HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells.
Albertus T J WierengaAlan CunninghamAyşegül ErdemNuria Vilaplana LoperaAnnet Z Brouwers-VosMaurien PruisAndré B MulderUlrich L GüntherJoost H A MartensEdo VellengaJan Jacob SchuringaPublished in: Cancer & metabolism (2019)
These data indicate that, while HIFs exert control over glycolysis but not OxPHOS gene expression in human leukemic cells, this is not critically important for their metabolic state. In contrast, inhibition of BCR-ABL did impact on glucose consumption and lactate production regardless of the presence of HIFs. These data indicate that oncogene-mediated control over glycolysis can occur independently of hypoxic signaling modules.
Keyphrases
- gene expression
- endothelial cells
- dna methylation
- electronic health record
- acute myeloid leukemia
- induced pluripotent stem cells
- induced apoptosis
- tyrosine kinase
- pluripotent stem cells
- big data
- magnetic resonance
- magnetic resonance imaging
- chronic myeloid leukemia
- blood pressure
- metabolic syndrome
- cell cycle arrest
- cell death
- skeletal muscle
- machine learning
- artificial intelligence
- insulin resistance