Suwen Zhao

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 54

Top Venues

Nature communications

Journal of medicinal chemistry

Cell research

Cell discovery

ShanghaiTech University

Columbia University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

ShanghaiTech University Nov 22 2014

China

Assisstant Professor :: iHuman Institute/School of Life Science and Technology

University of California San Francisco May 01 2010 - Nov 20 2014

United States

Postdoc :: Pharmaceutical Chemistry

Education History

Columbia University Aug 18 2004 - Apr 30 2010

United States

PHD :: Chemistry

Publications

Peng Cheng, Cong Mao, Jin Tang, Sen Yang, Yu Cheng, Wuke Wang, Qiuxi Gu, Wei Han, Hao Chen, Sihan Li, Yaofeng Chen, Jianglin Zhou, Wuju Li, Aimin Pan, Suwen Zhao, Xing-Xu Huang, Shiqiang Zhu, Jun Zhang, Wenjie Shu, Shengqi Wang
Zero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering. Cell research (2024)
Luis E Gimenez, Charlotte Martin, Jing Yu, Charlie Hollanders, Ciria C Hernandez, Yiran Wu, Deqiang Yao, Gye Won Han, Naima S Dahir, Lijie Wu, Olivier Van der Poorten, Arthur Lamouroux, Morgane Mannes, Suwen Zhao, Dirk Tourwé, Raymond C Stevens, Roger D Cone, Steven Ballet
Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design. Journal of medicinal chemistry (2024)
Zhibin Zhang, Xi Lin, Ling Wei, Yiran Wu, Lu Xu, Lijie Wu, Xiaohu Wei, Suwen Zhao, Xiangjia Zhu, Tingting Wu
A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways. Cell discovery 10 (1) (2024)
Luis E Gimenez, Charlotte Martin, Jing Yu, Charlie Hollanders, Ciria C Hernandez, Yiran Wu, Deqiang Yao, Gye Won Han, Naima S Dahir, Lijie Wu, Olivier Van der Poorten, Arthur Lamouroux, Morgane Mannes, Suwen Zhao, Dirk Tourwé, Raymond C Stevens, Roger D Cone, Steven Ballet
Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design. Journal of medicinal chemistry 67 (4) (2024)
Peng Cheng, Cong Mao, Jin Tang, Sen Yang, Yu Cheng, Wuke Wang, Qiuxi Gu, Wei Han, Hao Chen, Sihan Li, Yaofeng Chen, Jianglin Zhou, Wuju Li, Aimin Pan, Suwen Zhao, Xing-Xu Huang, Shiqiang Zhu, Jun Zhang, Wenjie Shu, Shengqi Wang
Zero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering. Cell research 34 (9) (2024)
Wei Han, Siyu Bao, Jintao Liu, Yiran Wu, Liting Zeng, Tao Zhang, Ningmeng Chen, Kai Yao, Shunguo Fan, Aiping Huang, Yuanyuan Feng, Guiquan Zhang, Ruiyi Zhang, Hongjin Zhu, Tian Hua, Zhijie Liu, Lina Cao, Xing-Xu Huang, Suwen Zhao
CORD: The chordata olfactory receptor database. Protein & cell (2024)
Zhibin Zhang, Xi Lin, Ling Wei, Yiran Wu, Lu Xu, Lijie Wu, Xiaohu Wei, Suwen Zhao, Xiangjia Zhu, Tingting Wu
A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways. Cell discovery 10 (1) (2024)
