Jianjun Chen

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 47

Top Topics

Histone Deacetylase

Dna Damage Response

Top Venues

Journal of medicinal chemistry

Signal transduction and targeted therapy

Organic letters

Molecular pharmaceutics

This page only lists publications with an associated author ORCID identifier.

Publications

Xiaopeng Peng, Zhiqiang Sun, Peihua Kuang, Ling Li, Jingxuan Chen, Jianjun Chen
Correction to "Copper-Catalyzed Selective Arylation of Nitriles with Cyclic Diaryl Iodonium Salts: Direct Access to Structurally Diversified Diarylmethane Amides with Potential Neuroprotective and Anticancer Activities". Organic letters 26 (29) (2024)
Zhiqiang Sun, Chenglong Xu, Jinmei Cheng, Zichao Yang, Ting Liu, Bulian Deng, Xuewen Zhang, Xiaopeng Peng, Jianjun Chen
Discovery of Novel HDAC3 Inhibitors with PD-L1 Downregulating/Degrading and Antitumor Immune Effects. Journal of medicinal chemistry (2024)
Xiaopeng Peng, Yichang Ren, Wanyi Pan, Jin Liu, Jianjun Chen
Correction to "Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects". Journal of medicinal chemistry 67 (15) (2024)
Binbin Cheng, Wei Wang, Xiaoge Niu, Yichang Ren, Ting Liu, Hao Cao, Shuanghu Wang, Ying-Feng Tu, Jingxuan Chen, Shu-Wen Liu, Xuchao Yang, Jianjun Chen
Correction to "Discovery of Novel and Highly Potent Resorcinol Dibenzyl Ether-Based PD-1/PD-L1 Inhibitors with Improved Drug-like and Pharmacokinetic Properties for Cancer Treatment". Journal of medicinal chemistry 67 (14) (2024)
Zhiqiang Sun, Chenglong Xu, Jinmei Cheng, Zichao Yang, Ting Liu, Bulian Deng, Xuewen Zhang, Xiaopeng Peng, Jianjun Chen
Discovery of Novel HDAC3 Inhibitors with PD-L1 Downregulating/Degrading and Antitumor Immune Effects. Journal of medicinal chemistry 67 (15) (2024)
Binbin Cheng, Wei Wang, Xiaoge Niu, Yichang Ren, Ting Liu, Hao Cao, Shuanghu Wang, Ying-Feng Tu, Jingxuan Chen, Shu-Wen Liu, Xuchao Yang, Jianjun Chen
Correction to "Discovery of Novel and Highly Potent Resorcinol Dibenzyl Ether-Based PD-1/PD-L1 Inhibitors with Improved Drug-like and Pharmacokinetic Properties for Cancer Treatment". Journal of medicinal chemistry (2024)
Zichao Yang, Ziqing Liu, Shanhe Wan, Jianwei Xu, Yaqi Huang, Haiqi He, Ting Liu, Ling Li, Yichang Ren, Jiajie Zhang, Jianjun Chen
Discovery of Novel Small-Molecule-Based Potential PD-L1/EGFR Dual Inhibitors with High Druggability for Glioblastoma Immunotherapy. Journal of medicinal chemistry 67 (10) (2024)
Zhijie Wang, Lin Yuan, Xiaotong Liao, Xia Guo, Jianjun Chen
Reducing PD-L1 Expression by Degraders and Downregulators as a Novel Strategy to Target the PD-1/PD-L1 Pathway. Journal of medicinal chemistry (2024)
Shuanghu Wang, Zhihua Kong, Yaru Shi, Chuxiao Shao, Wei Wang, Zhenhong Su, Jin Liu, Yingxing Zhou, Xiaoting Fei, Binbin Cheng, Jianjun Chen, Yiyu Lu, Zhou-Guang Wang
Discovery of Small and Bifunctional Molecules Targeting PD-L1/CD73 for Cancer Dual Immunotherapy. Journal of medicinal chemistry (2024)
Zhijie Wang, Lin Yuan, Xiaotong Liao, Xia Guo, Jianjun Chen
Reducing PD-L1 Expression by Degraders and Downregulators as a Novel Strategy to Target the PD-1/PD-L1 Pathway. Journal of medicinal chemistry 67 (8) (2024)
Zichao Yang, Ziqing Liu, Shanhe Wan, Jianwei Xu, Yaqi Huang, Haiqi He, Ting Liu, Ling Li, Yichang Ren, Jiajie Zhang, Jianjun Chen
