Mikko Metsä-Ketelä

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 30

Top Topics

Molecular Dynamics Simulations

Early Breast Cancer

Top Venues

ACS chemical biology

ACS synthetic biology

The FEBS journal

This page only lists publications with an associated author ORCID identifier.

Publications

Rongbin Wang, Benjamin Nji Wandi, Nora Schwartz, Jacob Hecht, Larissa Ponomareva, Kendall Paige, Alexis West, Kathryn Desanti, Jennifer Nguyen, Jarmo Niemi, Jon S Thorson, Khaled A Shaaban, Mikko Metsä-Ketelä, Stephen Eric Nybo
Diverse Combinatorial Biosynthesis Strategies for C-H Functionalization of Anthracyclinones. ACS synthetic biology 13 (5) (2024)
Aleksi Nuutila, Xiansha Xiao, Helga U van der Heul, Gilles P van Wezel, Pedro Dinis, Somayah S Elsayed, Mikko Metsä-Ketelä
Divergence of Classical and C-Ring-Cleaved Angucyclines: Elucidation of Early Tailoring Steps in Lugdunomycin and Thioangucycline Biosynthesis. ACS chemical biology 19 (5) (2024)
Aleksi Nuutila, Xiansha Xiao, Helga U van der Heul, Gilles P van Wezel, Pedro Dinis, Somayah S Elsayed, Mikko Metsä-Ketelä
Divergence of Classical and C-Ring-Cleaved Angucyclines: Elucidation of Early Tailoring Steps in Lugdunomycin and Thioangucycline Biosynthesis. ACS chemical biology (2024)
Aleksi Nuutila, Xiansha Xiao, Helga U van der Heul, Gilles P van Wezel, Pedro Dinis, Somayah S Elsayed, Mikko Metsä-Ketelä
Divergence of Classical and C-Ring-Cleaved Angucyclines: Elucidation of Early Tailoring Steps in Lugdunomycin and Thioangucycline Biosynthesis. ACS chemical biology 19 (5) (2024)
Aleksi Nuutila, Xiansha Xiao, Helga U van der Heul, Gilles P van Wezel, Pedro Dinis, Somayah S Elsayed, Mikko Metsä-Ketelä
Divergence of Classical and C-Ring-Cleaved Angucyclines: Elucidation of Early Tailoring Steps in Lugdunomycin and Thioangucycline Biosynthesis. ACS chemical biology 19 (5) (2024)
Aleksi Nuutila, Xiansha Xiao, Helga U van der Heul, Gilles P van Wezel, Pedro Dinis, Somayah S Elsayed, Mikko Metsä-Ketelä
Divergence of Classical and C-Ring-Cleaved Angucyclines: Elucidation of Early Tailoring Steps in Lugdunomycin and Thioangucycline Biosynthesis. ACS chemical biology 19 (5) (2024)
Rongbin Wang, Benjamin Nji Wandi, Nora Schwartz, Jacob Hecht, Larissa Ponomareva, Kendall Paige, Alexis West, Kathryn Desanti, Jennifer Nguyen, Jarmo Niemi, Jon S Thorson, Khaled A Shaaban, Mikko Metsä-Ketelä, Stephen Eric Nybo
Diverse Combinatorial Biosynthesis Strategies for C-H Functionalization of Anthracyclinones. ACS synthetic biology 13 (5) (2024)
Rongbin Wang, Benjamin Nji Wandi, Nora Schwartz, Jacob Hecht, Larissa Ponomareva, Kendall Paige, Alexis West, Kathryn Desanti, Jennifer Nguyen, Jarmo Niemi, Jon S Thorson, Khaled A Shaaban, Mikko Metsä-Ketelä, Stephen Eric Nybo
Diverse Combinatorial Biosynthesis Strategies for C-H Functionalization of Anthracyclinones. ACS synthetic biology (2024)
