Christian Haass

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 52

Top Topics

Cerebrospinal Fluid

Lipopolysaccharide Induced

Top Venues

The Journal of experimental medicine

EMBO molecular medicine

Nature neuroscience

Science translational medicine

This page only lists publications with an associated author ORCID identifier.

Publications

Marvin Reich, Matthew J Simon, Beate Polke, Iñaki Paris, Georg Werner, Christian Schrader, Lena Spieth, Sonnet S Davis, Sophie Robinson, Gabrielly Lunkes de Melo, Lennart Schlaphoff, Katrin Buschmann, Stefan A Berghoff, Todd Logan, Brigitte Nuscher, Lis de Weerd, Dieter Edbauer, Mikael Simons, Jung H Suh, Thomas Sandmann, Mihalis S Kariolis, Sarah L DeVos, Joseph W Lewcock, Dominik Paquet, Anja Capell, Gilbert Di Paolo, Christian Haass
Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration. Science translational medicine 16 (750) (2024)
Chen Yu, Eleonora M Lad, Rose Mathew, Nobuhiko Shiraki, Sejiro Littleton, Yun Chen, Jin-Chao Hou, Kai Schlepckow, Simone Degan, Lindsey A Chew, Joshua Amason, Joan Kalnitsky, Catherine Bowes Rickman, Alan D Proia, Marco Colonna, Christian Haass, Daniel R Saban
Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2. The Journal of experimental medicine 221 (3) (2024)
Chen Yu, Eleonora M Lad, Rose Mathew, Nobuhiko Shiraki, Sejiro Littleton, Yun Chen, Jin-Chao Hou, Kai Schlepckow, Simone Degan, Lindsey A Chew, Joshua Amason, Joan Kalnitsky, Catherine Bowes Rickman, Alan D Proia, Marco Colonna, Christian Haass, Daniel R Saban
Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2. The Journal of experimental medicine 221 (3) (2024)
Henrick Riemenschneider, Qiang Guo, Jakob Maximilian Bader, Frédéric Frottin, Daniel Farny, Gernot Kleinberger, Christian Haass, Matthias Mann, F Ulrich Hartl, Wolfgang Baumeister, Mark S Hipp, Rüdiger Klein, Rubén Fernández-Busnadiego, Dieter Edbauer
Author Correction: Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons. EMBO reports (2024)
Chen Yu, Eleonora M Lad, Rose Mathew, Nobuhiko Shiraki, Sejiro Littleton, Yun Chen, Jin-Chao Hou, Kai Schlepckow, Simone Degan, Lindsey A Chew, Joshua Amason, Joan Kalnitsky, Catherine Bowes Rickman, Alan D Proia, Marco Colonna, Christian Haass, Daniel R Saban
Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2. The Journal of experimental medicine 221 (3) (2024)
Marvin Reich, Matthew J Simon, Beate Polke, Iñaki Paris, Georg Werner, Christian Schrader, Lena Spieth, Sonnet S Davis, Sophie Robinson, Gabrielly Lunkes de Melo, Lennart Schlaphoff, Katrin Buschmann, Stefan A Berghoff, Todd Logan, Brigitte Nuscher, Lis de Weerd, Dieter Edbauer, Mikael Simons, Jung H Suh, Thomas Sandmann, Mihalis S Kariolis, Sarah L DeVos, Joseph W Lewcock, Dominik Paquet, Anja Capell, Gilbert Di Paolo, Christian Haass
Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration. Science translational medicine 16 (750) (2024)
Chen Yu, Eleonora M Lad, Rose Mathew, Nobuhiko Shiraki, Sejiro Littleton, Yun Chen, Jin-Chao Hou, Kai Schlepckow, Simone Degan, Lindsey A Chew, Joshua Amason, Joan Kalnitsky, Catherine Bowes Rickman, Alan D Proia, Marco Colonna, Christian Haass, Daniel R Saban
Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2. The Journal of experimental medicine 221 (3) (2024)
Chen Yu, Eleonora M Lad, Rose Mathew, Nobuhiko Shiraki, Sejiro Littleton, Yun Chen, Jin-Chao Hou, Kai Schlepckow, Simone Degan, Lindsey A Chew, Joshua Amason, Joan Kalnitsky, Catherine Bowes Rickman, Alan D Proia, Marco Colonna, Christian Haass, Daniel R Saban
Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2. The Journal of experimental medicine 221 (3) (2024)
Chen Yu, Eleonora M Lad, Rose Mathew, Nobuhiko Shiraki, Sejiro Littleton, Yun Chen, Jin-Chao Hou, Kai Schlepckow, Simone Degan, Lindsey A Chew, Joshua Amason, Joan Kalnitsky, Catherine Bowes Rickman, Alan D Proia, Marco Colonna, Christian Haass, Daniel R Saban
Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2. The Journal of experimental medicine 221 (3) (2024)
Chen Yu, Eleonora M Lad, Rose Mathew, Nobuhiko Shiraki, Sejiro Littleton, Yun Chen, Jin-Chao Hou, Kai Schlepckow, Simone Degan, Lindsey A Chew, Joshua Amason, Joan Kalnitsky, Catherine Bowes Rickman, Alan D Proia, Marco Colonna, Christian Haass, Daniel R Saban
Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2. The Journal of experimental medicine 221 (3) (2024)
Chen Yu, Eleonora M Lad, Rose Mathew, Nobuhiko Shiraki, Sejiro Littleton, Yun Chen, Jin-Chao Hou, Kai Schlepckow, Simone Degan, Lindsey A Chew, Joshua Amason, Joan Kalnitsky, Catherine Bowes Rickman, Alan D Proia, Marco Colonna, Christian Haass, Daniel R Saban
Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2. The Journal of experimental medicine 221 (3) (2024)
Chen Yu, Eleonora M Lad, Rose Mathew, Nobuhiko Shiraki, Sejiro Littleton, Yun Chen, Jin-Chao Hou, Kai Schlepckow, Simone Degan, Lindsey A Chew, Joshua Amason, Joan Kalnitsky, Catherine Bowes Rickman, Alan D Proia, Marco Colonna, Christian Haass, Daniel R Saban
Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2. The Journal of experimental medicine 221 (3) (2024)
Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David A Joy, Joshua I Park, David Tatarakis, Meredith Calvert, Selina Hummel, Steve Lianoglou, Michelle E Pizzo, Rachel Prorok, Elliot Thomsen, Laura M Bartos, Philipp Beumers, Anja Capell, Sonnet S Davis, Lis de Weerd, Jason C Dugas, Joseph Duque, Timothy Earr, Kapil Gadkar, Tina Giese, Audrey Gill, Johannes Gnörich, Connie Ha, Malavika Kannuswamy, Do Jin Kim, Sebastian T Kunte, Lea Helena Kunze, Diana Lac, Kendra Lechtenberg, Amy Wing-Sze Leung, Chun-Chi Liang, Isabel Lopez, Paul McQuade, Anuja Modi, Vanessa O Torres, Hoang N Nguyen, Ida Pesämaa, Nicholas Propson, Marvin Reich, Yaneth Robles-Colmenares, Kai Schlepckow, Luna Slemann, Hilda Solanoy, Jung H Suh, Robert G Thorne, Chandler Vieira, Karin Wind-Mark, Ken Xiong, Y Joy Yu Zuchero, Dolo Diaz, Mark S Dennis, Fen Huang, Kimberly A Scearce-Levie, Ryan J Watts, Christian Haass, Joseph W Lewcock, Gilbert Di Paolo, Matthias Brendel, Pascal E Sanchez, Kathryn M Monroe
A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nature neuroscience (2023)
Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David A Joy, Joshua I Park, David Tatarakis, Meredith Calvert, Selina Hummel, Steve Lianoglou, Michelle E Pizzo, Rachel Prorok, Elliot Thomsen, Laura M Bartos, Philipp Beumers, Anja Capell, Sonnet S Davis, Lis de Weerd, Jason C Dugas, Joseph Duque, Timothy Earr, Kapil Gadkar, Tina Giese, Audrey Gill, Johannes Gnörich, Connie Ha, Malavika Kannuswamy, Do Jin Kim, Sebastian T Kunte, Lea Helena Kunze, Diana Lac, Kendra Lechtenberg, Amy Wing-Sze Leung, Chun-Chi Liang, Isabel Lopez, Paul McQuade, Anuja Modi, Vanessa O Torres, Hoang N Nguyen, Ida Pesämaa, Nicholas Propson, Marvin Reich, Yaneth Robles-Colmenares, Kai Schlepckow, Luna Slemann, Hilda Solanoy, Jung H Suh, Robert G Thorne, Chandler Vieira, Karin Wind-Mark, Ken Xiong, Y Joy Yu Zuchero, Dolo Diaz, Mark S Dennis, Fen Huang, Kimberly A Scearce-Levie, Ryan J Watts, Christian Haass, Joseph W Lewcock, Gilbert Di Paolo, Matthias Brendel, Pascal E Sanchez, Kathryn M Monroe
