Eugene I Shakhnovich (Eugene Shakhnovich)

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 45

Top Topics

Molecular Dynamics Simulations

Antimicrobial Resistance

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Nature communications

bioRxiv : the preprint server for biology

This page only lists publications with an associated author ORCID identifier.

Publications

Aniruddha Chattaraj, Eugene I Shakhnovich
Multi-condensate state as a functional strategy to optimize the cell signaling output. Nature communications 15 (1) (2024)
Dianzhuo Wang, Marian Huot, Vaibhav Mohanty, Eugene I Shakhnovich
Biophysical principles predict fitness of SARS-CoV-2 variants. Proceedings of the National Academy of Sciences of the United States of America 121 (23) (2024)
Aniruddha Chattaraj, Eugene I Shakhnovich
Multi-condensate state as a functional strategy to optimize the cell signaling output. Nature communications 15 (1) (2024)
Dianzhuo Wang, Marian Huot, Vaibhav Mohanty, Eugene I Shakhnovich
Biophysical principles predict fitness of SARS-CoV-2 variants. Proceedings of the National Academy of Sciences of the United States of America 121 (23) (2024)
Dianzhuo Wang, Marian Huot, Vaibhav Mohanty, Eugene I Shakhnovich
Biophysical principles predict fitness of SARS-CoV-2 variants. Proceedings of the National Academy of Sciences of the United States of America 121 (23) (2024)
Dianzhuo Wang, Marian Huot, Vaibhav Mohanty, Eugene I Shakhnovich
Biophysical principles predict fitness of SARS-CoV-2 variants. Proceedings of the National Academy of Sciences of the United States of America 121 (23) (2024)
Dianzhuo Wang, Marian Huot, Vaibhav Mohanty, Eugene I Shakhnovich
Biophysical principles predict fitness of SARS-CoV-2 variants. Proceedings of the National Academy of Sciences of the United States of America 121 (23) (2024)
Aniruddha Chattaraj, Eugene I Shakhnovich
Multi-condensate state as a functional strategy to optimize the cell signaling output. Nature communications 15 (1) (2024)
Aniruddha Chattaraj, Eugene I Shakhnovich
Multi-condensate state as a functional strategy to optimize the cell signaling output. bioRxiv : the preprint server for biology (2024)
Dianzhuo Wang, Marian Huot, Vaibhav Mohanty, Eugene I Shakhnovich
Biophysical principles predict fitness of SARS-CoV-2 variants. Proceedings of the National Academy of Sciences of the United States of America 121 (23) (2024)
Aniruddha Chattaraj, Eugene I Shakhnovich
Multi-condensate state as a functional strategy to optimize the cell signaling output. bioRxiv : the preprint server for biology (2024)
Aniruddha Chattaraj, Eugene I Shakhnovich
Multi-condensate state as a functional strategy to optimize the cell signaling output. bioRxiv : the preprint server for biology (2024)
David Scheerer, Bharat V Adkar, Sanchari Bhattacharyya, Dorit Levy, Marija Iljina, Inbal Riven, Orly Dym, Gilad Haran, Eugene I Shakhnovich
Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase. Proceedings of the National Academy of Sciences of the United States of America 120 (18) (2023)
Srivastav Ranganathan, Pouria Dasmeh, Seth T E Furniss, Eugene I Shakhnovich
Phosphorylation sites are evolutionary checkpoints against liquid-solid transition in protein condensates. Proceedings of the National Academy of Sciences of the United States of America 120 (20) (2023)
David Scheerer, Bharat V Adkar, Sanchari Bhattacharyya, Dorit Levy, Marija Iljina, Inbal Riven, Orly Dym, Gilad Haran, Eugene I Shakhnovich
Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase. Proceedings of the National Academy of Sciences of the United States of America 120 (18) (2023)
C Brandon Ogbunugafor, Rafael F Guerrero, Eugene I Shakhnovich, Matthew D Shoulders
Epistasis meets pleiotropy in shaping biophysical protein subspaces associated with antimicrobial resistance. bioRxiv : the preprint server for biology (2023)
Srivastav Ranganathan, Pouria Dasmeh, Seth T E Furniss, Eugene I Shakhnovich
Phosphorylation sites are evolutionary checkpoints against liquid-solid transition in protein condensates. Proceedings of the National Academy of Sciences of the United States of America 120 (20) (2023)
Simon Axelrod, Eugene I Shakhnovich, Rafael Gomez-Bombarelli
Mapping the Space of Photoswitchable Ligands and Photodruggable Proteins with Computational Modeling. Journal of chemical information and modeling (2023)
Srivastav Ranganathan, Pouria Dasmeh, Seth T E Furniss, Eugene I Shakhnovich
Phosphorylation sites are evolutionary checkpoints against liquid-solid transition in protein condensates. Proceedings of the National Academy of Sciences of the United States of America 120 (20) (2023)
Simon Axelrod, Eugene I Shakhnovich, Rafael Gomez-Bombarelli
Thermal Half-Lives of Azobenzene Derivatives: Virtual Screening Based on Intersystem Crossing Using a Machine Learning Potential. ACS central science 9 (2) (2023)
David Scheerer, Bharat V Adkar, Sanchari Bhattacharyya, Dorit Levy, Marija Iljina, Inbal Riven, Orly Dym, Gilad Haran, Eugene I Shakhnovich
Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase. Proceedings of the National Academy of Sciences of the United States of America 120 (18) (2023)
Srivastav Ranganathan, Pouria Dasmeh, Seth T E Furniss, Eugene I Shakhnovich
