Ruth Nussinov (R Nussinov)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 79

Top Topics

Chronic Myeloid Leukemia

Tyrosine Kinase

Artificial Intelligence

Top Venues

Nature communications

Chemical science

Journal of chemical information and modeling

Cancer communications (London, England)

This page only lists publications with an associated author ORCID identifier.

Publications

Weiqiang Lu, Jiayan Cui, Wanyan Wang, Qian Hu, Yun Xue, Xi Liu, Ting Gong, Yiping Lu, Hui Ma, Xinyu Yang, Bo Feng, Qi Wang, Naixia Zhang, Yechun Xu, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Hongbin Ji, Jin Huang
PPIA dictates NRF2 stability to promote lung cancer progression. Nature communications 15 (1) (2024)
Louise Thines, Hyunbum Jang, Zhigang Li, Samar Sayedyahossein, Ryan Maloney, Ruth Nussinov, David B Sacks
Disruption of Ca 2+ /calmodulin:KSR1 interaction lowers ERK activation. Protein science : a publication of the Protein Society 33 (5) (2024)
Ruth Nussinov, Hyunbum Jang
The value of protein allostery in rational anticancer drug design: an update. Expert opinion on drug discovery (2024)
Tingting Li, Xuanbai Ren, Xiaoli Luo, Zhuole Wang, Zhenlu Li, Xiaoyan Luo, Jun Shen, Yun Li, Dan Yuan, Ruth Nussinov, Xiangxiang Zeng, Junfeng Shi, Feixiong Cheng
A Foundation Model Identifies Broad-Spectrum Antimicrobial Peptides against Drug-Resistant Bacterial Infection. Nature communications 15 (1) (2024)
Yijing Tang, Yanxian Zhang, Dong Zhang, Yonglan Liu, Ruth Nussinov, Jie Zheng
Exploring pathological link between antimicrobial and amyloid peptides. Chemical Society reviews 53 (17) (2024)
Weiqiang Lu, Jiayan Cui, Wanyan Wang, Qian Hu, Yun Xue, Xi Liu, Ting Gong, Yiping Lu, Hui Ma, Xinyu Yang, Bo Feng, Qi Wang, Naixia Zhang, Yechun Xu, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Hongbin Ji, Jin Huang
PPIA dictates NRF2 stability to promote lung cancer progression. Nature communications 15 (1) (2024)
Wout Magits, Mikhail Steklov, Hyunbum Jang, Raj Nayan Sewduth, Amir Florentin, Benoit Lechat, Aidana Sheryazdanova, Mingzhen Zhang, Michal Simicek, Gali Prag, Ruth Nussinov, Anna A Sablina
K128 ubiquitination constrains RAS activity by expanding its binding interface with GAP proteins. The EMBO journal (2024)
Weiqiang Lu, Jiayan Cui, Wanyan Wang, Qian Hu, Yun Xue, Xi Liu, Ting Gong, Yiping Lu, Hui Ma, Xinyu Yang, Bo Feng, Qi Wang, Naixia Zhang, Yechun Xu, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Hongbin Ji, Jin Huang
PPIA dictates NRF2 stability to promote lung cancer progression. Nature communications 15 (1) (2024)
Nurit Haspel, Hyunbum Jang, Ruth Nussinov
Allosteric Activation of RhoA Complexed with p115-RhoGEF Deciphered by Conformational Dynamics. Journal of chemical information and modeling (2024)
Wout Magits, Mikhail Steklov, Hyunbum Jang, Raj Nayan Sewduth, Amir Florentin, Benoit Lechat, Aidana Sheryazdanova, Mingzhen Zhang, Michal Simicek, Gali Prag, Ruth Nussinov, Anna A Sablina
K128 ubiquitination constrains RAS activity by expanding its binding interface with GAP proteins. The EMBO journal 43 (14) (2024)
Yonglan Liu, Hyunbum Jang, Ruth Nussinov
SHP2-EGFR States in Dephosphorylation Can Inform Selective SHP2 Inhibitors, Dampening RasGAP Action. The journal of physical chemistry. B 128 (21) (2024)
Nurit Haspel, Hyunbum Jang, Ruth Nussinov
Allosteric Activation of RhoA Complexed with p115-RhoGEF Deciphered by Conformational Dynamics. Journal of chemical information and modeling 64 (3) (2024)
Yonglan Liu, Hyunbum Jang, Ruth Nussinov
