Brian M Hoffman (Brian Hoffman)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 88

Top Venues

Journal of the American Chemical Society

Biochemistry

Proceedings of the National Academy of Sciences of the United States of America

Inorganic chemistry

Northwestern University

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Northwestern University

United States

Professor :: Chemistry and Molecular Biosciences Departments

Publications

Douglas D Thomas, Marianne Palczewski, Hannah Kuschman, Brian M Hoffman, Hao Yang, Sharon Glynn, David Wilson, Eric Kool, William R Montfort, Jenny Chang, Aydolun Petenkaya, Constantinos Chronis, Thomas Cundari, Sushma Sappa, Kabirul Islam, Daniel W McVicar, Yu Fan, Qingrong Chen, Daoud Meerzaman, Michael Sierk
Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genome. Research square (2024)
Hao Yang, Madeline B Ho, Maike N Blakely, Martín A Mosquera, William E Broderick, Joan B Broderick, Brian M Hoffman
ENDOR Spectroscopy Reveals the "Free" 5'-Deoxyadenosyl Radical in a Radical SAM Enzyme Active Site Actually is Chaperoned by Close Interaction with the Methionine-Bound [4Fe-4S] 2+ Cluster. Journal of the American Chemical Society 146 (6) (2024)
Hao Yang, Madeline B Ho, Maike N Blakely, Martín A Mosquera, William E Broderick, Joan B Broderick, Brian M Hoffman
ENDOR Spectroscopy Reveals the "Free" 5'-Deoxyadenosyl Radical in a Radical SAM Enzyme Active Site Actually is Chaperoned by Close Interaction with the Methionine-Bound [4Fe-4S] 2+ Cluster. Journal of the American Chemical Society 146 (6) (2024)
Selamawit Ghebreamlak, Sebastian A Stoian, Nicholas S Lees, Bryan Cronin, Forrest Smith, Matthew O Ross, Joshua Telser, Brian M Hoffman, Evert C Duin
The Active-Site [4Fe-4S] Cluster in the Isoprenoid Biosynthesis Enzyme IspH Adopts Unexpected Redox States during Ligand Binding and Catalysis. Journal of the American Chemical Society 146 (6) (2024)
Hao Yang, Madeline B Ho, Maike N Blakely, Martín A Mosquera, William E Broderick, Joan B Broderick, Brian M Hoffman
ENDOR Spectroscopy Reveals the "Free" 5'-Deoxyadenosyl Radical in a Radical SAM Enzyme Active Site Actually is Chaperoned by Close Interaction with the Methionine-Bound [4Fe-4S] 2+ Cluster. Journal of the American Chemical Society 146 (6) (2024)
Chris Whittington, Ajay Sharma, S Gage Hill, Anthony T Iavarone, Brian M Hoffman, Adam R Offenbacher
Impact of N -Glycosylation on Protein Structure and Dynamics Linked to Enzymatic C-H Activation in the M. oryzae Lipoxygenase. Biochemistry (2024)
Alex Drena, Addison Fraker, Niklas B Thompson, Peter E Doan, Brian M Hoffman, Alex McSkimming
Correction to "Terminal Hydride Complex of High-Spin Mn". Journal of the American Chemical Society (2024)
Alex Drena, Addison Fraker, Niklas B Thompson, Peter E Doan, Brian M Hoffman, Alex McSkimming
Terminal Hydride Complex of High-Spin Mn. Journal of the American Chemical Society 146 (27) (2024)
Hao Yang, Madeline B Ho, Maike N Blakely, Martín A Mosquera, William E Broderick, Joan B Broderick, Brian M Hoffman
ENDOR Spectroscopy Reveals the "Free" 5'-Deoxyadenosyl Radical in a Radical SAM Enzyme Active Site Actually is Chaperoned by Close Interaction with the Methionine-Bound [4Fe-4S] 2+ Cluster. Journal of the American Chemical Society (2024)
Alex Drena, Addison Fraker, Niklas B Thompson, Peter E Doan, Brian M Hoffman, Alex McSkimming