A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nature neuroscience (2023)
Ida Pesämaa, Stephan A Müller, Sophie Robinson, Alana Darcher, Dominik Paquet, Henrik Zetterberg, Stefan F Lichtenthaler, Christian Haass
A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer's disease patients from controls. Molecular neurodegeneration 18 (1) (2023)
Erik C B Johnson, Shijia Bian, Rafi U Haque, E Kathleen Carter, Caroline M Watson, Brian A Gordon, Lingyan Ping, Duc M Duong, Michael P Epstein, Eric McDade, Nicolas R Barthélemy, Celeste M Karch, Chengjie Xiong, Cruchaga Carlos, Richard J Perrin, Aliza P Wingo, Thomas S Wingo, Jasmeer P Chhatwal, Gregory S Day, James M Noble, Sarah B Berman, Ralph Martins, Neill R Graff-Radford, Peter R Schofield, Takeshi Ikeuchi, Hiroshi Mori, Johannes Levin, Martin R Farlow, James J Lah, Christian Haass, Mathias Jucker, John C Morris, Tammie L S Benzinger, Blaine R Roberts, Randell J Bateman, Anne M Fagan, Nicholas T Seyfried, Allan L Levey, null null
Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease. Nature medicine (2023)
Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David A Joy, Joshua I Park, David Tatarakis, Meredith Calvert, Selina Hummel, Steve Lianoglou, Michelle E Pizzo, Rachel Prorok, Elliot Thomsen, Laura M Bartos, Philipp Beumers, Anja Capell, Sonnet S Davis, Lis de Weerd, Jason C Dugas, Joseph Duque, Timothy Earr, Kapil Gadkar, Tina Giese, Audrey Gill, Johannes Gnörich, Connie Ha, Malavika Kannuswamy, Do Jin Kim, Sebastian T Kunte, Lea Helena Kunze, Diana Lac, Kendra Lechtenberg, Amy Wing-Sze Leung, Chun-Chi Liang, Isabel Lopez, Paul McQuade, Anuja Modi, Vanessa O Torres, Hoang N Nguyen, Ida Pesämaa, Nicholas Propson, Marvin Reich, Yaneth Robles-Colmenares, Kai Schlepckow, Luna Slemann, Hilda Solanoy, Jung H Suh, Robert G Thorne, Chandler Vieira, Karin Wind-Mark, Ken Xiong, Y Joy Yu Zuchero, Dolo Diaz, Mark S Dennis, Fen Huang, Kimberly A Scearce-Levie, Ryan J Watts, Christian Haass, Joseph W Lewcock, Gilbert Di Paolo, Matthias Brendel, Pascal E Sanchez, Kathryn M Monroe
A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nature neuroscience 26 (3) (2023)
Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David A Joy, Joshua I Park, David Tatarakis, Meredith Calvert, Selina Hummel, Steve Lianoglou, Michelle E Pizzo, Rachel Prorok, Elliot Thomsen, Laura M Bartos, Philipp Beumers, Anja Capell, Sonnet S Davis, Lis de Weerd, Jason C Dugas, Joseph Duque, Timothy Earr, Kapil Gadkar, Tina Giese, Audrey Gill, Johannes Gnörich, Connie Ha, Malavika Kannuswamy, Do Jin Kim, Sebastian T Kunte, Lea Helena Kunze, Diana Lac, Kendra Lechtenberg, Amy Wing-Sze Leung, Chun-Chi Liang, Isabel Lopez, Paul McQuade, Anuja Modi, Vanessa O Torres, Hoang N Nguyen, Ida Pesämaa, Nicholas Propson, Marvin Reich, Yaneth Robles-Colmenares, Kai Schlepckow, Luna Slemann, Hilda Solanoy, Jung H Suh, Robert G Thorne, Chandler Vieira, Karin Wind-Mark, Ken Xiong, Y Joy Yu Zuchero, Dolo Diaz, Mark S Dennis, Fen Huang, Kimberly A Scearce-Levie, Ryan J Watts, Christian Haass, Joseph W Lewcock, Gilbert Di Paolo, Matthias Brendel, Pascal E Sanchez, Kathryn M Monroe
A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nature neuroscience 26 (3) (2023)