Luis E Gimenez, Charlotte Martin, Jing Yu, Charlie Hollanders, Ciria C Hernandez, Yiran Wu, Deqiang Yao, Gye Won Han, Naima S Dahir, Lijie Wu, Olivier Van der Poorten, Arthur Lamouroux, Morgane Mannes, Suwen Zhao, Dirk Tourwé, Raymond C Stevens, Roger D Cone, Steven Ballet
Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design. Journal of medicinal chemistry 67 (4) (2024)
Xi Lin, Shan Jiang, Yiran Wu, Xiaohu Wei, Gye-Won Han, Lijie Wu, Junlin Liu, Bo Chen, Zhibin Zhang, Suwen Zhao, Vadim Cherezov, Tingting Wu
The activation mechanism and antibody binding mode for orphan GPR20. Cell discovery 9 (1) (2023)
Tengfei Wang, Shuxiang Shi, Yuanyuan Shi, Peipei Jiang, Ganlu Hu, Qinying Ye, Zhan Shi, Kexin Yu, Chenguang Wang, Guoping Fan, Suwen Zhao, Susan J Baserga, Alex Chia Yu Chang, Zhi Li, Qian Bian, Chao-Po Lin
Chemical-induced phase transition and global conformational reorganization of chromatin. Nature communications 14 (1) (2023)
Yang Yang, Hye Jin Kang, Ruogu Gao, Jingjing Wang, Gye Won Han, Jeffrey F DiBerto, Lijie Wu, Jiahui Tong, Lu Qu, Yiran Wu, Ryan Pileski, Xuemei Li, Xuejun Cai Zhang, Suwen Zhao, Terry Kenakin, Quan Wang, Raymond C Stevens, Wei Peng, Bryan L Roth, Zihe Rao, Zhi-Jie Liu
Structural insights into the human niacin receptor HCA2-G i signalling complex. Nature communications 14 (1) (2023)
Xi Lin, Bo Chen, Yiran Wu, Yingqi Han, Ao Qi, Junyan Wang, Zhao Yang, Xiaohu Wei, Tingting Zhao, Lijie Wu, Xin Xie, Jinpeng Sun, Jie Zheng, Suwen Zhao, Tingting Wu
Cryo-EM structures of orphan GPR21 signaling complexes. Nature communications 14 (1) (2023)
Yang Tong, Xinying Wu, Yang Liu, Huiyu Chen, Yan Zhou, Li Jiang, Yuhan Huang, Suwen Zhao, Yan Zhang
Alternative Z-genome biosynthesis pathway shows evolutionary progression from Archaea to phage. Nature microbiology (2023)
Xi Lin, Shan Jiang, Yiran Wu, Xiaohu Wei, Gye-Won Han, Lijie Wu, Junlin Liu, Bo Chen, Zhibin Zhang, Suwen Zhao, Vadim Cherezov, Tingting Wu
The activation mechanism and antibody binding mode for orphan GPR20. Cell discovery 9 (1) (2023)
Xi Lin, Bo Chen, Yiran Wu, Yingqi Han, Ao Qi, Junyan Wang, Zhao Yang, Xiaohu Wei, Tingting Zhao, Lijie Wu, Xin Xie, Jinpeng Sun, Jie Zheng, Suwen Zhao, Tingting Wu
Cryo-EM structures of orphan GPR21 signaling complexes. Nature communications 14 (1) (2023)
Cuixia Li, Yiran Wu, Wenli Wang, Lu Xu, Yan Zhou, Yang Yue, Tingting Wu, Meifang Yang, Yanli Qiu, Minhao Huang, Fangfang Zhou, Yiqing Zhou, Piliang Hao, Zhixiong Lin, Ming-Wei Wang, Suwen Zhao, Dehua Yang, Fei Xu, Houchao Tao
Structure-Based Ligand Discovery Targeting the Transmembrane Domain of Frizzled Receptor FZD7. Journal of medicinal chemistry (2023)
Yang Yang, Hye Jin Kang, Ruogu Gao, Jingjing Wang, Gye Won Han, Jeffrey F DiBerto, Lijie Wu, Jiahui Tong, Lu Qu, Yiran Wu, Ryan Pileski, Xuemei Li, Xuejun Cai Zhang, Suwen Zhao, Terry Kenakin, Quan Wang, Raymond C Stevens, Wei Peng, Bryan L Roth, Zihe Rao, Zhi-Jie Liu
