Rafael G da Silva

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 24

Top Venues

Biochemistry

ACS catalysis

Nature communications

Communications chemistry

University of St Andrews

Universidade Federal do Rio Grande do Sul (MSC)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of St Andrews

United Kingdom

Research Fellow :: Biology

Pfizer Worldwide Research and Development

United States

Principal Scientist :: Worldwide Medicinal Chemistry

Pfizer Worldwide Research and Development

United States

Senior Scientist :: Worldwide Medicinal Chemistry

Albert Einstein College of Medicine

United States

Post-Doctoral Associate :: Biochemistry

Education History

Universidade Federal do Rio Grande do Sul

Brazil

MSC :: Biochemistry

Universidade Federal do Rio Grande do Sul

Brazil

BSC :: Biology

Publications

Benjamin J Read, John B O Mitchell, Rafael G da Silva
Allosteric activation unveils protein-mass modulation of ATP phosphoribosyltransferase product release. Communications chemistry 7 (1) (2024)
Peijun Tang, Christopher J Harding, Alison L Dickson, Rafael G da Silva, David J Harrison, Clarissa Melo Czekster
Snapshots of the Reaction Coordinate of a Thermophilic 2'-Deoxyribonucleoside/ribonucleoside Transferase. ACS catalysis 14 (5) (2024)
Peijun Tang, Christopher J Harding, Alison L Dickson, Rafael G da Silva, David J Harrison, Clarissa Melo Czekster
Snapshots of the Reaction Coordinate of a Thermophilic 2'-Deoxyribonucleoside/ribonucleoside Transferase. ACS catalysis 14 (5) (2024)
Benjamin J Read, John B O Mitchell, Rafael G da Silva
Allosteric activation unveils protein-mass modulation of ATP phosphoribosyltransferase product release. Communications chemistry 7 (1) (2024)
Peijun Tang, Christopher J Harding, Alison L Dickson, Rafael G da Silva, David J Harrison, Clarissa Melo Czekster
Snapshots of the Reaction Coordinate of a Thermophilic 2'-Deoxyribonucleoside/ribonucleoside Transferase. ACS catalysis 14 (5) (2024)
Benjamin J Read, Andrew F Cadzow, Magnus S Alphey, John B O Mitchell, Rafael G da Silva
Crystal Structure, Steady-State, and Pre-Steady-State Kinetics of Acinetobacter baumannii ATP Phosphoribosyltransferase. Biochemistry 63 (2) (2023)
Suneeta Devi, Anna E Carberry, Greice M Zickuhr, Alison L Dickson, David J Harrison, Rafael G da Silva
Human 2'-Deoxynucleoside 5'-Phosphate N -Hydrolase 1: Mechanism of 2'-Deoxyuridine 5'-Monophosphate Hydrolysis. Biochemistry (2023)
Benjamin J Read, Andrew F Cadzow, Magnus S Alphey, John B O Mitchell, Rafael G da Silva
Crystal Structure, Steady-State, and Pre-Steady-State Kinetics of Acinetobacter baumannii ATP Phosphoribosyltransferase. Biochemistry 63 (2) (2023)
Gemma Fisher, Ennio Pečaver, Benjamin J Read, Susannah K Leese, Erin Laing, Alison L Dickson, Clarissa M Czekster, Rafael G da Silva
Catalytic Cycle of the Bifunctional Enzyme Phosphoribosyl-ATP Pyrophosphohydrolase/Phosphoribosyl-AMP Cyclohydrolase. ACS catalysis 13 (11) (2023)
Benjamin J Read, Andrew F Cadzow, Magnus S Alphey, John B O Mitchell, Rafael G da Silva
Crystal Structure, Steady-State, and Pre-Steady-State Kinetics of Acinetobacter baumannii ATP Phosphoribosyltransferase. Biochemistry 63 (2) (2023)
Benjamin J Read, Andrew F Cadzow, Magnus S Alphey, John B O Mitchell, Rafael G da Silva
