Kazuhiro Iwai

Scopus Author ID Researcher Name Resolver ID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 25

Top Venues

Nature structural & molecular biology

Nature immunology

The Journal of experimental medicine

FEBS letters

京都大学 / Kyoto University

This page only lists publications with an associated author ORCID identifier.

Affiliation History

京都大学 / Kyoto University Apr 01 2012

Japan

教授 / Professor :: 医学研究科 / Graduate Schools of Medicine

Publications

Yukiko Takeda, Masahiro Ueki, Junpei Matsuhiro, Erik Walinda, Takayuki Tanaka, Masafumi Yamada, Hiroaki Fujita, Shunichiro Takezaki, Ichiro Kobayashi, Sakura Tamaki, Sanae Nagata, Noriko Miyake, Naomichi Matsumoto, Mitsujiro Osawa, Takahiro Yasumi, Toshio Heike, Fumiaki Ohtake, Megumu K Saito, Junya Toguchida, Junko Takita, Tadashi Ariga, Kazuhiro Iwai
A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome. The Journal of experimental medicine 221 (6) (2024)
Hirotsugu Oda, Kalpana Manthiram, Pallavi Pimpale Chavan, Eva Rieser, Önay Veli, Öykü Kaya, Charles Rauch, Shuichiro Nakabo, Hye Sun Kuehn, Mariël Swart, Yanli Wang, Nisa Ilgim Çelik, Anne Molitor, Vahid Ziaee, Nasim Movahedi, Mohammad Shahrooei, Nima Parvaneh, Nasrin Alipour-Olyei, Raphaël Carapito, Qin Xu, Silvia Preite, David B Beck, Jae Jin Chae, Michele Nehrebecky, Amanda K Ombrello, Patrycja Hoffmann, Tina Romeo, Natalie T Deuitch, Brynja Matthíasardóttir, May Christine V Malicdan, Hirsh Komarow, Jennifer Stoddard, Julie Niemela, A Kerry Dobbs, Colin L Sweeney, Holly Anderton, Kate E Lawlor, Hiroyuki Yoshitomi, Dan Yang, Manfred Boehm, Jeremy Davis, Pamela Mudd, Davide Randazzo, Wanxia Li Tsai, Massimo Gadina, Mariana J Kaplan, Junya Toguchida, Christian Thomas Mayer, Sergio D Rosenzweig, Luigi Daniele Notarangelo, Kazuhiro Iwai, John Silke, Pamela L Schwartzberg, Bertrand Boisson, Jean Laurent Casanova, Seiamak Bahram, Anand Prahalad Rao, Nieves Peltzer, Henning Walczak, Najoua Lalaoui, Ivona Aksentijevich, Daniel L Kastner
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency. Nature immunology 25 (5) (2024)
Yukiko Takeda, Masahiro Ueki, Junpei Matsuhiro, Erik Walinda, Takayuki Tanaka, Masafumi Yamada, Hiroaki Fujita, Shunichiro Takezaki, Ichiro Kobayashi, Sakura Tamaki, Sanae Nagata, Noriko Miyake, Naomichi Matsumoto, Mitsujiro Osawa, Takahiro Yasumi, Toshio Heike, Fumiaki Ohtake, Megumu K Saito, Junya Toguchida, Junko Takita, Tadashi Ariga, Kazuhiro Iwai
A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome. The Journal of experimental medicine 221 (6) (2024)
Hirotsugu Oda, Kalpana Manthiram, Pallavi Pimpale Chavan, Eva Rieser, Önay Veli, Öykü Kaya, Charles Rauch, Shuichiro Nakabo, Hye Sun Kuehn, Mariël Swart, Yanli Wang, Nisa Ilgim Çelik, Anne Molitor, Vahid Ziaee, Nasim Movahedi, Mohammad Shahrooei, Nima Parvaneh, Nasrin Alipour-Olyei, Raphaël Carapito, Qin Xu, Silvia Preite, David B Beck, Jae Jin Chae, Michele Nehrebecky, Amanda K Ombrello, Patrycja Hoffmann, Tina Romeo, Natalie T Deuitch, Brynja