Structural insights into the human niacin receptor HCA2-G i signalling complex. Nature communications 14 (1) (2023)
Xi Lin, Bo Chen, Yiran Wu, Yingqi Han, Ao Qi, Junyan Wang, Zhao Yang, Xiaohu Wei, Tingting Zhao, Lijie Wu, Xin Xie, Jinpeng Sun, Jie Zheng, Suwen Zhao, Tingting Wu
Cryo-EM structures of orphan GPR21 signaling complexes. Nature communications 14 (1) (2023)
Xi Lin, Bo Chen, Yiran Wu, Yingqi Han, Ao Qi, Junyan Wang, Zhao Yang, Xiaohu Wei, Tingting Zhao, Lijie Wu, Xin Xie, Jinpeng Sun, Jie Zheng, Suwen Zhao, Tingting Wu
Cryo-EM structures of orphan GPR21 signaling complexes. Nature communications 14 (1) (2023)
Wei-Tao Dou, Peng Qiu, Yuanyuan Shi, Ling Zhu, Chen Guo, Na Li, Yi Zang, Tingting Liu, Suwen Zhao, Yufei Pan, Liwei Dong, Jonathan L Sessler, Yexiong Tan, Jia Li, Hong-Yang Wang, He Tian, Xiao-Peng He
Orthogonally Engineered Albumin with Attenuated Macrophage Phagocytosis for the Targeted Visualization and Phototherapy of Liver Cancer. Journal of the American Chemical Society (2023)
Yang Yang, Hye Jin Kang, Ruogu Gao, Jingjing Wang, Gye Won Han, Jeffrey F DiBerto, Lijie Wu, Jiahui Tong, Lu Qu, Yiran Wu, Ryan Pileski, Xuemei Li, Xuejun Cai Zhang, Suwen Zhao, Terry Kenakin, Quan Wang, Raymond C Stevens, Wei Peng, Bryan L Roth, Zihe Rao, Zhi-Jie Liu
Structural insights into the human niacin receptor HCA2-G i signalling complex. Nature communications 14 (1) (2023)
Xi Lin, Bo Chen, Yiran Wu, Yingqi Han, Ao Qi, Junyan Wang, Zhao Yang, Xiaohu Wei, Tingting Zhao, Lijie Wu, Xin Xie, Jinpeng Sun, Jie Zheng, Suwen Zhao, Tingting Wu
Cryo-EM structures of orphan GPR21 signaling complexes. Nature communications 14 (1) (2023)
Jingjing Wang, Meng Wu, Zhangcheng Chen, Lijie Wu, Tian Wang, Dongmei Cao, Huan Wang, Shenhui Liu, Yueming Xu, Fei Li, Junlin Liu, Na Chen, Suwen Zhao, Jianjun Cheng, Sheng Wang, Tian Hua
The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands. Nature communications 13 (1) (2022)
Hua-Song Ai, Maoshen Sun, Aijun Liu, Zixian Sun, Tingting Liu, Lin Cao, Lujun Liang, Qian Qu, Zichen Li, Zhiheng Deng, Zebin Tong, Guochao Chu, Xiaolin Tian, Haiteng Deng, Suwen Zhao, Jia-Bin Li, Zhiyong Lou, Sanling Liu
H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity. Nature chemical biology 18 (9) (2022)
Yinbo Liu, Yifeng Wei, Tong Mei Teh, Dazhi Liu, Yan Zhou, Suwen Zhao, Ee Lui Ang, Huimin Zhao, Yan Zhang
Identification and Characterization of the Biosynthetic Pathway of the Sulfonolipid Capnine. Biochemistry (2022)
Weixiu Xu, Li-Jie Wu, Shenhui Liu, Xiao Liu, Xiaoling Cao, Cui Zhou, Jinyi Zhang, You Fu, Yu Guo, Yiran Wu, Qiwen Tan, Ling Wang, Junlin Liu, Longquan Jiang, Zhongbo Fan, Yuan Pei, Jingyi Yu, Jianjun Cheng, Suwen Zhao, Xiaojiang Hao, Zhi-Jie Liu, Tian Hua