Carla Palleis, Nicolai Franzmeier, Endy Weidinger, Alexander Maximilian Bernhardt, Sabrina Katzdobler, Stephan Wall, Christian Ferschmann, Stefanie Harris, Julia Schmitt, Sebastian Schuster, Johannes Gnörich, Anika Finze, Gloria Biechele, Simon Lindner, Nathalie L Albert, Peter Bartenstein, Osama Sabri, Henryk Barthel, Rainer Rupprecht, Brigitte Nuscher, Andrew W Stephens, Boris-Stephan Rauchmann, Matthias Brendel, Christian Haass, Matthias Brendel, Johannes Levin, Günter U Höglinger
Association of Neurofilament Light Chain, [ 18 F]PI-2620 Tau-PET, TSPO-PET, and Clinical Progression in Patients With β-Amyloid-Negative CBS. Neurology 102 (1) (2023)
Carla Palleis, Nicolai Franzmeier, Endy Weidinger, Alexander Maximilian Bernhardt, Sabrina Katzdobler, Stephan Wall, Christian Ferschmann, Stefanie Harris, Julia Schmitt, Sebastian Schuster, Johannes Gnörich, Anika Finze, Gloria Biechele, Simon Lindner, Nathalie L Albert, Peter Bartenstein, Osama Sabri, Henryk Barthel, Rainer Rupprecht, Brigitte Nuscher, Andrew W Stephens, Boris-Stephan Rauchmann, Matthias Brendel, Christian Haass, Matthias Brendel, Johannes Levin, Günter U Höglinger
Association of Neurofilament Light Chain, [ 18 F]PI-2620 Tau-PET, TSPO-PET, and Clinical Progression in Patients With β-Amyloid-Negative CBS. Neurology 102 (1) (2023)
Mar Bosch-Queralt, Ludovico Cantuti-Castelvetri, Alkmini Damkou, Martina Fetting, Kai Schlepckow, Ioannis Alexopoulos, Dieter Lütjohann, Christian Klose, Lenka Vaculčiaková, Takahiro Masuda, Marco Prinz, Kathryn M Monroe, Gilbert Di Paolo, Joseph W Lewcock, Christian Haass, Mikael Simons
Author Correction: Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination. Nature metabolism (2023)
Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David A Joy, Joshua I Park, David Tatarakis, Meredith Calvert, Selina Hummel, Steve Lianoglou, Michelle E Pizzo, Rachel Prorok, Elliot Thomsen, Laura M Bartos, Philipp Beumers, Anja Capell, Sonnet S Davis, Lis de Weerd, Jason C Dugas, Joseph Duque, Timothy Earr, Kapil Gadkar, Tina Giese, Audrey Gill, Johannes Gnörich, Connie Ha, Malavika Kannuswamy, Do Jin Kim, Sebastian T Kunte, Lea Helena Kunze, Diana Lac, Kendra Lechtenberg, Amy Wing-Sze Leung, Chun-Chi Liang, Isabel Lopez, Paul McQuade, Anuja Modi, Vanessa O Torres, Hoang N Nguyen, Ida Pesämaa, Nicholas Propson, Marvin Reich, Yaneth Robles-Colmenares, Kai Schlepckow, Luna Slemann, Hilda Solanoy, Jung H Suh, Robert G Thorne, Chandler Vieira, Karin Wind-Mark, Ken Xiong, Y Joy Yu Zuchero, Dolo Diaz, Mark S Dennis, Fen Huang, Kimberly A Scearce-Levie, Ryan J Watts, Christian Haass, Joseph W Lewcock, Gilbert Di Paolo, Matthias Brendel, Pascal E Sanchez, Kathryn M Monroe
A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nature neuroscience (2023)
Carla Palleis, Nicolai Franzmeier, Endy Weidinger, Alexander Maximilian Bernhardt, Sabrina Katzdobler, Stephan Wall, Christian Ferschmann, Stefanie Harris, Julia Schmitt, Sebastian Schuster, Johannes Gnörich, Anika Finze, Gloria Biechele, Simon Lindner, Nathalie L Albert, Peter Bartenstein, Osama Sabri, Henryk Barthel, Rainer Rupprecht, Brigitte Nuscher, Andrew W Stephens, Boris-Stephan Rauchmann, Matthias Brendel, Christian Haass, Matthias Brendel, Johannes Levin, Günter U Höglinger
Association of Neurofilament Light Chain, [ 18 F]PI-2620 Tau-PET, TSPO-PET, and Clinical Progression in Patients With β-Amyloid-Negative CBS. Neurology 102 (1) (2023)