SHP2-EGFR States in Dephosphorylation Can Inform Selective SHP2 Inhibitors, Dampening RasGAP Action. The journal of physical chemistry. B (2024)
Wout Magits, Mikhail Steklov, Hyunbum Jang, Raj Nayan Sewduth, Amir Florentin, Benoit Lechat, Aidana Sheryazdanova, Mingzhen Zhang, Michal Simicek, Gali Prag, Ruth Nussinov, Anna A Sablina
K128 ubiquitination constrains RAS activity by expanding its binding interface with GAP proteins. The EMBO journal 43 (14) (2024)
Nurit Haspel, Hyunbum Jang, Ruth Nussinov
Allosteric Activation of RhoA Complexed with p115-RhoGEF Deciphered by Conformational Dynamics. Journal of chemical information and modeling 64 (3) (2024)
Wout Magits, Mikhail Steklov, Hyunbum Jang, Raj Nayan Sewduth, Amir Florentin, Benoit Lechat, Aidana Sheryazdanova, Mingzhen Zhang, Michal Simicek, Gali Prag, Ruth Nussinov, Anna A Sablina
K128 ubiquitination constrains RAS activity by expanding its binding interface with GAP proteins. The EMBO journal 43 (14) (2024)
Nurit Haspel, Hyunbum Jang, Ruth Nussinov
Allosteric Activation of RhoA Complexed with p115-RhoGEF Deciphered by Conformational Dynamics. Journal of chemical information and modeling 64 (3) (2024)
Ruth Nussinov, Wengang Zhang, Yonglan Liu, Hyunbum Jang
Mitogen signaling strength and duration can control cell cycle decisions. Science advances 10 (27) (2024)
Yuan Lin, Theresa A Ramelot, Simge Senyuz, Attila Gürsoy, Hyunbum Jang, Ruth Nussinov, Ozlem Keskin, Yi Zheng
Tumor-derived RHOA mutants interact with effectors in the GDP-bound state. Nature communications 15 (1) (2024)
Nurit Haspel, Hyunbum Jang, Ruth Nussinov
Allosteric Activation of RhoA Complexed with p115-RhoGEF Deciphered by Conformational Dynamics. Journal of chemical information and modeling 64 (3) (2024)
Yuan Lin, Theresa A Ramelot, Simge Senyuz, Attila Gürsoy, Hyunbum Jang, Ruth Nussinov, Ozlem Keskin, Yi Zheng
Tumor-derived RHOA mutants interact with effectors in the GDP-bound state. Nature communications 15 (1) (2024)
Yonglan Liu, Hyunbum Jang, Ruth Nussinov
SHP2-EGFR States in Dephosphorylation Can Inform Selective SHP2 Inhibitors, Dampening RasGAP Action. The journal of physical chemistry. B 128 (21) (2024)
Wengang Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
CDK2 and CDK4: Cell Cycle Functions Evolve Distinct, Catalysis-Competent Conformations, Offering Drug Targets. JACS Au 4 (5) (2024)
Yijing Tang, Yanxian Zhang, Dong Zhang, Yonglan Liu, Ruth Nussinov, Jie Zheng
Exploring pathological link between antimicrobial and amyloid peptides. Chemical Society reviews (2024)
Louise Thines, Hyunbum Jang, Zhigang Li, Samar Sayedyahossein, Ryan Maloney, Ruth Nussinov, David B Sacks
Disruption of Ca 2+ /calmodulin:KSR1 interaction lowers ERK activation. Protein science : a publication of the Protein Society 33 (5) (2024)
Weiqiang Lu, Jiayan Cui, Wanyan Wang, Qian Hu, Yun Xue, Xi Liu, Ting Gong, Yiping Lu, Hui Ma, Xinyu Yang, Bo Feng, Qi Wang, Naixia Zhang, Yechun Xu, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Hongbin Ji, Jin Huang
PPIA dictates NRF2 stability to promote lung cancer progression. Nature communications 15 (1) (2024)
Yuan Lin, Theresa A Ramelot, Simge Senyuz, Attila Gürsoy, Hyunbum Jang, Ruth Nussinov, Ozlem Keskin, Yi Zheng
Tumor-derived RHOA mutants interact with effectors in the GDP-bound state. Nature communications 15 (1) (2024)
Wengang Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
CDK2 and CDK4: Cell Cycle Functions Evolve Distinct, Catalysis-Competent Conformations, Offering Drug Targets. JACS Au 4 (5) (2024)
