Edward P O'Brien

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 28

Top Topics

Respiratory Syndrome Coronavirus

Angiotensin Converting Enzyme

Molecular Dynamics

Top Venues

The journal of physical chemistry. B

PLoS computational biology

The Journal of chemical physics

This page only lists publications with an associated author ORCID identifier.

Publications

Yang Jiang, Charlotte M Deane, Garrett M Morris, Edward P O'Brien
It is theoretically possible to avoid misfolding into non-covalent lasso entanglements using small molecule drugs. PLoS computational biology 20 (3) (2024)
Pham Dang Lan, Daniel A Nissley, Edward P O'Brien, Toan The Nguyen, Mai Suan Li
Deciphering the free energy landscapes of SARS-CoV-2 wild type and Omicron variant interacting with human ACE2. The Journal of chemical physics 160 (5) (2024)
Pham Dang Lan, Daniel A Nissley, Edward P O'Brien, Toan The Nguyen, Mai Suan Li
Deciphering the free energy landscapes of SARS-CoV-2 wild type and Omicron variant interacting with human ACE2. The Journal of chemical physics 160 (5) (2024)
Yang Jiang, Charlotte M Deane, Garrett M Morris, Edward P O'Brien
It is theoretically possible to avoid misfolding into non-covalent lasso entanglements using small molecule drugs. PLoS computational biology 20 (3) (2024)
Pham Dang Lan, Daniel A Nissley, Edward P O'Brien, Toan The Nguyen, Mai Suan Li
Deciphering the free energy landscapes of SARS-CoV-2 wild type and Omicron variant interacting with human ACE2. The Journal of chemical physics 160 (5) (2024)
Pham Dang Lan, Daniel A Nissley, Edward P O'Brien, Toan The Nguyen, Mai Suan Li
Deciphering the free energy landscapes of SARS-CoV-2 wild type and Omicron variant interacting with human ACE2. The Journal of chemical physics 160 (5) (2024)
Pham Dang Lan, Daniel A Nissley, Edward P O'Brien, Toan The Nguyen, Mai Suan Li
Deciphering the free energy landscapes of SARS-CoV-2 wild type and Omicron variant interacting with human ACE2. The Journal of chemical physics 160 (5) (2024)
Yang Jiang, Charlotte M Deane, Garrett M Morris, Edward P O'Brien
It is theoretically possible to avoid misfolding into non-covalent lasso entanglements using small molecule drugs. PLoS computational biology 20 (3) (2024)
Yang Jiang, Charlotte M Deane, Garrett M Morris, Edward P O'Brien
It is theoretically possible to avoid misfolding into non-covalent lasso entanglements using small molecule drugs. PLoS computational biology 20 (3) (2024)
Quyen V Vu, Daniel A Nissley, Yang Jiang, Edward P O'Brien, Mai Suan Li
Is Posttranslational Folding More Efficient Than Refolding from a Denatured State: A Computational Study. The journal of physical chemistry. B (2023)
Ritaban Halder, Daniel A Nissley, Ian Sitarik, Yang Jiang, Yiyun Rao, Quyen V Vu, Mai Suan Li, Justin R Pritchard, Edward P O'Brien
How soluble misfolded proteins bypass chaperones at the molecular level. Nature communications 14 (1) (2023)
Joseph R Persichetti, Yang Jiang, Phillip S Hudson, Edward P O'Brien
Modeling Ensembles of Enzyme Reaction Pathways with Hi-MSM Reveals the Importance of Accounting for Pathway Diversity. The journal of physical chemistry. B 126 (47) (2022)
Hung Nguyen, Pham Dang Lan, Daniel A Nissley, Edward P O'Brien, Mai Suan Li
Cocktail of REGN Antibodies Binds More Strongly to SARS-CoV-2 Than Its Components, but the Omicron Variant Reduces Its Neutralizing Ability. The journal of physical chemistry. B 126 (15) (2022)
