Joan B Broderick

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 36

Top Venues

Journal of the American Chemical Society

Microbiology spectrum

Angewandte Chemie (International ed. in English)

Biochemistry

Montana State University Bozeman

Northwestern University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Montana State University Bozeman

United States

Professor :: Chemistry & Biochemistry

Michigan State University

United States

Asst., Assoc., Full Professor :: Chemistry

Amherst College

United States

Assistant Professor :: Chemistry

Massachusetts Institute of Technology

United States

Postdoctoral Fellow :: Chemistry

Education History

Northwestern University

United States

PHD :: Chemistry

Washington State University

United States

BSC :: Chemistry

Publications

William G Walls, Anna Lisa Vagstad, Tyler Delridge, Jörn Piel, William E Broderick, Joan B Broderick
Direct Detection of the α-Carbon Radical Intermediate Formed by OspD: Mechanistic Insights into Radical S -Adenosyl-l-methionine Peptide Epimerization. Journal of the American Chemical Society 146 (8) (2024)
Hao Yang, Madeline B Ho, Maike N Blakely, Martín A Mosquera, William E Broderick, Joan B Broderick, Brian M Hoffman
ENDOR Spectroscopy Reveals the "Free" 5'-Deoxyadenosyl Radical in a Radical SAM Enzyme Active Site Actually is Chaperoned by Close Interaction with the Methionine-Bound [4Fe-4S] 2+ Cluster. Journal of the American Chemical Society 146 (6) (2024)
Hao Yang, Madeline B Ho, Maike N Blakely, Martín A Mosquera, William E Broderick, Joan B Broderick, Brian M Hoffman
ENDOR Spectroscopy Reveals the "Free" 5'-Deoxyadenosyl Radical in a Radical SAM Enzyme Active Site Actually is Chaperoned by Close Interaction with the Methionine-Bound [4Fe-4S] 2+ Cluster. Journal of the American Chemical Society 146 (6) (2024)
Hunter Fausset, Rachel L Spietz, Savannah Cox, Gwendolyn Cooper, Scott Spurzem, Monika Tokmina-Lukaszewska, Jennifer L DuBois, Joan B Broderick, Eric M Shepard, Eric S Boyd, Brian Bothner
A shift between mineral and nonmineral sources of iron and sulfur causes proteome-wide changes in Methanosarcina barkeri . Microbiology spectrum (2024)
Hunter Fausset, Rachel L Spietz, Savannah Cox, Gwendolyn Cooper, Scott Spurzem, Monika Tokmina-Lukaszewska, Jennifer L DuBois, Joan B Broderick, Eric M Shepard, Eric S Boyd, Brian Bothner
A shift between mineral and nonmineral sources of iron and sulfur causes proteome-wide changes in Methanosarcina barkeri . Microbiology spectrum 12 (2) (2024)
Hao Yang, Madeline B Ho, Maike N Blakely, Martín A Mosquera, William E Broderick, Joan B Broderick, Brian M Hoffman
ENDOR Spectroscopy Reveals the "Free" 5'-Deoxyadenosyl Radical in a Radical SAM Enzyme Active Site Actually is Chaperoned by Close Interaction with the Methionine-Bound [4Fe-4S] 2+ Cluster. Journal of the American Chemical Society 146 (6) (2024)
William G Walls, Anna Lisa Vagstad, Tyler Delridge, Jörn Piel, William E Broderick, Joan B Broderick
Direct Detection of the α-Carbon Radical Intermediate Formed by OspD: Mechanistic Insights into Radical S -Adenosyl-l-methionine Peptide Epimerization. Journal of the American Chemical Society 146 (8) (2024)
William G Walls, Anna Lisa Vagstad, Tyler Delridge, Jörn Piel, William E Broderick, Joan B Broderick
Direct Detection of the α-Carbon Radical Intermediate Formed by OspD: Mechanistic Insights into Radical S -Adenosyl-l-methionine Peptide Epimerization. Journal of the American Chemical Society 146 (8) (2024)
William G Walls, Anna Lisa Vagstad, Tyler Delridge, Jörn Piel, William E Broderick, Joan B Broderick
Direct Detection of the α-Carbon Radical Intermediate Formed by OspD: Mechanistic Insights into Radical S -Adenosyl-l-methionine Peptide Epimerization. Journal of the American Chemical Society 146 (8) (2024)
Hao Yang, Madeline B Ho, Maike N Blakely, Martín A Mosquera, William E Broderick, Joan B Broderick, Brian M Hoffman
ENDOR Spectroscopy Reveals the "Free" 5'-Deoxyadenosyl Radical in a Radical SAM Enzyme Active Site Actually is Chaperoned by Close Interaction with the Methionine-Bound [4Fe-4S] 2+ Cluster. Journal of the American Chemical Society (2024)
