Hiroshi Handa

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 20

Top Topics

Multiple Myeloma

Top Venues

Nature chemical biology

Communications biology

This page only lists publications with an associated author ORCID identifier.

Publications

Kiwamu Hatakeyama, Yoshikane Kikushige, Daisuke Ishihara, Shunsuke Yamamoto, Gentaro Kawano, Taro Tochigi, Toshihiro Miyamoto, Teppei Sakoda, Andy Christoforou, Yuya Kunisaki, Mitsuhiro Fukata, Koji Kato, Takumi Ito, Hiroshi Handa, Koichi Akashi
Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drug-induced thromboembolism. Blood advances 8 (3) (2024)
Kiwamu Hatakeyama, Yoshikane Kikushige, Daisuke Ishihara, Shunsuke Yamamoto, Gentaro Kawano, Taro Tochigi, Toshihiro Miyamoto, Teppei Sakoda, Andy Christoforou, Yuya Kunisaki, Mitsuhiro Fukata, Koji Kato, Takumi Ito, Hiroshi Handa, Koichi Akashi
Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drug-induced thromboembolism. Blood advances 8 (3) (2024)
Kiwamu Hatakeyama, Yoshikane Kikushige, Daisuke Ishihara, Shunsuke Yamamoto, Gentaro Kawano, Taro Tochigi, Toshihiro Miyamoto, Teppei Sakoda, Andy Christoforou, Yuya Kunisaki, Mitsuhiro Fukata, Koji Kato, Takumi Ito, Hiroshi Handa, Koichi Akashi
Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drug-induced thromboembolism. Blood advances 8 (3) (2024)
Kiwamu Hatakeyama, Yoshikane Kikushige, Daisuke Ishihara, Shunsuke Yamamoto, Gentaro Kawano, Taro Tochigi, Toshihiro Miyamoto, Teppei Sakoda, Andy Christoforou, Yuya Kunisaki, Mitsuhiro Fukata, Koji Kato, Takumi Ito, Hiroshi Handa, Koichi Akashi
Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drugs-induced thromboembolism. Blood advances (2024)
Kiwamu Hatakeyama, Yoshikane Kikushige, Daisuke Ishihara, Shunsuke Yamamoto, Gentaro Kawano, Taro Tochigi, Toshihiro Miyamoto, Teppei Sakoda, Andy Christoforou, Yuya Kunisaki, Mitsuhiro Fukata, Koji Kato, Takumi Ito, Hiroshi Handa, Koichi Akashi
Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drug-induced thromboembolism. Blood advances 8 (3) (2024)
Tatsuya Onishi, Kisyo Mihara, Sachiko Matsuda, Satoshi Sakamato, Akihiro Kuwahata, Masaki Sekino, Moriaki Kusakabe, Hiroshi Handa, Yuko Kitagawa
Application of Magnetic Nanoparticles for Rapid Detection and In Situ Diagnosis in Clinical Oncology. Cancers 14 (2) (2022)
Junichi Yamamoto, Takumi Ito, Yuki Yamaguchi, Hiroshi Handa
Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders. Chemical Society reviews 51 (15) (2022)
Kazuhide Asakawa, Hiroshi Handa, Koichi Kawakami
Multi-phaseted problems of TDP-43 in selective neuronal vulnerability in ALS. Cellular and molecular life sciences : CMLS 78 (10) (2021)
Nobuyuki Shimizu, Tomoko Okumura, Junichi Yamamoto, Yuki Yamaguchi, Hiroshi Handa, Takumi Ito
PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates. Communications biology 4 (1) (2021)
Mariko Ishibashi, Junichi Yamamoto, Takumi Ito, Hiroshi Handa, Mika Sunakawa-Kii, Koiti Inokuchi, Rimpei Morita, Hideto Tamura
Durvalumab Combined with Immunomodulatory Drugs (IMiD) Overcomes Suppression of Antitumor Responses due to IMiD-induced PD-L1 Upregulation on Myeloma Cells. Molecular cancer therapeutics 20 (7) (2021)
