Dennis E Discher

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 25

Top Topics

Monoclonal Antibody

Top Venues

The Journal of cell biology

Journal of cell science

Nature biomedical engineering

This page only lists publications with an associated author ORCID identifier.

Publications

Brandon H Hayes, Mai Wang, Hui Zhu, Steven H Phan, Lawrence J Dooling, Jason C Andrechak, Alexander H Chang, Michael P Tobin, Nicholas M Ontko, Tristan Marchena, Dennis E Discher
Chromosomal instability induced in cancer can enhance macrophage-initiated immune responses that include anti-tumor IgG. eLife 12 (2024)
Brandon H Hayes, Mai Wang, Hui Zhu, Steven H Phan, Lawrence J Dooling, Jason C Andrechak, Alexander H Chang, Michael P Tobin, Nicholas M Ontko, Tristan Marchena, Dennis E Discher
Chromosomal instability induced in cancer can enhance macrophage-initiated immune responses that include anti-tumor IgG. eLife 12 (2024)
Brandon H Hayes, Mai Wang, Hui Zhu, Steven H Phan, Lawrence J Dooling, Jason C Andrechak, Alexander H Chang, Michael P Tobin, Nicholas M Ontko, Tristan Marchena, Dennis E Discher
Chromosomal instability induced in cancer can enhance macrophage-initiated immune responses that include anti-tumor IgG. eLife 12 (2024)
Brandon H Hayes, Hui Zhu, Jason C Andrechak, Lawrence J Dooling, Dennis E Discher
Titrating CD47 by mismatch CRISPR-interference reveals incomplete repression can eliminate IgG-opsonized tumors but limits induction of antitumor IgG. PNAS nexus 2 (8) (2023)
Lawrence J Dooling, Jason C Andrechak, Brandon H Hayes, Siddhant Kadu, William Zhang, Ruby Pan, Manasvita Vashisth, Jerome Irianto, Cory M Alvey, Leyuan Ma, Dennis E Discher
Cooperative phagocytosis of solid tumours by macrophages triggers durable anti-tumour responses. Nature biomedical engineering (2023)
Lawrence J Dooling, Jason C Andrechak, Brandon H Hayes, Siddhant Kadu, William Zhang, Ruby Pan, Manasvita Vashisth, Jerome Irianto, Cory M Alvey, Leyuan Ma, Dennis E Discher
Cooperative phagocytosis of solid tumours by macrophages triggers durable anti-tumour responses. Nature biomedical engineering (2023)
Mai Wang, Steven Phan, Brandon H Hayes, Dennis E Discher
Genetic heterogeneity in p53-null leukemia increases transiently with spindle assembly checkpoint inhibition and is not rescued by p53. Chromosoma (2023)
Irena L Ivanovska, Michael P Tobin, Tianyi Bai, Lawrence J Dooling, Dennis E Discher
Small lipid droplets are rigid enough to indent a nucleus, dilute the lamina, and cause rupture. The Journal of cell biology 222 (8) (2023)
Brandon H Hayes, Peter Kuangzheng Zhu, Mai Wang, Charlotte R Pfeifer, Yuntao Xia, Steven Phan, Jason C Andrechak, Junhong Du, Michael P Tobin, Alisya Anlas, Lawrence J Dooling, Manasvita Vashisth, Jerome Irianto, Michael A Lampson, Dennis E Discher
Confinement plus myosin-II suppression maximizes heritable loss of chromosomes, as revealed by live-cell ChReporters. Journal of cell science 136 (11) (2023)
Lawrence J Dooling, Jason C Andrechak, Brandon H Hayes, Siddhant Kadu, William Zhang, Ruby Pan, Manasvita Vashisth, Jerome Irianto, Cory M Alvey, Leyuan Ma, Dennis E Discher
Cooperative phagocytosis of solid tumours by macrophages triggers durable anti-tumour responses. Nature biomedical engineering (2023)
Irena L Ivanovska, Michael P Tobin, Tianyi Bai, Lawrence J Dooling, Dennis E Discher
Small lipid droplets are rigid enough to indent a nucleus, dilute the lamina, and cause rupture. The Journal of cell biology 222 (8) (2023)
