John Silke (J Silke)

ResearcherID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2013-2024
Publications (10 Years): 86

Top Venues

Nature communications

Cell death and differentiation

The EMBO journal

Cell death & disease

The Walter and Eliza Hall Institute

Universitat Zurich (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

The Walter and Eliza Hall Institute Jan 01 2019

Australia

Theme Leader :: Infection, Inflammation & Immunity

Education History

Universitat Zurich Nov 01 1992 - Jan 01 1997

Switzerland

PHD :: Molekular Biologie II

Publications

Panxue Wang, John Silke
RIPK1 and necroptosis role in premature ageing. Nature cell biology 26 (4) (2024)
Hirotsugu Oda, Kalpana Manthiram, Pallavi Pimpale Chavan, Eva Rieser, Önay Veli, Öykü Kaya, Charles Rauch, Shuichiro Nakabo, Hye Sun Kuehn, Mariël Swart, Yanli Wang, Nisa Ilgim Çelik, Anne Molitor, Vahid Ziaee, Nasim Movahedi, Mohammad Shahrooei, Nima Parvaneh, Nasrin Alipour-Olyei, Raphaël Carapito, Qin Xu, Silvia Preite, David B Beck, Jae Jin Chae, Michele Nehrebecky, Amanda K Ombrello, Patrycja Hoffmann, Tina Romeo, Natalie T Deuitch, Brynja Matthíasardóttir, May Christine V Malicdan, Hirsh Komarow, Jennifer Stoddard, Julie Niemela, A Kerry Dobbs, Colin L Sweeney, Holly Anderton, Kate E Lawlor, Hiroyuki Yoshitomi, Dan Yang, Manfred Boehm, Jeremy Davis, Pamela Mudd, Davide Randazzo, Wanxia Li Tsai, Massimo Gadina, Mariana J Kaplan, Junya Toguchida, Christian Thomas Mayer, Sergio D Rosenzweig, Luigi Daniele Notarangelo, Kazuhiro Iwai, John Silke, Pamela L Schwartzberg, Bertrand Boisson, Jean Laurent Casanova, Seiamak Bahram, Anand Prahalad Rao, Nieves Peltzer, Henning Walczak, Najoua Lalaoui, Ivona Aksentijevich, Daniel L Kastner
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency. Nature immunology 25 (5) (2024)
Pascal Meier, Arnaud J Legrand, Dieter Adam, John Silke
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity. Nature reviews. Cancer 24 (5) (2024)
Panxue Wang, John Silke
RIPK1 and necroptosis role in premature ageing. Nature cell biology (2024)
Hong Tri Tran, Tobias Kratina, Auriane Coutansais, Dominika Michalek, Benjamin M Hogan, Kate E Lawlor, James E Vince, John Silke, Najoua Lalaoui
RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation. Cell death and differentiation 31 (5) (2024)
Nishma Gupta, John Silke
Blocking cell death limits lung damage and inflammation from influenza. Nature (2024)
Hong Tri Tran, Tobias Kratina, Auriane Coutansais, Dominika Michalek, Benjamin M Hogan, Kate E Lawlor, James E Vince, John Silke, Najoua Lalaoui
RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation. Cell death and differentiation (2024)
Shene Chiou, Aysha H Al-Ani, Yi Pan, Komal M Patel, Isabella Y Kong, Lachlan W Whitehead, Amanda Light, Samuel N Young, Marilou Barrios, Callum Sargeant, Pradeep Rajasekhar, Leah Zhu, Anne Hempel, Ann Lin, James A Rickard, Cathrine Hall, Pradnya Gangatirkar, Raymond K H Yip, Wayne Cawthorne, Annette V Jacobsen, Christopher R Horne, Katherine R Martin, Lisa J Ioannidis, Diana S Hansen, Jessica Day, Ian P Wicks, Charity Law, Matthew E Ritchie, Rory Bowden, Joanne M Hildebrand, Lorraine Ann O'Reilly, John Silke, Lisa Giulino-Roth, Ellen Tsui, Kelly L Rogers, Edwin D Hawkins, Britt Christensen, James G Murphy, André L Samson
An immunohistochemical atlas of necroptotic pathway expression. EMBO molecular medicine 16 (7) (2024)
Pascal Meier, Arnaud J Legrand, Dieter Adam, John Silke
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity. Nature reviews. Cancer (2024)
Shene Chiou, Aysha H Al-Ani, Yi Pan, Komal M Patel, Isabella Y Kong, Lachlan W Whitehead, Amanda Light, Samuel N Young, Marilou Barrios, Callum Sargeant, Pradeep Rajasekhar, Leah Zhu, Anne Hempel, Ann Lin, James A Rickard, Cathrine Hall, Pradnya Gangatirkar, Raymond K H Yip, Wayne Cawthorne, Annette V Jacobsen, Christopher R Horne, Katherine R Martin, Lisa J Ioannidis, Diana S Hansen, Jessica Day, Ian P Wicks, Charity Law, Matthew E Ritchie, Rory Bowden, Joanne M Hildebrand, Lorraine Ann O'Reilly, John Silke, Lisa Giulino-Roth, Ellen Tsui, Kelly L Rogers, Edwin D Hawkins, Britt Christensen, James G Murphy, André L Samson
