Hyunbum Jang (Marc R Knecht, H Jang)

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 48

Top Topics

Molecular Dynamics Simulations

Top Venues

The journal of physical chemistry. B

Chemical science

Journal of chemical information and modeling

Journal of chemical theory and computation

This page only lists publications with an associated author ORCID identifier.

Publications

Ruth Nussinov, Hyunbum Jang
The value of protein allostery in rational anticancer drug design: an update. Expert opinion on drug discovery (2024)
Nurit Haspel, Hyunbum Jang, Ruth Nussinov
Allosteric Activation of RhoA Complexed with p115-RhoGEF Deciphered by Conformational Dynamics. Journal of chemical information and modeling (2024)
Yonglan Liu, Hyunbum Jang, Ruth Nussinov
SHP2-EGFR States in Dephosphorylation Can Inform Selective SHP2 Inhibitors, Dampening RasGAP Action. The journal of physical chemistry. B 128 (21) (2024)
Nurit Haspel, Hyunbum Jang, Ruth Nussinov
Allosteric Activation of RhoA Complexed with p115-RhoGEF Deciphered by Conformational Dynamics. Journal of chemical information and modeling 64 (3) (2024)
Yonglan Liu, Hyunbum Jang, Ruth Nussinov
SHP2-EGFR States in Dephosphorylation Can Inform Selective SHP2 Inhibitors, Dampening RasGAP Action. The journal of physical chemistry. B (2024)
Nurit Haspel, Hyunbum Jang, Ruth Nussinov
Allosteric Activation of RhoA Complexed with p115-RhoGEF Deciphered by Conformational Dynamics. Journal of chemical information and modeling 64 (3) (2024)
Nurit Haspel, Hyunbum Jang, Ruth Nussinov
Allosteric Activation of RhoA Complexed with p115-RhoGEF Deciphered by Conformational Dynamics. Journal of chemical information and modeling 64 (3) (2024)
Ruth Nussinov, Wengang Zhang, Yonglan Liu, Hyunbum Jang
Mitogen signaling strength and duration can control cell cycle decisions. Science advances 10 (27) (2024)
Yuan Lin, Theresa A Ramelot, Simge Senyuz, Attila Gürsoy, Hyunbum Jang, Ruth Nussinov, Ozlem Keskin, Yi Zheng
Tumor-derived RHOA mutants interact with effectors in the GDP-bound state. Nature communications 15 (1) (2024)
Nurit Haspel, Hyunbum Jang, Ruth Nussinov
Allosteric Activation of RhoA Complexed with p115-RhoGEF Deciphered by Conformational Dynamics. Journal of chemical information and modeling 64 (3) (2024)
Yuan Lin, Theresa A Ramelot, Simge Senyuz, Attila Gürsoy, Hyunbum Jang, Ruth Nussinov, Ozlem Keskin, Yi Zheng
Tumor-derived RHOA mutants interact with effectors in the GDP-bound state. Nature communications 15 (1) (2024)
Yonglan Liu, Hyunbum Jang, Ruth Nussinov
SHP2-EGFR States in Dephosphorylation Can Inform Selective SHP2 Inhibitors, Dampening RasGAP Action. The journal of physical chemistry. B 128 (21) (2024)
Wengang Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
CDK2 and CDK4: Cell Cycle Functions Evolve Distinct, Catalysis-Competent Conformations, Offering Drug Targets. JACS Au 4 (5) (2024)
Yuan Lin, Theresa A Ramelot, Simge Senyuz, Attila Gürsoy, Hyunbum Jang, Ruth Nussinov, Ozlem Keskin, Yi Zheng
Tumor-derived RHOA mutants interact with effectors in the GDP-bound state. Nature communications 15 (1) (2024)
Wengang Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
CDK2 and CDK4: Cell Cycle Functions Evolve Distinct, Catalysis-Competent Conformations, Offering Drug Targets. JACS Au 4 (5) (2024)
Ruth Nussinov, Yonglan Liu, Wengang Zhang, Hyunbum Jang