Terminal Hydride Complex of High-Spin Mn. Journal of the American Chemical Society (2024)
Selamawit Ghebreamlak, Sebastian A Stoian, Nicholas S Lees, Bryan Cronin, Forrest Smith, Matthew O Ross, Joshua Telser, Brian M Hoffman, Evert C Duin
The Active-Site [4Fe-4S] Cluster in the Isoprenoid Biosynthesis Enzyme IspH Adopts Unexpected Redox States during Ligand Binding and Catalysis. Journal of the American Chemical Society 146 (6) (2024)
Douglas D Thomas, Marianne Palczewski, Hannah Kuschman, Brian M Hoffman, Hao Yang, Sharon Glynn, David Wilson, Eric Kool, William R Montfort, Jenny Chang, Aydolun Petenkaya, Constantinos Chronis, Thomas Cundari, Sushma Sappa, Kabirul Islam, Daniel W McVicar, Yu Fan, Qingrong Chen, Daoud Meerzaman, Michael Sierk
Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genome. Research square (2024)
Chris Whittington, Ajay Sharma, S Gage Hill, Anthony T Iavarone, Brian M Hoffman, Adam R Offenbacher
Impact of N -Glycosylation on Protein Structure and Dynamics Linked to Enzymatic C-H Activation in the M. oryzae Lipoxygenase. Biochemistry 63 (10) (2024)
Alex Drena, Addison Fraker, Niklas B Thompson, Peter E Doan, Brian M Hoffman, Alex McSkimming
Terminal Hydride Complex of High-Spin Mn. Journal of the American Chemical Society 146 (27) (2024)
Richard J Jodts, Madeline B Ho, Reyvin M Reyes, Yun Ji Park, Peter E Doan, Amy C Rosenzweig, Brian M Hoffman
Initial Steps in Methanobactin Biosynthesis: Substrate Binding by the Mixed-Valent Diiron Enzyme MbnBC. Biochemistry 63 (9) (2024)
Richard J Jodts, Madeline B Ho, Reyvin M Reyes, Yun Ji Park, Peter E Doan, Amy C Rosenzweig, Brian M Hoffman
Initial Steps in Methanobactin Biosynthesis: Substrate Binding by the Mixed-Valent Diiron Enzyme MbnBC. Biochemistry (2024)
Selamawit Ghebreamlak, Sebastian A Stoian, Nicholas S Lees, Bryan Cronin, Forrest Smith, Matthew O Ross, Joshua Telser, Brian M Hoffman, Evert C Duin
The Active-Site [4Fe-4S] Cluster in the Isoprenoid Biosynthesis Enzyme IspH Adopts Unexpected Redox States during Ligand Binding and Catalysis. Journal of the American Chemical Society (2024)
Douglas D Thomas, Marianne Palczewski, Hannah Kuschman, Brian M Hoffman, Hao Yang, Sharon Glynn, David Wilson, Eric Kool, William R Montfort, Jenny Chang, Aydolun Petenkaya, Constantinos Chronis, Thomas Cundari, Sushma Sappa, Kabirul Islam, Daniel W McVicar, Yu Fan, Qingrong Chen, Daoud Meerzaman, Michael Sierk
Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genome. Research square (2024)
Selamawit Ghebreamlak, Sebastian A Stoian, Nicholas S Lees, Bryan Cronin, Forrest Smith, Matthew O Ross, Joshua Telser, Brian M Hoffman, Evert C Duin
The Active-Site [4Fe-4S] Cluster in the Isoprenoid Biosynthesis Enzyme IspH Adopts Unexpected Redox States during Ligand Binding and Catalysis. Journal of the American Chemical Society 146 (6) (2024)
Hao Yang, Madeline B Ho, Maike N Blakely, Martín A Mosquera, William E Broderick, Joan B Broderick, Brian M Hoffman
ENDOR Spectroscopy Reveals the "Free" 5'-Deoxyadenosyl Radical in a Radical SAM Enzyme Active Site Actually is Chaperoned by Close Interaction with the Methionine-Bound [4Fe-4S] 2+ Cluster. Journal of the American Chemical Society 146 (6) (2024)
Richard J Jodts, Madeline B Ho, Reyvin M Reyes, Yun Ji Park, Peter E Doan, Amy C Rosenzweig, Brian M Hoffman
Initial Steps in Methanobactin Biosynthesis: Substrate Binding by the Mixed-Valent Diiron Enzyme MbnBC. Biochemistry 63 (9) (2024)
