Matthew K Higgins (Matt K Higgins)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 50

Top Venues

Nature communications

Nature

Infection and immunity

eLife

University of Oxford

University of Cambridge (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Oxford Oct 01 2015

United Kingdom

Professor of Molecular Parasitology :: Department of Biochemistry

University of Oxford Oct 01 2010 - Oct 01 2015

United Kingdom

University Lecturer :: Department of Biochemistry

University of Cambridge Jan 01 2006 - Oct 01 2010

United Kingdom

Royal Society Research Fellow :: Department of Biochemistry

MRC Laboratory of Molecular Biology Division of Structural Studies Oct 01 2002 - Dec 31 2005

United Kingdom

Postdoctoral Researcher :: Structural Studies

University of Cambridge Oct 01 2001 - Oct 01 2002

United Kingdom

Research Fellow :: Department of Pathology

Education History

University of Cambridge Oct 01 1997 - Oct 01 2001

United Kingdom

PHD :: Laboratory of Molecular Biology

Publications

Florent Colomb, Adefunke Ogunkanbi, Abhishek Jamwal, Beverly Dong, Rick M Maizels, Constance A M Finney, James D Wasmuth, Matthew K Higgins, Henry J McSorley
IL-33-binding HpARI family homologues with divergent effects in suppressing or enhancing type 2 immune responses. Infection and immunity 92 (3) (2024)
Abhishek Jamwal, Florent Colomb, Henry J McSorley, Matthew K Higgins
Structural basis for IL-33 recognition and its antagonism by the helminth effector protein HpARI2. Nature communications 15 (1) (2024)
Abhishek Jamwal, Florent Colomb, Henry J McSorley, Matthew K Higgins
Structural basis for IL-33 recognition and its antagonism by the helminth effector protein HpARI2. Nature communications 15 (1) (2024)
Barnabas G Williams, Lloyd D W King, David Pulido, Doris Quinkert, Amelia M Lias, Sarah E Silk, Robert J Ragotte, Hannah Davies, Jordan R Barrett, Kirsty McHugh, Cassandra A Rigby, Daniel G W Alanine, Lea K Barfod, Michael W Shea, Li An Cowley, Rebecca A Dabbs, David J Pattinson, Alexander D Douglas, Oliver R Lyth, Joseph J Illingworth, Jing Jin, Cecilia Carnrot, Vinayaka Kotraiah, Jayne M Christen, Amy R Noe, Randall S MacGill, C Richter King, Ashley J Birkett, Lorraine A Soisson, Katherine Skinner, Kazutoyo Miura, Carole A Long, Matthew K Higgins, Simon J Draper
Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex. Nature communications 15 (1) (2024)
Abhishek Jamwal, Florent Colomb, Henry J McSorley, Matthew K Higgins
Structural basis for IL-33 recognition and its antagonism by the helminth effector protein HpARI2. Nature communications 15 (1) (2024)
Barnabas G Williams, Lloyd D W King, David Pulido, Doris Quinkert, Amelia M Lias, Sarah E Silk, Robert J Ragotte, Hannah Davies, Jordan R Barrett, Kirsty McHugh, Cassandra A Rigby, Daniel G W Alanine, Lea K Barfod, Michael W Shea, Li An Cowley, Rebecca A Dabbs, David J Pattinson, Alexander D Douglas, Oliver R Lyth, Joseph J Illingworth, Jing Jin, Cecilia Carnrot, Vinayaka Kotraiah, Jayne M Christen, Amy R Noe, Randall S MacGill, C Richter King, Ashley J Birkett, Lorraine A Soisson, Katherine Skinner, Kazutoyo Miura, Carole A Long, Matthew K Higgins, Simon J Draper
Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex. Nature communications 15 (1) (2024)