Matthíasardóttir, May Christine V Malicdan, Hirsh Komarow, Jennifer Stoddard, Julie Niemela, A Kerry Dobbs, Colin L Sweeney, Holly Anderton, Kate E Lawlor, Hiroyuki Yoshitomi, Dan Yang, Manfred Boehm, Jeremy Davis, Pamela Mudd, Davide Randazzo, Wanxia Li Tsai, Massimo Gadina, Mariana J Kaplan, Junya Toguchida, Christian Thomas Mayer, Sergio D Rosenzweig, Luigi Daniele Notarangelo, Kazuhiro Iwai, John Silke, Pamela L Schwartzberg, Bertrand Boisson, Jean Laurent Casanova, Seiamak Bahram, Anand Prahalad Rao, Nieves Peltzer, Henning Walczak, Najoua Lalaoui, Ivona Aksentijevich, Daniel L Kastner
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency. Nature immunology (2024)
Hirotsugu Oda, Kalpana Manthiram, Pallavi Pimpale Chavan, Eva Rieser, Önay Veli, Öykü Kaya, Charles Rauch, Shuichiro Nakabo, Hye Sun Kuehn, Mariël Swart, Yanli Wang, Nisa Ilgim Çelik, Anne Molitor, Vahid Ziaee, Nasim Movahedi, Mohammad Shahrooei, Nima Parvaneh, Nasrin Alipour-Olyei, Raphaël Carapito, Qin Xu, Silvia Preite, David B Beck, Jae Jin Chae, Michele Nehrebecky, Amanda K Ombrello, Patrycja Hoffmann, Tina Romeo, Natalie T Deuitch, Brynja Matthíasardóttir, May Christine V Malicdan, Hirsh Komarow, Jennifer Stoddard, Julie Niemela, A Kerry Dobbs, Colin L Sweeney, Holly Anderton, Kate E Lawlor, Hiroyuki Yoshitomi, Dan Yang, Manfred Boehm, Jeremy Davis, Pamela Mudd, Davide Randazzo, Wanxia Li Tsai, Massimo Gadina, Mariana J Kaplan, Junya Toguchida, Christian Thomas Mayer, Sergio D Rosenzweig, Luigi Daniele Notarangelo, Kazuhiro Iwai, John Silke, Pamela L Schwartzberg, Bertrand Boisson, Jean Laurent Casanova, Seiamak Bahram, Anand Prahalad Rao, Nieves Peltzer, Henning Walczak, Najoua Lalaoui, Ivona Aksentijevich, Daniel L Kastner
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency. Nature immunology 25 (5) (2024)
Hiroaki Fujita, Yu-Ki Tanaka, Seiryo Ogata, Noriyuki Suzuki, Sota Kuno, Uladzimir Barayeu, Takaaki Akaike, Yasumitsu Ogra, Kazuhiro Iwai
PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis. Nature structural & molecular biology 31 (8) (2024)
Hiroaki Fujita, Yu-Ki Tanaka, Seiryo Ogata, Noriyuki Suzuki, Sota Kuno, Uladzimir Barayeu, Takaaki Akaike, Yasumitsu Ogra, Kazuhiro Iwai
PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis. Nature structural & molecular biology 31 (8) (2024)
Hiroaki Fujita, Yu-Ki Tanaka, Seiryo Ogata, Noriyuki Suzuki, Sota Kuno, Uladzimir Barayeu, Takaaki Akaike, Yasumitsu Ogra, Kazuhiro Iwai
PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis. Nature structural & molecular biology 31 (8) (2024)
Hirotsugu Oda, Kalpana Manthiram, Pallavi Pimpale Chavan, Eva Rieser, Önay Veli, Öykü Kaya, Charles Rauch, Shuichiro Nakabo, Hye Sun Kuehn, Mariël Swart, Yanli Wang, Nisa Ilgim Çelik, Anne Molitor, Vahid Ziaee, Nasim Movahedi, Mohammad Shahrooei, Nima Parvaneh, Nasrin Alipour-Olyei, Raphaël Carapito, Qin Xu, Silvia Preite, David B Beck, Jae Jin Chae, Michele Nehrebecky, Amanda K Ombrello, Patrycja Hoffmann, Tina Romeo, Natalie T Deuitch, Brynja