Brandon H Hayes, Peter Kuangzheng Zhu, Mai Wang, Charlotte R Pfeifer, Yuntao Xia, Steven Phan, Jason C Andrechak, Junhong Du, Michael P Tobin, Alisya Anlas, Lawrence J Dooling, Manasvita Vashisth, Jerome Irianto, Michael A Lampson, Dennis E Discher
Confinement plus Myosin-II suppression maximizes heritable loss of chromosomes, as revealed by live-cell ChReporters. Journal of cell science (2023)
Mai Wang, Irena Ivanovska, Manasvita Vashisth, Dennis E Discher
Nuclear mechanoprotection: From tissue atlases as blueprints to distinctive regulation of nuclear lamins. APL bioengineering 6 (2) (2022)
AbdelAziz R Jalil, Michael P Tobin, Dennis E Discher
Suppressing or Enhancing Macrophage Engulfment through the Use of CD47 and Related Peptides. Bioconjugate chemistry 33 (11) (2022)
Jason C Andrechak, Lawrence J Dooling, Michael P Tobin, William Zhang, Brandon H Hayes, Justine Y Lee, Xiaoling Jin, Jerome Irianto, Dennis E Discher
CD47-SIRPα Checkpoint Disruption in Metastases Requires Tumor-Targeting Antibody for Molecular and Engineered Macrophage Therapies. Cancers 14 (8) (2022)
AbdelAziz R Jalil, Jason C Andrechak, Brandon H Hayes, David M Chenoweth, Dennis E Discher
Human CD47-Derived Cyclic Peptides Enhance Engulfment of mAb-Targeted Melanoma by Primary Macrophages. Bioconjugate chemistry 33 (11) (2022)
Brandon H Hayes, Richard K Tsai, Lawrence J Dooling, Siddhant Kadu, Justine Y Lee, Diego Pantano, Pia L Rodriguez, Shyamsundar Subramanian, Jae-Won Shin, Dennis E Discher
Macrophages show higher levels of engulfment after disruption of cis interactions between CD47 and the checkpoint receptor SIRPα. Journal of cell science 133 (5) (2020)
AbdelAziz R Jalil, Brandon H Hayes, Jason C Andrechak, Yuntao Xia, David M Chenoweth, Dennis E Discher
Multivalent, Soluble Nano-Self Peptides Increase Phagocytosis of Antibody-Opsonized Targets while Suppressing "Self" Signaling. ACS nano 14 (11) (2020)
AbdelAziz R Jalil, Jason C Andrechak, Dennis E Discher
Macrophage checkpoint blockade: results from initial clinical trials, binding analyses, and CD47-SIRPα structure-function. Antibody therapeutics 3 (2) (2020)
Yuntao Xia, Charlotte R Pfeifer, Kuangzheng Zhu, Jerome Irianto, Dazhen Liu, Kalia Pannell, Emily J Chen, Lawrence J Dooling, Michael P Tobin, Mai Wang, Irena L Ivanovska, Lucas R Smith, Roger A Greenberg, Dennis E Discher
Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. The Journal of cell biology 218 (8) (2019)
Karanvir Saini, Dennis E Discher
Forced Unfolding of Proteins Directs Biochemical Cascades. Biochemistry 58 (49) (2019)
Praful R Nair, Cory Alvey, Xiaoling Jin, Jerome Irianto, Irena Ivanovska, Dennis E Discher
Filomicelles Deliver a Chemo-Differentiation Combination of Paclitaxel and Retinoic Acid That Durably Represses Carcinomas in Liver to Prolong Survival. Bioconjugate chemistry 29 (4) (2018)
Yuntao Xia, Irena L Ivanovska, Kuangzheng Zhu, Lucas Smith, Jerome Irianto, Charlotte R Pfeifer, Cory M Alvey, Jiazheng Ji, Dazhen Liu, Sangkyun Cho, Rachel R Bennett, Andrea J Liu, Roger A Greenberg, Dennis E Discher
Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. The Journal of cell biology 217 (11) (2018)
Jan Steinkühler, Bartosz Różycki, Cory Alvey, Reinhard Lipowsky, Thomas R Weikl, Rumiana Dimova, Dennis E Discher
Membrane fluctuations and acidosis regulate cooperative binding of 'marker of self' protein CD47 with the macrophage checkpoint receptor SIRPα. Journal of cell science 132 (4) (2018)
Sangkyun Cho, Jerome Irianto, Dennis E Discher
Mechanosensing by the nucleus: From pathways to scaling relationships. The Journal of cell biology 216 (2) (2017)