Thomas E Harrison, Nawsad Alam, Brendan Farrell, Doris Quinkert, Amelia M Lias, Lloyd D W King, Lea K Barfod, Simon J Draper, Ivan Campeotto, Matthew K Higgins
Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5. EMBO molecular medicine (2024)
Barnabas G Williams, Lloyd D W King, David Pulido, Doris Quinkert, Amelia M Lias, Sarah E Silk, Robert J Ragotte, Hannah Davies, Jordan R Barrett, Kirsty McHugh, Cassandra A Rigby, Daniel G W Alanine, Lea K Barfod, Michael W Shea, Li An Cowley, Rebecca A Dabbs, David J Pattinson, Alexander D Douglas, Oliver R Lyth, Joseph J Illingworth, Jing Jin, Cecilia Carnrot, Vinayaka Kotraiah, Jayne M Christen, Amy R Noe, Randall S MacGill, C Richter King, Ashley J Birkett, Lorraine A Soisson, Katherine Skinner, Kazutoyo Miura, Carole A Long, Matthew K Higgins, Simon J Draper
Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex. Nature communications 15 (1) (2024)
Alexander D Cook, Mark Carrington, Matthew K Higgins
Molecular mechanism of complement inhibition by the trypanosome receptor ISG65. eLife 12 (2024)
Florent Colomb, Adefunke Ogunkanbi, Abhishek Jamwal, Beverly Dong, Rick M Maizels, Constance A M Finney, James D Wasmuth, Matthew K Higgins, Henry J McSorley
IL-33-binding HpARI family homologues with divergent effects in suppressing or enhancing type 2 immune responses. Infection and immunity 92 (3) (2024)
Abhishek Jamwal, Florent Colomb, Henry J McSorley, Matthew K Higgins
Structural basis for IL-33 recognition and its antagonism by the helminth effector protein HpARI2. Nature communications 15 (1) (2024)
Alexander D Cook, Mark Carrington, Matthew K Higgins
Molecular mechanism of complement inhibition by the trypanosome receptor ISG65. eLife 12 (2024)
Barnabas G Williams, Lloyd D W King, David Pulido, Doris Quinkert, Amelia M Lias, Sarah E Silk, Robert J Ragotte, Hannah Davies, Jordan R Barrett, Kirsty McHugh, Cassandra A Rigby, Daniel G W Alanine, Lea K Barfod, Michael W Shea, Li An Cowley, Rebecca A Dabbs, David J Pattinson, Alexander D Douglas, Oliver R Lyth, Joseph J Illingworth, Jing Jin, Cecilia Carnrot, Vinayaka Kotraiah, Jayne M Christen, Amy R Noe, Randall S MacGill, C Richter King, Ashley J Birkett, Lorraine A Soisson, Katherine Skinner, Kazutoyo Miura, Carole A Long, Matthew K Higgins, Simon J Draper
Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex. Nature communications 15 (1) (2024)
Florent Colomb, Adefunke Ogunkanbi, Abhishek Jamwal, Beverly Dong, Rick M Maizels, Constance A M Finney, James D Wasmuth, Matthew K Higgins, Henry J McSorley
IL-33-binding HpARI family homologues with divergent effects in suppressing or enhancing type 2 immune responses. Infection and immunity 92 (3) (2024)
Alexander D Cook, Mark Carrington, Matthew K Higgins
Molecular mechanism of complement inhibition by the trypanosome receptor ISG65. eLife 12 (2024)
Abhishek Jamwal, Florent Colomb, Henry J McSorley, Matthew K Higgins
Structural basis for IL-33 recognition and its antagonism by the helminth effector protein HpARI2. Nature communications 15 (1) (2024)
Florent Colomb, Adefunke Ogunkanbi, Abhishek Jamwal, Beverly Dong, Rick M Maizels, Constance A M Finney, James D Wasmuth, Matthew K Higgins, Henry J McSorley