Ruth Nussinov, Yonglan Liu, Wengang Zhang, Hyunbum Jang
Protein conformational ensembles in function: roles and mechanisms. RSC chemical biology 4 (11) (2023)
Hyunbum Jang, Jiaye Chen, Lilia M Iakoucheva, Ruth Nussinov
How PTEN mutations degrade function at the membrane and life expectancy of carriers of mutations in the human brain. bioRxiv : the preprint server for biology (2023)
Yonglan Liu, Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov
The allosteric mechanism of mTOR activation can inform bitopic inhibitor optimization. Chemical science 15 (3) (2023)
Mingzhen Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
Strategy toward Kinase-Selective Drug Discovery. Journal of chemical theory and computation 19 (5) (2023)
Wengang Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
Cell cycle progression mechanisms: slower cyclin-D/CDK4 activation and faster cyclin-E/CDK2. bioRxiv : the preprint server for biology (2023)
Yonglan Liu, Wengang Zhang, Hyunbum Jang, Ruth Nussinov
SHP2 clinical phenotype, cancer, or RASopathies, can be predicted by mutant conformational propensities. Cellular and molecular life sciences : CMLS 81 (1) (2023)
Ruth Nussinov, Bengi Ruken Yavuz, M Kaan Arici, Habibe Cansu Demirel, Mingzhen Zhang, Yonglan Liu, Chung-Jung Tsai, Hyunbum Jang, Nurcan Tuncbag
Neurodevelopmental disorders, like cancer, are connected to impaired chromatin remodelers, PI3K/mTOR, and PAK1-regulated MAPK. Biophysical reviews 15 (2) (2023)
Hyunbum Jang, Jiaye Chen, Lilia M Iakoucheva, Ruth Nussinov
How PTEN mutations degrade function at the membrane and life expectancy of carriers of mutations in the human brain. bioRxiv : the preprint server for biology (2023)
Ruth Nussinov, Bengi Ruken Yavuz, M Kaan Arici, Habibe Cansu Demirel, Mingzhen Zhang, Yonglan Liu, Chung-Jung Tsai, Hyunbum Jang, Nurcan Tuncbag
Neurodevelopmental disorders, like cancer, are connected to impaired chromatin remodelers, PI3K/mTOR, and PAK1-regulated MAPK. Biophysical reviews 15 (2) (2023)
Mingzhen Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
Strategy toward Kinase-Selective Drug Discovery. Journal of chemical theory and computation 19 (5) (2023)
Mingzhen Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
Strategy toward Kinase-Selective Drug Discovery. Journal of chemical theory and computation 19 (5) (2023)
Mingzhen Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
Strategy toward Kinase-Selective Drug Discovery. Journal of chemical theory and computation (2023)
Yonglan Liu, Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov
The allosteric mechanism of mTOR activation can inform bitopic inhibitor optimization. Chemical science 15 (3) (2023)
Mingzhen Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
Strategy toward Kinase-Selective Drug Discovery. Journal of chemical theory and computation 19 (5) (2023)
Yonglan Liu, Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov
The allosteric mechanism of mTOR activation can inform bitopic inhibitor optimization. Chemical science 15 (3) (2023)
Bengi Ruken Yavuz, M Kaan Arici, Habibe Cansu Demirel, Chung-Jung Tsai, Hyunbum Jang, Ruth Nussinov, Nurcan Tuncbag
Neurodevelopmental disorders and cancer networks share pathways, but differ in mechanisms, signaling strength, and outcome. NPJ genomic medicine 8 (1) (2023)
Mingzhen Zhang, Ryan Maloney, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
Activation mechanisms of clinically distinct B-Raf V600E and V600K mutants. Cancer communications (London, England) 43 (3) (2022)