An immunohistochemical atlas of necroptotic pathway expression. EMBO molecular medicine 16 (7) (2024)
Pascal Meier, Arnaud J Legrand, Dieter Adam, John Silke
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity. Nature reviews. Cancer 24 (5) (2024)
Hong Tri Tran, Tobias Kratina, Auriane Coutansais, Dominika Michalek, Benjamin M Hogan, Kate E Lawlor, James E Vince, John Silke, Najoua Lalaoui
RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation. Cell death and differentiation 31 (5) (2024)
Nishma Gupta, John Silke
Blocking cell death limits lung damage and inflammation from influenza. Nature 628 (8009) (2024)
Nishma Gupta, John Silke
Blocking cell death limits lung damage and inflammation from influenza. Nature 628 (8009) (2024)
Hirotsugu Oda, Kalpana Manthiram, Pallavi Pimpale Chavan, Eva Rieser, Önay Veli, Öykü Kaya, Charles Rauch, Shuichiro Nakabo, Hye Sun Kuehn, Mariël Swart, Yanli Wang, Nisa Ilgim Çelik, Anne Molitor, Vahid Ziaee, Nasim Movahedi, Mohammad Shahrooei, Nima Parvaneh, Nasrin Alipour-Olyei, Raphaël Carapito, Qin Xu, Silvia Preite, David B Beck, Jae Jin Chae, Michele Nehrebecky, Amanda K Ombrello, Patrycja Hoffmann, Tina Romeo, Natalie T Deuitch, Brynja Matthíasardóttir, May Christine V Malicdan, Hirsh Komarow, Jennifer Stoddard, Julie Niemela, A Kerry Dobbs, Colin L Sweeney, Holly Anderton, Kate E Lawlor, Hiroyuki Yoshitomi, Dan Yang, Manfred Boehm, Jeremy Davis, Pamela Mudd, Davide Randazzo, Wanxia Li Tsai, Massimo Gadina, Mariana J Kaplan, Junya Toguchida, Christian Thomas Mayer, Sergio D Rosenzweig, Luigi Daniele Notarangelo, Kazuhiro Iwai, John Silke, Pamela L Schwartzberg, Bertrand Boisson, Jean Laurent Casanova, Seiamak Bahram, Anand Prahalad Rao, Nieves Peltzer, Henning Walczak, Najoua Lalaoui, Ivona Aksentijevich, Daniel L Kastner
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency. Nature immunology (2024)
Hirotsugu Oda, Kalpana Manthiram, Pallavi Pimpale Chavan, Eva Rieser, Önay Veli, Öykü Kaya, Charles Rauch, Shuichiro Nakabo, Hye Sun Kuehn, Mariël Swart, Yanli Wang, Nisa Ilgim Çelik, Anne Molitor, Vahid Ziaee, Nasim Movahedi, Mohammad Shahrooei, Nima Parvaneh, Nasrin Alipour-Olyei, Raphaël Carapito, Qin Xu, Silvia Preite, David B Beck, Jae Jin Chae, Michele Nehrebecky, Amanda K Ombrello, Patrycja Hoffmann, Tina Romeo, Natalie T Deuitch, Brynja Matthíasardóttir, May Christine V Malicdan, Hirsh Komarow, Jennifer Stoddard, Julie Niemela, A Kerry Dobbs, Colin L Sweeney, Holly Anderton, Kate E Lawlor, Hiroyuki Yoshitomi, Dan Yang, Manfred Boehm, Jeremy Davis, Pamela Mudd, Davide Randazzo, Wanxia Li Tsai, Massimo Gadina, Mariana J Kaplan, Junya Toguchida, Christian Thomas Mayer, Sergio D Rosenzweig, Luigi Daniele Notarangelo, Kazuhiro Iwai, John Silke, Pamela L Schwartzberg, Bertrand Boisson, Jean Laurent Casanova, Seiamak Bahram, Anand Prahalad Rao, Nieves Peltzer, Henning Walczak, Najoua Lalaoui, Ivona Aksentijevich, Daniel L Kastner
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency. Nature immunology 25 (5) (2024)
Pascal Meier, Arnaud J Legrand, Dieter Adam, John Silke
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity. Nature reviews. Cancer (2024)
Pascal Meier, Arnaud J Legrand, Dieter Adam, John Silke
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity. Nature reviews. Cancer 24 (5) (2024)