Chris Whittington, Ajay Sharma, S Gage Hill, Anthony T Iavarone, Brian M Hoffman, Adam R Offenbacher
Impact of N -Glycosylation on Protein Structure and Dynamics Linked to Enzymatic C-H Activation in the M. oryzae Lipoxygenase. Biochemistry 63 (10) (2024)
Mehmet Can, Macon Jedediah Abernathy, Seth Wiley, Claire Griffith, Christopher D James, Jin Xiong, Yisong Guo, Brian M Hoffman, Stephen W Ragsdale, Ritimukta Sarangi
Characterization of Methyl- and Acetyl-Ni Intermediates in Acetyl CoA Synthase Formed during Anaerobic CO 2 and CO Fixation. Journal of the American Chemical Society (2023)
Edward D Badding, Suppachai Srisantitham, Dmitriy A Lukoyanov, Brian M Hoffman, Daniel L M Suess
Connecting the geometric and electronic structures of the nitrogenase iron-molybdenum cofactor through site-selective 57 Fe labelling. Nature chemistry (2023)
Zhi-Yong Yang, Artavazd Badalyan, Brian M Hoffman, Dennis R Dean, Lance C Seefeldt
The Fe Protein Cycle Associated with Nitrogenase Catalysis Requires the Hydrolysis of Two ATP for Each Single Electron Transfer Event. Journal of the American Chemical Society (2023)
Ajay Sharma, Chris Whittington, Mohammed A Jabed, S Gage Hill, Anastasiia Kostenko, Tao Yu, Pengfei Li, Peter E Doan, Brian M Hoffman, Adam R Offenbacher
13 C Electron Nuclear Double Resonance Spectroscopy-Guided Molecular Dynamics Computations Reveal the Structure of the Enzyme-Substrate Complex of an Active, N -Linked Glycosylated Lipoxygenase. Biochemistry 62 (10) (2023)
Ajay Sharma, Chris Whittington, Mohammed A Jabed, S Gage Hill, Anastasiia Kostenko, Tao Yu, Pengfei Li, Peter E Doan, Brian M Hoffman, Adam R Offenbacher
13 C Electron Nuclear Double Resonance Spectroscopy-Guided Molecular Dynamics Computations Reveal the Structure of the Enzyme-Substrate Complex of an Active, N -Linked Glycosylated Lipoxygenase. Biochemistry 62 (10) (2023)
Richard J Jodts, M Wittkop, Madeline B Ho, William E Broderick, Joan B Broderick, Brian M Hoffman, Martín A Mosquera
Computational Description of Alkylated Iron-Sulfur Organometallic Clusters. Journal of the American Chemical Society (2023)
Ajay Sharma, Chris Whittington, Mohammed A Jabed, S Gage Hill, Anastasiia Kostenko, Tao Yu, Pengfei Li, Peter E Doan, Brian M Hoffman, Adam R Offenbacher
13 C Electron Nuclear Double Resonance Spectroscopy-Guided Molecular Dynamics Computations Reveal the Structure of the Enzyme-Substrate Complex of an Active, N -Linked Glycosylated Lipoxygenase. Biochemistry (2023)
Zhi-Yong Yang, Artavazd Badalyan, Brian M Hoffman, Dennis R Dean, Lance C Seefeldt
The Fe Protein Cycle Associated with Nitrogenase Catalysis Requires the Hydrolysis of Two ATP for Each Single Electron Transfer Event. Journal of the American Chemical Society 145 (10) (2023)
Zhi-Yong Yang, Artavazd Badalyan, Brian M Hoffman, Dennis R Dean, Lance C Seefeldt
The Fe Protein Cycle Associated with Nitrogenase Catalysis Requires the Hydrolysis of Two ATP for Each Single Electron Transfer Event. Journal of the American Chemical Society 145 (10) (2023)
Dmitriy A Lukoyanov, Zhi-Yong Yang, Krista Shisler, John W Peters, Simone Raugei, Dennis R Dean, Lance C Seefeldt, Brian M Hoffman
A conformational equilibrium in the nitrogenase MoFe protein with an α-V70I amino acid substitution illuminates the mechanism of H 2 formation. Faraday discussions (2023)
Maike N Blakely, Hao Yang, William E Broderick, Brian M Hoffman, Joan B Broderick