Rongbin Wang, Benjamin Nji Wandi, Nora Schwartz, Jacob Hecht, Larissa Ponomareva, Kendall Paige, Alexis West, Kathryn Desanti, Jennifer Nguyen, Jarmo Niemi, Jon S Thorson, Khaled A Shaaban, Mikko Metsä-Ketelä, Stephen Eric Nybo
Diverse Combinatorial Biosynthesis Strategies for C-H Functionalization of Anthracyclinones. ACS synthetic biology 13 (5) (2024)
Aleksi Nuutila, Xiansha Xiao, Helga U van der Heul, Gilles P van Wezel, Pedro Dinis, Somayah S Elsayed, Mikko Metsä-Ketelä
Divergence of Classical and C-Ring-Cleaved Angucyclines: Elucidation of Early Tailoring Steps in Lugdunomycin and Thioangucycline Biosynthesis. ACS chemical biology 19 (5) (2024)
Rongbin Wang, Benjamin Nji Wandi, Nora Schwartz, Jacob Hecht, Larissa Ponomareva, Kendall Paige, Alexis West, Kathryn Desanti, Jennifer Nguyen, Jarmo Niemi, Jon S Thorson, Khaled A Shaaban, Mikko Metsä-Ketelä, Stephen Eric Nybo
Diverse Combinatorial Biosynthesis Strategies for C-H Functionalization of Anthracyclinones. ACS synthetic biology 13 (5) (2024)
Pedro Dinis, Heli Tirkkonen, Benjamin Nji Wandi, Vilja Siitonen, Jarmo Niemi, Thadée Grocholski, Mikko Metsä-Ketelä
Evolution-inspired engineering of anthracycline methyltransferases. PNAS nexus 2 (2) (2023)
Erika Artukka, Robert Schnell, Kaisa Palmu, Petja Rosenqvist, Edit Szodorai, Jarmo Niemi, Pasi Virta, Gunter Schneider, Mikko Metsä-Ketelä
Pseudouridine-Modifying Enzymes SapB and SapH Control Entry into the Pseudouridimycin Biosynthetic Pathway. ACS chemical biology (2023)
Bikash Baral, Soheila Matroodi, Vilja Siitonen, Keshav Thapa, Amir Akhgari, Keith Yamada, Aleksi Nuutila, Mikko Metsä-Ketelä
Co-factor independent oxidases ncnN and actVA-3 are involved in the dimerization of benzoisochromanequinone antibiotics in naphthocyclinone and actinorhodin biosynthesis. FEMS microbiology letters (2023)
Pedro Dinis, Heli Tirkkonen, Benjamin Nji Wandi, Vilja Siitonen, Jarmo Niemi, Thadée Grocholski, Mikko Metsä-Ketelä
Evolution-inspired engineering of anthracycline methyltransferases. PNAS nexus 2 (2) (2023)
Heli Tirkkonen, Katelyn V Brown, Magdalena Niemczura, Zélie Faudemer, Courtney Brown, Larissa V Ponomareva, Yosra A Helmy, Jon S Thorson, Stephen Eric Nybo, Mikko Metsä-Ketelä, Khaled A Shaaban
Engineering BioBricks for Deoxysugar Biosynthesis and Generation of New Tetracenomycins. ACS omega 8 (23) (2023)
Mandy B Hulst, Thadee Grocholski, Jacques J C Neefjes, Gilles P van Wezel, Mikko Metsä-Ketelä
Anthracyclines: biosynthesis, engineering and clinical applications. Natural product reports 39 (4) (2022)
Rongbin Wang, Jennifer Nguyen, Jacob Hecht, Nora Schwartz, Katelyn V Brown, Larissa V Ponomareva, Magdalena Niemczura, Dino van Dissel, Gilles P van Wezel, Jon S Thorson, Mikko Metsä-Ketelä, Khaled A Shaaban, Stephen Eric Nybo
A BioBricks Metabolic Engineering Platform for the Biosynthesis of Anthracyclinones in Streptomyces coelicolor . ACS synthetic biology (2022)