Structural basis for strychnine activation of human bitter taste receptor TAS2R46. Science (New York, N.Y.) 377 (6612) (2022)
Wenzhong Yan, Lijun Ling, Yiran Wu, Kexin Yang, Ruiquan Liu, Jinfeng Zhang, Simeng Zhao, Guisheng Zhong, Suwen Zhao, Hualiang Jiang, Chengying Xie, Jianjun Cheng
Structure-Based Design of Dual-Acting Compounds Targeting Adenosine A2A Receptor and Histone Deacetylase as Novel Tumor Immunotherapeutic Agents. Journal of medicinal chemistry 64 (22) (2021)
Xuefeng Zhang, Chenglin He, Mu Wang, Qingtong Zhou, Dehua Yang, Ya Zhu, Wenbo Feng, Hui Zhang, Antao Dai, Xiaojing Chu, Jia Wang, Zhenlin Yang, Yi Jiang, Ulrich Sensfuss, Qiuxiang Tan, Shuo Han, Steffen Reedtz-Runge, H Eric Xu, Suwen Zhao, Ming-Wei Wang, Beili Wu, Qiang Zhao
Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nature chemical biology 17 (12) (2021)
Fei Zhao, Yiran Wu, Fang Zhou, Dongxiang Xue, Simeng Zhao, Wanglong Lu, Xiaoyan Liu, Tao Hu, Yanli Qiu, Rongyan Li, Tangjie Gu, Yueming Xu, Fei Xu, Guisheng Zhong, Zhong-Xing Jiang, Suwen Zhao, Houchao Tao
Elucidation of Distinct Modular Assemblies of Smoothened Receptor by Bitopic Ligand Measurement. Journal of medicinal chemistry 64 (18) (2021)
Tao Hu, Guoxun Zheng, Dongxiang Xue, Simeng Zhao, Fei Li, Fang Zhou, Fei Zhao, Linshan Xie, Cuiping Tian, Tian Hua, Suwen Zhao, Yueming Xu, Guisheng Zhong, Zhi-Jie Liu, Alexandros Makriyannis, Raymond C Stevens, Houchao Tao
Rational Remodeling of Atypical Scaffolds for the Design of Photoswitchable Cannabinoid Receptor Tools. Journal of medicinal chemistry 64 (18) (2021)
Jiahui Tong, Suwen Zhao
Large-Scale Analysis of Bioactive Ligand Conformational Strain Energy by Ab Initio Calculation. Journal of chemical information and modeling 61 (3) (2021)
Yan Zhou, Xuexia Xu, Yifeng Wei, Yu Cheng, Yu Guo, Ivan Khudyakov, Fuli Liu, Ping He, Zhangyue Song, Zhi Li, Yan Gao, Ee Lui Ang, Huimin Zhao, Yan Zhang, Suwen Zhao
A widespread pathway for substitution of adenine by diaminopurine in phage genomes. Science (New York, N.Y.) 372 (6541) (2021)
Yan Lu, Hongyue Liu, Dehua Yang, Li Zhong, Ye Xin, Suwen Zhao, Ming-Wei Wang, Qingtong Zhou, Wenqing Shui
Affinity Mass Spectrometry-Based Fragment Screening Identified a New Negative Allosteric Modulator of the Adenosine A2A Receptor Targeting the Sodium Ion Pocket. ACS chemical biology 16 (6) (2021)
Charlotte Martin, Luis E Gimenez, Savannah Y Williams, Yu Jing, Yiran Wu, Charlie Hollanders, Olivier Van der Poorten, Simon Gonzalez, Kevin Van Holsbeeck, Santo Previti, Arthur Lamouroux, Suwen Zhao, Dirk Tourwé, Raymond C Stevens, Roger D Cone, Steven Ballet
Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure†. Journal of medicinal chemistry 64 (1) (2020)
