Karl Gruber (K Gruber)

Scopus Author ID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 38

Top Venues

ACS catalysis

Angewandte Chemie (International ed. in English)

Scientific reports

Proteins

University of Graz

University of Graz (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Graz Oct 01 2016

Austria

Full professor :: Institute of Molecular Biosciences

University of Graz

Austria

Director, Doctoral School of Molecular Biology and Biochemistry

acib - Austrian Centre of Industrial Biotechnology

Austria

Key researcher

University of Graz

Austria

Associate professor :: Institute of Molecular Biosciences

University of Graz

Austria

Full professor (Biocomputing) :: Institute of Molecular Biosciences

Kplus center "Applied Biocatalysis"

Austria

Key researcher/Module manager

University of Graz

Austria

Assistant professor :: Department of Chemistry

Scripps Research Institute

United States

Research associate (Erwin-Schrödinger-fellowship)

Education History

University of Graz

Austria

PHD

University of Graz

Austria

MSC

Publications

Gregor Wirnsberger, Iva Pritišanac, Gustav Oberdorfer, Karl Gruber
Flattening the curve-How to get better results with small deep-mutational-scanning datasets. Proteins (2024)
Michael Friess, Amit Singh Sahrawat, Bianca Kerschbaumer, Silvia Wallner, Ana Torvisco, Roland C Fischer, Karl Gruber, Peter Macheroux, Rolf Breinbauer
Asymmetric Synthesis of Chiral 2-Cyclohexenones with Quaternary Stereocenters via Ene-Reductase Catalyzed Desymmetrization of 2,5-Cyclohexadienones. ACS catalysis 14 (9) (2024)
Lena Parigger, Andreas Krassnigg, Michael Hetmann, Anna Hofmann, Karl Gruber, Georg Steinkellner, Christian C Gruber
CavitOmiX Drug Discovery: Engineering Antivirals with Enhanced Spectrum and Reduced Side Effects for Arboviral Diseases. Viruses 16 (8) (2024)
Gregor Wirnsberger, Iva Pritišanac, Gustav Oberdorfer, Karl Gruber
Flattening the curve-How to get better results with small deep-mutational-scanning datasets. Proteins 92 (7) (2024)
Amit Singh Sahrawat, Nakia Polidori, Wolfgang Kroutil, Karl Gruber
Deciphering the Unconventional Reduction of C=N Bonds by Old Yellow Enzymes Using QM/MM. ACS catalysis 14 (3) (2024)
Kamela Myrtollari, Elia Calderini, Daniel Kracher, Tobias Schöngaßner, Stela Galušić, Anita Slavica, Andreas Taden, Daniel Mokos, Anna Schrüfer, Gregor Wirnsberger, Karl Gruber, Bastian Daniel, Ascensión Martínez-Márquez
Stability Increase of Phenolic Acid Decarboxylase by a Combination of Protein and Solvent Engineering Unlocks Applications at Elevated Temperatures. ACS sustainable chemistry & engineering 12 (9) (2024)
Lena Parigger, Andreas Krassnigg, Michael Hetmann, Anna Hofmann, Karl Gruber, Georg Steinkellner, Christian C Gruber
CavitOmiX Drug Discovery: Engineering Antivirals with Enhanced Spectrum and Reduced Side Effects for Arboviral Diseases. Viruses 16 (8) (2024)
Erna Zukic, Daniel Mokos, Melanie Weber, Niklas Stix, Klaus Ditrich, Valerio Ferrario, Henrik Müller, Christian Willrodt, Karl Gruber, Bastian Daniel, Wolfgang Kroutil
Biocatalytic Heteroaromatic Amide Formation in Water Enabled by a Catalytic Tetrad and Two Access Tunnels. ACS catalysis 14 (11) (2024)