Hirotsugu Oda, Kalpana Manthiram, Pallavi Pimpale Chavan, Eva Rieser, Önay Veli, Öykü Kaya, Charles Rauch, Shuichiro Nakabo, Hye Sun Kuehn, Mariël Swart, Yanli Wang, Nisa Ilgim Çelik, Anne Molitor, Vahid Ziaee, Nasim Movahedi, Mohammad Shahrooei, Nima Parvaneh, Nasrin Alipour-Olyei, Raphaël Carapito, Qin Xu, Silvia Preite, David B Beck, Jae Jin Chae, Michele Nehrebecky, Amanda K Ombrello, Patrycja Hoffmann, Tina Romeo, Natalie T Deuitch, Brynja Matthíasardóttir, May Christine V Malicdan, Hirsh Komarow, Jennifer Stoddard, Julie Niemela, A Kerry Dobbs, Colin L Sweeney, Holly Anderton, Kate E Lawlor, Hiroyuki Yoshitomi, Dan Yang, Manfred Boehm, Jeremy Davis, Pamela Mudd, Davide Randazzo, Wanxia Li Tsai, Massimo Gadina, Mariana J Kaplan, Junya Toguchida, Christian Thomas Mayer, Sergio D Rosenzweig, Luigi Daniele Notarangelo, Kazuhiro Iwai, John Silke, Pamela L Schwartzberg, Bertrand Boisson, Jean Laurent Casanova, Seiamak Bahram, Anand Prahalad Rao, Nieves Peltzer, Henning Walczak, Najoua Lalaoui, Ivona Aksentijevich, Daniel L Kastner
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency. Nature immunology 25 (5) (2024)
Emily J Lelliott, Jonathan Naddaf, Katherine Ganio, Jessica Michie, Shelly Wang, Lin Liu, Natasha Silke, Antonio Ahn, Kelly M Ramsbottom, Amelia J Brennan, Andrew J Freeman, Shom Goel, Stephin J Vervoort, Conor J Kearney, Paul A Beavis, Christopher A McDevitt, John Silke, Jane Oliaro
Intracellular zinc protects tumours from T cell-mediated cytotoxicity. Cell death and differentiation (2024)
Shene Chiou, Aysha H Al-Ani, Yi Pan, Komal M Patel, Isabella Y Kong, Lachlan W Whitehead, Amanda Light, Samuel N Young, Marilou Barrios, Callum Sargeant, Pradeep Rajasekhar, Leah Zhu, Anne Hempel, Ann Lin, James A Rickard, Cathrine Hall, Pradnya Gangatirkar, Raymond K H Yip, Wayne Cawthorne, Annette V Jacobsen, Christopher R Horne, Katherine R Martin, Lisa J Ioannidis, Diana S Hansen, Jessica Day, Ian P Wicks, Charity Law, Matthew E Ritchie, Rory Bowden, Joanne M Hildebrand, Lorraine Ann O'Reilly, John Silke, Lisa Giulino-Roth, Ellen Tsui, Kelly L Rogers, Edwin D Hawkins, Britt Christensen, James G Murphy, André L Samson
An immunohistochemical atlas of necroptotic pathway expression. EMBO molecular medicine 16 (7) (2024)
Panxue Wang, John Silke
RIPK1 and necroptosis role in premature ageing. Nature cell biology 26 (4) (2024)
Hirotsugu Oda, Kalpana Manthiram, Pallavi Pimpale Chavan, Eva Rieser, Önay Veli, Öykü Kaya, Charles Rauch, Shuichiro Nakabo, Hye Sun Kuehn, Mariël Swart, Yanli Wang, Nisa Ilgim Çelik, Anne Molitor, Vahid Ziaee, Nasim Movahedi, Mohammad Shahrooei, Nima Parvaneh, Nasrin Alipour-Olyei, Raphaël Carapito, Qin Xu, Silvia Preite, David B Beck, Jae Jin Chae, Michele Nehrebecky, Amanda K Ombrello, Patrycja Hoffmann, Tina Romeo, Natalie T Deuitch, Brynja Matthíasardóttir, May Christine V Malicdan, Hirsh Komarow, Jennifer Stoddard, Julie Niemela, A Kerry Dobbs, Colin L Sweeney, Holly Anderton, Kate E Lawlor, Hiroyuki Yoshitomi, Dan Yang, Manfred Boehm, Jeremy Davis, Pamela Mudd, Davide Randazzo, Wanxia Li Tsai, Massimo Gadina, Mariana J Kaplan, Junya Toguchida, Christian Thomas Mayer, Sergio D Rosenzweig, Luigi Daniele Notarangelo, Kazuhiro Iwai, John Silke, Pamela L Schwartzberg, Bertrand Boisson, Jean Laurent Casanova, Seiamak Bahram, Anand Prahalad Rao, Nieves Peltzer, Henning Walczak, Najoua Lalaoui, Ivona Aksentijevich, Daniel L Kastner
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency. Nature immunology (2024)
Shene Chiou, Aysha H Al-Ani, Yi Pan, Komal M Patel, Isabella Y Kong, Lachlan W Whitehead, Amanda Light, Samuel N Young, Marilou Barrios, Callum Sargeant, Pradeep Rajasekhar, Leah Zhu, Anne Hempel, Ann Lin, James A Rickard, Cathrine Hall, Pradnya Gangatirkar, Raymond K H Yip, Wayne Cawthorne, Annette V Jacobsen, Christopher R Horne, Katherine R Martin, Lisa J Ioannidis, Diana S Hansen, Jessica Day, Ian P Wicks, Charity Law, Matthew E Ritchie, Rory Bowden, Joanne M Hildebrand, Lorraine Ann O'Reilly, John Silke, Lisa Giulino-Roth, Ellen Tsui, Kelly L Rogers, Edwin D Hawkins, Britt Christensen, James G Murphy, André L Samson
An immunohistochemical atlas of necroptotic pathway expression. EMBO molecular medicine (2024)
Hong Tri Tran, Tobias Kratina, Auriane Coutansais, Dominika Michalek, Benjamin M Hogan, Kate E Lawlor, James E Vince, John Silke, Najoua Lalaoui
RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation. Cell death and differentiation 31 (5) (2024)
Pascal Meier, Arnaud J Legrand, Dieter Adam, John Silke