Wen Sun, Li-Nan Chen, Qingtong Zhou, Li-Hua Zhao, Dehua Yang, Huibing Zhang, Zhaotong Cong, Dan-Dan Shen, Fenghui Zhao, Fulai Zhou, Xiaoqing Cai, Yan Chen, Yan Zhou, Sarina Gadgaard, Wijnand J C van der Velden, Suwen Zhao, Yi Jiang, Mette M Rosenkilde, H Eric Xu, Yan Zhang, Ming-Wei Wang
A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor. Cell research 30 (12) (2020)
Kai-Wen Liu, Lijie Wu, Shuguang Yuan, Meng Wu, Yueming Xu, Qianqian Sun, Shu Li, Suwen Zhao, Tian Hua, Zhi-Jie Liu
Structural basis of CXC chemokine receptor 2 activation and signalling. Nature 585 (7823) (2020)
Huiyan Sun, Yi Zhou, Michael Francis Skaro, Yiran Wu, Zexing Qu, Fenglou Mao, Suwen Zhao, Ying Xu
Metabolic Reprogramming in Cancer Is Induced to Increase Proton Production. Cancer research 80 (5) (2020)
Mengna Ma, Shimeng Guo, Xi Lin, Shanshan Li, Yiran Wu, Yanping Zeng, Youhong Hu, Suwen Zhao, Fei Xu, Xin Xie, Wenqing Shui
Targeted Proteomics Combined with Affinity Mass Spectrometry Analysis Reveals Antagonist E7 Acts As an Intracellular Covalent Ligand of Orphan Receptor GPR52. ACS chemical biology 15 (12) (2020)
Jing Yu, Luis E Gimenez, Ciria C Hernandez, Yiran Wu, Ariel H Wein, Gye Won Han, Kyle McClary, Sanraj R Mittal, Kylie Burdsall, Benjamin Stauch, Li-Jie Wu, Sophia N Stevens, Alys Peisley, Savannah Y Williams, Valerie Chen, Glenn L Millhauser, Suwen Zhao, Roger D Cone, Raymond C Stevens
Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding. Science (New York, N.Y.) 368 (6489) (2020)
Fulai Zhou, Huibing Zhang, Zhaotong Cong, Li-Hua Zhao, Qingtong Zhou, Chunyou Mao, Xi Cheng, Dan-Dan Shen, Xiaoqing Cai, Cheng Ma, Yuzhe Wang, Antao Dai, Yan Zhou, Wen Sun, Fenghui Zhao, Suwen Zhao, Hualiang Jiang, Yi Jiang, Dehua Yang, H Eric Xu, Yan Zhang, Ming-Wei Wang
Structural basis for activation of the growth hormone-releasing hormone receptor. Nature communications 11 (1) (2020)
Ya Zhang, Hongyuan Zhang, Zhipeng Wang, Zhaowei Wu, Yu Wang, Na Tang, Xuexia Xu, Suwen Zhao, Weizhong Chen, Quanjiang Ji
Programmable adenine deamination in bacteria using a Cas9-adenine-deaminase fusion. Chemical science 11 (6) (2020)
Liang Tan, Qingtong Zhou, Wenzhong Yan, Jian Sun, Alan P Kozikowski, Suwen Zhao, Xi-Ping Huang, Jianjun Cheng
Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands. Journal of medicinal chemistry 63 (9) (2020)
Meng Wu, Liping Sun, Qingtong Zhou, Yao Peng, Zhijie Liu, Suwen Zhao
Molecular Mechanism of Acetate Transport through the Acetate Channel SatP. Journal of chemical information and modeling 59 (5) (2019)
Qingtong Zhou, Dehua Yang, Meng Wu, Yu Guo, Wanjing Guo, Li Zhong, Xiaoqing Cai, Antao Dai, Wonjo Jang, Eugene I Shakhnovich, Zhi-Jie Liu, Raymond C Stevens, Nevin A Lambert, M Madan Babu, Ming-Wei Wang, Suwen Zhao
