Jake Baum

ORCID

Publication Activity (10 Years)

Years Active: 2014-2023
Publications (10 Years): 34

Top Venues

Nature communications

Disease models & mechanisms

Antimicrobial agents and chemotherapy

PLoS pathogens

Imperial College London

London School of Hygiene and Tropical Medicine (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Imperial College London Sep 01 2017

United Kingdom

Professor of Cell Biology and Infectious Diseases :: Department of Life Sciences

Imperial College London Oct 01 2013 - Aug 30 2017

United Kingdom

Reader in Parasite Cell Biology :: Department of Life Sciences

Walter and Eliza Hall Institute of Medical Research Feb 01 2003 - Sep 30 2013

Australia

Research officer, Senior research officer, Lab Head :: Division of Infection and Immunity

Education History

London School of Hygiene and Tropical Medicine Jun 01 1999 - Aug 01 2002

United Kingdom

PHD :: Parasite Molecular Biology and Biochemistry

University of Oxford Oct 01 1997 - Jun 30 1998

United Kingdom

MSC :: Biological Anthropology

Publications

Sabrina Yahiya, Charlie N Saunders, Sarah Hassan, Ursula Straschil, Oliver J Fischer, Ainoa Rueda-Zubiaurre, Silvia Haase, Gema Vizcay-Barrena, Mufuliat Toyin Famodimu, Sarah Jordan, Michael J Delves, Edward William Tate, Anna Barnard, Matthew John Fuchter, Jake Baum
A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein. Disease models & mechanisms 16 (2) (2023)
Sabrina Yahiya, Charlie N Saunders, Sarah Hassan, Ursula Straschil, Oliver J Fischer, Ainoa Rueda-Zubiaurre, Silvia Haase, Gema Vizcay-Barrena, Mufuliat Toyin Famodimu, Sarah Jordan, Michael J Delves, Edward William Tate, Anna Barnard, Matthew John Fuchter, Jake Baum
A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein. Disease models & mechanisms 16 (2) (2023)
Sabrina Yahiya, Charlie N Saunders, Sarah Hassan, Ursula Straschil, Oliver J Fischer, Ainoa Rueda-Zubiaurre, Silvia Haase, Gema Vizcay-Barrena, Mufuliat Toyin Famodimu, Sarah Jordan, Michael J Delves, Edward William Tate, Anna Barnard, Matthew John Fuchter, Jake Baum
A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein. Disease models & mechanisms 16 (2) (2023)
Sabrina Yahiya, Charlie N Saunders, Sarah Hassan, Ursula Straschil, Oliver J Fischer, Ainoa Rueda-Zubiaurre, Silvia Haase, Gema Vizcay-Barrena, Mufuliat Toyin Famodimu, Sarah Jordan, Michael J Delves, Edward William Tate, Anna Barnard, Matthew John Fuchter, Jake Baum
A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein. Disease models & mechanisms 16 (2) (2023)
Dihia Moussaoui, James P Robblee, Julien Robert-Paganin, Daniel Auguin, Fabio Fisher, Patricia M Fagnant, Jill E Macfarlane, Julia Schaletzky, Eddie Wehri, Christoph Mueller-Dieckmann, Jake Baum, Kathleen M Trybus, Anne Houdusse
Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design. Nature communications 14 (1) (2023)
Jem Murdoch, Jake Baum
A sting in the tail-are antibodies against the C-terminus of Plasmodium falciparum circumsporozoite protein protective? EMBO molecular medicine (2023)
Jem Murdoch, Jake Baum
A sting in the tail-are antibodies against the C-terminus of Plasmodium falciparum circumsporozoite protein protective? EMBO molecular medicine (2023)
Jem Murdoch, Jake Baum
A sting in the tail-are antibodies against the C-terminus of Plasmodium falciparum circumsporozoite protein protective? EMBO molecular medicine (2023)
Sabrina Yahiya, Charlie N Saunders, Sarah Hassan, Ursula Straschil, Oliver J Fischer, Ainoa Rueda-Zubiaurre, Silvia Haase, Gema Vizcay-Barrena, Mufuliat Toyin Famodimu, Sarah Jordan, Michael J Delves, Edward William Tate, Anna Barnard, Matthew John Fuchter, Jake Baum