Discovery of Novel Small-Molecule-Based Potential PD-L1/EGFR Dual Inhibitors with High Druggability for Glioblastoma Immunotherapy. Journal of medicinal chemistry (2024)
Binbin Cheng, Wei Wang, Xiaoge Niu, Yichang Ren, Ting Liu, Hao Cao, Shuanghu Wang, Ying-Feng Tu, Jingxuan Chen, Shu-Wen Liu, Xuchao Yang, Jianjun Chen
Correction to "Discovery of Novel and Highly Potent Resorcinol Dibenzyl Ether-Based PD-1/PD-L1 Inhibitors with Improved Drug-like and Pharmacokinetic Properties for Cancer Treatment". Journal of medicinal chemistry 67 (14) (2024)
Shuanghu Wang, Zhihua Kong, Yaru Shi, Chuxiao Shao, Wei Wang, Zhenhong Su, Jin Liu, Yingxing Zhou, Xiaoting Fei, Binbin Cheng, Jianjun Chen, Yiyu Lu, Zhou-Guang Wang
Discovery of Small and Bifunctional Molecules Targeting PD-L1/CD73 for Cancer Dual Immunotherapy. Journal of medicinal chemistry 67 (11) (2024)
Xiaopeng Peng, Yichang Ren, Wanyi Pan, Jin Liu, Jianjun Chen
Correction to "Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects". Journal of medicinal chemistry (2024)
Binbin Cheng, Yaru Shi, Chuxiao Shao, Shuanghu Wang, Zhenhong Su, Jin Liu, Yingxing Zhou, Xiaoting Fei, Wei Pan, Jianjun Chen, Yiyu Lu, Zhou-Guang Wang
Discovery of Novel Heterotricyclic Compounds as DNA-Dependent Protein Kinase (DNA-PK) Inhibitors with Enhanced Chemosensitivity, Oral Bioavailability, and the Ability to Potentiate Cancer Immunotherapy. Journal of medicinal chemistry 67 (8) (2024)
Junli Huang, Zeli Ma, Xiaopeng Peng, Zichao Yang, Yuhao Wu, Guanghong Zhong, Tianfeng Ouyang, Zhen Chen, Yao Liu, Qirui Wang, Jianjun Chen, Ting Chen, Zhenhua Zeng
Discovery of Novel Potent and Fast BTK PROTACs for the Treatment of Osteoclasts-Related Inflammatory Diseases. Journal of medicinal chemistry 67 (4) (2024)
Junli Huang, Zeli Ma, Xiaopeng Peng, Zichao Yang, Yuhao Wu, Guanghong Zhong, Tianfeng Ouyang, Zhen Chen, Yao Liu, Qirui Wang, Jianjun Chen, Ting Chen, Zhenhua Zeng
Discovery of Novel Potent and Fast BTK PROTACs for the Treatment of Osteoclasts-Related Inflammatory Diseases. Journal of medicinal chemistry 67 (4) (2024)
Zhiqiang Sun, Chenglong Xu, Jinmei Cheng, Zichao Yang, Ting Liu, Bulian Deng, Xuewen Zhang, Xiaopeng Peng, Jianjun Chen
Discovery of Novel HDAC3 Inhibitors with PD-L1 Downregulating/Degrading and Antitumor Immune Effects. Journal of medicinal chemistry 67 (15) (2024)
Xiaopeng Peng, Zhiqiang Sun, Peihua Kuang, Ling Li, Jingxuan Chen, Jianjun Chen
Correction to "Copper-Catalyzed Selective Arylation of Nitriles with Cyclic Diaryl Iodonium Salts: Direct Access to Structurally Diversified Diarylmethane Amides with Potential Neuroprotective and Anticancer Activities". Organic letters (2024)
Junli Huang, Zeli Ma, Xiaopeng Peng, Zichao Yang, Yuhao Wu, Guanghong Zhong, Tianfeng Ouyang, Zhen Chen, Yao Liu, Qirui Wang, Jianjun Chen, Ting Chen, Zhenhua Zeng
Discovery of Novel Potent and Fast BTK PROTACs for the Treatment of Osteoclasts-Related Inflammatory Diseases. Journal of medicinal chemistry (2024)
Binbin Cheng, Xiaoting Fei, Zongbao Ding, Xiaopeng Peng, Zhenhong Su, Wei Pan, Jianjun Chen
Recent Progress in DNA Damage Response-Targeting PROTAC Degraders. Journal of medicinal chemistry 67 (9) (2024)
Zichao Yang, Ziqing Liu, Shanhe Wan, Jianwei Xu, Yaqi Huang, Haiqi He, Ting Liu, Ling Li, Yichang Ren, Jiajie Zhang, Jianjun Chen