Pyruvate formate-lyase activating enzyme: The catalytically active 5'-deoxyadenosyl radical caught in the act of H-atom abstraction. Proceedings of the National Academy of Sciences of the United States of America 120 (47) (2023)
Dmitriy A Lukoyanov, Derek F Harris, Zhi-Yong Yang, Ana Pérez-González, Dennis R Dean, Lance C Seefeldt, Brian M Hoffman
The One-Electron Reduced Active-Site FeFe-Cofactor of Fe-Nitrogenase Contains a Hydride Bound to a Formally Oxidized Metal-Ion Core. Inorganic chemistry 61 (14) (2022)
Adrien Pagnier, Batuhan Balci, Eric M Shepard, Hao Yang, Douglas M Warui, Stella Impano, Squire J Booker, Brian M Hoffman, William E Broderick, Joan B Broderick
[FeFe]-Hydrogenase: Defined Lysate-Free Maturation Reveals a Key Role for Lipoyl-H-Protein in DTMA Ligand Biosynthesis. Angewandte Chemie (International ed. in English) 61 (22) (2022)
Conner V Wilson, Dongyoung Kim, Ajay Sharma, Reagan X Hooper, Rinaldo Poli, Brian M Hoffman, Patrick L Holland
Cobalt-Carbon Bonding in a Salen-Supported Cobalt(IV) Alkyl Complex Postulated in Oxidative MHAT Catalysis. Journal of the American Chemical Society 144 (23) (2022)
Madeline B Ho, Richard J Jodts, Youngsuk Kim, Alex McSkimming, Daniel L M Suess, Brian M Hoffman
Characterization by ENDOR Spectroscopy of the Iron-Alkyl Bond in a Synthetic Counterpart of Organometallic Intermediates in Radical SAM Enzymes. Journal of the American Chemical Society 144 (38) (2022)
Dmitriy A Lukoyanov, Zhi-Yong Yang, Ana Pérez-González, Simone Raugei, Dennis R Dean, Lance C Seefeldt, Brian M Hoffman
13 C ENDOR Characterization of the Central Carbon within the Nitrogenase Catalytic Cofactor Indicates That the CFe 6 Core Is a Stabilizing "Heart of Steel". Journal of the American Chemical Society 144 (40) (2022)
Roman Davydov, Austin E Herzog, Richard J Jodts, Kenneth D Karlin, Brian M Hoffman
End-On Copper(I) Superoxo and Cu(II) Peroxo and Hydroperoxo Complexes Generated by Cryoreduction/Annealing and Characterized by EPR/ENDOR Spectroscopy. Journal of the American Chemical Society 144 (1) (2022)
Maike N Blakely, Raymond Sarksian, Hao Yang, Richard J Jodts, Adrien Pagnier, Donald F Smith, Martín A Mosquera, Wilfred A van der Donk, Brian M Hoffman, William E Broderick, Joan B Broderick
Mechanism of Radical S -Adenosyl- l-methionine Adenosylation: Radical Intermediates and the Catalytic Competence of the 5'-Deoxyadenosyl Radical. Journal of the American Chemical Society 144 (11) (2022)
Yun Ji Park, Richard J Jodts, Jeffrey W Slater, Reyvin M Reyes, Valerie J Winton, Rana A Montaser, Paul M Thomas, William B Dowdle, Anahi Ruiz, Michael P Snyder, J Martin Bollinger, Carsten Krebs, Brian M Hoffman, Amy C Rosenzweig
A mixed-valent Fe(II)Fe(III) species converts cysteine to an oxazolone/thioamide pair in methanobactin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America 119 (13) (2022)
Juan A Valdez-Moreira, Daniel M Beagan, Hao Yang, Joshua Telser, Brian M Hoffman, Maren Pink, Veronica Carta, Jeremy M Smith
Hydrocarbon Oxidation by an Exposed, Multiply Bonded Iron(III) Oxo Complex. ACS central science 7 (10) (2021)
Igor D Petrik, Roman Davydov, Maximilian Kahle, Braddock Sandoval, Sudharsan Dwaraknath, Pia Ädelroth, Brian M Hoffman, Yi Lu
An Engineered Glutamate in Biosynthetic Models of Heme-Copper Oxidases Drives Complete Product Selectivity by Tuning the Hydrogen-Bonding Network. Biochemistry 60 (4) (2021)