IL-33-binding HpARI family homologues with divergent effects in suppressing or enhancing type 2 immune responses. Infection and immunity 92 (3) (2024)
Florent Colomb, Adefunke Ogunkanbi, Abhishek Jamwal, Beverly Dong, Rick M Maizels, Constance A M Finney, James D Wasmuth, Matthew K Higgins, Henry J McSorley
IL-33-binding HpARI family homologues with divergent effects in suppressing or enhancing type 2 immune responses. Infection and immunity 92 (3) (2024)
Florent Colomb, Adefunke Ogunkanbi, Abhishek Jamwal, Beverly Dong, Rick M Maizels, Constance A M Finney, James D Wasmuth, Matthew K Higgins, Henry J McSorley
IL-33-binding HpARI family homologues with divergent effects in suppressing or enhancing type 2 immune responses. Infection and immunity (2024)
Florent Colomb, Adefunke Ogunkanbi, Abhishek Jamwal, Beverly Dong, Rick M Maizels, Constance A M Finney, James D Wasmuth, Matthew K Higgins, Henry J McSorley
IL-33-binding HpARI family homologues with divergent effects in suppressing or enhancing type 2 immune responses. Infection and immunity 92 (3) (2024)
Brendan Farrell, Nawsad Alam, Melissa N Hart, Abhishek Jamwal, Robert J Ragotte, Hannah Walters-Morgan, Simon J Draper, Ellen Knuepfer, Matthew K Higgins
The PfRCR complex bridges malaria parasite and erythrocyte during invasion. Nature 625 (7995) (2023)
Brendan Farrell, Nawsad Alam, Melissa N Hart, Abhishek Jamwal, Robert J Ragotte, Hannah Walters-Morgan, Simon J Draper, Ellen Knuepfer, Matthew K Higgins
The PfRCR complex bridges malaria parasite and erythrocyte during invasion. Nature 625 (7995) (2023)
Brendan Farrell, Nawsad Alam, Melissa N Hart, Abhishek Jamwal, Robert J Ragotte, Hannah Walters-Morgan, Simon J Draper, Ellen Knuepfer, Matthew K Higgins
The PfRCR complex bridges malaria parasite and erythrocyte during invasion. Nature 625 (7995) (2023)
Brendan Farrell, Nawsad Alam, Melissa N Hart, Abhishek Jamwal, Robert J Ragotte, Hannah Walters-Morgan, Simon J Draper, Ellen Knuepfer, Matthew K Higgins
The PfRCR complex bridges malaria parasite and erythrocyte during invasion. Nature 625 (7995) (2023)
Brendan Farrell, Nawsad Alam, Melissa N Hart, Abhishek Jamwal, Robert J Ragotte, Hannah Walters-Morgan, Simon J Draper, Ellen Knuepfer, Matthew K Higgins
The PfRCR complex bridges malaria parasite and erythrocyte during invasion. Nature 625 (7995) (2023)
Abhishek Jamwal, Cristina F Constantin, Stephan Hirshi, Sebastian Henrich, Wolfgang Bildl, Bernd Fakler, Simon J Draper, Uwe Schulte, Matthew K Higgins
Erythrocyte invasion-neutralising antibodies prevent Plasmodium falciparum RH5 from binding to basigin-containing membrane protein complexes. eLife 12 (2023)
Brendan Farrell, Nawsad Alam, Melissa N Hart, Abhishek Jamwal, Robert J Ragotte, Hannah Walters-Morgan, Simon J Draper, Ellen Knuepfer, Matthew K Higgins
The PfRCR complex bridges malaria parasite and erythrocyte during invasion. Nature (2023)
Brendan Farrell, Nawsad Alam, Melissa N Hart, Abhishek Jamwal, Robert J Ragotte, Hannah Walters-Morgan, Simon J Draper, Ellen Knuepfer, Matthew K Higgins
The PfRCR complex bridges malaria parasite and erythrocyte during invasion. Nature 625 (7995) (2023)
Brendan Farrell, Nawsad Alam, Melissa N Hart, Abhishek Jamwal, Robert J Ragotte, Hannah Walters-Morgan, Simon J Draper, Ellen Knuepfer, Matthew K Higgins
