Jan Jacob Schuringa

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 21

Top Venues

University Medical Center Groningen, University of Groningen

University of Groningen (MSC)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University Medical Center Groningen, University of Groningen

Netherlands

full professor :: Experimental Hematology

University medical Center Groningen, University of Groningen

Netherlands

Associate professor :: Experimental Hematology

University Medical Center Groningen, University of Groningen

Netherlands

Assistant professor :: Experimental Hematology

Memorial Sloan-Kettering Cancer Center

United States

post-doc, EMBO fellow :: Developmental Hematopoiesis

University of Groningen

Netherlands

post-doc :: Department of Developmental Genetics

University of Groningen

Netherlands

PhD :: Department of Developmental Genetics

Education History

University of Groningen

Netherlands

MSC :: Department of Biochemistry

Publications

Min Chul Kwon, Jan Willem Thuring, Olivier Querolle, Xuedong Dai, Tinne Verhulst, Vineet Pande, Ann Marien, Dries Goffin, Daniela V Wenge, Hong Yue, Jevon A Cutler, Cyrus Jin, Florian Perner, Shanna M Hogeling, Paul L Shaffer, Frank Jacobs, Petra Vinken, Wei Cai, Vikki Keersmaekers, Filmon Eyassu, Balpreet Bhogal, Karin Verstraeten, Sara El Ashkar, Jennifer A Perry, Prathiba Jayaguru, Laura Barreyro, Anna Kuchnio, Nicolas Darville, Daniel Krosky, Gregor Urbanietz, Bie Verbist, James P Edwards, Glenn S Cowley, Robert Kirkpatrick, Ruth A Steele, Lucille Ferrante, Christina Guttke, Nikki Daskalakis, E Christine Pietsch, David Matthew Wilson, Ricardo M Attar, Yusri A Elsayed, Eric S Fischer, Jan Jacob Schuringa, Scott A Armstrong, Kathryn Packman, Ulrike Philippar
Preclinical efficacy of potent and selective menin-KMT2A inhibitor JNJ-75276617 in KMT2A- and NPM1-altered leukemias. Blood (2024)
Min Chul Kwon, Jan Willem Thuring, Olivier Querolle, Xuedong Dai, Tinne Verhulst, Vineet Pande, Ann Marien, Dries Goffin, Daniela V Wenge, Hong Yue, Jevon A Cutler, Cyrus Jin, Florian Perner, Shanna M Hogeling, Paul L Shaffer, Frank Jacobs, Petra Vinken, Wei Cai, Vikki Keersmaekers, Filmon Eyassu, Balpreet Bhogal, Karin Verstraeten, Sara El Ashkar, Jennifer A Perry, Prathiba Jayaguru, Laura Barreyro, Anna Kuchnio, Nicolas Darville, Daniel Krosky, Gregor Urbanietz, Bie Verbist, James P Edwards, Glenn S Cowley, Robert Kirkpatrick, Ruth A Steele, Lucille Ferrante, Christina Guttke, Nikki Daskalakis, E Christine Pietsch, David Matthew Wilson, Ricardo M Attar, Yusri A Elsayed, Eric S Fischer, Jan Jacob Schuringa, Scott A Armstrong, Kathryn Packman, Ulrike Philippar
Preclinical efficacy of potent and selective menin-KMT2A inhibitor JNJ-75276617 in KMT2A- and NPM1-altered leukemias. Blood (2024)
Emmanuel Griessinger, Diego Antonio Pereira-Martins, Marielle Nebout, Claudie Bosc, Estelle Saland, Emeline Boet, Ambrine Sahal, Johanna Chiche, Delphine Debayle, Lucile Fleuriot, Maurien Pruis, Véronique De Mas, François Vergez, Christian Recher, Gerwin A Huls, Jean-Emmanuel Sarry, Jan Jacob Schuringa, Jean-François Peyron
Oxidative phosphorylation fueled by fatty acid oxidation sensitizes leukemic stem cells to cold. Cancer research (2023)