Matthíasardóttir, May Christine V Malicdan, Hirsh Komarow, Jennifer Stoddard, Julie Niemela, A Kerry Dobbs, Colin L Sweeney, Holly Anderton, Kate E Lawlor, Hiroyuki Yoshitomi, Dan Yang, Manfred Boehm, Jeremy Davis, Pamela Mudd, Davide Randazzo, Wanxia Li Tsai, Massimo Gadina, Mariana J Kaplan, Junya Toguchida, Christian Thomas Mayer, Sergio D Rosenzweig, Luigi Daniele Notarangelo, Kazuhiro Iwai, John Silke, Pamela L Schwartzberg, Bertrand Boisson, Jean Laurent Casanova, Seiamak Bahram, Anand Prahalad Rao, Nieves Peltzer, Henning Walczak, Najoua Lalaoui, Ivona Aksentijevich, Daniel L Kastner
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency. Nature immunology 25 (5) (2024)
Yukiko Takeda, Masahiro Ueki, Junpei Matsuhiro, Erik Walinda, Takayuki Tanaka, Masafumi Yamada, Hiroaki Fujita, Shunichiro Takezaki, Ichiro Kobayashi, Sakura Tamaki, Sanae Nagata, Noriko Miyake, Naomichi Matsumoto, Mitsujiro Osawa, Takahiro Yasumi, Toshio Heike, Fumiaki Ohtake, Megumu K Saito, Junya Toguchida, Junko Takita, Tadashi Ariga, Kazuhiro Iwai
A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome. The Journal of experimental medicine 221 (6) (2024)
Hiroaki Fujita, Yu-Ki Tanaka, Seiryo Ogata, Noriyuki Suzuki, Sota Kuno, Uladzimir Barayeu, Takaaki Akaike, Yasumitsu Ogra, Kazuhiro Iwai
PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis. Nature structural & molecular biology (2024)
Hirotsugu Oda, Kalpana Manthiram, Pallavi Pimpale Chavan, Eva Rieser, Önay Veli, Öykü Kaya, Charles Rauch, Shuichiro Nakabo, Hye Sun Kuehn, Mariël Swart, Yanli Wang, Nisa Ilgim Çelik, Anne Molitor, Vahid Ziaee, Nasim Movahedi, Mohammad Shahrooei, Nima Parvaneh, Nasrin Alipour-Olyei, Raphaël Carapito, Qin Xu, Silvia Preite, David B Beck, Jae Jin Chae, Michele Nehrebecky, Amanda K Ombrello, Patrycja Hoffmann, Tina Romeo, Natalie T Deuitch, Brynja Matthíasardóttir, May Christine V Malicdan, Hirsh Komarow, Jennifer Stoddard, Julie Niemela, A Kerry Dobbs, Colin L Sweeney, Holly Anderton, Kate E Lawlor, Hiroyuki Yoshitomi, Dan Yang, Manfred Boehm, Jeremy Davis, Pamela Mudd, Davide Randazzo, Wanxia Li Tsai, Massimo Gadina, Mariana J Kaplan, Junya Toguchida, Christian Thomas Mayer, Sergio D Rosenzweig, Luigi Daniele Notarangelo, Kazuhiro Iwai, John Silke, Pamela L Schwartzberg, Bertrand Boisson, Jean Laurent Casanova, Seiamak Bahram, Anand Prahalad Rao, Nieves Peltzer, Henning Walczak, Najoua Lalaoui, Ivona Aksentijevich, Daniel L Kastner
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency. Nature immunology (2024)
Yukiko Takeda, Masahiro Ueki, Junpei Matsuhiro, Erik Walinda, Takayuki Tanaka, Masafumi Yamada, Hiroaki Fujita, Shunichiro Takezaki, Ichiro Kobayashi, Sakura Tamaki, Sanae Nagata, Noriko Miyake, Naomichi Matsumoto, Mitsujiro Osawa, Takahiro Yasumi, Toshio Heike, Fumiaki Ohtake, Megumu K Saito, Junya Toguchida, Junko Takita, Tadashi Ariga, Kazuhiro Iwai
A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome. The Journal of experimental medicine 221 (6) (2024)
