Kaspar P Locher (K P Locher)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 30

Top Topics

Molecular Dynamics Simulations

Structural Basis

Binding Protein

Cancer Stem Cells

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Nature communications

Science (New York, N.Y.)

Nature structural & molecular biology

This page only lists publications with an associated author ORCID identifier.

Publications

Hongtao Liu, Dariusz Zakrzewicz, Kamil Nosol, Rossitza N Irobalieva, Somnath Mukherjee, Rose Bang-Sørensen, Nora Goldmann, Sebastian Kunz, Lorenzo Rossi, Anthony A Kossiakoff, Stephan Urban, Dieter Glebe, Joachim Geyer, Kaspar P Locher
Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP. Nature communications 15 (1) (2024)
Hongtao Liu, Dariusz Zakrzewicz, Kamil Nosol, Rossitza N Irobalieva, Somnath Mukherjee, Rose Bang-Sørensen, Nora Goldmann, Sebastian Kunz, Lorenzo Rossi, Anthony A Kossiakoff, Stephan Urban, Dieter Glebe, Joachim Geyer, Kaspar P Locher
Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP. Nature communications 15 (1) (2024)
Hongtao Liu, Dariusz Zakrzewicz, Kamil Nosol, Rossitza N Irobalieva, Somnath Mukherjee, Rose Bang-Sørensen, Nora Goldmann, Sebastian Kunz, Lorenzo Rossi, Anthony A Kossiakoff, Stephan Urban, Dieter Glebe, Joachim Geyer, Kaspar P Locher
Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP. Nature communications 15 (1) (2024)
Hongtao Liu, Rossitza N Irobalieva, Julia Kowal, Dongchun Ni, Kamil Nosol, Rose Bang-Sørensen, Loïck Lancien, Henning Stahlberg, Bruno Stieger, Kaspar P Locher
Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP. Nature communications 14 (1) (2023)
Anca-Denise Ciută, Kamil Nosol, Julia Kowal, Somnath Mukherjee, Ana S Ramírez, Bruno Stieger, Anthony A Kossiakoff, Kaspar P Locher
Structure of human drug transporters OATP1B1 and OATP1B3. Nature communications 14 (1) (2023)
Joël S Bloch, Alan John, Runyu Mao, Somnath Mukherjee, Jérémy Boilevin, Rossitza N Irobalieva, Tamis Darbre, Nichollas E Scott, Jean-Louis Reymond, Anthony A Kossiakoff, Ethan D Goddard-Borger, Kaspar P Locher
Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase. Nature chemical biology (2023)
Joël S Bloch, Alan John, Runyu Mao, Somnath Mukherjee, Jérémy Boilevin, Rossitza N Irobalieva, Tamis Darbre, Nichollas E Scott, Jean-Louis Reymond, Anthony A Kossiakoff, Ethan D Goddard-Borger, Kaspar P Locher
Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase. Nature chemical biology (2023)
Ana S Ramírez, Mario de Capitani, Giorgio Pesciullesi, Julia Kowal, Joël S Bloch, Rossitza N Irobalieva, Jean-Louis Reymond, Markus Aebi, Kaspar P Locher
Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase. Nature communications 13 (1) (2022)
Ali Rasouli, Qin Yu, Sepehr Dehghani-Ghahnaviyeh, Po-Chao Wen, Julia Kowal, Kaspar P Locher, Emad Tajkhorshid
Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Ali Rasouli, Qin Yu, Sepehr Dehghani-Ghahnaviyeh, Po-Chao Wen, Julia Kowal, Kaspar P Locher, Emad Tajkhorshid
Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Ali Rasouli, Qin Yu, Sepehr Dehghani-Ghahnaviyeh, Po-Chao Wen, Julia Kowal, Kaspar P Locher, Emad Tajkhorshid
Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Ali Rasouli, Qin Yu, Sepehr Dehghani-Ghahnaviyeh, Po-Chao Wen, Julia Kowal, Kaspar P Locher, Emad Tajkhorshid
Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Joël S Bloch, Jeffrey M Sequeira, Ana S Ramírez, Edward V Quadros, Kaspar P Locher
Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B 12 uptake route. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 36 (4) (2022)
Hongtao Liu, Rossitza N Irobalieva, Rose Bang-Sørensen, Kamil Nosol, Somnath Mukherjee, Parth Agrawal, Bruno Stieger, Anthony A Kossiakoff, Kaspar P Locher
Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver. Cell research 32 (8) (2022)