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity. Nature reviews. Cancer 24 (5) (2024)
Pascal Meier, Arnaud J Legrand, Dieter Adam, John Silke
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity. Nature reviews. Cancer (2024)
Nishma Gupta, John Silke
Blocking cell death limits lung damage and inflammation from influenza. Nature 628 (8009) (2024)
Shene Chiou, Aysha H Al-Ani, Yi Pan, Komal M Patel, Isabella Y Kong, Lachlan W Whitehead, Amanda Light, Samuel N Young, Marilou Barrios, Callum Sargeant, Pradeep Rajasekhar, Leah Zhu, Anne Hempel, Ann Lin, James A Rickard, Cathrine Hall, Pradnya Gangatirkar, Raymond K H Yip, Wayne Cawthorne, Annette V Jacobsen, Christopher R Horne, Katherine R Martin, Lisa J Ioannidis, Diana S Hansen, Jessica Day, Ian P Wicks, Charity Law, Matthew E Ritchie, Rory Bowden, Joanne M Hildebrand, Lorraine Ann O'Reilly, John Silke, Lisa Giulino-Roth, Ellen Tsui, Kelly L Rogers, Edwin D Hawkins, Britt Christensen, James G Murphy, André L Samson
An immunohistochemical atlas of necroptotic pathway expression. EMBO molecular medicine (2024)
Xiangyi S Wang, Thomas R Cotton, Sarah J Trevelyan, Lachlan W Richardson, Wei Ting Lee, John Silke, Bernhard C Lechtenberg
The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family. Nature communications 14 (1) (2023)
Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James G Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco J Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lan-Lan Geng, James E Vince
Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency. The EMBO journal 42 (5) (2023)
Xiangyi S Wang, Thomas R Cotton, Sarah J Trevelyan, Lachlan W Richardson, Wei Ting Lee, John Silke, Bernhard C Lechtenberg
The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family. Nature communications 14 (1) (2023)
Daniel S Simpson, Holly Anderton, Jumana Yousef, Vineet Vaibhav, Simon A Cobbold, Esther Bandala-Sanchez, Andrew J Kueh, Laura F Dagley, Marco J Herold, John Silke, James E Vince, Rebecca Feltham
Mind bomb 2 limits inflammatory dermatitis in Sharpin mutant mice independently of cell death. PNAS nexus 3 (1) (2023)
Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James G Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco J Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lan-Lan Geng, James E Vince
Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency. The EMBO journal (2023)
Destiny Dalseno, Holly Anderton, Andrew Kueh, Marco J Herold, John Silke, Andreas Strasser, Philippe Bouillet
Deletion of Gpatch2 does not alter Tnf expression in mice. Cell death & disease 14 (3) (2023)
Xiangyi S Wang, Thomas R Cotton, Sarah J Trevelyan, Lachlan W Richardson, Wei Ting Lee, John Silke, Bernhard C Lechtenberg
The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family. Nature communications 14 (1) (2023)
Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James G Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco J Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lan-Lan Geng, James E Vince
Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency. The EMBO journal 42 (5) (2023)
Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James G Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco J Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lan-Lan Geng, James E Vince
Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency. The EMBO journal (2023)
Destiny Dalseno, Holly Anderton, Andrew Kueh, Marco J Herold, John Silke, Andreas Strasser, Philippe Bouillet
Deletion of Gpatch2 does not alter Tnf expression in mice. Cell death & disease 14 (3) (2023)
Sarah E Garnish, Katherine R Martin, Maria Kauppi, Victoria E Jackson, Rebecca Ambrose, Vik Ven Eng, Shene Chiou, Yanxiang Meng, Daniel Frank, Emma C Tovey Crutchfield, Komal M Patel, Annette V Jacobsen, Georgia K Atkin-Smith, Ladina Di Rago, Marcel Doerflinger, Christopher R Horne, Cathrine Hall, Samuel N Young, Matthew C Cook, Vicki Athanasopoulos, Carola G Vinuesa, Kate E Lawlor, Ian P Wicks, Gregor Ebert, Ashley P Ng, Charlotte A Slade, Jaclyn S Pearson, André L Samson, John Silke, James G Murphy, Joanne M Hildebrand
