Joseph W Lewcock

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 16

Top Venues

Science translational medicine

eLife

The Journal of neuroscience : the official journal of the Society for Neuroscience

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Marvin Reich, Matthew J Simon, Beate Polke, Iñaki Paris, Georg Werner, Christian Schrader, Lena Spieth, Sonnet S Davis, Sophie Robinson, Gabrielly Lunkes de Melo, Lennart Schlaphoff, Katrin Buschmann, Stefan A Berghoff, Todd Logan, Brigitte Nuscher, Lis de Weerd, Dieter Edbauer, Mikael Simons, Jung H Suh, Thomas Sandmann, Mihalis S Kariolis, Sarah L DeVos, Joseph W Lewcock, Dominik Paquet, Anja Capell, Gilbert Di Paolo, Christian Haass
Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration. Science translational medicine 16 (750) (2024)
Scarlett J Barker, Mai B Thayer, Chaeyoung Kim, David Tatarakis, Matthew J Simon, Rebekah Dial, Lizanne Greer Nilewski, Robert C Wells, Yinhan Zhou, Megan Afetian, Padma Akkapeddi, Alfred E Chappell, Kylie S Chew, Johann Chow, Allisa Clemens, Claire B Discenza, Jason C Dugas, Chrissa Dwyer, Timothy Earr, Connie Ha, Yvonne S Ho, David Huynh, Edwin I Lozano, Srini Jayaraman, Wanda Kwan, Cathal S Mahon, Michelle E Pizzo, Yaneth Robles-Colmenares, Elysia Roche, Laura Sanders, Alexander Stergioulis, Raymond Tong, Hai L Tran, Y Joy Yu Zuchero, Anthony A Estrada, Kapil Gadkar, Christopher M M Koth, Pascal E Sanchez, Robert G Thorne, Ryan J Watts, Thomas Sandmann, Lesley A Kane, Frank Rigo, Mark S Dennis, Joseph W Lewcock, Sarah L DeVos
Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier. Science translational medicine 16 (760) (2024)
Marvin Reich, Matthew J Simon, Beate Polke, Iñaki Paris, Georg Werner, Christian Schrader, Lena Spieth, Sonnet S Davis, Sophie Robinson, Gabrielly Lunkes de Melo, Lennart Schlaphoff, Katrin Buschmann, Stefan A Berghoff, Todd Logan, Brigitte Nuscher, Lis de Weerd, Dieter Edbauer, Mikael Simons, Jung H Suh, Thomas Sandmann, Mihalis S Kariolis, Sarah L DeVos, Joseph W Lewcock, Dominik Paquet, Anja Capell, Gilbert Di Paolo, Christian Haass
Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration. Science translational medicine 16 (750) (2024)
Ernie Yulyaningsih, Jung H Suh, Melania Fanok, Roni Chau, Hilda Solanoy, Ryan Takahashi, Anna I Bakardjiev, Isabel Becerra, N Butch Benitez, Chi-Lu Chiu, Sonnet S Davis, William E Dowdle, Timothy Earr, Anthony A Estrada, Audrey Gill, Connie Ha, Patrick C G Haddick, Kirk R Henne, Martin Larhammar, Amy W-S Leung, Romeo Maciuca, Bahram Memarzadeh, Hoang N Nguyen, Alicia A Nugent, Maksim Osipov, Yingqing Ran, Kevin Rebadulla, Elysia Roche, Thomas Sandman, Jing Wang, Joseph W Lewcock, Kimberly Scearce-Levie, Lesley A Kane, Pascal E Sanchez
DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response. eLife 12 (2024)
Takeshi Iwatsubo, Michael C Irizarry, Joseph W Lewcock, Maria C Carrillo
Alzheimer's targeted treatments: focus on amyloid and inflammation. The Journal of neuroscience : the official journal of the Society for Neuroscience (2023)
Kylie S Chew, Robert C Wells, Arash Moshkforoush, Darren Chan, Kendra J Lechtenberg, Hai L Tran, Johann Chow, Do Jin Kim, Yaneth Robles-Colmenares, Devendra B Srivastava, Raymond K Tong, Mabel Tong, Kaitlin Xa, Alexander Yang, Yinhan Zhou, Padma Akkapeddi, Lakshman Annamalai, Kaja Bajc, Marie Blanchette, Gerald Maxwell Cherf, Timothy K Earr, Audrey Gill, David Huynh, David A Joy, Kristen N Knight, Diana Lac, Amy Wing-Sze Leung, Katrina W Lexa, Nicholas P D Liau, Isabel Becerra, Mario Malfavon, Joseph McInnes, Hoang N Nguyen, Edwin I Lozano, Michelle E Pizzo, Elysia Roche, Patricia Sacayon, Meredith E K Calvert, Richard Daneman, Mark S Dennis, Joseph Duque, Kapil Gadkar, Joseph W Lewcock, Cathal S Mahon, René Meisner, Hilda Solanoy, Robert G Thorne, Ryan J Watts, Y Joy Yu Zuchero, Mihalis S Kariolis
CD98hc is a target for brain delivery of biotherapeutics. Nature communications 14 (1) (2023)