Anastasia C Manesis, Richard J Jodts, Brian M Hoffman, Amy C Rosenzweig
Copper binding by a unique family of metalloproteins is dependent on kynurenine formation. Proceedings of the National Academy of Sciences of the United States of America 118 (23) (2021)
Usha F Lingappa, Chris M Yeager, Ajay Sharma, Nina L Lanza, Demosthenes P Morales, Gary Xie, Ashley D Atencio, Grayson L Chadwick, Danielle R Monteverde, John S Magyar, Samuel M Webb, Joan Selverstone Valentine, Brian M Hoffman, Woodward W Fischer
An ecophysiological explanation for manganese enrichment in rock varnish. Proceedings of the National Academy of Sciences of the United States of America 118 (25) (2021)
Megan L Shelby, Andrew Wildman, Dugan Hayes, Michael W Mara, Patrick J Lestrange, Marco Cammarata, Lodovico Balducci, Maxim Artamonov, Henrik Till Lemke, Diling Zhu, Tamar Seideman, Brian M Hoffman, Xiaosong Li, Lin X Chen
Interplays of electron and nuclear motions along CO dissociation trajectory in myoglobin revealed by ultrafast X-rays and quantum dynamics calculations. Proceedings of the National Academy of Sciences of the United States of America 118 (14) (2021)
Ana Pérez-González, Zhi-Yong Yang, Dmitriy A Lukoyanov, Dennis R Dean, Lance C Seefeldt, Brian M Hoffman
Exploring the Role of the Central Carbide of the Nitrogenase Active-Site FeMo-cofactor through Targeted 13C Labeling and ENDOR Spectroscopy. Journal of the American Chemical Society 143 (24) (2021)
Zhi-Yong Yang, Emilio Jimenez-Vicente, Hayden Kallas, Dmitriy A Lukoyanov, Hao Yang, Julia S Martin Del Campo, Dennis R Dean, Brian M Hoffman, Lance C Seefeldt
The electronic structure of FeV-cofactor in vanadium-dependent nitrogenase. Chemical science 12 (20) (2021)
Abigail L Schroeter, Hao Yang, Christopher D James, Brian M Hoffman, Peter E Doan
A New Reaction for Improved Calibration of EPR Rapid-Freeze Quench Times: Kinetics of Ethylene Diamine Tetraacetate (EDTA) Transfer from Calcium(II) to Copper(II). Applied magnetic resonance 53 (7-9) (2021)
John W Peters, Oliver Einsle, Dennis R Dean, Serena DeBeer, Brian M Hoffman, Patrick L Holland, Lance C Seefeldt
Comment on "Structural evidence for a dynamic metallocofactor during N2 reduction by Mo-nitrogenase". Science (New York, N.Y.) 371 (6530) (2021)
Richard J Jodts, Matthew O Ross, Christopher W Koo, Peter E Doan, Amy C Rosenzweig, Brian M Hoffman
Coordination of the Copper Centers in Particulate Methane Monooxygenase: Comparison between Methanotrophs and Characterization of the CuC Site by EPR and ENDOR Spectroscopies. Journal of the American Chemical Society 143 (37) (2021)
Adam R Offenbacher, Ajay Sharma, Peter E Doan, Judith P Klinman, Brian M Hoffman
The Soybean Lipoxygenase-Substrate Complex: Correlation between the Properties of Tunneling-Ready States and ENDOR-Detected Structures of Ground States. Biochemistry 59 (7) (2020)
Stella Impano, Hao Yang, Richard J Jodts, Adrien Pagnier, Ryan Swimley, Elizabeth C McDaniel, Eric M Shepard, William E Broderick, Joan B Broderick, Brian M Hoffman
Active-Site Controlled, Jahn-Teller Enabled Regioselectivity in Reductive S-C Bond Cleavage of S-Adenosylmethionine in Radical SAM Enzymes. Journal of the American Chemical Society 143 (1) (2020)
Lance C Seefeldt, Zhi-Yong Yang, Dmitriy A Lukoyanov, Derek F Harris, Dennis R Dean, Simone Raugei, Brian M Hoffman
Reduction of Substrates by Nitrogenases. Chemical reviews 120 (12) (2020)
