Mechanosensing by the nucleus: From pathways to scaling relationships.
Sangkyun ChoJerome IriantoDennis E DischerPublished in: The Journal of cell biology (2017)
The nucleus is linked mechanically to the extracellular matrix via multiple polymers that transmit forces to the nuclear envelope and into the nuclear interior. Here, we review some of the emerging mechanisms of nuclear mechanosensing, which range from changes in protein conformation and transcription factor localization to chromosome reorganization and membrane dilation up to rupture. Nuclear mechanosensing encompasses biophysically complex pathways that often converge on the main structural proteins of the nucleus, the lamins. We also perform meta-analyses of public transcriptomics and proteomics data, which indicate that some of the mechanosensing pathways relaying signals from the collagen matrix to the nucleus apply to a broad range of species, tissues, and diseases.
Keyphrases
- extracellular matrix
- transcription factor
- meta analyses
- systematic review
- healthcare
- mass spectrometry
- gene expression
- randomized controlled trial
- mental health
- electronic health record
- big data
- single cell
- molecular dynamics simulations
- deep learning
- copy number
- dna methylation
- machine learning
- artificial intelligence
- label free
- data analysis
- genome wide identification