Ali Rasouli, Qin Yu, Sepehr Dehghani-Ghahnaviyeh, Po-Chao Wen, Julia Kowal, Kaspar P Locher, Emad Tajkhorshid
Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Kamil Nosol, Rose Bang-Sørensen, Rossitza N Irobalieva, Satchal K Erramilli, Bruno Stieger, Anthony A Kossiakoff, Kaspar P Locher
Structures of ABCB4 provide insight into phosphatidylcholine translocation. Proceedings of the National Academy of Sciences of the United States of America 118 (33) (2021)
Qin Yu, Dongchun Ni, Julia Kowal, Ioannis Manolaridis, Scott M Jackson, Henning Stahlberg, Kaspar P Locher
Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism. Nature communications 12 (1) (2021)
Joël S Bloch, Somnath Mukherjee, Julia Kowal, Ekaterina V Filippova, Martina Niederer, Els Pardon, Jan Steyaert, Anthony A Kossiakoff, Kaspar P Locher
Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proceedings of the National Academy of Sciences of the United States of America 118 (47) (2021)
Ana S Ramírez, Julia Kowal, Kaspar P Locher
Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. Science (New York, N.Y.) 366 (6471) (2020)
Kamil Nosol, Ksenija Romane, Rossitza N Irobalieva, Amer Alam, Julia Kowal, Naoya Fujita, Kaspar P Locher
Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1. Proceedings of the National Academy of Sciences of the United States of America 117 (42) (2020)
Jeppe A Olsen, Amer Alam, Julia Kowal, Bruno Stieger, Kaspar P Locher
Structure of the human lipid exporter ABCB4 in a lipid environment. Nature structural & molecular biology 27 (1) (2019)
Amer Alam, Julia Kowal, Eugenia Broude, Igor B Roninson, Kaspar P Locher
Structural insight into substrate and inhibitor discrimination by human P-glycoprotein. Science (New York, N.Y.) 363 (6428) (2019)
Maja Napiórkowska, Jérémy Boilevin, Tamis Darbre, Jean-Louis Reymond, Kaspar P Locher
Structure of bacterial oligosaccharyltransferase PglB bound to a reactive LLO and an inhibitory peptide. Scientific reports 8 (1) (2018)
Amer Alam, Raphael Küng, Julia Kowal, Robert A McLeod, Nina Tremp, Eugenia V Broude, Igor B Roninson, Henning Stahlberg, Kaspar P Locher
Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1. Proceedings of the National Academy of Sciences of the United States of America 115 (9) (2018)
Ana S Ramírez, Jérémy Boilevin, Ahmad Reza Mehdipour, Gerhard Hummer, Tamis Darbre, Jean-Louis Reymond, Kaspar P Locher
Structural basis of the molecular ruler mechanism of a bacterial glycosyltransferase. Nature communications 9 (1) (2018)
Rebekka Wild, Julia Kowal, Jillianne Eyring, Elsy M Ngwa, Markus Aebi, Kaspar P Locher
Structure of the yeast oligosaccharyltransferase complex gives insight into eukaryotic N-glycosylation. Science (New York, N.Y.) 359 (6375) (2018)
Scott M Jackson, Ioannis Manolaridis, Julia Kowal, Melanie Zechner, Nicholas M I Taylor, Manuel Bause, Stefanie Bauer, Ruben Bartholomaeus, Guenther Bernhardt, Burkhard Koenig, Armin Buschauer, Henning Stahlberg, Karl-Heinz Altmann, Kaspar P Locher
Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nature structural & molecular biology 25 (4) (2018)
Maja Napiórkowska, Jérémy Boilevin, Tina Sovdat, Tamis Darbre, Jean-Louis Reymond, Markus Aebi, Kaspar P Locher
Molecular basis of lipid-linked oligosaccharide recognition and processing by bacterial oligosaccharyltransferase. Nature structural & molecular biology 24 (12) (2017)
S A Mireku, M M Sauer, R Glockshuber, Kaspar P Locher
Structural basis of nanobody-mediated blocking of BtuF, the cognate substrate-binding protein of the Escherichia coli vitamin B12 transporter BtuCD. Scientific reports 7 (1) (2017)
Joël S Bloch, Markus Ruetz, Bernhard Kräutler, Kaspar P Locher
Structure of the human transcobalamin beta domain in four distinct states. PloS one 12 (9) (2017)