Protein conformational ensembles in function: roles and mechanisms. RSC chemical biology 4 (11) (2023)
Hyunbum Jang, Jiaye Chen, Lilia M Iakoucheva, Ruth Nussinov
How PTEN mutations degrade function at the membrane and life expectancy of carriers of mutations in the human brain. bioRxiv : the preprint server for biology (2023)
Yonglan Liu, Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov
The allosteric mechanism of mTOR activation can inform bitopic inhibitor optimization. Chemical science 15 (3) (2023)
Mingzhen Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
Strategy toward Kinase-Selective Drug Discovery. Journal of chemical theory and computation 19 (5) (2023)
Wengang Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
Cell cycle progression mechanisms: slower cyclin-D/CDK4 activation and faster cyclin-E/CDK2. bioRxiv : the preprint server for biology (2023)
Yuliana Perdomo, Joseph M Slocik, David M Phillips, Hyunbum Jang
Peptide/Nanoparticle Biointerfaces for Multistep Tandem Catalysis. Journal of the American Chemical Society (2023)
Hyunbum Jang, Jiaye Chen, Lilia M Iakoucheva, Ruth Nussinov
How PTEN mutations degrade function at the membrane and life expectancy of carriers of mutations in the human brain. bioRxiv : the preprint server for biology (2023)
Mingzhen Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
Strategy toward Kinase-Selective Drug Discovery. Journal of chemical theory and computation 19 (5) (2023)
Mingzhen Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
Strategy toward Kinase-Selective Drug Discovery. Journal of chemical theory and computation 19 (5) (2023)
Mingzhen Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
Strategy toward Kinase-Selective Drug Discovery. Journal of chemical theory and computation (2023)
Yonglan Liu, Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov
The allosteric mechanism of mTOR activation can inform bitopic inhibitor optimization. Chemical science 15 (3) (2023)
Mingzhen Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
Strategy toward Kinase-Selective Drug Discovery. Journal of chemical theory and computation 19 (5) (2023)
Yonglan Liu, Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov
The allosteric mechanism of mTOR activation can inform bitopic inhibitor optimization. Chemical science 15 (3) (2023)
Bengi Ruken Yavuz, M Kaan Arici, Habibe Cansu Demirel, Chung-Jung Tsai, Hyunbum Jang, Ruth Nussinov, Nurcan Tuncbag
Neurodevelopmental disorders and cancer networks share pathways, but differ in mechanisms, signaling strength, and outcome. NPJ genomic medicine 8 (1) (2023)
Ruth Nussinov, Chung-Jung Tsai, Hyunbum Jang
A New View of Activating Mutations in Cancer. Cancer research 82 (22) (2022)
Ruth Nussinov, Chung-Jung Tsai, Hyunbum Jang
How can same-gene mutations promote both cancer and developmental disorders? Science advances 8 (2) (2022)
Ruth Nussinov, Mingzhen Zhang, Yonglan Liu, Hyunbum Jang
AlphaFold, Artificial Intelligence (AI), and Allostery. The journal of physical chemistry. B 126 (34) (2022)
Mingzhen Zhang, Ryan C Maloney, Hyunbum Jang, Ruth Nussinov
The mechanism of Raf activation through dimerization. Chemical science 12 (47) (2021)
Ruth Nussinov, Mingzhen Zhang, Ryan Maloney, Chung-Jung Tsai, Bengi Ruken Yavuz, Nurcan Tuncbag, Hyunbum Jang
Mechanism of activation and the rewired network: New drug design concepts. Medicinal research reviews (2021)