Hunter Fausset, Rachel L Spietz, Savannah Cox, Gwendolyn Cooper, Scott Spurzem, Monika Tokmina-Lukaszewska, Jennifer L DuBois, Joan B Broderick, Eric M Shepard, Eric S Boyd, Brian Bothner
A shift between mineral and nonmineral sources of iron and sulfur causes proteome-wide changes in Methanosarcina barkeri . Microbiology spectrum 12 (2) (2024)
William G Walls, Anna Lisa Vagstad, Tyler Delridge, Jörn Piel, William E Broderick, Joan B Broderick
Direct Detection of the α-Carbon Radical Intermediate Formed by OspD: Mechanistic Insights into Radical S -Adenosyl-l-methionine Peptide Epimerization. Journal of the American Chemical Society (2024)
William G Walls, Anna Lisa Vagstad, Tyler Delridge, Jörn Piel, William E Broderick, Joan B Broderick
Direct Detection of the α-Carbon Radical Intermediate Formed by OspD: Mechanistic Insights into Radical S -Adenosyl-l-methionine Peptide Epimerization. Journal of the American Chemical Society 146 (8) (2024)
Hunter Fausset, Rachel L Spietz, Savannah Cox, Gwendolyn Cooper, Scott Spurzem, Monika Tokmina-Lukaszewska, Jennifer L DuBois, Joan B Broderick, Eric M Shepard, Eric S Boyd, Brian Bothner
A shift between mineral and nonmineral sources of iron and sulfur causes proteome-wide changes in Methanosarcina barkeri . Microbiology spectrum 12 (2) (2024)
Hao Yang, Madeline B Ho, Maike N Blakely, Martín A Mosquera, William E Broderick, Joan B Broderick, Brian M Hoffman
ENDOR Spectroscopy Reveals the "Free" 5'-Deoxyadenosyl Radical in a Radical SAM Enzyme Active Site Actually is Chaperoned by Close Interaction with the Methionine-Bound [4Fe-4S] 2+ Cluster. Journal of the American Chemical Society 146 (6) (2024)
William G Walls, Anna Lisa Vagstad, Tyler Delridge, Jörn Piel, William E Broderick, Joan B Broderick
Direct Detection of the α-Carbon Radical Intermediate Formed by OspD: Mechanistic Insights into Radical S -Adenosyl-l-methionine Peptide Epimerization. Journal of the American Chemical Society 146 (8) (2024)
Richard J Jodts, M Wittkop, Madeline B Ho, William E Broderick, Joan B Broderick, Brian M Hoffman, Martín A Mosquera
Computational Description of Alkylated Iron-Sulfur Organometallic Clusters. Journal of the American Chemical Society (2023)
Batuhan Balci, Roark D O'Neill, Eric M Shepard, Adrien Pagnier, Alexander Marlott, Michael T Mock, William E Broderick, Joan B Broderick
Semisynthetic maturation of [FeFe]-hydrogenase using [Fe 2 (μ-SH) 2 (CN) 2 (CO) 4 ] 2- : key roles for HydF and GTP. Chemical communications (Cambridge, England) (2023)
Maike N Blakely, Hao Yang, William E Broderick, Brian M Hoffman, Joan B Broderick
Pyruvate formate-lyase activating enzyme: The catalytically active 5'-deoxyadenosyl radical caught in the act of H-atom abstraction. Proceedings of the National Academy of Sciences of the United States of America 120 (47) (2023)
Adrien Pagnier, Batuhan Balci, Eric M Shepard, Hao Yang, Douglas M Warui, Stella Impano, Squire J Booker, Brian M Hoffman, William E Broderick, Joan B Broderick
[FeFe]-Hydrogenase: Defined Lysate-Free Maturation Reveals a Key Role for Lipoyl-H-Protein in DTMA Ligand Biosynthesis. Angewandte Chemie (International ed. in English) 61 (22) (2022)
Katherine F Steward, Devon Payne, William M Kincannon, Christina Johnson, Malachi Lensing, Hunter Fausset, Brigitta Németh, Eric M Shepard, William E Broderick, Joan B Broderick, Jennifer L DuBois, Brian Bothner
Proteomic Analysis of Methanococcus voltae Grown in the Presence of Mineral and Nonmineral Sources of Iron and Sulfur. Microbiology spectrum 10 (4) (2022)
Adrien Pagnier, Batuhan Balci, Eric M Shepard, William E Broderick, Joan B Broderick
[FeFe]-Hydrogenase In Vitro Maturation. Angewandte Chemie (International ed. in English) 61 (49) (2022)
Joan B Broderick, William E Broderick, Brian M Hoffman
Radical SAM enzymes: Nature's choice for radical reactions. FEBS letters (2022)
Maike N Blakely, Raymond Sarksian, Hao Yang, Richard J Jodts, Adrien Pagnier, Donald F Smith, Martín A Mosquera, Wilfred A van der Donk, Brian M Hoffman, William E Broderick, Joan B Broderick
Mechanism of Radical S -Adenosyl- l-methionine Adenosylation: Radical Intermediates and the Catalytic Competence of the 5'-Deoxyadenosyl Radical. Journal of the American Chemical Society 144 (11) (2022)