Alan Cunningham, Lieve Oudejans, Marjan Geugien, Diego A Pereira-Martins, Albertus Tj Wierenga, Ayşegül Erdem, Dominique Sternadt, Gerwin A Huls, Jan Jacob Schuringa
The 'non-essential' amino acid cysteine is required to prevent ferroptosis in acute myeloid leukemia. Blood advances (2023)
Priscilla Kamphuis, Isabelle A van Zeventer, Aniek O de Graaf, Giulio Genovese, Jonas B Salzbrunn, Avinash G Dinmohamed, Bert A van der Reijden, Jan Jacob Schuringa, Joop H Jansen, Gerwin A Huls
Clonal Hematopoiesis Defined by Somatic Mutations Infrequently Co-occurs With Mosaic Loss of the Y Chromosome in a Population-based Cohort. HemaSphere 7 (10) (2023)
Isabel Weinhäuser, Diego Antonio Pereira-Martins, Luciana Yamamoto de Almeida, Jacobien R Hilberink, Douglas Rafaele Almeida Silveira, Lynn Quek, César Alexander Ortiz, Cleide Lúcia Araújo Silva, Thiago M Bianco, Antônio Roberto Lucena de Araujo, Jose Mauricio Mota, Shanna M Hogeling, Dominique Sternadt, Nienke Visser, Arjan Diepstra, Emanuele Ammatuna, Gerwin Huls, Eduardo Magalhaes Rego, Jan Jacob Schuringa
M2 macrophages drive leukemic transformation by imposing resistance to phagocytosis and improving mitochondrial metabolism. Science advances 9 (15) (2023)
Nuria Vilaplana-Lopera, Vincent Cuminetti, Ruba Almaghrabi, Grigorios Papatzikas, Ashok Kumar Rout, Mark Jeeves, Elena González, Yara Alyahyawi, Alan Cunningham, Ayşegül Erdem, Frank Schnütgen, Manoj Raghavan, Sandeep Potluri, Jean-Baptiste Cazier, Jan Jacob Schuringa, Michelle A C Reed, Lorena Arranz, Ulrich L Günther, Paloma Garcia
Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells. eLife 11 (2022)
Alan Cunningham, Ayşegül Erdem, Islam Alshamleh, Marjan Geugien, Maurien Pruis, Diego Antonio Pereira-Martins, Fiona A J van den Heuvel, Albertus T J Wierenga, Hilde Ten Berge, Robin Dennebos, Vincent van den Boom, Shanna M Hogeling, Isabel Weinhäuser, Ruth Knops, Pim de Blaauw, M Rebecca Heiner-Fokkema, Carolien M Woolthuis, Ulrich L Günther, Eduardo Magalhaes Rego, Joost H A Martens, Joop H Jansen, Harald Schwalbe, Gerwin Huls, Jan Jacob Schuringa
Dietary methionine starvation impairs acute myeloid leukemia progression. Blood 140 (19) (2022)
Ayşegül Erdem, Silvia Marín, Diego Antonio Pereira-Martins, Marjan Geugien, Alan Cunningham, Maurien G Pruis, Isabel Weinhäuser, Albert Gerding, Barbara M Bakker, Albertus T J Wierenga, Eduardo M Rego, Gerwin Huls, Marta Cascante, Jan Jacob Schuringa
Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability. Nature communications 13 (1) (2022)
Ayşegül Erdem, Silvia Marín, Diego A Pereira-Martins, Roldán Cortés, Alan Cunningham, Maurien G Pruis, Bauke de Boer, Fiona A J van den Heuvel, Marjan Geugien, Albertus T J Wierenga, Annet Z Brouwers-Vos, Eduardo M Rego, Gerwin Huls, Marta Cascante, Jan Jacob Schuringa
The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia. Nature communications 13 (1) (2022)
Carin Hazenberg, Aniek O de Graaf, René Mulder, Laura Bungener, Maaike G J M van Bergen, André B Mulder, Goda Choi, Jan Jacob Schuringa, Marco de Groot, Edo Vellenga, Joop H Jansen, Gerwin Huls, Isabelle A van Zeventer