A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation. Nature communications 14 (1) (2023)
Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James G Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco J Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lan-Lan Geng, James E Vince
Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency. The EMBO journal 42 (5) (2023)
Destiny Dalseno, Holly Anderton, Andrew Kueh, Marco J Herold, John Silke, Andreas Strasser, Philippe Bouillet
Deletion of Gpatch2 does not alter Tnf expression in mice. Cell death & disease 14 (3) (2023)
Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James G Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco J Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lan-Lan Geng, James E Vince
Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency. The EMBO journal 42 (5) (2023)
Fabian Schorn, J Paul Werthenbach, Mattes Hoffmann, Mila Daoud, Johanna Stachelscheid, Lars M Schiffmann, Ximena Hildebrandt, Su Ir Lyu, Nieves Peltzer, Alexander Quaas, Domagoj Vucic, John Silke, Manolis Pasparakis, Hamid Kashkar
cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation. The EMBO journal (2023)
Emma C Tovey Crutchfield, Sarah E Garnish, Jessica Day, Holly Anderton, Shene Chiou, Anne Hempel, Cathrine Hall, Komal M Patel, Pradnya Gangatirkar, Katherine R Martin, Connie Li Wai Suen, Alexandra L Garnham, Andrew J Kueh, Ian P Wicks, John Silke, Ueli Nachbur, André L Samson, James G Murphy, Joanne M Hildebrand
MLKL deficiency protects against low-grade, sterile inflammation in aged mice. Cell death and differentiation (2023)
Ali I Mohammed, Antonio Celentano, Rita Paolini, Jun T Low, John Silke, Lorraine Ann O'Reilly, Michael McCullough, Nicola Cirillo
High molecular weight hyaluronic acid drastically reduces chemotherapy-induced mucositis and apoptotic cell death. Cell death & disease 14 (7) (2023)
Xiangyi S Wang, Thomas R Cotton, Sarah J Trevelyan, Lachlan W Richardson, Wei Ting Lee, John Silke, Bernhard C Lechtenberg
The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family. Nature communications 14 (1) (2023)
Emma C Tovey Crutchfield, Sarah E Garnish, Jessica Day, Holly Anderton, Shene Chiou, Anne Hempel, Cathrine Hall, Komal M Patel, Pradnya Gangatirkar, Katherine R Martin, Connie Li Wai Suen, Alexandra L Garnham, Andrew J Kueh, Ian P Wicks, John Silke, Ueli Nachbur, André L Samson, James G Murphy, Joanne M Hildebrand
MLKL deficiency protects against low-grade, sterile inflammation in aged mice. Cell death and differentiation (2023)
Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James G Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco J Herold, Ivan K H Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lan-Lan Geng, James E Vince
Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency. The EMBO journal 42 (5) (2023)
Xiangyi S Wang, Thomas R Cotton, Sarah J Trevelyan, Lachlan W Richardson, Wei Ting Lee, John Silke, Bernhard C Lechtenberg
The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family. Nature communications 14 (1) (2023)
Daniel S Simpson, Holly Anderton, Jumana Yousef, Vineet Vaibhav, Simon A Cobbold, Esther Bandala-Sanchez, Andrew J Kueh, Laura F Dagley, Marco J Herold, John Silke, James E Vince, Rebecca Feltham
Mind bomb 2 limits inflammatory dermatitis in Sharpin mutant mice independently of cell death. PNAS nexus 3 (1) (2023)
Emma C Tovey Crutchfield, Sarah E Garnish, Jessica Day, Holly Anderton, Shene Chiou, Anne Hempel, Cathrine Hall, Komal M Patel, Pradnya Gangatirkar, Katherine R Martin, Connie Li Wai Suen, Alexandra L Garnham, Andrew J Kueh, Ian P Wicks, John Silke, Ueli Nachbur, André L Samson, James G Murphy, Joanne M Hildebrand
MLKL deficiency protects against low-grade, sterile inflammation in aged mice. Cell death and differentiation (2023)