Michael Friess, Amit Singh Sahrawat, Bianca Kerschbaumer, Silvia Wallner, Ana Torvisco, Roland C Fischer, Karl Gruber, Peter Macheroux, Rolf Breinbauer
Asymmetric Synthesis of Chiral 2-Cyclohexenones with Quaternary Stereocenters via Ene-Reductase Catalyzed Desymmetrization of 2,5-Cyclohexadienones. ACS catalysis 14 (9) (2024)
Gregor Wirnsberger, Iva Pritišanac, Gustav Oberdorfer, Karl Gruber
Flattening the curve-How to get better results with small deep-mutational-scanning datasets. Proteins 92 (7) (2024)
Amit Singh Sahrawat, Nakia Polidori, Wolfgang Kroutil, Karl Gruber
Deciphering the Unconventional Reduction of C=N Bonds by Old Yellow Enzymes Using QM/MM. ACS catalysis 14 (3) (2024)
Kamela Myrtollari, Elia Calderini, Daniel Kracher, Tobias Schöngaßner, Stela Galušić, Anita Slavica, Andreas Taden, Daniel Mokos, Anna Schrüfer, Gregor Wirnsberger, Karl Gruber, Bastian Daniel, Ascensión Martínez-Márquez
Stability Increase of Phenolic Acid Decarboxylase by a Combination of Protein and Solvent Engineering Unlocks Applications at Elevated Temperatures. ACS sustainable chemistry & engineering 12 (9) (2024)
Kamela Myrtollari, Elia Calderini, Daniel Kracher, Tobias Schöngaßner, Stela Galušić, Anita Slavica, Andreas Taden, Daniel Mokos, Anna Schrüfer, Gregor Wirnsberger, Karl Gruber, Bastian Daniel, Ascensión Martínez-Márquez
Stability Increase of Phenolic Acid Decarboxylase by a Combination of Protein and Solvent Engineering Unlocks Applications at Elevated Temperatures. ACS sustainable chemistry & engineering 12 (9) (2024)
Erna Zukic, Daniel Mokos, Melanie Weber, Niklas Stix, Klaus Ditrich, Valerio Ferrario, Henrik Müller, Christian Willrodt, Karl Gruber, Bastian Daniel, Wolfgang Kroutil
Biocatalytic Heteroaromatic Amide Formation in Water Enabled by a Catalytic Tetrad and Two Access Tunnels. ACS catalysis 14 (11) (2024)
Andrea M Chánique, Nakia Polidori, Lucija Sovic, Daniel Kracher, Leen Assil-Companioni, Philipp Galuska, Loreto P Parra, Karl Gruber, Ascensión Martínez-Márquez
A Cold-Active Flavin-Dependent Monooxygenase from Janthinobacterium svalbardensis Unlocks Applications of Baeyer-Villiger Monooxygenases at Low Temperature. ACS catalysis 13 (6) (2023)
Lena Parigger, Andreas Krassnigg, Stefan Grabuschnig, Karl Gruber, Georg Steinkellner, Christian C Gruber
AI-assisted structural consensus-proteome prediction of human monkeypox viruses isolated within a year after the 2022 multi-country outbreak. Microbiology spectrum (2023)
M Hetmann, C Langner, V Durmaz, M Cespugli, K Köchl, A Krassnigg, K Blaschitz, S Groiss, M Loibner, D Ruau, Kurt Zatloukal, Karl Gruber, G Steinkellner, C C Gruber
Identification and validation of fusidic acid and flufenamic acid as inhibitors of SARS-CoV-2 replication using DrugSolver CavitomiX. Scientific reports 13 (1) (2023)
Willem B Breukelaar, Nakia Polidori, Amit Singh, Bastian Daniel, Silvia M Glueck, Karl Gruber, Wolfgang Kroutil
Mechanistic Insights into the Ene-Reductase-Catalyzed Promiscuous Reduction of Oximes to Amines. ACS catalysis 13 (4) (2023)
Willem B Breukelaar, Nakia Polidori, Amit Singh, Bastian Daniel, Silvia M Glueck, Karl Gruber, Wolfgang Kroutil
Mechanistic Insights into the Ene-Reductase-Catalyzed Promiscuous Reduction of Oximes to Amines. ACS catalysis 13 (4) (2023)