Ruth Nussinov, Chung-Jung Tsai, Hyunbum Jang
A New View of Activating Mutations in Cancer. Cancer research 82 (22) (2022)
Mingzhen Zhang, Ryan Maloney, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
Activation mechanisms of clinically distinct B-Raf V600E and V600K mutants. Cancer communications (London, England) (2022)
Kazi Lutful Kabir, Buyong Ma, Ruth Nussinov, Amarda Shehu
Fewer Dimensions, More Structures for Improved Discrete Models of Dynamics of Free versus Antigen-Bound Antibody. Biomolecules 12 (7) (2022)
Mingzhen Zhang, Ryan Maloney, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
Activation mechanisms of clinically distinct B-Raf V600E and V600K mutants. Cancer communications (London, England) 43 (3) (2022)
Ruth Nussinov, Chung-Jung Tsai, Hyunbum Jang
How can same-gene mutations promote both cancer and developmental disorders? Science advances 8 (2) (2022)
E Sila Ozdemir, Srivathsan V Ranganathan, Ruth Nussinov
How has artificial intelligence impacted COVID-19 drug repurposing and what lessons have we learned? Expert opinion on drug discovery 17 (10) (2022)
Hao Zhang, Duan Ni, Jigang Fan, Minyu Li, Jian Zhang, Chen Hua, Ruth Nussinov, Shaoyong Lu
Markov State Models and Molecular Dynamics Simulations Reveal the Conformational Transition of the Intrinsically Disordered Hypervariable Region of K-Ras4B to the Ordered Conformation. Journal of chemical information and modeling 62 (17) (2022)
Ruth Nussinov, Mingzhen Zhang, Yonglan Liu, Hyunbum Jang
AlphaFold, Artificial Intelligence (AI), and Allostery. The journal of physical chemistry. B 126 (34) (2022)
Ryan C Maloney, Mingzhen Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
The mechanism of activation of MEK1 by B-Raf and KSR1. Cellular and molecular life sciences : CMLS 79 (5) (2022)
Mingzhen Zhang, Ryan Maloney, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
Activation mechanisms of clinically distinct B-Raf V600E and V600K mutants. Cancer communications (London, England) 43 (3) (2022)
Yonglan Liu, Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov
Higher order interactions of Bcr-Abl can broaden chronic myeloid leukemia (CML) drug repertoire. Protein science : a publication of the Protein Society (2022)
Mingzhen Zhang, Ryan Maloney, Yonglan Liu, Hyunbum Jang, Ruth Nussinov
Activation mechanisms of clinically distinct B-Raf V600E and V600K mutants. Cancer communications (London, England) 43 (3) (2022)
Kohei Tsuji, David Hymel, Buyong Ma, Hirokazu Tamamura, Ruth Nussinov, Terrence R Burke
Development of ultra-high affinity bivalent ligands targeting the polo-like kinase 1. RSC chemical biology 3 (9) (2022)
Mingzhen Zhang, Ryan C Maloney, Hyunbum Jang, Ruth Nussinov
The mechanism of Raf activation through dimerization. Chemical science 12 (47) (2021)
Ruth Nussinov, Mingzhen Zhang, Ryan Maloney, Chung-Jung Tsai, Bengi Ruken Yavuz, Nurcan Tuncbag, Hyunbum Jang
Mechanism of activation and the rewired network: New drug design concepts. Medicinal research reviews (2021)
Tsung-Jen Liao, Hyunbum Jang, David Fushman, Ruth Nussinov
SOS1 interacts with Grb2 through regions that induce closed nSH3 conformations. The Journal of chemical physics 153 (4) (2021)
Jun Zhao, Nishant Mohan, Ruth Nussinov, Buyong Ma, Wen Jin Wu
Trastuzumab Blocks the Receiver Function of HER2 Leading to the Population Shifts of HER2-Containing Homodimers and Heterodimers. Antibodies (Basel, Switzerland) 10 (1) (2021)
Ruth Nussinov, Mingzhen Zhang, Ryan Maloney, Hyunbum Jang
Drugging multiple same-allele driver mutations in cancer. Expert opinion on drug discovery 16 (8) (2021)