Liang Ding, Yong Fu, Nisha Zhu, Mengxiang Zhao, Zhuang Ding, Xiaoxin Zhang, Yuxian Song, Yue Jing, Qian Zhang, Sheng Chen, Xiaofeng Huang, Lorraine Ann O'Reilly, John Silke, Qingang Hu, Yan-Hong Ni
OXTR High stroma fibroblasts control the invasion pattern of oral squamous cell carcinoma via ERK5 signaling. Nature communications 13 (1) (2022)
Annette V Jacobsen, Catia L Pierotti, Kym N Lowes, Amanda E Au, Ying Zhang, Nima Etemadi, Cheree Fitzgibbon, Wilhelmus J A Kersten, André L Samson, Mark F van Delft, David Ching Siang Huang, Hélène Jousset Sabroux, Guillaume L Lessene, John Silke, James G Murphy
The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL. Cell death & disease 13 (4) (2022)
Lin Liu, Jarrod John Sandow, Deena M Leslie Pedrioli, André L Samson, Natasha Silke, Tobias Kratina, Rebecca L Ambrose, Marcel Doerflinger, Zhaoqing Hu, Emma Morrish, Diep Chau, Andrew J Kueh, Cheree Fitzibbon, Marc Pellegrini, Jaclyn S Pearson, Michael O Hottiger, Andrew Ian Webb, Najoua Lalaoui, John Silke
Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death. Science advances 8 (19) (2022)
Christoph Grohmann, Charlene M Magtoto, Joel R Walker, Ngee Kiat Chua, Anna Gabrielyan, Mary Hall, Simon A Cobbold, Stephen Mieruszynski, Martin Brzozowski, Daniel S Simpson, Hao Dong, Bridget Dorizzi, Annette V Jacobsen, Emma Morrish, Natasha Silke, James G Murphy, Joan Kathleen Heath, Andrea Testa, Chiara Maniaci, Alessio Ciulli, Guillaume L Lessene, John Silke, Rebecca Feltham
Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms. Nature communications 13 (1) (2022)
Diane Moujalled, Pradnya Gangatirkar, Maria Kauppi, Jason Corbin, Marion Lebois, James G Murphy, Najoua Lalaoui, Joanne M Hildebrand, John Silke, Warren S Alexander, Emma C Josefsson
The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis. Cell death & disease 12 (1) (2021)
Jun T Low, Gwo-Yaw Ho, Mark Scott, Chin Wee Tan, Lachlan W Whitehead, Kathy Barber, Hon Yan Kelvin Yip, Johanna F Dekkers, Yumiko Hirokawa, John Silke, Antony W Burgess, Andreas Strasser, Tracy L Putoczki, Lorraine Ann O'Reilly
Transplantable programmed death ligand 1 expressing gastroids from gastric cancer prone Nfkb1-/- mice. Cell death & disease 12 (12) (2021)
Zikou Liu, Laura F Dagley, Kristy Shield-Artin, Samuel N Young, Aleksandra Bankovacki, Xiangyi Wang, Michelle Tang, Jason Howitt, Che A Stafford, Ueli Nachbur, Cheree Fitzgibbon, Sarah E Garnish, Andrew Ian Webb, David Komander, James G Murphy, Joanne M Hildebrand, John Silke
Oligomerization-driven MLKL ubiquitylation antagonizes necroptosis. The EMBO journal 40 (23) (2021)
John Silke, Lorraine Ann O'Reilly
NF-κB and Pancreatic Cancer; Chapter and Verse. Cancers 13 (18) (2021)
Reema Jain, Kelin Zhao, Julie M Sheridan, Melanie Heinlein, Fiona Kupresanin, Waruni Abeysekera, Cathrine Hall, James Rickard, Philippe Bouillet, Henning Walczak, Andreas Strasser, John Silke, Daniel H D Gray
Dual roles for LUBAC signaling in thymic epithelial cell development and survival. Cell death and differentiation 28 (10) (2021)
Andrew J Freeman, Stephin J Vervoort, Jessica Michie, Kelly M Ramsbottom, John Silke, Conor J Kearney, Jane Oliaro
HOIP limits anti-tumor immunity by protecting against combined TNF and IFN-gamma-induced apoptosis. EMBO reports 22 (11) (2021)
Joanne M Hildebrand, Maria Kauppi, Ian J Majewski, Zikou Liu, Allison J Cox, Sanae Miyake, Emma J Petrie, Michael A Silk, Zhixiu Li, Maria C Tanzer, Gabriela Brumatti, Samuel N Young, Cathrine Hall, Sarah E Garnish, Jason Corbin, Michael D Stutz, Ladina Di Rago, Pradnya Gangatirkar, Emma C Josefsson, Kristin Rigbye, Holly Anderton, James A Rickard, Anne Tripaydonis, Julie M Sheridan, Thomas S Scerri, Victoria E Jackson, Peter E Czabotar, Jian-Guo Zhang, Leila Varghese, Cody C Allison, Marc Pellegrini, Gillian M Tannahill, Esme C Hatchell, Tracy A Willson, Dina Stockwell, Carolyn A de Graaf, Janelle Collinge, Adrienne Hilton, Natasha Silke, Sukhdeep K Spall, Diep Chau, Vicki Athanasopoulos, Donald Metcalf, Ronald M Laxer, Alexander G Bassuk, Benjamin W Darbro, Maria A Fiatarone Singh, Nicole Vlahovich, David Hughes, Maria Kozlovskaia, David Benjamin Ascher, Klaus Warnatz, Nils Venhoff, Jens Thiel, Christine Biben, Stefan Blum, John Reveille, Michael S Hildebrand, Carola G Vinuesa, Pamela A McCombe, Matthew A Brown, Benjamin T Kile, Catriona A Mclean, Melanie Bahlo, Seth L Masters, Hiroyasu Nakano, Polly J Ferguson, James G Murphy, Warren S Alexander, John Silke