Andrea M Chánique, Nakia Polidori, Lucija Sovic, Daniel Kracher, Leen Assil-Companioni, Philipp Galuska, Loreto P Parra, Karl Gruber, Ascensión Martínez-Márquez
A Cold-Active Flavin-Dependent Monooxygenase from Janthinobacterium svalbardensis Unlocks Applications of Baeyer-Villiger Monooxygenases at Low Temperature. ACS catalysis 13 (6) (2023)
Karl Gruber, Vanessa Csitkovits, Andrzej Łyskowski, Christoph Kratky, Bernhard Kräutler
Structure-Based Demystification of Radical Catalysis by a Coenzyme B 12 Dependent Enzyme-Crystallographic Study of Glutamate Mutase with Cofactor Homologues. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 134 (35) (2022)
Karl Gruber, Vanessa Csitkovits, Andrzej Łyskowski, Christoph Kratky, Bernhard Kräutler
Structure-Based Demystification of Radical Catalysis by a Coenzyme B 12 Dependent Enzyme-Crystallographic Study of Glutamate Mutase with Cofactor Homologues. Angewandte Chemie (International ed. in English) 61 (35) (2022)
Bastian Daniel, Chiam Hashem, Marlene Leithold, Theo Sagmeister, Adrian Tripp, Holly Stolterfoht-Stock, Julia Messenlehner, Ronan Keegan, Christoph K Winkler, Jonathan Guyang Ling, Sabry H H Younes, Gustav Oberdorfer, Farah Diba Abu Bakar, Karl Gruber, Tea Pavkov-Keller, Margit Winkler
Structure of the Reductase Domain of a Fungal Carboxylic Acid Reductase and Its Substrate Scope in Thioester and Aldehyde Reduction. ACS catalysis 12 (24) (2022)
Vedat Durmaz, Katharina Köchl, Andreas Krassnigg, Lena Parigger, Michael Hetmann, Amit Singh Sahrawat, Daniel Nutz, Alexander Korsunsky, Ursula Kahler, Centina König, Lee Chang, Marius Krebs, Riccardo Bassetto, Tea Pavkov-Keller, Verena Resch, Karl Gruber, Georg Steinkellner, Christian C Gruber
Structural bioinformatics analysis of SARS-CoV-2 variants reveals higher hACE2 receptor binding affinity for Omicron B.1.1.529 spike RBD compared to wild type reference. Scientific reports 12 (1) (2022)
Bastian Daniel, Chiam Hashem, Marlene Leithold, Theo Sagmeister, Adrian Tripp, Holly Stolterfoht-Stock, Julia Messenlehner, Ronan Keegan, Christoph K Winkler, Jonathan Guyang Ling, Sabry H H Younes, Gustav Oberdorfer, Farah Diba Abu Bakar, Karl Gruber, Tea Pavkov-Keller, Margit Winkler
Structure of the Reductase Domain of a Fungal Carboxylic Acid Reductase and Its Substrate Scope in Thioester and Aldehyde Reduction. ACS catalysis 12 (24) (2022)
Karl Gruber, Vanessa Csitkovits, Andrzej Łyskowski, Christoph Kratky, Bernhard Kräutler
Structure-Based Demystification of Radical Catalysis by a Coenzyme B 12 Dependent Enzyme-Crystallographic Study of Glutamate Mutase with Cofactor Homologues. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 134 (35) (2022)
Gernot F Grabner, Nikolaus Guttenberger, Nicole Mayer, Anna K Migglautsch-Sulzer, Christian Lembacher-Fadum, Nermeen Fawzy, Dominik Bulfon, Peter Hofer, Thomas Züllig, Lennart Hartig, Natalia Kulminskaya, Gabriel Chalhoub, Margarita Schratter, Franz P W Radner, Karina Preiss-Landl, Sarah Masser, Achim Lass, Rudolf Zechner, Karl Gruber, Monika Oberer, Rolf Breinbauer, Robert Zimmermann
Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes. Journal of the American Chemical Society 144 (14) (2022)
