Florian Nachon (F Nachon)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 19

Top Topics

Cerebrospinal Fluid

Crystal Structure

Molecular Dynamics

Top Venues

Journal of medicinal chemistry

Protein and peptide letters

Chembiochem : a European journal of chemical biology

Molecules (Basel, Switzerland)

This page only lists publications with an associated author ORCID identifier.

Publications

A R Satvik Iyengar, Prakash Y Khandave, Janek Bzdrenga, Florian Nachon, Xavier Brazzolotto, Abhay H Pande
Warfare Nerve Agents and Paraoxonase-1 as a Potential Prophylactic Therapy against Intoxication. Protein and peptide letters 31 (5) (2024)
A R Satvik Iyengar, Prakash Y Khandave, Janek Bzdrenga, Florian Nachon, Xavier Brazzolotto, Abhay H Pande
Warfare Nerve Agents and Paraoxonase-1 as a Potential Prophylactic Therapy against Intoxication. Protein and peptide letters (2024)
Florian Nachon, Xavier Brazzolotto, José Dias, Charlotte Courageux, Wojciech Drożdż, Xiao-Yu Cao, Artur R Stefankiewicz, Jean-Marie Lehn
Grid-Type Quaternary Metallosupramolecular Compounds Inhibit Human Cholinesterases through Dynamic Multivalent Interactions. Chembiochem : a European journal of chemical biology 23 (23) (2022)
Ophélie Da Silva, Nicolas Probst, Christophe Landry, Anne-Sophie Hanak, Pierre Warnault, Caroline Coisne, André-Guilhem Calas, Fabien Gosselet, Charlotte Courageux, Anne-Julie Gastellier, Marilène Trancart, Rachid Baati, Marie-Pierre Dehouck, Ludovic Jean, Florian Nachon, Pierre-Yves Renard, José Dias
A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning. Journal of medicinal chemistry 65 (6) (2022)
F Fémy, G Meesemaecker, N Belverge, C Courageux, A Nervo, R Goulay, C Reymond, F Chantegreil, M Madi, Florian Nachon, N Taudon, N Jaffré
Toxicokinetics of plasmatic VX in a swine model: comparison of a simple enzymatic titration method with a mass spectrometry method. Archives of toxicology (2022)
Daniel Chavarria, Ophelie Da Silva, Sofia Benfeito, Sandra Barreiro, Jorge M P J Garrido, Fernando Cagide, Pedro Soares, Fernando Remiao, Xavier Brazzolotto, Florian Nachon, Paulo J Oliveira, José Dias, Fernanda Borges
Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases. Antioxidants (Basel, Switzerland) 10 (2) (2021)
Leslie E Dubrana, Anja Knoll-Gellida, Laure M Bourcier, Théo Mercé, Sandra Pedemay, Florian Nachon, André-Guilhem Calas, Rachid Baati, Magalie Soares, Patrick J Babin
An Antidote Screening System for Organophosphorus Poisoning Using Zebrafish Larvae. ACS chemical neuroscience 12 (15) (2021)
Janek Bzdrenga, Elodie Trenet, Fabien Chantegreil, Kevin Bernal, Florian Nachon, Xavier Brazzolotto
A Thermophilic Bacterial Esterase for Scavenging Nerve Agents: A Kinetic, Biophysical and Structural Study. Molecules (Basel, Switzerland) 26 (3) (2021)
Michele Rossi, Michela Freschi, Luciana de Camargo Nascente, Alessandra Salerno, Sarah de Melo Viana Teixeira, Florian Nachon, Fabien Chantegreil, Ondrej Soukup, Lukáš Prchal, Marco Malaguti, Christian Bergamini, Manuela Bartolini, Cristina Angeloni, Silvana Hrelia, Luiz Antonio Soares Romeiro, Maria Laura Bolognesi
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease. Journal of medicinal chemistry 64 (8) (2021)
Julie Enderlin, Alexandre Igert, Stėphane Auvin, Florian Nachon, Gregory Dal-Bo, Nina Dupuis
Characterization of organophosphate-induced brain injuries in a convulsive mouse model of diisopropylfluorophosphate exposure. Epilepsia 61 (6) (2020)
Xavier Brazzolotto, Sébastien Courcelle, Christophe Sauvanet, Virginia Guillon, Alexandre Igert, Joseph Kononchik, Florian Nachon, Franck Ceppa, Hervé Delacour
Characterization of four BCHE mutations associated with prolonged effect of suxamethonium. The pharmacogenomics journal 21 (2) (2020)
André-Guilhem Calas, Anne-Sophie Hanak, Nina Jaffré, Aurélie Nervo, José Dias, Catherine Rousseau, Charlotte Courageux, Xavier Brazzolotto, Pascal Villa, Adeline Obrecht, Jean-François Goossens, Christophe Landry, Johan Hachani, Fabien Gosselet, Marie-Pierre Dehouck, Jagadeesh Yerri, Maria Kliachyna, Rachid Baati, Florian Nachon
Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime. Biomolecules 10 (6) (2020)
Florian Nachon, Terrone L Rosenberry, Israel Silman, Joel L Sussman
A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides. Molecules (Basel, Switzerland) 25 (5) (2020)
Sofya V Lushchekina, Gaetan Inidjel, Nicolas Martinez, Patrick Masson, Marie Trovaslet-Leroy, Florian Nachon, Michael Marek Koza, Tilo Seydel, Judith Peters
Impact of Sucrose as Osmolyte on Molecular Dynamics of Mouse Acetylcholinesterase. Biomolecules 10 (12) (2020)
Gianluca Santoni, Julien de Sousa, Eugenio de la Mora, José Dias, Ludovic Jean, Joel L Sussman, Israel Silman, Pierre-Yves Renard, Richard C D Brown, Martin Weik, Rachid Baati, Florian Nachon
Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents. Journal of medicinal chemistry 61 (17) (2018)
Tamara Zorbaz, Anissa Braïki, Nikola Maraković, Julien Renou, Eugenio de la Mora, Nikolina Maček Hrvat, Maja Katalinić, Israel Silman, Joel L Sussman, Guillaume Mercey, Catherine Gomez, Romain Mougeot, Belén Pérez, Rachid Baati, Florian Nachon, Martin Weik, Ludovic Jean, Zrinka Kovarik, Pierre-Yves Renard
Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration. Chemistry (Weinheim an der Bergstrasse, Germany) 24 (38) (2018)
Martijn C de Koning, Marloes J A Joosen, Franz Worek, Florian Nachon, Marco van Grol, Steven D Klaassen, Duurt P W Alkema, Timo Wille, Hans M de Bruijn
Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase. Journal of medicinal chemistry 60 (22) (2017)
Thomas Driant, Florian Nachon, Cyril Ollivier, Pierre-Yves Renard, Etienne Derat
On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach. Chembiochem : a European journal of chemical biology 18 (7) (2017)
Urban Košak, Boris Brus, Damijan Knez, Simon Žakelj, Jurij Trontelj, Anja Pišlar, Roman Šink, Marko Jukič, Marko Živin, Adrian Podkowa, Florian Nachon, Xavier Brazzolotto, Jure Stojan, Janko Kos, Nicolas Coquelle, Kinga Sałat, Jacques-Philippe Colletier, Stanislav Gobec
The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity. Journal of medicinal chemistry 61 (1) (2017)