Janne J Mäkinen, Yeonoh Shin, Eeva Vieras, Pasi Virta, Mikko Metsä-Ketelä, Katsuhiko S Murakami, Georgiy A Belogurov
The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases. Nature communications 12 (1) (2021)
Muhammad N Ahmed, Matti Wahlsten, Jouni Kalevi Jokela, Matthias Nees, Ulf-Håkan Stenman, Danillo Oliveira Alvarenga, Tomas Strandin, Kaarina Sivonen, Antti Poso, Perttu Permi, Mikko Metsä-Ketelä, Hannu Koistinen, David Peter Fewer
Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products. ACS chemical biology 16 (11) (2021)
Xuechen Zhu, Vilja Siitonen, Charles E Melançon Iii, Mikko Metsä-Ketelä
Biosynthesis of Diverse Type II Polyketide Core Structures in Streptomyces coelicolor M1152. ACS synthetic biology 10 (2) (2021)
Benjamin Nji Wandi, Vilja Siitonen, Kaisa Palmu, Mikko Metsä-Ketelä
The Rieske Oxygenase SnoT Catalyzes 2''-Hydroxylation of l-Rhodosamine in Nogalamycin Biosynthesis. Chembiochem : a European journal of chemical biology 21 (21) (2020)
Katelyn V Brown, Benjamin Nji Wandi, Mikko Metsä-Ketelä, Stephen Eric Nybo
Pathway Engineering of Anthracyclines: Blazing Trails in Natural Product Glycodiversification. The Journal of organic chemistry 85 (19) (2020)
Benjamin Nji Wandi, Vilja Siitonen, Pedro Dinis, Vladimir Vukic, Tiina A Salminen, Mikko Metsä-Ketelä
Evolution-guided engineering of non-heme iron enzymes involved in nogalamycin biosynthesis. The FEBS journal 287 (14) (2020)
Xiansha Xiao, Somayah S Elsayed, Changsheng Wu, Helga U van der Heul, Mikko Metsä-Ketelä, Chao Du, Andrea E Prota, Chun-Chi Chen, Weidong Liu, Rey-Ting Guo, Jan Pieter Abrahams, Gilles P van Wezel
Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway. ACS chemical biology 15 (9) (2020)
Thadée Grocholski, Yamada Keith, Jari Sinkkonen, Heli Tirkkonen, Jarmo Niemi, Mikko Metsä-Ketelä
Evolutionary Trajectories for the Functional Diversification of Anthracycline Methyltransferases. ACS chemical biology 14 (5) (2019)
David Peter Fewer, Mikko Metsä-Ketelä
A pharmaceutical model for the molecular evolution of microbial natural products. The FEBS journal 287 (7) (2019)
Keith Yamada, Arina Koroleva, Mitchell Laughlin, Niko Oksanen, Amir Akhgari, Vera Safronova, Elena Yakovleva, Vera Kolodyaznaya, Tatiana Buldakova, Mikko Metsä-Ketelä
Characterization and overproduction of cell-associated cholesterol oxidase ChoD from Streptomyces lavendulae YAKB-15. Scientific reports 9 (1) (2019)
Vilja Siitonen, Benjamin Nji Wandi, Akke-Pekka Törmänen, Mikko Metsä-Ketelä
Enzymatic Synthesis of the C-Glycosidic Moiety of Nogalamycin R. ACS chemical biology 13 (9) (2018)
Kaisa Palmu, Petja Rosenqvist, Keshav Thapa, Yulia Ilina, Vilja Siitonen, Bikash Baral, Janne Mäkinen, Georgi Belogurov, Pasi Virta, Jarmo Niemi, Mikko Metsä-Ketelä
Discovery of the Showdomycin Gene Cluster from Streptomyces showdoensis ATCC 15227 Yields Insight into the Biosynthetic Logic of C-Nucleoside Antibiotics. ACS chemical biology 12 (6) (2017)