A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein. Disease models & mechanisms 16 (2) (2023)
Stanley C Xie, Riley D Metcalfe, Elyse A Dunn, Craig J Morton, Shih-Chung Huang, Tanya Puhalovich, Yawei Du, Sergio Wittlin, Shuai Nie, Madeline R Luth, Liting Ma, Mi-Sook Kim, Charisse Flerida A Pasaje, Krittikorn Kumpornsin, Carlo Giannangelo, Fiona J Houghton, Alisje Churchyard, Mufuliat T Famodimu, Daniel C Barry, David L Gillett, Sumanta Dey, Clara C Kosasih, William Newman, Jacquin C Niles, Marcus Chee San Lee, Jake Baum, Sabine Ottilie, Elizabeth A Winzeler, Darren John Creek, Nicholas A Williamson, Michael W Parker, Stephen Brand, Steven P Langston, Lawrence R Dick, Michael D W Griffin, Alexandra E Gould, Leann Tilley
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy. Science (New York, N.Y.) 376 (6597) (2022)
Hayley E Bullen, Paul R Sanders, Madeline G Dans, Thorey K Jonsdottir, David T Riglar, Oliver Looker, Catherine S Palmer, Betty Kouskousis, Sarah C Charnaud, Tony Triglia, Mikha Gabriela, Molly Parkyn Schneider, Jo-Anne Chan, Tania F de Koning-Ward, Jake Baum, James W Kazura, James G Beeson, Alan F Cowman, Paul R Gilson, Brendan S Crabb
The Plasmodium falciparum parasitophorous vacuole protein P113 interacts with the parasite protein export machinery and maintains normal vacuole architecture. Molecular microbiology 117 (5) (2022)
Sabrina Yahiya, Sarah Jordan, Holly X Smith, David C A Gaboriau, Mufuliat T Famodimu, Farah Aida Dahalan, Alisje Churchyard, George W Ashdown, Jake Baum
Live-cell fluorescence imaging of microgametogenesis in the human malaria parasite Plasmodium falciparum. PLoS pathogens 18 (2) (2022)
Laura E de Vries, Patrick A M Jansen, Catalina Barcelo, Justin Munro, Julie M J Verhoef, Charisse Flerida A Pasaje, Kelly Rubiano, Josefine Striepen, Nada Abla, Luuk Berning, Judith M Bolscher, Claudia Demarta-Gatsi, Rob W M Henderson, Tonnie Huijs, Karin M J Koolen, Patrick K Tumwebaze, Tomas Yeo, Anna C C Aguiar, Inigo Angulo-Barturen, Alisje Churchyard, Jake Baum, Benigno Crespo Fernández, Aline Fuchs, Francisco-Javier Gamo, Rafael Victorio Carvalho Guido, María Belén Jiménez-Diaz, Dhelio Batista Pereira, Rosemary Rochford, Camille Roesch, Laura Maria Sanz, Graham Trevitt, Benoit Witkowski, Sergio Wittlin, Roland A Cooper, Philip J Rosenthal, Robert W Sauerwein, Joost Schalkwijk, Pedro H H Hermkens, Roger V Bonnert, Brice Campo, David A Fidock, Manuel Llinás, Jacquin C Niles, Taco W A Kooij, Koen J Dechering
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183. Nature communications 13 (1) (2022)
Mira S Davidson, Clare Andradi-Brown, Sabrina Yahiya, Jill Chmielewski, Aidan J O'Donnell, Pratima Gurung, Myriam D Jeninga, Parichat Prommana, Dean W Andrew, Michaela Petter, Chairat Uthaipibull, Michelle J Boyle, George W Ashdown, Jeffrey D Dvorin, Sarah E Reece, Danny W Wilson, Kane A Cunningham, D Michael Ando, Michelle Dimon, Jake Baum
Automated detection and staging of malaria parasites from cytological smears using convolutional neural networks. Biological imaging 1 (2021)
Eliana Real, Virginia M Howick, Farah A Dahalan, Kathrin Witmer, Juliana Cudini, Clare Andradi-Brown, Joshua Blight, Mira S Davidson, Sunil Kumar Dogga, Adam J Reid, Jake Baum, Mara N K Lawniczak
A single-cell atlas of Plasmodium falciparum transmission through the mosquito. Nature communications 12 (1) (2021)
Joshua Blight, Katarzyna A Sala, Erwan Atcheson, Holger B Kramer, Aadil El Turabi, Eliana Real, Farah A Dahalan, Paulo J G Bettencourt, Emma Dickinson-Craig, Eduardo Alves, Ahmed M Salman, Chris J Janse, Frances M Ashcroft, Adrian V S Hill, Arturo Reyes-Sandoval, Andrew M Blagborough, Jake Baum
Dissection-independent production of Plasmodium sporozoites from whole mosquitoes. Life science alliance 4 (7) (2021)