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction. Nature communications 11 (1) (2020)
Emma Morrish, Liana Mackiewicz, Natasha Silke, Marc Pellegrini, John Silke, Gabriela Brumatti, Gregor Ebert
Combinatorial Treatment of Birinapant and Zosuquidar Enhances Effective Control of HBV Replication In Vivo. Viruses 12 (8) (2020)
Najoua Lalaoui, Delphine Merino, Goknur Giner, François Vaillant, Diep Chau, Lin Liu, Tobias Kratina, Bhupinder Pal, James R Whittle, Nima Etemadi, Jean Berthelet, Julius Gräsel, Cathrine Hall, Matthew E Ritchie, Matthias Ernst, Aaron T L Lun, David L Vaux, Jane E Visvader, Geoffrey J Lindeman, John Silke
Targeting triple-negative breast cancers with the Smac-mimetic birinapant. Cell death and differentiation 27 (10) (2020)
Holly Anderton, Ian P Wicks, John Silke
Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease. Nature reviews. Rheumatology 16 (9) (2020)
Yan-Hong Ni, Tami Yap, Natasha Silke, John Silke, Michael J McCullough, Antonio Celentano, Lorraine Ann O'Reilly
Loss of NF-kB1 and c-Rel accelerates oral carcinogenesis in mice. Oral diseases 27 (2) (2020)
Jiahuai Han, Jianfeng Wu, John Silke
An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling. F1000Research 9 (2020)
Valentin J Heim, Laura F Dagley, Che A Stafford, Fynn M Hansen, Elise Clayer, Aleksandra Bankovacki, Andrew I Webb, Isabelle S Lucet, John Silke, Ueli Nachbur
A regulatory region on RIPK2 is required for XIAP binding and NOD signaling activity. EMBO reports 21 (11) (2020)
André L Samson, Ying Zhang, Niall D Geoghegan, Xavier J Gavin, Katherine A Davies, Michael J Mlodzianoski, Lachlan W Whitehead, Daniel Frank, Sarah E Garnish, Cheree Fitzgibbon, Anne Hempel, Samuel N Young, Annette V Jacobsen, Wayne Cawthorne, Emma J Petrie, Maree C Faux, Kristy Shield-Artin, Najoua Lalaoui, Joanne M Hildebrand, John Silke, Kelly L Rogers, Guillaume L Lessene, Edwin D Hawkins, James G Murphy
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis. Nature communications 11 (1) (2020)
Shin Murai, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, Mai Yamagishi, Ryodai Shindo, Joanne M Hildebrand, Ryosuke Miura, Osamu Nakabayashi, Mamoru Totsuka, Taichiro Tomida, Satomi Adachi-Akahane, Sotaro Uemura, John Silke, Hideo Yagita, Masayuki Miura, Hiroyasu Nakano
Addendum: A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs. Nature communications 10 (1) (2019)
Jessica Michie, Paul A Beavis, Andrew J Freeman, Stephin J Vervoort, Kelly M Ramsbottom, Vignesh Narasimhan, Emily J Lelliott, Najoua Lalaoui, Robert George Ramsay, Ricky W Johnstone, John Silke, Phillip K Darcy, Ilia Voskoboinik, Conor J Kearney, Jane Oliaro
Antagonism of IAPs Enhances CAR T-cell Efficacy. Cancer immunology research 7 (2) (2019)
Conor J Kearney, Stephin J Vervoort, Simon J Hogg, Kelly M Ramsbottom, Andrew J Freeman, Najoua Lalaoui, Lizzy Pijpers, Jessica Michie, Kristin K Brown, Deborah A Knight, Vivien R Sutton, Paul A Beavis, Ilia Voskoboinik, Phillip K Darcy, John Silke, Joseph A Trapani, Ricky W Johnstone, Jane Oliaro
Tumor immune evasion arises through loss of TNF sensitivity. Science immunology 3 (23) (2019)
Emma J Petrie, Jarrod J Sandow, Annette V Jacobsen, Brian J Smith, Michael D W Griffin, Isabelle S Lucet, Weiwen Dai, Samuel N Young, Maria C Tanzer, Ahmad Wardak, Lung-Yu Liang, Angus D Cowan, Joanne M Hildebrand, Wilhelmus J A Kersten, Guillaume L Lessene, John Silke, Peter E Czabotar, Andrew I Webb, James M Murphy
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis. Nature communications 9 (1) (2018)
