Anastassis Perrakis
Characterization and structure determination of a llama-derived nanobody targeting the J-base binding protein 1. Acta crystallographica. Section F, Structural biology communications 74 (Pt 11) (2018)
Paul S Miller, Suzanne Scott, Simonas Masiulis, Luigi De Colibus, Els Pardon, Jan Steyaert, A Radu Aricescu
Structural basis for GABAA receptor potentiation by neurosteroids. Nature structural & molecular biology 24 (11) (2017)

Jan Steyaert.css-eqlu8i{font-size:small;padding-left:4px;} (J Steyaert)

Publication Activity (10 Years)

Top Topics

Top Venues

Jan Steyaert (J Steyaert)