Kazuhiro Irie

ResearcherID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 35

Top Venues

Bioscience, biotechnology, and biochemistry

ACS chemical neuroscience

Organic letters

RSC chemical biology

Kyoto Daigaku

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Kyoto Daigaku Jul 01 2007

Japan

Professor :: Graduate School of Agriculture

京都大学 / Kyoto University Jul 01 2007

Japan

教授 / Professor :: 農学研究科 / Graduate Schools of Agriculture

京都大学 / Kyoto University Apr 01 2007 - Jun 30 2007

Japan

准教授 / Associate Professor :: 農学研究科 / Graduate Schools of Agriculture

京都大学 / Kyoto University Apr 01 1999 - Mar 31 2007

Japan

助教授 / Associate Professor :: 農学研究科 / Graduate Schools of Agriculture

Publications

Ryo C Yanagita, Yoshiyuki Suzuki, Yasuhiro Kawanami, Yusuke Hanaki, Kazuhiro Irie
Effect of phenolic-hydroxy-group incorporation on the biological activity of a simplified aplysiatoxin analog with an (R)-(-)-carvone-based core. Bioscience, biotechnology, and biochemistry (2024)
Ryo C Yanagita, Yoshiyuki Suzuki, Yasuhiro Kawanami, Yusuke Hanaki, Kazuhiro Irie
Effect of phenolic-hydroxy-group incorporation on the biological activity of a simplified aplysiatoxin analog with an (R)-(-)-carvone-based core. Bioscience, biotechnology, and biochemistry 88 (9) (2024)
Hidetaka Kuroiwa, Soichiro Suzuki, Kazuhiro Irie, Chihiro Tsukano
Total Synthesis and Structure Revision of (+)-Lancilactone C. Journal of the American Chemical Society (2023)
Shun Sato, Kana Yamamoto, Moeno Ito, Katsutoshi Nishino, Takanao Otsuka, Kazuhiro Irie, Masaya Nagao
Enhancement of Inhibitory Activity by Combining Allosteric Inhibitors Putatively Binding to Different Allosteric Sites on Cathepsin K. Molecules (Basel, Switzerland) 28 (10) (2023)
Kota Taniwa, Kazuma Murakami, Yoshiki Sakaguchi, Naotaka Izuo, Mizuho Hanaki, Nobuaki Sampa, Toshiaki Kume, Takahiko Shimizu, Kazuhiro Irie
Detection of Dietary Chalcone and Flavonoid Metabolites in Mice Using UPLC-MS/MS and Their Modulatory Effects on Amyloid β Aggregation. Journal of agricultural and food chemistry (2023)
Chihiro Tsukano, Ayumi Uchino, Kazuhiro Irie
Synthesis and applications of symmetric amino acid derivatives. Organic & biomolecular chemistry (2023)
Sogen Okuda, Chihiro Tsukano, Kazuhiro Irie
Synthesis of Stereoisomeric Simplified Analogs of Alotaketals toward the Elucidation of the Structural Requirements of Protein Kinase C Isozyme-Selective Binding. Organic letters 25 (5) (2023)
Sogen Okuda, Chihiro Tsukano, Kazuhiro Irie
Synthesis of Stereoisomeric Simplified Analogs of Alotaketals toward the Elucidation of the Structural Requirements of Protein Kinase C Isozyme-Selective Binding. Organic letters 25 (5) (2023)
Jumpei Maki, Yusuke Hanaki, Ryo C Yanagita, Masayuki Kikumori, Anastasiia Kovba, Ayaka Washizaki, Chihiro Tsukano, Hirofumi Akari, Kazuhiro Irie
Biological evaluation of a phosphate ester prodrug of 10-methyl-aplog-1, a simplified analogue of aplysiatoxin, as a possible latency-reversing agent for HIV reactivation. Bioscience, biotechnology, and biochemistry (2023)
Sogen Okuda, Chihiro Tsukano, Kazuhiro Irie
Synthesis of Stereoisomeric Simplified Analogs of Alotaketals toward the Elucidation of the Structural Requirements of Protein Kinase C Isozyme-Selective Binding. Organic letters (2023)
Sogen Okuda, Chihiro Tsukano, Kazuhiro Irie