The PfRCR complex bridges malaria parasite and erythrocyte during invasion. Nature 625 (7995) (2023)
Re'em Moskovitz, Tossapol Pholcharee, Sophia M DonVito, Bora Guloglu, Edward D Lowe, Franziska Mohring, Robert William Moon, Matthew K Higgins
Structural basis for DARC binding in reticulocyte invasion by Plasmodium vivax. Nature communications 14 (1) (2023)
Robert J Ragotte, David Pulido, Amelia M Lias, Doris Quinkert, Daniel G W Alanine, Abhishek Jamwal, Hannah Davies, Adéla Nacer, Edward D Lowe, Geoffrey W Grime, Joseph J Illingworth, Robert F Donat, Elspeth F Garman, Paul W Bowyer, Matthew K Higgins, Simon J Draper
Heterotypic interactions drive antibody synergy against a malaria vaccine candidate. Nature communications 13 (1) (2022)
Olivia J S Macleod, Alexander D Cook, Helena Webb, Mandy Crow, Roisin Burns, Maria Redpath, Stefanie Seisenberger, Camilla E Trevor, Lori Peacock, Angela Schwede, Nicola Kimblin, Amanda Fortes Francisco, Julia Pepperl, Steve Rust, Paul Voorheis, Wendy Gibson, Martin Craig Taylor, Matthew K Higgins, Mark Carrington
Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor. Nature communications 13 (1) (2022)
Kuang-Ting Ko, Frank Lennartz, David Mekhaiel, Bora Guloglu, Arianna Marini, Danielle J Deuker, Carole A Long, Matthijs M Jore, Kazutoyo Miura, Sumi Biswas, Matthew K Higgins
Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies. Nature communications 13 (1) (2022)
Natalie M Barber, Clinton K Y Lau, Louise Turner, Gareth Watson, Susan Thrane, John P A Lusingu, Thomas Lavstsen, Matthew K Higgins
Structure-Guided Design of a Synthetic Mimic of an Endothelial Protein C Receptor-Binding PfEMP1 Protein. mSphere 6 (1) (2021)
Yaw Aniweh, Jonathan Suurbaar, Collins M Morang'a, Prince B Nyarko, Katherine E Wright, Kwadwo A Kusi, Felix Ansah, Emmanuel K Baafour, Evelyn Quansah, Jessica Asante, Laty Gaye Thiam, Matthew K Higgins, Gordon Akanzuwine Awandare
Analysis of Plasmodium falciparum Rh2b deletion polymorphism across different transmission areas. Scientific reports 10 (1) (2020)
Ivan Campeotto, Francis Galaway, Shahid Mehmood, Lea K Barfod, Doris Quinkert, Vinayaka Kotraiah, Timothy W Phares, Katherine E Wright, Ambrosius P Snijders, Simon J Draper, Matthew K Higgins, Gavin J Wright
The Structure of the Cysteine-Rich Domain of Plasmodium falciparum P113 Identifies the Location of the RH5 Binding Site. mBio 11 (5) (2020)
Olivia J S Macleod, Jean-Mathieu Bart, Paula MacGregor, Lori Peacock, Nicholas J Savill, Svenja Hester, Sophie Ravel, Jack Daniel Sunter, Camilla Trevor, Steven Rust, Tristan J Vaughan, Ralph R Minter, Shabaz Mohammad, Wendy Gibson, Martin Craig Taylor, Matthew K Higgins, Mark Carrington
A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies. Nature communications 11 (1) (2020)
Thomas E Harrison, Alexander M Mørch, James H Felce, Akihito Sakoguchi, Adam J Reid, Hisashi Arase, Michael L Dustin, Matthew K Higgins
Structural basis for RIFIN-mediated activation of LILRB1 in malaria. Nature 587 (7833) (2020)
Thomas E Harrison, Adam J Reid, Deirdre Cunningham, Jean Langhorne, Matthew K Higgins
Structure of the Plasmodium-interspersed repeat proteins of the malaria parasite. Proceedings of the National Academy of Sciences of the United States of America 117 (50) (2020)
