Edgar Specker

Publication Activity (10 Years)

Years Active: 2022-2024
Publications (10 Years): 8

Top Topics

Structural Basis

Pulmonary Arterial Hypertension

Tyrosine Kinase

Top Venues

Journal of the American Heart Association

Journal of medicinal chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Radoslaw Wesolowski, Dirk Pleimes, Edgar Specker, Michael Bader
TPT-004, a Next-Generation Inhibitor of Tryptophan Hydroxylase, Ameliorates Pulmonary Arterial Hypertension in Rats. Journal of the American Heart Association (2024)
Radoslaw Wesolowski, Dirk Pleimes, Edgar Specker, Michael Bader
TPT-004, a Next-Generation Inhibitor of Tryptophan Hydroxylase, Ameliorates Pulmonary Arterial Hypertension in Rats. Journal of the American Heart Association 13 (10) (2024)
Radoslaw Wesolowski, Dirk Pleimes, Edgar Specker, Michael Bader
TPT-004, a Next-Generation Inhibitor of Tryptophan Hydroxylase, Ameliorates Pulmonary Arterial Hypertension in Rats. Journal of the American Heart Association 13 (10) (2024)
Radoslaw Wesolowski, Dirk Pleimes, Edgar Specker, Michael Bader
TPT-004, a Next-Generation Inhibitor of Tryptophan Hydroxylase, Ameliorates Pulmonary Arterial Hypertension in Rats. Journal of the American Heart Association 13 (10) (2024)
Edgar Specker, Radoslaw Wesolowski, Anja Schütz, Susann Matthes, Keven Mallow, Malgorzata Wasinska-Kalwa, Lars Winkler, Andreas Oder, Natalia V Alenina, Dirk Pleimes, Jens Peter von Kries, Udo Heinemann, Michael Bader, Marc Nazare
Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors. Journal of medicinal chemistry (2023)
Murat Kücükdisli, Hassen Bel-Abed, Davide Cirillo, Wen-Ting Lo, Nina-Louisa Efrém, André Horatscheck, Liudmila Perepelittchenko, Polina Prokofeva, Theresa A L Ehret, Silke Radetzki, Martin Neuenschwander, Edgar Specker, Guillaume Médard, Susanne Müller, Stephanie Wilhelm, Bernhard Kuster, Jens Peter von Kries, Volker Haucke, Marc Nazare
Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition. Journal of medicinal chemistry (2023)
Edgar Specker, Susann Matthes, Radoslaw Wesolowski, Anja Schütz, Maik Grohmann, Natalia V Alenina, Dirk Pleimes, Keven Mallow, Martin Neuenschwander, Angelina Gogolin, Marie Weise, Jochen Pfeifer, Nandor Ziebart, Udo Heinemann, Jens Peter von Kries, Marc Nazare, Michael Bader
Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. Journal of medicinal chemistry 65 (16) (2022)
María Isabel Fernández-Bachiller, Songhwan Hwang, María Elena Schembri, Peter Lindemann, Mónica Guberman, Svenja Herziger, Edgar Specker, Hans Matter, David W Will, Jörg Czech, Michael Wagner, Armin Bauer, Herman Schreuder, Kurt Ritter, Matthias Urmann, Volkmar Wehner, Han Sun, Marc Nazare
Probing Factor Xa Protein-Ligand Interactions: Accurate Free Energy Calculations and Experimental Validations of Two Series of High-Affinity Ligands. Journal of medicinal chemistry 65 (19) (2022)