Phosphorylation sites are evolutionary checkpoints against liquid-solid transition in protein condensates. Proceedings of the National Academy of Sciences of the United States of America 120 (20) (2023)
Sourav Chowdhury, Daniel C Zielinski, Christopher Dalldorf, Joao V Rodrigues, Bernhard O Palsson, Eugene I Shakhnovich
Empowering drug off-target discovery with metabolic and structural analysis. Nature communications 14 (1) (2023)
Simon Axelrod, Eugene I Shakhnovich, Rafael Gomez-Bombarelli
Thermal Half-Lives of Azobenzene Derivatives: Virtual Screening Based on Intersystem Crossing Using a Machine Learning Potential. ACS central science 9 (2) (2023)
Srivastav Ranganathan, Pouria Dasmeh, Seth T E Furniss, Eugene I Shakhnovich
Phosphorylation sites are evolutionary checkpoints against liquid-solid transition in protein condensates. Proceedings of the National Academy of Sciences of the United States of America 120 (20) (2023)
David Scheerer, Bharat V Adkar, Sanchari Bhattacharyya, Dorit Levy, Marija Iljina, Inbal Riven, Orly Dym, Gilad Haran, Eugene I Shakhnovich
Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase. Proceedings of the National Academy of Sciences of the United States of America 120 (18) (2023)
David Scheerer, Bharat V Adkar, Sanchari Bhattacharyya, Dorit Levy, Marija Iljina, Inbal Riven, Orly Dym, Gilad Haran, Eugene I Shakhnovich
Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase. Proceedings of the National Academy of Sciences of the United States of America 120 (18) (2023)
David Scheerer, Bharat V Adkar, Sanchari Bhattacharyya, Dorit Levy, Marija Iljina, Inbal Riven, Orly Dym, Gilad Haran, Eugene I Shakhnovich
Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase. Proceedings of the National Academy of Sciences of the United States of America 120 (18) (2023)
David Scheerer, Bharat V Adkar, Sanchari Bhattacharyya, Dorit Levy, Marija Iljina, Inbal Riven, Orly Dym, Gilad Haran, Eugene I Shakhnovich
Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase. Proceedings of the National Academy of Sciences of the United States of America 120 (18) (2023)
David Scheerer, Bharat V Adkar, Sanchari Bhattacharyya, Dorit Levy, Marija Iljina, Inbal Riven, Orly Dym, Gilad Haran, Eugene I Shakhnovich
Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase. Proceedings of the National Academy of Sciences of the United States of America 120 (18) (2023)
Eugene Serebryany, Sourav Chowdhury, Christopher N Woods, David C Thorn, Nicki E Watson, Arthur A McClelland, Rachel E Klevit, Eugene I Shakhnovich
A native chemical chaperone in the human eye lens. eLife 11 (2022)
Sanchari Bhattacharyya, Shimon Bershtein, Bharat V Adkar, Jaie Woodard, Eugene I Shakhnovich
Metabolic response to point mutations reveals principles of modulation of in vivo enzyme activity and phenotype. Molecular systems biology 17 (6) (2022)
Srivastav Ranganathan, Junlang Liu, Eugene I Shakhnovich
Different states and the associated fates of biomolecular condensates. Essays in biochemistry (2022)
Amir Bitran, Kibum Park, Eugene Serebryany, Eugene I Shakhnovich
Cotranslational formation of disulfides guides folding of the SARS COV-2 receptor binding domain. bioRxiv : the preprint server for biology (2022)
Haichun Liu, Sourav Chowdhury, João V Rodrigues, Eugene I Shakhnovich
Development of antibacterial compounds that constrain evolutionary pathways to resistance. eLife 10 (2021)
Srivastav Ranganathan, Eugene I Shakhnovich
Effect of RNA on Morphology and Dynamics of Membraneless Organelles. The journal of physical chemistry. B 125 (19) (2021)
Srivastav Ranganathan, Eugene I Shakhnovich
Dynamic metastable long-living droplets formed by sticker-spacer proteins. eLife 9 (2020)
Amir Bitran, William M Jacobs, Eugene I Shakhnovich
Validation of DBFOLD: An efficient algorithm for computing folding pathways of complex proteins. PLoS computational biology 16 (11) (2020)
Michael Manhart, Bharat V Adkar, Eugene I Shakhnovich
Trade-offs between microbial growth phases lead to frequency-dependent and non-transitive selection. Proceedings. Biological sciences 285 (1872) (2019)
Qingtong Zhou, Dehua Yang, Meng Wu, Yu Guo, Wanjing Guo, Li Zhong, Xiaoqing Cai, Antao Dai, Wonjo Jang, Eugene I Shakhnovich, Zhi-Jie Liu, Raymond C Stevens, Nevin A Lambert, M Madan Babu, Ming-Wei Wang, Suwen Zhao
Common activation mechanism of class A GPCRs. eLife 8 (2019)
João V Rodrigues, Eugene I Shakhnovich
Adaptation to mutational inactivation of an essential gene converges to an accessible suboptimal fitness peak. eLife 8 (2019)
William M Jacobs, Eugene I Shakhnovich
Accurate Protein-Folding Transition-Path Statistics from a Simple Free-Energy Landscape. The journal of physical chemistry. B 122 (49) (2018)
Michael Manhart, Eugene I Shakhnovich
Growth tradeoffs produce complex microbial communities on a single limiting resource. Nature communications 9 (1) (2018)
Bharat V Adkar, Michael Manhart, Sanchari Bhattacharyya, Jian Tian, Michael Musharbash, Eugene I Shakhnovich
Optimization of lag phase shapes the evolution of a bacterial enzyme. Nature ecology & evolution 1 (6) (2017)
Sanchari Bhattacharyya, Shimon Bershtein, Jin Yan, Tijda Argun, Amy I Gilson, Sunia A Trauger, Eugene I Shakhnovich
Transient protein-protein interactions perturb E. coli metabolome and cause gene dosage toxicity. eLife 5 (2016)