Carla Palleis, Nicolai Franzmeier, Endy Weidinger, Alexander Maximilian Bernhardt, Sabrina Katzdobler, Stephan Wall, Christian Ferschmann, Stefanie Harris, Julia Schmitt, Sebastian Schuster, Johannes Gnörich, Anika Finze, Gloria Biechele, Simon Lindner, Nathalie L Albert, Peter Bartenstein, Osama Sabri, Henryk Barthel, Rainer Rupprecht, Brigitte Nuscher, Andrew W Stephens, Boris-Stephan Rauchmann, Matthias Brendel, Christian Haass, Matthias Brendel, Johannes Levin, Günter U Höglinger
Association of Neurofilament Light Chain, [ 18 F]PI-2620 Tau-PET, TSPO-PET, and Clinical Progression in Patients With β-Amyloid-Negative CBS. Neurology 102 (1) (2023)
Ida Pesämaa, Stephan A Müller, Sophie Robinson, Alana Darcher, Dominik Paquet, Henrik Zetterberg, Stefan F Lichtenthaler, Christian Haass
A MICROGLIAL ACTIVITY STATE BIOMARKER PANEL DIFFERENTIATES FTD-GRANULIN AND ALZHEIMER'S DISEASE PATIENTS FROM CONTROLS. bioRxiv : the preprint server for biology (2023)
Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David A Joy, Joshua I Park, David Tatarakis, Meredith Calvert, Selina Hummel, Steve Lianoglou, Michelle E Pizzo, Rachel Prorok, Elliot Thomsen, Laura M Bartos, Philipp Beumers, Anja Capell, Sonnet S Davis, Lis de Weerd, Jason C Dugas, Joseph Duque, Timothy Earr, Kapil Gadkar, Tina Giese, Audrey Gill, Johannes Gnörich, Connie Ha, Malavika Kannuswamy, Do Jin Kim, Sebastian T Kunte, Lea Helena Kunze, Diana Lac, Kendra Lechtenberg, Amy Wing-Sze Leung, Chun-Chi Liang, Isabel Lopez, Paul McQuade, Anuja Modi, Vanessa O Torres, Hoang N Nguyen, Ida Pesämaa, Nicholas Propson, Marvin Reich, Yaneth Robles-Colmenares, Kai Schlepckow, Luna Slemann, Hilda Solanoy, Jung H Suh, Robert G Thorne, Chandler Vieira, Karin Wind-Mark, Ken Xiong, Y Joy Yu Zuchero, Dolo Diaz, Mark S Dennis, Fen Huang, Kimberly A Scearce-Levie, Ryan J Watts, Christian Haass, Joseph W Lewcock, Gilbert Di Paolo, Matthias Brendel, Pascal E Sanchez, Kathryn M Monroe
A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nature neuroscience 26 (3) (2023)
Constanze Depp, Ting Sun, Andrew Octavian Sasmita, Lena Spieth, Stefan A Berghoff, Taisiia Nazarenko, Katharina Overhoff, Agnes A Steixner-Kumar, Swati Subramanian, Sahab Arinrad, Torben Ruhwedel, Wiebke Möbius, Sandra Göbbels, Gesine Saher, Hauke B Werner, Alkmini Damkou, Silvia Zampar, Oliver Wirths, Maik Thalmann, Mikael Simons, Takashi Saito, Takaomi C Saido, Dilja Krueger-Burg, Riki Kawaguchi, Michael Willem, Christian Haass, Daniel H Geschwind, Hannelore Ehrenreich, Ruth Stassart, Klaus-Armin Nave
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease. Nature (2023)
Xianyuan Xiang, Sabina Tahirovic, Sibylle Ziegler, Christian Haass, Matthias Brendel
Response to Comment on "Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases". Science translational medicine 14 (659) (2022)
Henrick Riemenschneider, Qiang Guo, Jakob Maximilian Bader, Frédéric Frottin, Daniel Farny, Gernot Kleinberger, Christian Haass, Matthias Mann, F Ulrich Hartl, Wolfgang Baumeister, Mark S Hipp, Rüdiger Klein, Rubén Fernández-Busnadiego, Dieter Edbauer
Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons. EMBO reports 23 (6) (2022)
Christian Haass, Dennis J Selkoe
If amyloid drives Alzheimer disease, why have anti-amyloid therapies not yet slowed cognitive decline? PLoS biology 20 (7) (2022)
Anika Reifschneider, Sophie Robinson, Bettina van Lengerich, Johannes Gnörich, Todd Logan, Steffanie Heindl, Miriam A Vogt, Endy Weidinger, Lina Riedl, Karin Wind, Artem Zatcepin, Ida Pesämaa, Sophie Haberl, Brigitte Nuscher, Gernot Kleinberger, Julien Klimmt, Julia K Götzl, Arthur Liesz, Katharina Bürger, Matthias Brendel, Johannes Levin, Janine Diehl-Schmid, Jung Suh, Gilbert Di Paolo, Joseph W Lewcock, Kathryn M Monroe, Dominik Paquet, Anja Capell, Christian Haass