Daniel A Nissley, Yang Jiang, Fabio Trovato, Ian Sitarik, Karthik B Narayan, Philip To, Yingzi Xia, Stephen D Fried, Edward P O'Brien
Universal protein misfolding intermediates can bypass the proteostasis network and remain soluble and less functional. Nature communications 13 (1) (2022)
Sarah E Leininger, Judith Rodriguez, Quyen V Vu, Yang Jiang, Mai Suan Li, Carol Deutsch, Edward P O'Brien
Correction to "Ribosome Elongation Kinetics of Consecutively Charged Residues Are Coupled to Electrostatic Force". Biochemistry 61 (2) (2022)
Yang Jiang, Syam Sundar Neti, Ian Sitarik, Priya Pradhan, Philip To, Yingzi Xia, Stephen D Fried, Squire J Booker, Edward P O'Brien
How synonymous mutations alter enzyme structure and function over long timescales. Nature chemistry (2022)
Boyang Zhao, Yiyun Rao, Scott Leighow, Edward P O'Brien, Luke A Gilbert, Justin R Pritchard
A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments. Nature communications 13 (1) (2022)
Hung Nguyen, Pham Dang Lan, Daniel A Nissley, Edward P O'Brien, Mai Suan Li
Electrostatic Interactions Explain the Higher Binding Affinity of the CR3022 Antibody for SARS-CoV-2 than the 4A8 Antibody. The journal of physical chemistry. B 125 (27) (2021)
Sarah E Leininger, Judith Rodriguez, Quyen V Vu, Yang Jiang, Mai Suan Li, Carol Deutsch, Edward P O'Brien
Ribosome Elongation Kinetics of Consecutively Charged Residues Are Coupled to Electrostatic Force. Biochemistry 60 (43) (2021)
Yang Jiang, Edward P O'Brien
Mechanical Forces Have a Range of Effects on the Rate of Ribosome Catalyzed Peptidyl Transfer Depending on Direction. The journal of physical chemistry. B 125 (26) (2021)
Daniel A Nissley, Quyen V Vu, Fabio Trovato, Nabeel Ahmed, Yang Jiang, Mai Suan Li, Edward P O'Brien
Electrostatic Interactions Govern Extreme Nascent Protein Ejection Times from Ribosomes and Can Delay Ribosome Recycling. Journal of the American Chemical Society 142 (13) (2020)
Nguyen Hoang Linh, Pham Dang Lan, Nguyen Quoc Thai, Daniel A Nissley, Edward P O'Brien, Mai Suan Li
Does SARS-CoV-2 Bind to Human ACE2 More Strongly Than Does SARS-CoV? The journal of physical chemistry. B 124 (34) (2020)
David K Wolfe, Joseph R Persichetti, Ajeet K Sharma, Phillip S Hudson, H Lee Woodcock, Edward P O'Brien
Hierarchical Markov State Model Building to Describe Molecular Processes. Journal of chemical theory and computation 16 (3) (2020)
Ajeet K Sharma, Pietro Sormanni, Nabeel Ahmed, Prajwal Ciryam, Ulrike Anne Friedrich, Günter Kramer, Edward P O'Brien
A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data. PLoS computational biology 15 (5) (2019)
Sarah E Leininger, Karthik Narayan, Carol Deutsch, Edward P O'Brien
Mechanochemistry in Translation. Biochemistry 58 (47) (2019)
Benjamin Fritch, Andrey Kosolapov, Phillip Hudson, Daniel A Nissley, H Lee Woodcock, Carol Deutsch, Edward P O'Brien
Origins of the Mechanochemical Coupling of Peptide Bond Formation to Protein Synthesis. Journal of the American Chemical Society 140 (15) (2018)
Daniel A Nissley, Edward P O'Brien
Structural Origins of FRET-Observed Nascent Chain Compaction on the Ribosome. The journal of physical chemistry. B 122 (43) (2018)
Ajeet K Sharma, Edward P O'Brien
Increasing Protein Production Rates Can Decrease the Rate at Which Functional Protein Is Produced and Their Steady-State Levels. The journal of physical chemistry. B 121 (28) (2017)