Synthesis of Stereoisomeric Simplified Analogs of Alotaketals toward the Elucidation of the Structural Requirements of Protein Kinase C Isozyme-Selective Binding. Organic letters 25 (5) (2023)
Kazuma Murakami, Yoshiki Sakaguchi, Kota Taniwa, Naotaka Izuo, Mizuho Hanaki, Taiji Kawase, Kenji Hirose, Takahiko Shimizu, Kazuhiro Irie
Lysine-targeting inhibition of amyloid β oligomerization by a green perilla-derived metastable chalcone in vitro and in vivo . RSC chemical biology 3 (12) (2022)
Yoshiyuki Suzuki, Keiichi Moritoki, Mizuki Kajiwara, Ryo C Yanagita, Yasuhiro Kawanami, Yusuke Hanaki, Kazuhiro Irie
Design, synthesis, and biological activity of a synthetically accessible analog of aplysiatoxin with an (R)-(-)-carvone-based conformation-controlling unit. Bioscience, biotechnology, and biochemistry 86 (8) (2022)
Yohei Morishita, Kento Tsukada, Kazuma Murakami, Kazuhiro Irie, Teigo Asai
Synthetic Biology-Based Discovery of Diterpenoid Pyrones from the Genome of Eupenicillium shearii . Journal of natural products 85 (2) (2022)
Kazuma Murakami, Yoshiki Sakaguchi, Kota Taniwa, Naotaka Izuo, Mizuho Hanaki, Taiji Kawase, Kenji Hirose, Takahiko Shimizu, Kazuhiro Irie
Lysine-targeting inhibition of amyloid β oligomerization by a green perilla-derived metastable chalcone in vitro and in vivo . RSC chemical biology 3 (12) (2022)
Takahiro Konno, Masahito Sawahata, Ichiro Akutsu, Shohei Amaike, Genki Hiramatsu, Daisuke Uta, Naotaka Izuo, Takahiko Shimizu, Kazuhiro Irie, Toshiaki Kume
APP Knock-In Mice Produce E22P-Aβ Exhibiting an Alzheimer's Disease-like Phenotype with Dysregulation of Hypoxia-Inducible Factor Expression. International journal of molecular sciences 23 (21) (2022)
Jumpei Maki, Asami Oshimura, Chihiro Tsukano, Ryo C Yanagita, Yutaka Saito, Yasubumi Sakakibara, Kazuhiro Irie
AI and computational chemistry-accelerated development of an alotaketal analogue with conventional PKC selectivity. Chemical communications (Cambridge, England) 58 (47) (2022)
Yuka Matsushima, Yumi Irie, Yusuke Kageyama, Jean-Pierre Bellier, Ikuo Tooyama, Takahito Maki, Toshiaki Kume, Ryo C Yanagita, Kazuhiro Irie
Structure Optimization of the Toxic Conformation Model of Amyloid β42 by Intramolecular Disulfide Bond Formation. Chembiochem : a European journal of chemical biology 23 (8) (2022)
Ayaka Chikugo, Yumi Irie, Chihiro Tsukano, Ayumi Uchino, Takahito Maki, Toshiaki Kume, Taiji Kawase, Kenji Hirose, Yusuke Kageyama, Ikuo Tooyama, Kazuhiro Irie
Optimization of the Linker Length in the Dimer Model of E22P-Aβ40 Tethered at Position 38. ACS chemical neuroscience 13 (19) (2022)
Ayumi Uchino, Yumi Irie, Chihiro Tsukano, Taiji Kawase, Kenji Hirose, Yusuke Kageyama, Ikuo Tooyama, Ryo C Yanagita, Kazuhiro Irie
Synthesis and Characterization of Propeller- and Parallel-Type Full-Length Amyloid β40 Trimer Models. ACS chemical neuroscience 13 (16) (2022)
Kazuma Murakami, Shiori Horii, Mizuho Hanaki, Kazuhiro Irie
Searching for Natural Products That Delay Nucleation Phase and Promote Elongation Phase of Amyloid β42 toward Alzheimer's Disease Therapeutics. ACS chemical neuroscience 12 (18) (2021)
Chihiro Tsukano, Ryotaro Yagita, Takayoshi Heike, Tagwa A Mohammed, Kazuya Nishibayashi, Kazuhiro Irie, Yoshiji Takemoto
Asymmetric Total Synthesis of Shagenes A and B. Angewandte Chemie (International ed. in English) 60 (43) (2021)
Ayaka Washizaki, Megumi Murata, Yohei Seki, Masayuki Kikumori, Yinpui Tang, Weikeat Tan, Nadita P Wardani, Kazuhiro Irie, Hirofumi Akari
