Laurence H Pearl

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 19

Top Topics

Endoplasmic Reticulum

Top Venues

Nature communications

Nature chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

Matthew Day, Bilal Tetik, Milena Parlak, Yasser Almeida-Hernández, Markus Räschle, Farnusch Kaschani, Heike Siegert, Anika Marko, Elsa Sanchez-Garcia, Markus Kaiser, Isabel A Barker, Laurence H Pearl, Antony W Oliver, Dominik Boos
TopBP1 utilises a bipartite GINS binding mode to support genome replication. Nature communications 15 (1) (2024)
Sarah K Wooller, Laurence H Pearl, Frances M G Pearl
Identifying actionable synthetically lethal cancer gene pairs using mutual exclusivity. FEBS letters 598 (16) (2024)
Matthew Day, Bilal Tetik, Milena Parlak, Yasser Almeida-Hernández, Markus Räschle, Farnusch Kaschani, Heike Siegert, Anika Marko, Elsa Sanchez-Garcia, Markus Kaiser, Isabel A Barker, Laurence H Pearl, Antony W Oliver, Dominik Boos
TopBP1 utilises a bipartite GINS binding mode to support genome replication. Nature communications 15 (1) (2024)
Matthew Day, Bilal Tetik, Milena Parlak, Yasser Almeida-Hernández, Markus Räschle, Farnusch Kaschani, Heike Siegert, Anika Marko, Elsa Sanchez-Garcia, Markus Kaiser, Isabel A Barker, Laurence H Pearl, Antony W Oliver, Dominik Boos
TopBP1 utilises a bipartite GINS binding mode to support genome replication. Nature communications 15 (1) (2024)
Sarah K Wooller, Laurence H Pearl, Frances M G Pearl
Identifying actionable synthetically lethal cancer gene pairs using mutual exclusivity. FEBS letters (2024)
Angel Rivera-Calzada, Raquel Arribas-Bosacoma, Alba Ruiz-Ramos, Paloma Escudero-Bravo, Jasminka Boskovic, Rafael Fernandez-Leiro, Antony W Oliver, Laurence H Pearl, Oscar Llorca
Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus. Nature communications 13 (1) (2022)
Jasmeen Oberoi, Xavi Aran Guiu, Emily A Outwin, Pascale Schellenberger, Theodoros I Roumeliotis, Jyoti Sharma Choudhary, Laurence H Pearl
HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation. Nature communications 13 (1) (2022)
Matthew Day, Antony W Oliver, Laurence H Pearl
Structure of the human RAD17-RFC clamp loader and 9-1-1 checkpoint clamp bound to a dsDNA-ssDNA junction. Nucleic acids research 50 (14) (2022)
Xiangrong Chen, Yusuf I Ali, Charlotte El Fisher, Raquel Arribas-Bosacoma, Mohan B Rajasekaran, Gareth Williams, Sarah Walker, Jessica R Booth, Jessica J R Hudson, S Mark Roe, Laurence H Pearl, Simon E Ward, Frances M G Pearl, Antony W Oliver
Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein. eLife 10 (2021)
John F Darby, Lewis R Vidler, Peter J Simpson, Bissan Al-Lazikani, Stephen J Matthews, Swee Y Sharp, Laurence H Pearl, Swen Hoelder, Paul Workman
Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches. Scientific reports 10 (1) (2020)
Nicolas Bigot, Matthew Day, Robert A Baldock, Felicity Z Watts, Antony W Oliver, Laurence H Pearl
Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint. eLife 8 (2019)
Fabrizio Martino, Mohinder Pal, Hugo Muñoz-Hernández, Carlos F Rodríguez, Rafael Núñez-Ramírez, David Gil-Carton, Gianluca Degliesposti, J Mark Skehel, S Mark Roe, Chrisostomos Prodromou, Laurence H Pearl, Oscar Llorca
RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex. Nature communications 9 (1) (2018)
Matthew Day, Mathieu Rappas, Katie Ptasinska, Dominik Boos, Antony W Oliver, Laurence H Pearl
BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands. eLife 7 (2018)
Fabrizio Martino, Mohinder Pal, Hugo Muñoz-Hernández, Carlos F Rodríguez, Rafael Núñez-Ramírez, David Gil-Carton, Gianluca Degliesposti, J Mark Skehel, S Mark Roe, Chrisostomos Prodromou, Laurence H Pearl, Oscar Llorca
Author Correction: RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex. Nature communications 9 (1) (2018)
Aaron Alt, Hung Q Dang, Owen S Wells, Luis M Polo, Matt A Smith, Grant A McGregor, Thomas Welte, Alan R Lehmann, Laurence H Pearl, Johanne M Murray, Antony W Oliver
Specialized interfaces of Smc5/6 control hinge stability and DNA association. Nature communications 8 (2017)
Andrea Schulze, Gerti Beliu, Dominic A Helmerich, Jonathan Schubert, Laurence H Pearl, Chrisostomos Prodromou, Hannes Neuweiler
Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism. Nature chemical biology 12 (8) (2016)
Gabrielle J Grundy, Stuart L Rulten, Raquel Arribas-Bosacoma, Kathryn Davidson, Zuzanna Kozik, Antony W Oliver, Laurence H Pearl, Keith W Caldecott
The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins. Nature communications 7 (2016)
Ruth M Densham, Alexander J Garvin, Helen R Stone, Joanna Strachan, Robert A Baldock, Manuel Daza-Martin, Alice Fletcher, Sarah Blair-Reid, James Beesley, Balraj Johal, Laurence H Pearl, Robert Neely, Nicholas H Keep, Felicity Z Watts, Joanna R Morris
Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection. Nature structural & molecular biology 23 (7) (2016)
Gabrielle J Grundy, Luis M Polo, Zhihong Zeng, Stuart L Rulten, Nicolas C Hoch, Pathompong Paomephan, Yingqi Xu, Steve M Sweet, Alan W Thorne, Antony W Oliver, Steve J Matthews, Laurence H Pearl, Keith W Caldecott
PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2). Nature communications 7 (2016)