Stanley C Xie, Riley D Metcalfe, Hirotake Mizutani, Tanya Puhalovich, Eric Hanssen, Craig J Morton, Yawei Du, Con Dogovski, Shih-Chung Huang, Jeffrey Ciavarri, Paul Hales, Robert J Griffin, Lawrence H Cohen, Bei-Ching Chuang, Sergio Wittlin, Ioanna Deni, Tomas Yeo, Kurt E Ward, Daniel C Barry, Boyin Liu, David L Gillett, Benigno F Crespo-Fernandez, Sabine Ottilie, Nimisha Mittal, Alisje Churchyard, Daniel Ferguson, Anna Caroline Campos Aguiar, Rafael Victorio Carvalho Guido, Jake Baum, Kirsten K Hanson, Elizabeth A Winzeler, Francisco Javier Gamo, David A Fidock, Delphine Baud, Michael W Parker, Stephen Brand, Lawrence R Dick, Michael D W Griffin, Alexandra E Gould, Leann Tilley
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome. Proceedings of the National Academy of Sciences of the United States of America 118 (39) (2021)
Katherine M Ellis, Leonardo Lucantoni, Marina Chavchich, Matthew Abraham, Amanda De Paoli, Madeline R Luth, Anne-Marie Zeeman, Michael J Delves, Fernando Sánchez-Román Terán, Ursula Straschil, Jake Baum, Clemens H M Kocken, Stuart A Ralph, Elizabeth A Winzeler, Vicky M Avery, Michael D Edstein, Jonathan B Baell, Darren John Creek
The Novel bis-1,2,4-Triazine MIPS-0004373 Demonstrates Rapid and Potent Activity against All Blood Stages of the Malaria Parasite. Antimicrobial agents and chemotherapy 65 (11) (2021)
Dihia Moussaoui, James P Robblee, Daniel Auguin, Elena B Krementsova, Silvia Haase, Thomas C A Blake, Jake Baum, Julien Robert-Paganin, Kathleen M Trybus, Anne Houdusse
Full-length Plasmodium falciparum myosin A and essential light chain PfELC structures provide new anti-malarial targets. eLife 9 (2020)
Thomas C A Blake, Silvia Haase, Jake Baum
Actomyosin forces and the energetics of red blood cell invasion by the malaria parasite Plasmodium falciparum. PLoS pathogens 16 (10) (2020)
Mark D Wilkinson, Hung-En Lai, Paul S Freemont, Jake Baum
A Biosynthetic Platform for Antimalarial Drug Discovery. Antimicrobial agents and chemotherapy 64 (5) (2020)
George W Ashdown, Michelle Dimon, Minjie Fan, Fernando Sánchez-Román Terán, Kathrin Witmer, David C A Gaboriau, Zan Armstrong, D Michael Ando, Jake Baum
A machine learning approach to define antimalarial drug action from heterogeneous cell-based screens. Science advances 6 (39) (2020)
Kathrin Witmer, Farah A Dahalan, Michael J Delves, Sabrina Yahiya, Oliver J Watson, Ursula Straschil, Darunee Chiwcharoen, Boodtee Sornboon, Sasithon Pukrittayakamee, Richard D Pearson, Virginia M Howick, Mara K N Lawniczak, Nicholas J White, Arjen M Dondorp, Lucy C Okell, Kesinee Chotivanich, Andrea Ruecker, Jake Baum
Transmission of Artemisinin-Resistant Malaria Parasites to Mosquitoes under Antimalarial Drug Pressure. Antimicrobial agents and chemotherapy 65 (1) (2020)
Oriol Llorà-Batlle, Lucas Michel-Todó, Kathrin Witmer, Haruka Toda, Carmen Fernández-Becerra, Jake Baum, Alfred Cortes
Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum. Science advances 6 (24) (2020)
Beatriz Baragaña, Barbara Forte, Ryan Choi, Stephen Nakazawa Hewitt, Juan A Bueren-Calabuig, João Pedro Pisco, Caroline Peet, David M Dranow, David A Robinson, Chimed Jansen, Neil R Norcross, Sumiti Vinayak, Mark Anderson, Carrie F Brooks, Caitlin A Cooper, Sebastian Damerow, Michael Delves, Karen Dowers, James Duffy, Thomas E Edwards, Irene Hallyburton, Benjamin G Horst, Matthew A Hulverson, Liam Ferguson, María Belén Jiménez-Díaz, Rajiv S Jumani, Donald D Lorimer, Melissa S Love, Steven Maher, Holly Matthews, Case W McNamara, Peter Miller, Sandra O'Neill, Kayode K Ojo, Maria Osuna-Cabello, Erika Pinto, John Post, Jennifer Riley, Matthias Rottmann, Laura M Sanz, Paul