Christopher D James, Seth Wiley, Stephen W Ragsdale, Brian M Hoffman
13C Electron Nuclear Double Resonance Spectroscopy Shows Acetyl-CoA Synthase Binds Two Substrate CO in Multiple Binding Modes and Reveals the Importance of a CO-Binding "Alcove". Journal of the American Chemical Society 142 (36) (2020)
Dmitriy A Lukoyanov, Zhi-Yong Yang, Dennis R Dean, Lance C Seefeldt, Simone Raugei, Brian M Hoffman
Electron Redistribution within the Nitrogenase Active Site FeMo-Cofactor During Reductive Elimination of H2 to Achieve N≡N Triple-Bond Activation. Journal of the American Chemical Society 142 (52) (2020)
Adrien Pagnier, Hao Yang, Richard J Jodts, Christopher D James, Eric M Shepard, Stella Impano, William E Broderick, Brian M Hoffman, Joan B Broderick
Radical SAM Enzyme Spore Photoproduct Lyase: Properties of the Ω Organometallic Intermediate and Identification of Stable Protein Radicals Formed during Substrate-Free Turnover. Journal of the American Chemical Society 142 (43) (2020)
Jorge L Martinez, Sean A Lutz, Hao Yang, Jiaze Xie, Joshua Telser, Brian M Hoffman, Veronica Carta, Maren Pink, Yaroslav Losovyj, Jeremy M Smith
Structural and spectroscopic characterization of an Fe(VI) bis(imido) complex. Science (New York, N.Y.) 370 (6514) (2020)
Matthew O Ross, Oriana S Fisher, Marcos N Morgada, Matthew D Krzyaniak, Michael R Wasielewski, Alejandro J Vila, Brian M Hoffman, Amy C Rosenzweig
Formation and Electronic Structure of an Atypical CuA Site. Journal of the American Chemical Society 141 (11) (2019)
Veronika Hoeke, Laura Tociu, David A Case, Lance C Seefeldt, Simone Raugei, Brian M Hoffman
High-Resolution ENDOR Spectroscopy Combined with Quantum Chemical Calculations Reveals the Structure of Nitrogenase Janus Intermediate E4(4H). Journal of the American Chemical Society 141 (30) (2019)
Hao Yang, Stella Impano, Eric M Shepard, Christopher D James, William E Broderick, Joan B Broderick, Brian M Hoffman
Photoinduced Electron Transfer in a Radical SAM Enzyme Generates an S-Adenosylmethionine Derived Methyl Radical. Journal of the American Chemical Society 141 (40) (2019)
Matthew O Ross, Fraser MacMillan, Jingzhou Wang, Alex Nisthal, Thomas J Lawton, Barry D Olafson, Stephen L Mayo, Amy C Rosenzweig, Brian M Hoffman
Particulate methane monooxygenase contains only mononuclear copper centers. Science (New York, N.Y.) 364 (6440) (2019)
Hao Yang, Elizabeth C McDaniel, Stella Impano, Amanda S Byer, Richard J Jodts, Kenichi Yokoyama, William E Broderick, Joan B Broderick, Brian M Hoffman
The Elusive 5'-Deoxyadenosyl Radical: Captured and Characterized by Electron Paramagnetic Resonance and Electron Nuclear Double Resonance Spectroscopies. Journal of the American Chemical Society 141 (30) (2019)
Veronika Hoeke, Laura Tociu, David A Case, Lance C Seefeldt, Simone Raugei, Brian M Hoffman
Correction to "High-Resolution ENDOR Spectroscopy Combined with Quantum Chemical Calculations Reveals the Structure of Nitrogenase Janus Intermediate E4(4H)". Journal of the American Chemical Society 141 (50) (2019)
Dmitriy A Lukoyanov, Matthew D Krzyaniak, Dennis R Dean, Michael R Wasielewski, Lance C Seefeldt, Brian M Hoffman
Time-Resolved EPR Study of H2 Reductive Elimination from the Photoexcited Nitrogenase Janus E4(4H) Intermediate. The journal of physical chemistry. B 123 (41) (2019)
Derek F Harris, Dmitriy A Lukoyanov, Hayden Kallas, Christian Trncik, Zhi-Yong Yang, Phil Compton, Michael P Snyder, Oliver Einsle, Dennis R Dean, Brian M Hoffman, Lance C Seefeldt