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency. The EMBO journal 41 (4) (2022)
Franziska J Vettermann, Stefanie Harris, Julia Schmitt, Marcus Unterrainer, Simon Lindner, Boris-Stephan Rauchmann, Carla Palleis, Endy Weidinger, Leonie Beyer, Florian Eckenweber, Sebastian Schuster, Gloria Biechele, Christian Ferschmann, Vladimir M Milenkovic, Christian H Wetzel, Rainer Rupprecht, Daniel Janowitz, Katharina Buerger, Robert Perneczky, Günter U Höglinger, Johannes Levin, Christian Haass, Joerg C Tonn, Maximilian Niyazi, Peter Bartenstein, Nathalie L Albert, Matthias Brendel
Impact of TSPO Receptor Polymorphism on [18F]GE-180 Binding in Healthy Brain and Pseudo-Reference Regions of Neurooncological and Neurodegenerative Disorders. Life (Basel, Switzerland) 11 (6) (2021)
Mar Bosch-Queralt, Ludovico Cantuti-Castelvetri, Alkmini Damkou, Martina Fetting, Kai Schlepckow, Ioannis Alexopoulos, Dieter Lütjohann, Christian Klose, Lenka Vaculčiaková, Takahiro Masuda, Marco Prinz, Kathryn M Monroe, Gilbert Di Paolo, Joseph W Lewcock, Christian Haass, Mikael Simons
Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination. Nature metabolism 3 (2) (2021)
Xianyuan Xiang, Karin Wind, Thomas Wiedemann, Tanja Blume, Yuan Shi, Nils Briel, Leonie Beyer, Gloria Biechele, Florian Eckenweber, Artem Zatcepin, Sven Lammich, Sara Ribicic, Sabina Tahirovic, Michael Willem, Maximilian Deussing, Carla Palleis, Boris-Stephan Rauchmann, Franz-Josef Gildehaus, Simon Lindner, Charlotte Spitz, Nicolai Franzmeier, Karlheinz Baumann, Axel Rominger, Peter Bartenstein, Sibylle Ziegler, Alexander Drzezga, Gesine Respondek, Katharina Buerger, Matthias Brendel, Johannes Levin, Günter U Höglinger, Jochen Herms, Christian Haass, Matthias Brendel
Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases. Science translational medicine 13 (615) (2021)
Michael Ewers, Gloria Biechele, Marc Suarez-Calvet, Christian Sacher, Tanja Blume, Estrella Morenas-Rodriguez, Yuetiva K Deming, Laura Piccio, Carlos Cruchaga, Gernot Kleinberger, Leslie Shaw, John Q Trojanowski, Jochen Herms, Martin Dichgans, null null, Matthias Brendel, Christian Haass, Nicolai Franzmeier
Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation. EMBO molecular medicine 12 (9) (2020)
Yuetiva K Deming, Fabia Filipello, Francesca Cignarella, Claudia Cantoni, Simon Hsu, Robert Mikesell, Zeran Li, Jorge L Del-Aguila, Umber Dube, Fabiana Geraldo Farias, Joseph Bradley, John P Budde, Ibanez Laura, Maria Victoria Fernandez, Kaj Blennow, Henrik Zetterberg, Amanda J Heslegrave, Per Mårten Johansson, Johan Svensson, Bengt Nellgård, Alberto Lleo, Daniel Alcolea, Jordi Clarimón, Lorena Rami, José Luis Molinuevo, Marc Suarez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Michael Ewers, Oscar Harari, Christian Haass, Thomas J Brett, Bruno A Benitez, Celeste M Karch, Laura Piccio, Cruchaga Carlos
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk. Science translational medicine 11 (505) (2020)
Andrea Steiner, Kai Schlepckow, Bettina Brunner, Harald Steiner, Christian Haass, Franz Hagn
γ-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics. The EMBO journal 39 (20) (2020)
Georg Werner, Markus Damme, Martin Schludi, Johannes Gnörich, Karin Wind, Katrin Fellerer, Benedikt Wefers, Wolfgang Wurst, Dieter Edbauer, Matthias Brendel, Christian Haass, Anja Capell
Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice. EMBO reports 21 (10) (2020)