The Novel PKC Activator 10-Methyl-Aplog-1 Combined with JQ1 Induced Strong and Synergistic HIV Reactivation with Tolerable Global T Cell Activation. Viruses 13 (10) (2021)
Yusuke Kageyama, Yumi Irie, Yuka Matsushima, Tatsuya Segawa, Jean-Pierre Bellier, Kumi Hidaka, Hiroshi Sugiyama, Daita Kaneda, Yoshio Hashizume, Hiroyasu Akatsu, Kunio Miki, Akiko Kita, Douglas G Walker, Kazuhiro Irie, Ikuo Tooyama
Characterization of a Conformation-Restricted Amyloid β Peptide and Immunoreactivity of Its Antibody in Human AD brain. ACS chemical neuroscience 12 (18) (2021)
Yusuke Araki, Yusuke Hanaki, Masaki Kita, Koutaro Hayakawa, Kazuhiro Irie, Yoshihiko Nokura, Atsuo Nakazaki, Toshio Nishikawa
Total synthesis and biological evaluation of oscillatoxins D, E, and F. Bioscience, biotechnology, and biochemistry 85 (6) (2021)
Yuka Matsushima, Ryo C Yanagita, Kazuhiro Irie
Control of the toxic conformation of amyloid β42 by intramolecular disulfide bond formation. Chemical communications (Cambridge, England) 56 (29) (2020)
Kento Tsukada, Shono Shinki, Akiho Kaneko, Kazuma Murakami, Kazuhiro Irie, Masatoshi Murai, Hideto Miyoshi, Shingo Dan, Kumi Kawaji, Hironori Hayashi, Eiichi N Kodama, Aki Hori, Emil Salim, Takayuki Kuraishi, Naoya Hirata, Yasunari Kanda, Teigo Asai
Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones. Nature communications 11 (1) (2020)
Kazuma Murakami, Yayoi Obata, Asa Sekikawa, Haruka Ueda, Naotaka Izuo, Tatsuya Awano, Keiji Takabe, Takahiko Shimizu, Kazuhiro Irie
An RNA aptamer with potent affinity for a toxic dimer of amyloid β42 has potential utility for histochemical studies of Alzheimer's disease. The Journal of biological chemistry 295 (15) (2020)
Kazuma Murakami, Tomomi Yamaguchi, Naotaka Izuo, Toshiaki Kume, Hideyuki Hara, Kazuhiro Irie
Synthetic and Biophysical Studies on the Toxic Conformer in Amyloid β with the E22Δ Mutation in Alzheimer Pathology. ACS chemical neuroscience 11 (19) (2020)
Kazuma Murakami, Haruka Kato, Mizuho Hanaki, Yoko Monobe, Ken-Ichi Akagi, Taiji Kawase, Kenji Hirose, Kazuhiro Irie
Synthetic and biochemical studies on the effect of persulfidation on disulfide dimer models of amyloid β42 at position 35 in Alzheimer's etiology. RSC advances 10 (33) (2020)
Kazuma Murakami, Kazuhiro Irie
Three Structural Features of Functional Food Components and Herbal Medicine with Amyloid β42 Anti-Aggregation Properties. Molecules (Basel, Switzerland) 24 (11) (2019)
Kazuhiro Irie
New diagnostic method for Alzheimer's disease based on the toxic conformation theory of amyloid β. Bioscience, biotechnology, and biochemistry 84 (1) (2019)
Yusuke Kageyama, Atsushi Saito, Olga Pletnikova, Gay L Rudow, Yumi Irie, Yang An, Kazuma Murakami, Kazuhiro Irie, Susan M Resnick, David R Fowler, Lee J Martin, Juan C Troncoso
Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques. Scientific reports 8 (1) (2018)
Naotaka Izuo, Chihiro Kasahara, Kazuma Murakami, Toshiaki Kume, Masahiro Maeda, Kazuhiro Irie, Koutaro Yokote, Takahiko Shimizu
A Toxic Conformer of Aβ42 with a Turn at 22-23 is a Novel Therapeutic Target for Alzheimer's Disease. Scientific reports 7 (1) (2017)
Yumi Irie, Kazuma Murakami, Mizuho Hanaki, Yusuke Hanaki, Takashi Suzuki, Yoko Monobe, Tomoyo Takai, Ken-Ichi Akagi, Taiji Kawase, Kenji Hirose, Kazuhiro Irie
Synthetic Models of Quasi-Stable Amyloid β40 Oligomers with Significant Neurotoxicity. ACS chemical neuroscience 8 (4) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Kazuhiro Irie