Mo-, V-, and Fe-Nitrogenases Use a Universal Eight-Electron Reductive-Elimination Mechanism To Achieve N2 Reduction. Biochemistry 58 (30) (2019)
Casey Van Stappen, Roman Davydov, Zhi-Yong Yang, Ruixi Fan, Yisong Guo, Eckhard Bill, Lance C Seefeldt, Brian M Hoffman, Serena DeBeer
Spectroscopic Description of the E1 State of Mo Nitrogenase Based on Mo and Fe X-ray Absorption and Mössbauer Studies. Inorganic chemistry 58 (18) (2019)
Jingguang G Chen, Richard M Crooks, Lance C Seefeldt, Kara L Bren, R Morris Bullock, Marcetta Y Darensbourg, Patrick L Holland, Brian M Hoffman, Michael J Janik, Anne K Jones, Mercouri G Kanatzidis, Paul W King, Kyle M Lancaster, Sergei V Lymar, Peter Pfromm, William F Schneider, Richard R Schrock
Beyond fossil fuel-driven nitrogen transformations. Science (New York, N.Y.) 360 (6391) (2018)
Hao Yang, Jonathan Rittle, Amy R Marts, Jonas C Peters, Brian M Hoffman
ENDOR Characterization of (N2)FeII(μ-H)2FeI(N2)-: A Spectroscopic Model for N2 Binding by the Di-μ-hydrido Nitrogenase Janus Intermediate. Inorganic chemistry 57 (19) (2018)
Min Dong, Venkatesan Kathiresan, Michael K Fenwick, Andrew T Torelli, Yang Zhang, Jonathan D Caranto, Boris Dzikovski, Ajay Sharma, Kyle M Lancaster, Jack H Freed, Steven E Ealick, Brian M Hoffman, Hening Lin
Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis. Science (New York, N.Y.) 359 (6381) (2018)
Derek F Harris, Zhi-Yong Yang, Dennis R Dean, Lance C Seefeldt, Brian M Hoffman
Kinetic Understanding of N2 Reduction versus H2 Evolution at the E4(4H) Janus State in the Three Nitrogenases. Biochemistry 57 (39) (2018)
William E Broderick, Brian M Hoffman, Joan B Broderick
Mechanism of Radical Initiation in the Radical S-Adenosyl-l-methionine Superfamily. Accounts of chemical research 51 (11) (2018)
Amanda S Byer, Hao Yang, Elizabeth C McDaniel, Venkatesan Kathiresan, Stella Impano, Adrien Pagnier, Hope Watts, Carly Denler, Anna L Vagstad, Jörn Piel, Kaitlin S Duschene, Eric M Shepard, Thomas P Shields, Lincoln G Scott, Edward A Lilla, Kenichi Yokoyama, William E Broderick, Brian M Hoffman, Joan B Broderick
Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis. Journal of the American Chemical Society 140 (28) (2018)
Simone Raugei, Lance C Seefeldt, Brian M Hoffman
Critical computational analysis illuminates the reductive-elimination mechanism that activates nitrogenase for N2 reduction. Proceedings of the National Academy of Sciences of the United States of America 115 (45) (2018)
Rahul Purohit, Matthew O Ross, Sharon Batelu, April Kusowski, Timothy L Stemmler, Brian M Hoffman, Amy C Rosenzweig
Cu+-specific CopB transporter: Revising P1B-type ATPase classification. Proceedings of the National Academy of Sciences of the United States of America 115 (9) (2018)
Lance C Seefeldt, Brian M Hoffman, John W Peters, Simone Raugei, David N Beratan, Edwin Antony, Dennis R Dean
Energy Transduction in Nitrogenase. Accounts of chemical research 51 (9) (2018)
Derek F Harris, Dmitriy A Lukoyanov, Sudipta Shaw, Phil Compton, Monika Tokmina-Lukaszewska, Brian Bothner, Michael P Snyder, Dennis R Dean, Brian M Hoffman, Lance C Seefeldt
Mechanism of N2 Reduction Catalyzed by Fe-Nitrogenase Involves Reductive Elimination of H2. Biochemistry 57 (5) (2018)
Dmitriy A Lukoyanov, Nimesh Khadka, Zhi-Yong Yang, Dennis R Dean, Lance C Seefeldt, Brian M Hoffman