Common activation mechanism of class A GPCRs. eLife 8 (2019)
Weiping Sun, Yinbo Huo, Yuxuan Mei, Qingtong Zhou, Suwen Zhao, Min Zhuang
Identification of a Small Probe That Can Be Conjugated to Proteins by Proximity Labeling. ACS chemical biology 15 (1) (2019)
Fang Zhou, Kang Ding, Yiqing Zhou, Yang Liu, Xiaoyan Liu, Fei Zhao, Yiran Wu, Xianjun Zhang, Qiwen Tan, Fei Xu, Wenfu Tan, Youli Xiao, Suwen Zhao, Houchao Tao
Colocalization Strategy Unveils an Underside Binding Site in the Transmembrane Domain of Smoothened Receptor. Journal of medicinal chemistry 62 (21) (2019)
Biao Qiu, Bingqing Xia, Qingtong Zhou, Yan Lu, Miaomiao He, Kazuya Hasegawa, Zhiqiang Ma, Fengyu Zhang, Lichuan Gu, Qionglei Mao, Feng Wang, Suwen Zhao, Zhaobing Gao, Jun Liao
Succinate-acetate permease from Citrobacter koseri is an anion channel that unidirectionally translocates acetate. Cell research 28 (6) (2018)
Huasong Ai, Yu Guo, Demeng Sun, Sanling Liu, Yunkun Qi, Jing Guo, Qian Qu, Qingyue Gong, Suwen Zhao, Jia-Bin Li, Lei Liu
Examination of the Deubiquitylation Site Selectivity of USP51 by Using Chemically Synthesized Ubiquitylated Histones. Chembiochem : a European journal of chemical biology 20 (2) (2018)
Dazhi Liu, Yifeng Wei, Xuyang Liu, Yan Zhou, Li Jiang, Jinyu Yin, Feifei Wang, Yiling Hu, Ankanahalli N Nanjaraj Urs, Yanhong Liu, Ee Lui Ang, Suwen Zhao, Huimin Zhao, Yan Zhang
Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole. Nature communications 9 (1) (2018)
Xuyang Liu, Zhan-Guo Gao, Yiran Wu, Raymond C Stevens, Kenneth A Jacobson, Suwen Zhao
Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors. Scientific reports 8 (1) (2018)
Yi Shuang Wang, Bo Zhang, Jiapeng Zhu, Cheng Long Yang, Yu Guo, Cheng Li Liu, Fang Liu, Huiqin Huang, Suwen Zhao, Yong Liang, Rui Hua Jiao, Ren Xiang Tan, Hui Ming Ge
Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis. Journal of the American Chemical Society 140 (34) (2018)
Sara Calhoun, Magdalena Korczynska, Daniel J Wichelecki, Brian San Francisco, Suwen Zhao, Dmitry A Rodionov, Matthew W Vetting, Nawar F Al-Obaidi, Henry Lin, Matthew J O'Meara, David A Scott, John H Morris, Daniel Russel, Steven C Almo, Andrei L Osterman, John A Gerlt, Matthew P Jacobson, Brian K Shoichet, Andrej Sali
Prediction of enzymatic pathways by integrative pathway mapping. eLife 7 (2018)
Xuyang Liu, Zhan-Guo Gao, Yiran Wu, Raymond C Stevens, Kenneth A Jacobson, Suwen Zhao
Author Correction: Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors. Scientific reports 8 (1) (2018)
Zhenjian Li, Yannan Tang, Yiran Wu, Suwen Zhao, Juan Bao, Yitian Luo, Dianfan Li
Structural insights into the committed step of bacterial phospholipid biosynthesis. Nature communications 8 (1) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Suwen Zhao