Yasuaki Kabe, Ikko Koike, Tatsuya Yamamoto, Miwa Hirai, Ayaka Kanai, Ryogo Furuhata, Hitoshi Tsugawa, Erisa Harada, Kenji Sugase, Kazue Hanadate, Nobuji Yoshikawa, Hiroaki Hayashi, Masanori Noda, Susumu Uchiyama, Hiroki Yamazaki, Hirotoshi Tanaka, Takuya Kobayashi, Hiroshi Handa, Makoto Suematsu
Glycyrrhizin Derivatives Suppress Cancer Chemoresistance by Inhibiting Progesterone Receptor Membrane Component 1. Cancers 13 (13) (2021)
Jaeyong Cho, Yukio Horikawa, Mayumi Enya, Jun Takeda, Yoichi Imai, Yumi Imai, Hiroshi Handa, Takeshi Imai
L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells. Communications biology 3 (1) (2020)
Shumpei Tateno, Midori Iida, Satoshi Fujii, Tetsufumi Suwa, Miki Katayama, Haruka Tokuyama, Junichi Yamamoto, Takumi Ito, Satoshi Sakamato, Hiroshi Handa, Yuki Yamaguchi
Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide. Scientific reports 10 (1) (2020)
Kazuhide Asakawa, Hiroshi Handa, Koichi Kawakami
Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons. Nature communications 11 (1) (2020)
Yasuaki Kabe, Daisuke Takemoto, Ayaka Kanai, Miwa Hirai, Yoshiko Ono, Sota Akazawa, Manabu Horikawa, Yoshinori Kitagawa, Hiroshi Handa, Tomohiro Rogi, Hiroshi Shibata, Makoto Suematsu
Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites. NPJ science of food 4 (2020)
Takahiro Yokose, Yasuaki Kabe, Atsushi Matsuda, Minoru Kitago, Sachiko Matsuda, Miwa Hirai, Tomomi Nakagawa, Yohei Masugi, Takako Hishiki, Yuki Nakamura, Masahiro Shinoda, Hiroshi Yagi, Yuta Abe, Go Oshima, Shutaro Hori, Yutaka Nakano, Kazufumi Honda, Ayumi Kashiro, Chigusa Morizane, Satoshi Nara, Shojiro Kikuchi, Takahiko Shibahara, Makoto Itonaga, Masayuki Ono, Naoko Minegishi, Seizo Koshiba, Masayuki Yamamoto, Atsushi Kuno, Hiroshi Handa, Michiie Sakamoto, Makoto Suematsu, Yuko Kitagawa
O-Glycan-Altered Extracellular Vesicles: A Specific Serum Marker Elevated in Pancreatic Cancer. Cancers 12 (9) (2020)
Tomoko Okumura, Takumi Ito, Hiroshi Handa
Molecular Mechanisms of the Teratogenic Effects of Thalidomide. Pharmaceuticals (Basel, Switzerland) 13 (5) (2020)
Junichi Yamamoto, Tetsufumi Suwa, Yuki Murase, Shumpei Tateno, Hirotaka Mizutome, Tomoko Okumura, Nobuyuki Shimizu, Tsutomu Kishi, Shuji Momose, Masahiro Kizaki, Takumi Ito, Yuki Yamaguchi, Hiroshi Handa
ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells. Nature chemical biology 16 (11) (2020)
Hitoshi Tsugawa, Yasuaki Kabe, Ayaka Kanai, Yuki Sugiura, Shigeaki Hida, Shun'ichiro Taniguchi, Toshio Takahashi, Hidenori Matsui, Zenta Yasukawa, Hiroyuki Itou, Keiyo Takubo, Hidekazu Suzuki, Kenya Honda, Hiroshi Handa, Makoto Suematsu
Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection. PLoS biology 18 (9) (2020)
Tomoko Okumura, Hideki Ando, Marco De Simone, Junichi Yamamoto, Tomomi Sato, Nobuyuki Shimizu, Kazuhide Asakawa, Yuki Yamaguchi, Takumi Ito, Luisa Guerrini, Hiroshi Handa
p63 is a cereblon substrate involved in thalidomide teratogenicity. Nature chemical biology 15 (11) (2019)