Discovery of Novel Small-Molecule-Based Potential PD-L1/EGFR Dual Inhibitors with High Druggability for Glioblastoma Immunotherapy. Journal of medicinal chemistry 67 (10) (2024)
Binbin Cheng, Xiaoting Fei, Zongbao Ding, Xiaopeng Peng, Zhenhong Su, Wei Pan, Jianjun Chen
Recent Progress in DNA Damage Response-Targeting PROTAC Degraders. Journal of medicinal chemistry (2024)
Binbin Cheng, Yaru Shi, Chuxiao Shao, Shuanghu Wang, Zhenhong Su, Jin Liu, Yingxing Zhou, Xiaoting Fei, Wei Pan, Jianjun Chen, Yiyu Lu, Zhou-Guang Wang
Discovery of Novel Heterotricyclic Compounds as DNA-Dependent Protein Kinase (DNA-PK) Inhibitors with Enhanced Chemosensitivity, Oral Bioavailability, and the Ability to Potentiate Cancer Immunotherapy. Journal of medicinal chemistry (2024)
Binbin Cheng, Wei Wang, Ting Liu, Hao Cao, Wei Pan, Yao Xiao, Shu-Wen Liu, Jianjun Chen
Bifunctional small molecules targeting PD-L1/CXCL12 as dual immunotherapy for cancer treatment. Signal transduction and targeted therapy 8 (1) (2023)
Binbin Cheng, Wei Wang, Ting Liu, Hao Cao, Wei Pan, Yao Xiao, Shu-Wen Liu, Jianjun Chen
Bifunctional small molecules targeting PD-L1/CXCL12 as dual immunotherapy for cancer treatment. Signal transduction and targeted therapy 8 (1) (2023)
Binbin Cheng, Wei Wang, Ting Liu, Hao Cao, Wei Pan, Yao Xiao, Shu-Wen Liu, Jianjun Chen
Bifunctional small molecules targeting PD-L1/CXCL12 as dual immunotherapy for cancer treatment. Signal transduction and targeted therapy 8 (1) (2023)
Jin Liu, Yao Cheng, Lin Yuan, Ting Liu, Yong Ruan, Yichang Ren, Ling Li, Sheng Jiang, Yibei Xiao, Jianjun Chen
Discovery and Crystallography Study of Novel Biphenyl Ether and Oxadiazole Thioether (Non-Arylmethylamine)-Based Small-Molecule PD-1/PD-L1 Inhibitors as Immunotherapeutic Agents. Journal of medicinal chemistry (2023)
Binbin Cheng, Wei Wang, Ting Liu, Hao Cao, Wei Pan, Yao Xiao, Shu-Wen Liu, Jianjun Chen
Bifunctional small molecules targeting PD-L1/CXCL12 as dual immunotherapy for cancer treatment. Signal transduction and targeted therapy 8 (1) (2023)
Binbin Cheng, Wei Wang, Ting Liu, Hao Cao, Wei Pan, Yao Xiao, Shu-Wen Liu, Jianjun Chen
Bifunctional small molecules targeting PD-L1/CXCL12 as dual immunotherapy for cancer treatment. Signal transduction and targeted therapy 8 (1) (2023)
Zongbao Ding, Shuanghu Wang, Yaru Shi, Xiaoting Fei, Binbin Cheng, Yiyu Lu, Jianjun Chen
Discovery of Novel d-(+)-Biotin-Conjugated Resorcinol Dibenzyl Ether-Based PD-L1 Inhibitors for Targeted Cancer Immunotherapy. Journal of medicinal chemistry (2023)
Yichang Ren, Yu-Xi Wang, Jin Liu, Ting Liu, Lin Yuan, Chengyong Wu, Zichao Yang, Jianjun Chen
X-ray Crystal Structure-Guided Discovery of Novel Indole Analogues as Colchicine-Binding Site Tubulin Inhibitors with Immune-Potentiating and Antitumor Effects against Melanoma. Journal of medicinal chemistry (2023)
Xiaopeng Peng, Yichang Ren, Wanyi Pan, Jin Liu, Jianjun Chen
Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects. Journal of medicinal chemistry 66 (1) (2022)
Xiaopeng Peng, Yichang Ren, Wanyi Pan, Jin Liu, Jianjun Chen
Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects. Journal of medicinal chemistry (2022)
Jin Liu, Lin Yuan, Yong Ruan, Bulian Deng, Zicao Yang, Yichang Ren, Ling Li, Ting Liu, Huiting Zhao, Ruiyao Mai, Jianjun Chen
Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy. Journal of medicinal chemistry 65 (9) (2022)
Xiaopeng Peng, Ling Li, Jingxuan Chen, Yichang Ren, Jin Liu, Ziwen Yu, Hao Cao, Jianjun Chen
Discovery of Novel Histone Deacetylase 6 (HDAC6) Inhibitors with Enhanced Antitumor Immunity of Anti-PD-L1 Immunotherapy in Melanoma. Journal of medicinal chemistry 65 (3) (2022)
Ruiyao Mai, Bulian Deng, Huiting Zhao, Ling Li, Yuyu Fang, Siming Li, Xin Deng, Jianjun Chen
Design, Synthesis, and Bioevaluation of Novel Enzyme-Triggerable Cell Penetrating Peptide-Based Dendrimers for Targeted Delivery of Camptothecin and Cancer Therapy. Journal of medicinal chemistry 65 (7) (2022)
Xiaopeng Peng, Yichang Ren, Wanyi Pan, Jin Liu, Jianjun Chen
Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects. Journal of medicinal chemistry 66 (1) (2022)
Xiaopeng Peng, Yichang Ren, Wanyi Pan, Jin Liu, Jianjun Chen
Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects. Journal of medicinal chemistry 66 (1) (2022)
Xiaopeng Peng, Jingxuan Chen, Ling Li, Zhiqiang Sun, Jin Liu, Yichang Ren, Junli Huang, Jianjun Chen
Efficient Synthesis and Bioevaluation of Novel Dual Tubulin/Histone Deacetylase 3 Inhibitors as Potential Anticancer Agents. Journal of medicinal chemistry 64 (12) (2021)
Yupeng Wang, Zhijian Luo, Dongfang Zhou, Xuefeng Wang, Jianjun Chen, Shipeng Gong, Zhi-Qiang Yu
Nano-assembly of ursolic acid with platinum prodrug overcomes multiple deactivation pathways in platinum-resistant ovarian cancer. Biomaterials science 9 (11) (2021)
Yichang Ren, Yuxi Wang, Gang Li, Zherong Zhang, Lingling Ma, Binbin Cheng, Jianjun Chen
Discovery of Novel Benzimidazole and Indazole Analogues as Tubulin Polymerization Inhibitors with Potent Anticancer Activities. Journal of medicinal chemistry 64 (8) (2021)
Binbin Cheng, Yao Xiao, Mingming Xue, Hao Cao, Jianjun Chen
Recent Advances in the Development of PD-L1 Modulators: Degraders, Downregulators, and Covalent Inhibitors. Journal of medicinal chemistry 63 (24) (2020)
Xiaopeng Peng, Zhiqiang Sun, Peihua Kuang, Ling Li, Jingxuan Chen, Jianjun Chen
Copper-Catalyzed Selective Arylation of Nitriles with Cyclic Diaryl Iodonium Salts: Direct Access to Structurally Diversified Diarylmethane Amides with Potential Neuroprotective and Anticancer Activities. Organic letters 22 (15) (2020)
Youmei Bao, Shenqi Zhang, Zeming Chen, Ann T Chen, Junning Ma, Gang Deng, Weiguo Xu, Jiangbing Zhou, Zhi-Qiang Yu, Guangyu Yao, Jianjun Chen
Synergistic Chemotherapy for Breast Cancer and Breast Cancer Brain Metastases via Paclitaxel-Loaded Oleanolic Acid Nanoparticles. Molecular pharmaceutics 17 (4) (2020)
Binbin Cheng, Wei Wang, Xiaoge Niu, Yichang Ren, Ting Liu, Hao Cao, Shuanghu Wang, Ying-Feng Tu, Jingxuan Chen, Shu-Wen Liu, Xuchao Yang, Jianjun Chen
Discovery of Novel and Highly Potent Resorcinol Dibenzyl Ether-Based PD-1/PD-L1 Inhibitors with Improved Drug-like and Pharmacokinetic Properties for Cancer Treatment. Journal of medicinal chemistry 63 (24) (2020)
Binbin Cheng, Yichang Ren, Xiaoge Niu, Wei Wang, Shuanghu Wang, Ying-Feng Tu, Shu-Wen Liu, Jin Wang, Deying Yang, Guochao Liao, Jianjun Chen
Discovery of Novel Resorcinol Dibenzyl Ethers Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction as Potential Anticancer Agents. Journal of medicinal chemistry 63 (15) (2020)