Ruth Nussinov, Mingzhen Zhang, Ryan Maloney, Hyunbum Jang
Ras isoform-specific expression, chromatin accessibility, and signaling. Biophysical reviews 13 (4) (2021)
Xiangxiang Zeng, Siyi Zhu, Weiqiang Lu, Zehui Liu, Jin Huang, Yadi Zhou, Jiansong Fang, Yin Huang, Huimin Guo, Lang Li, Bruce D Trapp, Ruth Nussinov, Charis Eng, Joseph Loscalzo, Feixiong Cheng
Target identification among known drugs by deep learning from heterogeneous networks. Chemical science 11 (7) (2020)
Chuang Liu, Junfei Zhao, Weiqiang Lu, Yao Dai, Jennifer Hockings, Yadi Zhou, Ruth Nussinov, Charis Eng, Feixiong Cheng
Individualized genetic network analysis reveals new therapeutic vulnerabilities in 6,700 cancer genomes. PLoS computational biology 16 (2) (2020)
Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov
PI3K inhibitors: review and new strategies. Chemical science 11 (23) (2020)
Ruth Nussinov, Hyunbum Jang, Chung-Jung Tsai, Feixiong Cheng
Precision medicine review: rare driver mutations and their biophysical classification. Biophysical reviews 11 (1) (2019)
Ruth Nussinov, Chung-Jung Tsai, Amarda Shehu, Hyunbum Jang
Computational Structural Biology: Successes, Future Directions, and Challenges. Molecules (Basel, Switzerland) 24 (3) (2019)
Ruth Nussinov, Hyunbum Jang, Chung-Jung Tsai, Feixiong Cheng
Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers. PLoS computational biology 15 (3) (2019)
Ruth Nussinov, Chung-Jung Tsai, Hyunbum Jang
Protein ensembles link genotype to phenotype. PLoS computational biology 15 (6) (2019)
He Peng, Xiangxiang Zeng, Yadi Zhou, Defu Zhang, Ruth Nussinov, Feixiong Cheng
A component overlapping attribute clustering (COAC) algorithm for single-cell RNA sequencing data analysis and potential pathobiological implications. PLoS computational biology 15 (2) (2019)
Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov
The mechanism of PI3Kα activation at the atomic level. Chemical science 10 (12) (2019)
M Steklov, S Pandolfi, Maria Francesca Baietti, A Batiuk, P Carai, P Najm, M Zhang, Hyunbum Jang, F Renzi, Y Cai, L Abbasi Asbagh, T Pastor, M De Troyer, M Simicek, Enrico Radaelli, Hilde Brems, Eric Legius, J Tavernier, Kris Gevaert, Francis Impens, L Messiaen, Ruth Nussinov, S Heymans, S Eyckerman, Anna A Sablina
Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination. Science (New York, N.Y.) 362 (6419) (2018)
Sneha Rangarajan, Yanan He, Yihong Chen, Melissa C Kerzic, Buyong Ma, Ragul Gowthaman, Brian G Pierce, Ruth Nussinov, Roy A Mariuzza, John Orban
Peptide-MHC (pMHC) binding to a human antiviral T cell receptor induces long-range allosteric communication between pMHC- and CD3-binding sites. The Journal of biological chemistry 293 (41) (2018)
Ruth Nussinov, Mingzhen Zhang, Chung-Jung Tsai, Tsung-Jen Liao, David Fushman, Hyunbum Jang
Autoinhibition in Ras effectors Raf, PI3Kα, and RASSF5: a comprehensive review underscoring the challenges in pharmacological intervention. Biophysical reviews 10 (5) (2018)
Jun Zhao, Ruth Nussinov, Buyong Ma
Antigen binding allosterically promotes Fc receptor recognition. mAbs 11 (1) (2018)
Hilary A Weismiller, Rachel Murphy, Guanghong Wei, Buyong Ma, Ruth Nussinov, Martin Margittai
Structural disorder in four-repeat Tau fibrils reveals a new mechanism for barriers to cross-seeding of Tau isoforms. The Journal of biological chemistry 293 (45) (2018)
Ruth Nussinov, Jason A Papin
How can computation advance microbiome research? PLoS computational biology 13 (9) (2017)