Kai Schlepckow, Kathryn M Monroe, Gernot Kleinberger, Ludovico Cantuti-Castelvetri, Samira Parhizkar, Dan Xia, Michael Willem, Georg Werner, Nadine Pettkus, Bettina Brunner, Alice Sülzen, Brigitte Nuscher, Heike Hampel, Xianyuan Xiang, Regina Feederle, Sabina Tahirovic, Joshua I Park, Rachel Prorok, Cathal Mahon, Chun-Chi Liang, Ju Shi, Do Jin Kim, Hanna Sabelström, Fen Huang, Gilbert Di Paolo, Mikael Simons, Joseph W Lewcock, Christian Haass
Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region. EMBO molecular medicine 12 (4) (2020)
Michael Ewers, Nicolai Franzmeier, Marc Suarez-Calvet, Estrella Morenas-Rodriguez, Miguel Angel Araque Caballero, Gernot Kleinberger, Laura Piccio, Cruchaga Carlos, Yuetiva K Deming, Martin Dichgans, John Q Trojanowski, Leslie M Shaw, Michael W Weiner, Christian Haass, null null
Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease. Science translational medicine 11 (507) (2020)
Julia K Götzl, Matthias Brendel, Georg Werner, Samira Parhizkar, Laura Sebastian Monasor, Gernot Kleinberger, Alessio-Vittorio Colombo, Maximilian Deussing, Matias Wagner, Juliane Winkelmann, Janine Diehl-Schmid, Johannes Levin, Katrin Fellerer, Anika Reifschneider, Sebastian Bultmann, Peter Bartenstein, Axel Rominger, Sabina Tahirovic, Scott T Smith, Charlotte Madore, Oleg Butovsky, Anja Capell, Christian Haass
Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism. EMBO molecular medicine 11 (6) (2020)
Eva M van Well, Verian Bader, Maria Patra, Ana Sánchez-Vicente, Jens Meschede, Nikolas Furthmann, Cathrin Schnack, Alina Blusch, Joseph Longworth, Elisabeth Petrasch-Parwez, Christian Haass, Thomas Arzberger, Dietrich Trümbach, Lena Angersbach, Cathrin Showkat, Dominik A Sehr, Lena A Berlemann, Petra Goldmann, Albrecht M Clement, Christian Behl, Andreas C Woerner, Carsten Saft, Wolfgang Wurst, Christian Haass, Gisa Ellrichmann, Ralf Gold, Gunnar Dittmar, Mark S Hipp, F Ulrich Hartl, Jörg Tatzelt, Konstanze F Winklhofer
A protein quality control pathway regulated by linear ubiquitination. The EMBO journal 38 (9) (2019)
Marc Suarez-Calvet, Anja Capell, Miguel Ángel Araque Caballero, Estrella Morenas-Rodríguez, Katrin Fellerer, Nicolai Franzmeier, Gernot Kleinberger, Erden Eren, Yuetiva K Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Katrina Paumier, Randall J Bateman, Anne M Fagan, John C Morris, Johannes Levin, Adrian Danek, Mathias Jucker, Colin L Masters, Martin N Rossor, John M Ringman, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers, Christian Haass, null null, null null
CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. EMBO molecular medicine 10 (12) (2019)
Nicolai Franzmeier, Jinyi Ren, Alexander Damm, Gemma Monté-Rubio, Mercè Boada, Agustín Ruiz, Alfredo Ramirez, Frank Jessen, Emrah Düzel, Octavio Rodríguez Gómez, Tammie Benzinger, Alison Mary Goate, Celeste M Karch, Anne M Fagan, Eric McDade, Katharina Buerger, Johannes Levin, Marco Duering, Martin Dichgans, Marc Suárez-Calvet, Christian Haass, Brian A Gordon, Yen Ying Lim, Colin L Masters, Daniel Janowitz, Cihan Catak, Steffen Wolfsgruber, Michael Wagner, Esther Milz, Sonia Moreno-Grau, Stefan Teipel, Michel J Grothe, Ingo Kilimann, Martin Rossor, Nick Fox, Christoph Laske, Jasmeer Chhatwal, Peter Falkai, Matthias Brendel, Jae-Hong Lee, Annika Spottke, Henning Boecker, Frederic Brosseron, Klaus Fliessbach, Michael T Heneka, Peter Nestor, Oliver Peters, Manuel Fuentes, Felix Menne, Josef Priller, Eike J Spruth, Christiana Franke, Anja Schneider, Christine Westerteicher, Oliver Speck, Jens Wiltfang, Claudia Bartels, Miguel Ángel Araque Caballero, Coraline Metzger, Daniel Bittner, Stephen P Salloway, Adrian Danek, Jason Hassenstab, Igor Yakushev, Peter R Schofield, John C Morris, Randall J Bateman, Michael Ewers