Tsung-Jen Liao, Hyunbum Jang, David Fushman, Ruth Nussinov
SOS1 interacts with Grb2 through regions that induce closed nSH3 conformations. The Journal of chemical physics 153 (4) (2021)
Ruth Nussinov, Mingzhen Zhang, Ryan Maloney, Hyunbum Jang
Drugging multiple same-allele driver mutations in cancer. Expert opinion on drug discovery 16 (8) (2021)
Ruth Nussinov, Mingzhen Zhang, Chung-Jung Tsai, Hyunbum Jang
Phosphorylation and Driver Mutations in PI3Kα and PTEN Autoinhibition. Molecular cancer research : MCR 19 (4) (2020)
Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov
PI3K inhibitors: review and new strategies. Chemical science 11 (23) (2020)
Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov
PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective. Cancer research 81 (2) (2020)
Mingzhen Zhang, Zhigang Li, Hyunbum Jang, Andrew C Hedman, David B Sacks, Ruth Nussinov
Ca2+-Dependent Switch of Calmodulin Interaction Mode with Tandem IQ Motifs in the Scaffolding Protein IQGAP1. Biochemistry 58 (49) (2019)
Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov
The mechanism of PI3Kα activation at the atomic level. Chemical science 10 (12) (2019)
M Steklov, S Pandolfi, Maria Francesca Baietti, A Batiuk, P Carai, P Najm, M Zhang, Hyunbum Jang, F Renzi, Y Cai, L Abbasi Asbagh, T Pastor, M De Troyer, M Simicek, Enrico Radaelli, Hilde Brems, Eric Legius, J Tavernier, Kris Gevaert, Francis Impens, L Messiaen, Ruth Nussinov, S Heymans, S Eyckerman, Anna A Sablina
Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination. Science (New York, N.Y.) 362 (6419) (2018)
Mingzhen Zhang, Zhigang Li, Guanqiao Wang, Hyunbum Jang, David B Sacks, Jian Zhang, Vadim Gaponenko, Ruth Nussinov
Calmodulin (CaM) Activates PI3Kα by Targeting the "Soft" CaM-Binding Motifs in Both the nSH2 and cSH2 Domains of p85α. The journal of physical chemistry. B 122 (49) (2018)
Guanqiao Wang, Mingzhen Zhang, Hyunbum Jang, Shaoyong Lu, Shizhou Lin, Guoqiang Chen, Ruth Nussinov, Jian Zhang, Vadim Gaponenko
Interaction of Calmodulin with the cSH2 Domain of the p85 Regulatory Subunit. Biochemistry 57 (12) (2018)
E Sila Ozdemir, Hyunbum Jang, Attila Gürsoy, Ozlem Keskin, Ruth Nussinov
Arl2-Mediated Allosteric Release of Farnesylated KRas4B from Shuttling Factor PDEδ. The journal of physical chemistry. B 122 (30) (2018)
Tsung-Jen Liao, Hyunbum Jang, Chung-Jung Tsai, David Fushman, Ruth Nussinov
The dynamic mechanism of RASSF5 and MST kinase activation by Ras. Physical chemistry chemical physics : PCCP 19 (9) (2018)
Serena Muratcioglu, Hyunbum Jang, Attila Gürsoy, Ozlem Keskin, Ruth Nussinov
PDEδ Binding to Ras Isoforms Provides a Route to Proper Membrane Localization. The journal of physical chemistry. B 121 (24) (2017)
Na Li, Hyunbum Jang, Ming Yuan, Wanrong Li, Xiaolin Yun, Joon Lee, Qiqige Du, Ruth Nussinov, Jiahua Hou, Ratnesh Lal, Feng Zhang
Graphite-Templated Amyloid Nanostructures Formed by a Potential Pentapeptide Inhibitor for Alzheimer's Disease: A Combined Study of Real-Time Atomic Force Microscopy and Molecular Dynamics Simulations. Langmuir : the ACS journal of surfaces and colloids 33 (27) (2017)
Shaoyong Lu, Avik Banerjee, Hyunbum Jang, Jian Zhang, Vadim Gaponenko, Ruth Nussinov
GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site. The Journal of biological chemistry 290 (48) (2015)