Scullion, Arvind Sharma, Sharon M Shepherd, Yoko Shishikura, Frederick R C Simeons, Erin E Stebbins, Laste Stojanovski, Ursula Straschil, Fabio K Tamaki, Jevgenia Tamjar, Leah S Torrie, Amélie Vantaux, Benoît Witkowski, Sergio Wittlin, Manickam Yogavel, Fabio Zuccotto, Iñigo Angulo-Barturen, Robert Sinden, Jake Baum, Francisco-Javier Gamo, Pascal Mäser, Dennis E Kyle, Elizabeth A Winzeler, Peter J Myler, Paul G Wyatt, David Floyd, David Matthews, Amit Sharma, Boris Striepen, Christopher D Huston, David W Gray, Alan H Fairlamb, Andrei V Pisliakov, Chris Walpole, Kevin D Read, Wesley C Van Voorhis, Ian H Gilbert
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. Proceedings of the National Academy of Sciences of the United States of America 116 (14) (2019)
Shira Warszawski, Elya Dekel, Ivan Campeotto, Jennifer M Marshall, Katherine E Wright, Oliver Lyth, Orli Knop, Neta Regev-Rudzki, Matthew K Higgins, Simon J Draper, Jake Baum, Sarel Jacob Fleishman
Design of a basigin-mimicking inhibitor targeting the malaria invasion protein RH5. Proteins 88 (1) (2019)
Julien Robert-Paganin, James P Robblee, Daniel Auguin, Thomas C A Blake, Carol S Bookwalter, Elena B Krementsova, Dihia Moussaoui, Michael J Previs, Guillaume Jousset, Jake Baum, Kathleen M Trybus, Anne Houdusse
Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism. Nature communications 10 (1) (2019)
Ellen Knuepfer, Katherine E Wright, Surendra Kumar Prajapati, Thomas A Rawlinson, Franziska Mohring, Marion Koch, Oliver R Lyth, Steven A Howell, Elizabeth Villasis, Ambrosius P Snijders, Robert William Moon, Simon J Draper, Anna Rosanas-Urgell, Matthew K Higgins, Jake Baum, Anthony A Holder
Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites. PLoS pathogens 15 (6) (2019)
Mario Del Rosario, Javier Periz, Georgios Pavlou, Oliver Lyth, Fernanda Latorre-Barragan, Sujaan Das, Gurman S Pall, Johannes Felix Stortz, Leandro Lemgruber, Jamie A Whitelaw, Jake Baum, Isabelle Tardieux, Markus Meissner
Apicomplexan F-actin is required for efficient nuclear entry during host cell invasion. EMBO reports 20 (12) (2019)
Timothy J Satchwell, Katherine E Wright, Katy L Haydn-Smith, Fernando Sánchez-Román Terán, Pedro Luis Moura, Joseph Hawksworth, Jan Frayne, Ashley Mark Toye, Jake Baum
Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements. Nature communications 10 (1) (2019)
Marion Koch, Jaimini Cegla, Ben Jones, Yuning Lu, Ziad Mallat, Andrew M Blagborough, Fiona Angrisano, Jake Baum
The effects of dyslipidaemia and cholesterol modulation on erythrocyte susceptibility to malaria parasite infection. Malaria journal 18 (1) (2019)
Xiaoyi Wang, Mark D Wilkinson, Xiaoyan Lin, Ren Ren, Keith Robert Willison, Aleksandar P Ivanov, Jake Baum, Joshua B Edel
Single-molecule nanopore sensing of actin dynamics and drug binding. Chemical science 11 (4) (2019)
Marion Koch, Katherine E Wright, Oliver Otto, Maik Herbig, Nichole D Salinas, Niraj H Tolia, Timothy J Satchwell, Jochen Guck, Nicholas J Brooks, Jake Baum
Plasmodium falciparum erythrocyte-binding antigen 175 triggers a biophysical change in the red blood cell that facilitates invasion. Proceedings of the National Academy of Sciences of the United States of America 114 (16) (2017)
Isabelle Tardieux, Jake Baum
Reassessing the mechanics of parasite motility and host-cell invasion. The Journal of cell biology 214 (5) (2017)
Wilson Wong, Xiao-chen Bai, Alan Brown, Israel S Fernandez, Eric Hanssen, Melanie Condron, Yan Hong Tan, Jake Baum, Sjors H W Scheres
Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine. eLife 3 (2014)

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Publication Activity (10 Years)

Top Topics

Top Venues

Jake Baum