Hydride Conformers of the Nitrogenase FeMo-cofactor Two-Electron Reduced State E2(2H), Assigned Using Cryogenic Intra Electron Paramagnetic Resonance Cavity Photolysis. Inorganic chemistry 57 (12) (2018)
Min Dong, Masaki Horitani, Boris Dzikovski, Jack H Freed, Steven E Ealick, Brian M Hoffman, Hening Lin
Substrate-Dependent Cleavage Site Selection by Unconventional Radical S-Adenosylmethionine Enzymes in Diphthamide Biosynthesis. Journal of the American Chemical Society 139 (16) (2017)
Nimesh Khadka, Ross D Milton, Sudipta Shaw, Dmitriy Lukoyanov, Dennis R Dean, Shelley D Minteer, Simone Raugei, Brian M Hoffman, Lance C Seefeldt
Mechanism of Nitrogenase H2 Formation by Metal-Hydride Protonation Probed by Mediated Electrocatalysis and H/D Isotope Effects. Journal of the American Chemical Society 139 (38) (2017)
Masaki Horitani, Adam R Offenbacher, Cody A Marcus Carr, Tao Yu, Veronika Hoeke, George E Cutsail, Sharon Hammes-Schiffer, Judith P Klinman, Brian M Hoffman
13C ENDOR Spectroscopy of Lipoxygenase-Substrate Complexes Reveals the Structural Basis for C-H Activation by Tunneling. Journal of the American Chemical Society 139 (5) (2017)
Krista A Shisler, Rachel U Hutcheson, Masaki Horitani, Kaitlin S Duschene, Adam V Crain, Amanda S Byer, Eric M Shepard, Ashley Rasmussen, Jian Yang, William E Broderick, Jessica L Vey, Catherine L Drennan, Brian M Hoffman, Joan B Broderick
Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme. Journal of the American Chemical Society 139 (34) (2017)
Ajay Sharma, Michael Roemelt, Michael Reithofer, Richard R Schrock, Brian M Hoffman, Frank Neese
EPR/ENDOR and Theoretical Study of the Jahn-Teller-Active [HIPTN3N]MoVL Complexes (L = N-, NH). Inorganic chemistry 56 (12) (2017)
Masaki Horitani, Katarzyna Grubel, Sean F McWilliams, Bryan D Stubbert, Brandon Q Mercado, Ying Yu, Prabhuodeyara M Gurubasavaraj, Nicholas S Lees, Patrick L Holland, Brian M Hoffman
ENDOR characterization of an iron-alkene complex provides insight into a corresponding organometallic intermediate of nitrogenase. Chemical science 8 (9) (2017)
Dmitriy Lukoyanov, Nimesh Khadka, Dennis R Dean, Simone Raugei, Lance C Seefeldt, Brian M Hoffman
Photoinduced Reductive Elimination of H2 from the Nitrogenase Dihydride (Janus) State Involves a FeMo-cofactor-H2 Intermediate. Inorganic chemistry 56 (4) (2017)
Ajay Sharma, Elena K Gaidamakova, Olga Grichenko, Vera Y Matrosova, Veronika Hoeke, Polina Klimenkova, Isabel H Conze, Robert P Volpe, Rok Tkavc, Cene Gostinčar, Nina Gunde-Cimerman, Jocelyne DiRuggiero, Igor Shuryak, Andrew Ozarowski, Brian M Hoffman, Michael J Daly
Across the tree of life, radiation resistance is governed by antioxidant Mn2+, gauged by paramagnetic resonance. Proceedings of the National Academy of Sciences of the United States of America 114 (44) (2017)
Audrey T Gallagher, Jung Yoon Lee, Venkatesan Kathiresan, John S Anderson, Brian M Hoffman, T David Harris
A structurally-characterized peroxomanganese(iv) porphyrin from reversible O2 binding within a metal-organic framework. Chemical science 9 (6) (2017)
Aaron T Smith, Matthew O Ross, Brian M Hoffman, Amy C Rosenzweig
Metal Selectivity of a Cd-, Co-, and Zn-Transporting P1B-type ATPase. Biochemistry 56 (1) (2016)

Brian M Hoffman.css-eqlu8i{font-size:small;padding-left:4px;} (Brian Hoffman)

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Brian M Hoffman (Brian Hoffman)