The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease. Molecular psychiatry 26 (2) (2019)
Estrella Morenas-Rodríguez, Daniel Alcolea, Marc Suárez-Calvet, Laia Muñoz-Llahuna, Eduard Vilaplana, Isabel Sala, Andrea Subirana, Marta Querol-Vilaseca, María Carmona-Iragui, Ignacio Illán-Gala, Roser Ribosa-Nogué, Rafael Blesa, Christian Haass, Juan Fortea, Alberto Lleó
Different pattern of CSF glial markers between dementia with Lewy bodies and Alzheimer's disease. Scientific reports 9 (1) (2019)
Qihui Zhou, Nikola Mareljic, Meike Michaelsen, Samira Parhizkar, Steffanie Heindl, Brigitte Nuscher, Daniel Farny, Mareike Czuppa, Carina Schludi, Alexander Graf, Stefan Krebs, Helmut Blum, Regina Feederle, Stefan Roth, Christian Haass, Thomas Arzberger, Arthur Liesz, Dieter Edbauer
Active poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model. EMBO molecular medicine 12 (2) (2019)
Samira Parhizkar, Thomas Arzberger, Matthias Brendel, Gernot Kleinberger, Maximilian Deussing, Carola Focke, Brigitte Nuscher, Monica Xiong, Alireza Ghasemigharagoz, Natalie Katzmarski, Susanne Krasemann, Stefan F Lichtenthaler, Stephan A Müller, Alessio Colombo, Laura Sebastian Monasor, Sabina Tahirovic, Jochen Herms, Michael Willem, Nadine Pettkus, Oleg Butovsky, Peter Bartenstein, Dieter Edbauer, Axel Rominger, Ali Erturk, Stefan A Grathwohl, Jonas J Neher, David M Holtzman, Melanie Meyer-Luehmann, Christian Haass
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE. Nature neuroscience 22 (2) (2019)
Kai Schlepckow, Gernot Kleinberger, Akio Fukumori, Regina Feederle, Stefan F Lichtenthaler, Harald Steiner, Christian Haass
An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function. EMBO molecular medicine 9 (10) (2018)
Gernot Kleinberger, Matthias Brendel, Eva Mracsko, Benedikt Wefers, Linda Groeneweg, Xianyuan Xiang, Carola Focke, Maximilian Deußing, Marc Suárez-Calvet, Fargol Mazaheri, Samira Parhizkar, Nadine Pettkus, Wolfgang Wurst, Regina Feederle, Peter Bartenstein, Thomas Mueggler, Thomas Arzberger, Irene Knuesel, Axel Rominger, Christian Haass
The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism. The EMBO journal 36 (13) (2017)
Fargol Mazaheri, Nicolas Snaidero, Gernot Kleinberger, Charlotte Madore, Anna Daria, Georg Werner, Susanne Krasemann, Anja Capell, Dietrich Trümbach, Wolfgang Wurst, Bettina Brunner, Sebastian Bultmann, Sabina Tahirovic, Martin Kerschensteiner, Thomas Misgeld, Oleg Butovsky, Christian Haass
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury. EMBO reports 18 (7) (2017)
Qihui Zhou, Carina Lehmer, Meike Michaelsen, Christian Haass, Dominik Alterauge, Dirk Baumjohann, Martin H Schludi, Johanna Greiling, Daniel Farny, Andrew Flatley, Regina Feederle, Stephanie May, Franziska Schreiber, Thomas Arzberger, Christoph Kuhm, Thomas Klopstock, Andreas Hermann, Christian Haass, Dieter Edbauer
Antibodies inhibit transmission and aggregation of C9orf72 poly-GA dipeptide repeat proteins. EMBO molecular medicine 9 (5) (2017)
Anna Daria, Alessio Colombo, Gemma Llovera, Heike Hampel, Michael Willem, Arthur Liesz, Christian Haass, Sabina Tahirovic
Young microglia restore amyloid plaque clearance of aged microglia. The EMBO journal 36 (5) (2016)