Hiroaki Fujita, Yu-Ki Tanaka, Seiryo Ogata, Noriyuki Suzuki, Sota Kuno, Uladzimir Barayeu, Takaaki Akaike, Yasumitsu Ogra, Kazuhiro Iwai
PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis. Nature structural & molecular biology 31 (8) (2024)
Victoria L Hartley, Arwa M Qaqish, Matthew J Wood, Brian T Studnicka, Kazuhiro Iwai, Ta-Chiang Liu, Donna A MacDuff
HOIL1 Regulates Group 3 Innate Lymphoid Cells in the Colon and Protects against Systemic Dissemination, Colonic Ulceration, and Lethality from Citrobacter rodentium Infection. Journal of immunology (Baltimore, Md. : 1950) (2023)
Katsuhiro Sasaki, Yoshie Hayamizu, Ryuji Murakami, Masakazu Toi, Kazuhiro Iwai
Linear ubiquitination-induced necrotic tumor remodeling elicits immune evasion. FEBS letters (2023)
Koji Jimbo, Ayuna Hattori, Shuhei Koide, Takahiro Ito, Katsuhiro Sasaki, Kazuhiro Iwai, Yasuhito Nannya, Atsushi Iwama, Arinobu Tojo, Takaaki Konuma
Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia. Leukemia (2022)
Yusuke Sakamoto, Katsuhiro Sasaki, Mayuki Omatsu, Kensuke Hamada, Yuki Nakanishi, Yoshiro Itatani, Kenji Kawada, Kazutaka Obama, Hiroshi Seno, Kazuhiro Iwai
Differential involvement of LUBAC-mediated linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation. The Journal of pathology (2022)
Sota Kuno, Hiroaki Fujita, Yu-Ki Tanaka, Yasumitsu Ogra, Kazuhiro Iwai
Iron-induced NCOA4 condensation regulates ferritin fate and iron homeostasis. EMBO reports 23 (5) (2022)
Yutaka Shinkawa, Koshi Imami, Yasuhiro Fuseya, Katsuhiro Sasaki, Koichiro Ohmura, Yasushi Ishihama, Akio Morinobu, Kazuhiro Iwai
ABIN1 is a signal-induced autophagy receptor that attenuates NF-κB activation by recognizing linear ubiquitin chains. FEBS letters 596 (9) (2022)
Yukiko Yoshida, Makoto Asahina, Arisa Murakami, Junko Kawawaki, Meari Yoshida, Reiko Fujinawa, Kazuhiro Iwai, Ryuichi Tozawa, Noriyuki Matsuda, Keiji Tanaka, Tadashi Suzuki
Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase. Proceedings of the National Academy of Sciences of the United States of America 118 (27) (2021)
Yasuhiro Fuseya, Hiroaki Fujita, Minsoo Kim, Fumiaki Ohtake, Akira Nishide, Katsuhiro Sasaki, Yasushi Saeki, Keiji Tanaka, Ryosuke Takahashi, Kazuhiro Iwai
The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC. Nature cell biology 22 (6) (2020)
Kazuhiro Iwai
Discovery of linear ubiquitination, a crucial regulator for immune signaling and cell death. The FEBS journal 288 (4) (2020)
Katsuhiro Sasaki, Ai Himeno, Tomoko Nakagawa, Yoshiteru Sasaki, Hiroshi Kiyonari, Kazuhiro Iwai
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death. Nature communications 10 (1) (2019)
Naoki Ishii, Erik Walinda, Naoto Iwakawa, Daichi Morimoto, Kazuhiro Iwai, Kenji Sugase, Masahiro Shirakawa
NMR resonance assignments of the NZF domain of mouse HOIL-1L free and bound to linear di-ubiquitin. Biomolecular NMR assignments 13 (1) (2018)

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Publication Activity (10 Years)

Top Topics

Top Venues

Kazuhiro Iwai