Francesco Vacca, Caroline Chauché, Abhishek Jamwal, Elizabeth C Hinchy, Graham Heieis, Holly Webster, Adefunke Ogunkanbi, Zala Sekne, William F Gregory, Martin Wear, Georgia Perona-Wright, Matthew K Higgins, Josquin A Nys, E Suzanne Cohen, Henry J McSorley
A helminth-derived suppressor of ST2 blocks allergic responses. eLife 9 (2020)
Thomas A Rawlinson, Natalie M Barber, Franziska Mohring, Jee Sun Cho, Varakorn Kosaisavee, Samuel F Gérard, Daniel G W Alanine, Geneviève M Labbé, Sean C Elias, Sarah E Silk, Doris Quinkert, Jing Jin, Jennifer M Marshall, Ruth O Payne, Angela M Minassian, Bruce Russell, Laurent Rénia, Francois H Nosten, Robert William Moon, Matthew K Higgins, Simon J Draper
Structural basis for inhibition of Plasmodium vivax invasion by a broadly neutralizing vaccine-induced human antibody. Nature microbiology 4 (9) (2019)
Frank Lennartz, Cameron Smith, Alister G Craig, Matthew K Higgins
Structural insights into diverse modes of ICAM-1 binding by Plasmodium falciparum-infected erythrocytes. Proceedings of the National Academy of Sciences of the United States of America 116 (40) (2019)
Ellen Knuepfer, Katherine E Wright, Surendra Kumar Prajapati, Thomas A Rawlinson, Franziska Mohring, Marion Koch, Oliver R Lyth, Steven A Howell, Elizabeth Villasis, Ambrosius P Snijders, Robert William Moon, Simon J Draper, Anna Rosanas-Urgell, Matthew K Higgins, Jake Baum, Anthony A Holder
Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites. PLoS pathogens 15 (6) (2019)
Camilla E Trevor, Andrea L Gonzalez-Munoz, Olivia J S Macleod, Peter G Woodcock, Steven Rust, Tristan J Vaughan, Elspeth F Garman, Ralph R Minter, Mark Carrington, Matthew K Higgins
Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion. Nature microbiology 4 (12) (2019)
Eilidh Carrington, Thomas D Otto, Tadge Szestak, Frank Lennartz, Matthew K Higgins, Chris I Newbold, Alister Gordon Craig
In silico guided reconstruction and analysis of ICAM-1-binding var genes from Plasmodium falciparum. Scientific reports 8 (1) (2018)
Frank Lennartz, Florian Brod, Rebecca Dabbs, Kazutoyo Miura, David Mekhaiel, Arianna Marini, Matthijs M Jore, Max M Søgaard, Thomas Jørgensen, Willem A de Jongh, Robert W Sauerwein, Carole A Long, Sumi Biswas, Matthew K Higgins
Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody. Nature communications 9 (1) (2018)
Sebastian Zoll, Harriet Lane-Serff, Shahid Mehmood, Jonathan Schneider, Carol V Robinson, Mark Carrington, Matthew K Higgins
The structure of serum resistance-associated protein and its implications for human African trypanosomiasis. Nature microbiology 3 (3) (2018)
Matthew K Higgins, Harriet Lane-Serff, Paula MacGregor, Mark Carrington
A Receptor's Tale: An Eon in the Life of a Trypanosome Receptor. PLoS pathogens 13 (1) (2017)
Fu-Lien Hsieh, Matthew K Higgins
The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition. eLife 6 (2017)
Harriet Lane-Serff, Paula MacGregor, Lori Peacock, Olivia Js Macleod, Christopher Kay, Wendy Gibson, Matthew K Higgins, Mark Carrington
Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor. eLife 5 (2016)

Matthew K Higgins.css-eqlu8i{font-size:small;padding-left:4px;} (Matt K Higgins)

Publication Activity (10 Years)

Top Topics

Top Venues

Matthew K Higgins (Matt K Higgins)