Eric M Shepard, Stella Impano, Benjamin R Duffus, Adrien Pagnier, Kaitlin S Duschene, Jeremiah N Betz, Amanda S Byer, Amanda Galambas, Elizabeth C McDaniel, Hope Watts, Shawn Erin McGlynn, John W Peters, William E Broderick, Joan B Broderick
HydG, the "dangler" iron, and catalytic production of free CO and CN-: implications for [FeFe]-hydrogenase maturation. Dalton transactions (Cambridge, England : 2003) 50 (30) (2021)
Stella Impano, Hao Yang, Richard J Jodts, Adrien Pagnier, Ryan Swimley, Elizabeth C McDaniel, Eric M Shepard, William E Broderick, Joan B Broderick, Brian M Hoffman
Active-Site Controlled, Jahn-Teller Enabled Regioselectivity in Reductive S-C Bond Cleavage of S-Adenosylmethionine in Radical SAM Enzymes. Journal of the American Chemical Society 143 (1) (2020)
Adrien Pagnier, Hao Yang, Richard J Jodts, Christopher D James, Eric M Shepard, Stella Impano, William E Broderick, Brian M Hoffman, Joan B Broderick
Radical SAM Enzyme Spore Photoproduct Lyase: Properties of the Ω Organometallic Intermediate and Identification of Stable Protein Radicals Formed during Substrate-Free Turnover. Journal of the American Chemical Society 142 (43) (2020)
Charles N Adelson, Esther M Johnston, Kimberly M Hilmer, Hope Watts, Somdatta Ghosh Dey, Doreen E Brown, Joan B Broderick, Eric M Shepard, David M Dooley, Edward I Solomon
Characterization of the Preprocessed Copper Site Equilibrium in Amine Oxidase and Assignment of the Reactive Copper Site in Topaquinone Biogenesis. Journal of the American Chemical Society 141 (22) (2019)
Hao Yang, Stella Impano, Eric M Shepard, Christopher D James, William E Broderick, Joan B Broderick, Brian M Hoffman
Photoinduced Electron Transfer in a Radical SAM Enzyme Generates an S-Adenosylmethionine Derived Methyl Radical. Journal of the American Chemical Society 141 (40) (2019)
Hao Yang, Elizabeth C McDaniel, Stella Impano, Amanda S Byer, Richard J Jodts, Kenichi Yokoyama, William E Broderick, Joan B Broderick, Brian M Hoffman
The Elusive 5'-Deoxyadenosyl Radical: Captured and Characterized by Electron Paramagnetic Resonance and Electron Nuclear Double Resonance Spectroscopies. Journal of the American Chemical Society 141 (30) (2019)
Amanda Galambas, Jacquelyn Miller, Morgan Jones, Elizabeth McDaniel, Molly Lukes, Hope Watts, Valerie Copie, Joan B Broderick, Robert K Szilagyi, Eric M Shepard
Radical S-adenosylmethionine maquette chemistry: Cx3Cx2C peptide coordinated redox active [4Fe-4S] clusters. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 24 (6) (2019)
William E Broderick, Brian M Hoffman, Joan B Broderick
Mechanism of Radical Initiation in the Radical S-Adenosyl-l-methionine Superfamily. Accounts of chemical research 51 (11) (2018)
Amanda S Byer, Hao Yang, Elizabeth C McDaniel, Venkatesan Kathiresan, Stella Impano, Adrien Pagnier, Hope Watts, Carly Denler, Anna L Vagstad, Jörn Piel, Kaitlin S Duschene, Eric M Shepard, Thomas P Shields, Lincoln G Scott, Edward A Lilla, Kenichi Yokoyama, William E Broderick, Brian M Hoffman, Joan B Broderick
Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis. Journal of the American Chemical Society 140 (28) (2018)
Krista A Shisler, Rachel U Hutcheson, Masaki Horitani, Kaitlin S Duschene, Adam V Crain, Amanda S Byer, Eric M Shepard, Ashley Rasmussen, Jian Yang, William E Broderick, Jessica L Vey, Catherine L Drennan, Brian M Hoffman, Joan B Broderick
Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme. Journal of the American Chemical Society 139 (34) (2017)
Eric M Shepard, Amanda S Byer, Joan B Broderick
Iron-Sulfur Cluster States of the Hydrogenase Maturase HydF. Biochemistry 56 (36) (2017)
Eric M Shepard, Amanda S Byer, Priyanka Aggarwal, Jeremiah N Betz, Anna G Scott, Krista A Shisler, Robert J Usselman, Gareth R Eaton, Sandra S Eaton, Joan B Broderick
Electron Spin Relaxation and Biochemical Characterization of the Hydrogenase Maturase HydF: Insights into [2Fe-2S] and [4Fe-4S] Cluster Communication and Hydrogenase Activation. Biochemistry 56 (25) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Joan B Broderick