Clonal hematopoiesis in patients with stem cell mobilization failure: a nested case-control study. Blood advances (2022)
Isabelle A van Zeventer, Aniek O de Graaf, Theresia N Koorenhof-Scheele, Bert A van der Reijden, Melanie M van der Klauw, Avinash G Dinmohamed, Arjan Diepstra, Jan Jacob Schuringa, Luca Malcovati, Gerwin Huls, Joop H Jansen
Monocytosis and its association with clonal hematopoiesis in community-dwelling individuals. Blood advances 6 (14) (2022)
Diego A Pereira-Martins, Isabel Weinhäuser, Juan Luiz Coelho-Silva, Pedro L França-Neto, Luciana Y Almeida, Thiago M Bianco, Cleide L Silva, Rafael Freitas de Oliveira Franca, Fabiola Traina, Eduardo M Rego, Jan Jacob Schuringa, Antônio Roberto Lucena de Araujo
MLL5 improves ATRA driven differentiation and promotes xenotransplant engraftment in acute promyelocytic leukemia model. Cell death & disease 12 (4) (2021)
Renata Stripecke, Christian Münz, Jan Jacob Schuringa, Karl-Dimiter Bissig, Brian Soper, Terrence Meeham, Li-Chin Yao, James P Di Santo, Michael Brehm, Estefania Rodriguez, Anja Kathrin Wege, Dominique Bonnet, Silvia Guionaud, Kristina E Howard, Scott Kitchen, Florian Klein, Kourosh Saeb-Parsy, Johannes Sam, Amar Deep Sharma, Flavia Carla Meotti, Livio Trusolino, Carol Bult, Leonard Shultz
Innovations, challenges, and minimal information for standardization of humanized mice. EMBO molecular medicine 12 (7) (2020)
Mylène Gerritsen, Guoqiang Yi, Esther Tijchon, Jorren Kuster, Jan Jacob Schuringa, Joost H A Martens, Edo Vellenga
RUNX1 mutations enhance self-renewal and block granulocytic differentiation in human in vitro models and primary AMLs. Blood advances 3 (3) (2020)
Hendrik Folkerts, Albertus T Wierenga, Fiona A van den Heuvel, Roy R Woldhuis, Darlyne S Kluit, Jennifer Jaques, Jan Jacob Schuringa, Edo Vellenga
Elevated VMP1 expression in acute myeloid leukemia amplifies autophagy and is protective against venetoclax-induced apoptosis. Cell death & disease 10 (6) (2019)
Maria Azkanaz, Aida Rodríguez López, Bauke de Boer, Wouter Huiting, Pierre-Olivier Angrand, Edo Vellenga, Harm H Kampinga, Steven Bergink, Joost Ha Martens, Jan Jacob Schuringa, Vincent van den Boom
Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock. eLife 8 (2019)
Albertus T J Wierenga, Alan Cunningham, Ayşegül Erdem, Nuria Vilaplana Lopera, Annet Z Brouwers-Vos, Maurien Pruis, André B Mulder, Ulrich L Günther, Joost H A Martens, Edo Vellenga, Jan Jacob Schuringa
HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells. Cancer & metabolism 7 (2019)
Hendrik Folkerts, Susan Hilgendorf, Albertus T J Wierenga, Jennifer Jaques, André B Mulder, Paul J Coffer, Jan Jacob Schuringa, Edo Vellenga
Inhibition of autophagy as a treatment strategy for p53 wild-type acute myeloid leukemia. Cell death & disease 8 (7) (2017)
Marco Carretta, Annet Z Brouwers-Vos, Matthieu Bosman, Sarah J Horton, Joost H A Martens, Edo Vellenga, Jan Jacob Schuringa
BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells. PloS one 12 (12) (2017)
Pallavi Sontakke, Jenny Jaques, Edo Vellenga, Jan Jacob Schuringa
Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models. Stem cells international 2016 (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Jan Jacob Schuringa