Dilys T H Leung, Trang Nguyen, Edwina May Oliver, Juliana Matti, Maria Alexiadis, John Silke, Thomas W Jobling, Peter J Fuller, Simon Chu
Combined PPARγ Activation and XIAP Inhibition as a Potential Therapeutic Strategy for Ovarian Granulosa Cell Tumors. Molecular cancer therapeutics 18 (2) (2018)
Holly Anderton, Esther Bandala-Sanchez, Daniel S Simpson, James A Rickard, Ashley P Ng, Ladina Di Rago, Cathrine Hall, James E Vince, John Silke, Gianmaria Liccardi, Rebecca Feltham
RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development. Cell death and differentiation 26 (5) (2018)
Shin Murai, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, Mai Yamagishi, Ryodai Shindo, Joanne M Hildebrand, Ryosuke Miura, Osamu Nakabayashi, Mamoru Totsuka, Taichiro Tomida, Satomi Adachi-Akahane, Sotaro Uemura, John Silke, Hideo Yagita, Masayuki Miura, Hiroyasu Nakano
A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs. Nature communications 9 (1) (2018)
Lucia Taraborrelli, Nieves Peltzer, Antonella Montinaro, Sebastian Kupka, Eva Rieser, Torsten Hartwig, Aida Sarr, Maurice Darding, Peter Draber, Tobias L Haas, Ayse Akarca, Teresa Marafioti, Manolis Pasparakis, John Bertin, Peter J Gough, Philippe Bouillet, Andreas Strasser, Martin Leverkus, John Silke, Henning Walczak
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L. Nature communications 9 (1) (2018)
Katherine A Davies, Maria C Tanzer, Michael D W Griffin, Yee Foong Mok, Samuel N Young, Rui Qin, Emma J Petrie, Peter E Czabotar, John Silke, James M Murphy
The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis. Cell death and differentiation 25 (9) (2018)
Michael D Stutz, Samar Ojaimi, Cody Allison, Simon Preston, Philip Arandjelovic, Joanne M Hildebrand, Jarrod J Sandow, Andrew I Webb, John Silke, Warren S Alexander, Marc Pellegrini
Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted. Cell death and differentiation 25 (5) (2017)
Charis E Teh, Najoua Lalaoui, Reema Jain, Antonia N Policheni, Melanie Heinlein, Silvia Alvarez-Diaz, Julie M Sheridan, Eva Rieser, Stefanie Deuser, Maurice Darding, Hui-Fern Koay, Yifang Hu, Fiona Kupresanin, Lorraine A O'Reilly, Dale I Godfrey, Aaron T L Lun, Philippe Bouillet, Andreas Strasser, Henning Walczak, John Silke, Daniel H D Gray
Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis. Nature communications 7 (2016)
Rebecca Feltham, Andrew I Webb, John Silke
SPATA2 - Keeping the TNF signal short and sweet. The EMBO journal 35 (17) (2016)
A V Jacobsen, K N Lowes, M C Tanzer, I S Lucet, J M Hildebrand, E J Petrie, M F van Delft, Z Liu, S A Conos, J-G Zhang, D C S Huang, John Silke, G Lessene, J M Murphy
HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death. Cell death & disease 7 (2016)
John Silke
Questions & Controversies. Cell death discovery 1 (2015)
Ueli Nachbur, Che A Stafford, Aleksandra Bankovacki, Yifan Zhan, Lisa M Lindqvist, Berthe K Fiil, Yelena Khakham, Hyun-Ja Ko, Jarrod J Sandow, Hendrik Falk, Jessica K Holien, Diep Chau, Joanne Hildebrand, James E Vince, Phillip P Sharp, Andrew I Webb, Katherine A Jackman, Sabrina Mühlen, Catherine L Kennedy, Kym N Lowes, James M Murphy, Mads Gyrd-Hansen, Michael W Parker, Elizabeth L Hartland, Andrew M Lew, David C S Huang, Guillaume Lessene, John Silke
A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production. Nature communications 6 (2015)
John Silke, James A Rickard, Mordechay Gerlic
The diverse role of RIP kinases in necroptosis and inflammation. Nature immunology 16 (7) (2015)
Nima Etemadi, John Silke, Ueli Nachbur
Response to the letter to the editor. Immunology and cell biology 92 (4) (2014)
C Maas, J M Tromp, J van Laar, R Thijssen, J A Elias, A Malara, A Krippner-Heidenreich, John Silke, M Hj van Oers, E Eldering
CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex. Cell death & disease 4 (2013)

John Silke.css-eqlu8i{font-size:small;padding-left:4px;} (J Silke)

Publication Activity (10 Years)

Top Topics

Top Venues

John Silke (J Silke)