Michael Prattes, Irina Grishkovskaya, Victor-Valentin Hodirnau, Ingrid Rössler, Isabella Klein, Christina Hetzmannseder, Gertrude Zisser, Christian C Gruber, Karl Gruber, David Haselbach, Helmut Bergler
Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine. Nature communications 12 (1) (2021)
Amit Singh Sahrawat, Georg Steinkellner, Katharina Köchl, Karl Gruber, Christian C Gruber
Serine 477 plays a crucial role in the interaction of the SARS-CoV-2 spike protein with the human receptor ACE2. Scientific reports 11 (1) (2021)
Mattia Lazzarotto, Lucas Hammerer, Michael Hetmann, Annika J E Borg, Luca Schmermund, Lorenz Steiner, Peter Hartmann, Ferdinand Belaj, Wolfgang Kroutil, Karl Gruber, Michael Fuchs
Chemoenzymatic Total Synthesis of Deoxy-, epi-, and Podophyllotoxin and a Biocatalytic Kinetic Resolution of Dibenzylbutyrolactones. Angewandte Chemie (International ed. in English) 58 (24) (2019)
Michael S Lukesch, Tea Pavkov-Keller, Karl Gruber, Klaus Zangger, Birgit Wiltschi
Substituting the catalytic proline of 4-oxalocrotonate tautomerase with non-canonical analogues reveals a finely tuned catalytic system. Scientific reports 9 (1) (2019)
Matthias Engleder, Gernot A Strohmeier, Hansjörg Weber, Georg Steinkellner, Erich Leitner, Monika Müller, Daniel Mink, Martin Schürmann, Karl Gruber, Harald Pichler
Evolving the Promiscuity of Elizabethkingia meningoseptica Oleate Hydratase for the Regio- and Stereoselective Hydration of Oleic Acid Derivatives. Angewandte Chemie (International ed. in English) 58 (22) (2019)
Kathrin Heckenbichler, Anna Schweiger, Lea Alexandra Brandner, Alexandra Binter, Marina Toplak, Peter Macheroux, Karl Gruber, Rolf Breinbauer
Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases. Angewandte Chemie (International ed. in English) 57 (24) (2018)
Tea Pavkov-Keller, Nina G Schmidt, Anna Żądło-Dobrowolska, Wolfgang Kroutil, Karl Gruber
Structure and Catalytic Mechanism of a Bacterial Friedel-Crafts Acylase. Chembiochem : a European journal of chemical biology 20 (1) (2018)
Tea Pavkov-Keller, Kerstin Steiner, Mario Faber, Martin Tengg, Helmut Schwab, Mandana Gruber-Khadjawi, Karl Gruber
Crystal Structure and Catalytic Mechanism of CouO, a Versatile C-Methyltransferase from Streptomyces rishiriensis. PloS one 12 (2) (2017)
Stefan E Payer, Stephen A Marshall, Natalie Bärland, Xiang Sheng, Tamara Reiter, Andela Dordic, Georg Steinkellner, Christiane Wuensch, Susann Kaltwasser, Karl Fisher, Stephen E J Rigby, Peter Macheroux, Janet Vonck, Karl Gruber, Kurt Faber, Fahmi Himo, David Leys, Tea Pavkov-Keller, Silvia M Glueck
Regioselective para-Carboxylation of Catechols with a Prenylated Flavin Dependent Decarboxylase. Angewandte Chemie (International ed. in English) 56 (44) (2017)
Karl Gruber, Bernhard Kräutler
Coenzyme B12 Repurposed for Photoregulation of Gene Expression. Angewandte Chemie (International ed. in English) 55 (19) (2016)
Chengjie Li, Klaus Wurst, Steffen Jockusch, Karl Gruber, Maren Podewitz, Klaus Roman Liedl, Bernhard Kräutler
Chlorophyll-Derived Yellow Phyllobilins of Higher Plants as Medium-Responsive Chiral Photoswitches. Angewandte Chemie (International ed. in English) 55 (51) (2016)

Karl Gruber.css-eqlu8i{font-size:small;padding-left:4px;} (K Gruber)

Publication Activity (10 Years)

Top Topics

Top Venues

Karl Gruber (K Gruber)