Kylie S Chew, Robert C Wells, Arash Moshkforoush, Darren Chan, Kendra J Lechtenberg, Hai L Tran, Johann Chow, Do Jin Kim, Yaneth Robles-Colmenares, Devendra B Srivastava, Raymond K Tong, Mabel Tong, Kaitlin Xa, Alexander Yang, Yinhan Zhou, Padma Akkapeddi, Lakshman Annamalai, Kaja Bajc, Marie Blanchette, Gerald Maxwell Cherf, Timothy K Earr, Audrey Gill, David Huynh, David A Joy, Kristen N Knight, Diana Lac, Amy Wing-Sze Leung, Katrina W Lexa, Nicholas P D Liau, Isabel Becerra, Mario Malfavon, Joseph McInnes, Hoang N Nguyen, Edwin I Lozano, Michelle E Pizzo, Elysia Roche, Patricia Sacayon, Meredith E K Calvert, Richard Daneman, Mark S Dennis, Joseph Duque, Kapil Gadkar, Joseph W Lewcock, Cathal S Mahon, René Meisner, Hilda Solanoy, Robert G Thorne, Ryan J Watts, Y Joy Yu Zuchero, Mihalis S Kariolis
Author Correction: CD98hc is a target for brain delivery of biotherapeutics. Nature communications 14 (1) (2023)
Xiang Wang, Vitaliy V Bondar, Oliver B Davis, Michael T Maloney, Maayan Agam, Marcus Y Chin, Audrey Cheuk-Nga Ho, Rajarshi Ghosh, Dara E Leto, David A Joy, Meredith E K Calvert, Joseph W Lewcock, Gilbert Di Paolo, Robert G Thorne, Zachary K Sweeney, Anastasia G Henry
Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes. eLife 12 (2023)
Annie Arguello, Cathal S Mahon, Meredith E K Calvert, Darren Chan, Jason C Dugas, Michelle E Pizzo, Elliot R Thomsen, Roni Chau, Lorna A Damo, Joseph Duque, Meng Fang, Tina Giese, Do Jin Kim, Nicholas Liang, Hoang N Nguyen, Hilda Solanoy, Buyankhishig Tsogtbaatar, Julie C Ullman, Junhua Wang, Mark S Dennis, Dolores Diaz, Kannan Gunasekaran, Kirk R Henne, Joseph W Lewcock, Pascal E Sanchez, Matthew D Troyer, Jeffrey M Harris, Kimberly A Scearce-Levie, Lu Shan, Ryan J Watts, Robert G Thorne, Anastasia G Henry, Mihalis S Kariolis
Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme. The Journal of experimental medicine 219 (3) (2022)
Anika Reifschneider, Sophie Robinson, Bettina van Lengerich, Johannes Gnörich, Todd Logan, Steffanie Heindl, Miriam A Vogt, Endy Weidinger, Lina Riedl, Karin Wind, Artem Zatcepin, Ida Pesämaa, Sophie Haberl, Brigitte Nuscher, Gernot Kleinberger, Julien Klimmt, Julia K Götzl, Arthur Liesz, Katharina Bürger, Matthias Brendel, Johannes Levin, Janine Diehl-Schmid, Jung Suh, Gilbert Di Paolo, Joseph W Lewcock, Kathryn M Monroe, Dominik Paquet, Anja Capell, Christian Haass
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency. The EMBO journal 41 (4) (2022)
Kimberly A Scearce-Levie, Pascal E Sanchez, Joseph W Lewcock
Leveraging preclinical models for the development of Alzheimer disease therapeutics. Nature reviews. Drug discovery 19 (7) (2020)
Kai Schlepckow, Kathryn M Monroe, Gernot Kleinberger, Ludovico Cantuti-Castelvetri, Samira Parhizkar, Dan Xia, Michael Willem, Georg Werner, Nadine Pettkus, Bettina Brunner, Alice Sülzen, Brigitte Nuscher, Heike Hampel, Xianyuan Xiang, Regina Feederle, Sabina Tahirovic, Joshua I Park, Rachel Prorok, Cathal Mahon, Chun-Chi Liang, Ju Shi, Do Jin Kim, Hanna Sabelström, Fen Huang, Gilbert Di Paolo, Mikael Simons, Joseph W Lewcock, Christian Haass
Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region. EMBO molecular medicine 12 (4) (2020)
Benjamin J Andreone, Laralynne Przybyla, Ceyda Llapashtica, Anil Rana, Sonnet S Davis, Bettina van Lengerich, Karin Lin, Ju Shi, Yuan Mei, Giuseppe Astarita, Gilbert Di Paolo, Thomas Sandmann, Kathryn M Monroe, Joseph W Lewcock
Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia. Nature neuroscience 23 (8) (2020)
Claire E Le Pichon, William J Meilandt, Sara Dominguez, Hilda Solanoy, Han Lin, Hai Ngu, Alvin Gogineni, Arundhati Sengupta Ghosh, Zhiyu Jiang, Seung-Hye Lee, Janice Maloney, Vineela D Gandham, Christine D Pozniak, Bei Wang, Sebum Lee, Michael Siu, Snahel Patel, Zora Modrusan, Xingrong Liu, York Rudhard, Miriam Baca, Amy Gustafson, Joshua S Kaminker, Richard A D Carano, Eric J Huang, Oded Foreman, Robby Weimer, Kimberly Scearce-Levie, Joseph W Lewcock
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease. Science translational medicine 9 (403) (2018)
Martin Larhammar, Sarah Huntwork-Rodriguez, York Rudhard, Arundhati Sengupta-Ghosh, Joseph W Lewcock
The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 37 (46) (2017)
Martin Larhammar, Sarah Huntwork-Rodriguez, Zhiyu Jiang, Hilda Solanoy, Arundhati Sengupta Ghosh, Bei Wang, Joshua S Kaminker, Kevin Huang, Jeffrey Eastham-Anderson, Michael Siu, Zora Modrusan, Madeline M Farley, Marc Tessier-Lavigne, Joseph W Lewcock, Trent A Watkins
Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult. eLife 6 (2017)

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Publication Activity (10 Years)

Top Topics

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Joseph W Lewcock