Crystal Structure, Steady-State, and Pre-Steady-State Kinetics of Acinetobacter baumannii ATP Phosphoribosyltransferase. Biochemistry (2023)
Benjamin J Read, Andrew F Cadzow, Magnus S Alphey, John B O Mitchell, Rafael G da Silva
Crystal Structure, Steady-State, and Pre-Steady-State Kinetics of Acinetobacter baumannii ATP Phosphoribosyltransferase. Biochemistry 63 (2) (2023)
Gemma Fisher, Marina Corbella, Magnus S Alphey, John Nicholson, Benjamin J Read, Shina Caroline Lynn Kamerlin, Rafael G da Silva
Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation. Nature communications 13 (1) (2022)
Gemma Fisher, Marina Corbella, Magnus S Alphey, John Nicholson, Benjamin J Read, Shina Caroline Lynn Kamerlin, Rafael G da Silva
Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation. Nature communications 13 (1) (2022)
Gemma Fisher, Marina Corbella, Magnus S Alphey, John Nicholson, Benjamin J Read, Shina Caroline Lynn Kamerlin, Rafael G da Silva
Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation. Nature communications 13 (1) (2022)
Gemma Fisher, Marina Corbella, Magnus S Alphey, John Nicholson, Benjamin J Read, Shina Caroline Lynn Kamerlin, Rafael G da Silva
Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation. Nature communications 13 (1) (2022)
Benjamin J Read, Gemma Fisher, Oliver L R Wissett, Teresa F G Machado, John Nicholson, John B O Mitchell, Rafael G da Silva
Allosteric Inhibition of Acinetobacter baumannii ATP Phosphoribosyltransferase by Protein:Dipeptide and Protein:Protein Interactions. ACS infectious diseases 8 (1) (2021)
Teresa F G Machado, Miha Purg, Johan Åqvist, Rafael G da Silva
Transition States for Psychrophilic and Mesophilic (R)-3-Hydroxybutyrate Dehydrogenase-Catalyzed Hydride Transfer at Sub-zero Temperatures. Biochemistry 60 (27) (2021)
Christine E Bowman, Rafael G da Silva, Amber Pham, Stephen W Young
An Exceptionally Potent Inhibitor of Human CD73. Biochemistry 58 (31) (2019)
Catherine M Thomson, Magnus S Alphey, Gemma Fisher, Rafael G da Silva
Mapping the Structural Path for Allosteric Inhibition of a Short-Form ATP Phosphoribosyltransferase by Histidine. Biochemistry 58 (28) (2019)
Teresa F G Machado, Tracey M Gloster, Rafael G da Silva
Linear Eyring Plots Conceal a Change in the Rate-Limiting Step in an Enzyme Reaction. Biochemistry 57 (49) (2018)
Laura A McAllister, Christopher R Butter, Scot Mente, Steven V O'Neil, Kari R Fonseca, Justin R Piro, Julie A Cianfrogna, Timothy L Foley, Adam M Gilbert, Anthony R Harris, Christopher J Helal, Douglas S Johnson, Justin I Montgomery, Deane M Nason, Stephen Noell, Jayvardhan Pandit, Bruce N Rogers, Tarek A Samad, Christopher L Shaffer, Rafael G da Silva, Daniel P Uccello, Damien Webb, Michael A Brodney
Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation. Journal of medicinal chemistry 61 (7) (2018)
Gemma Fisher, Catherine M Thomson, Rozanne Stroek, Clarissa M Czekster, Jennifer S Hirschi, Rafael G da Silva
Allosteric Activation Shifts the Rate-Limiting Step in a Short-Form ATP Phosphoribosyltransferase. Biochemistry 57 (29) (2018)
Rozanne Stroek, Ying Ge, Paul D Talbot, Mateusz K Glok, Klaudia E Bernaś, Catherine M Thomson, Eoin R Gould, Magnus S Alphey, Huanting Liu, Gordon J Florence, James H Naismith, Rafael G da Silva
Kinetics and Structure of a Cold-Adapted Hetero-Octameric ATP Phosphoribosyltransferase. Biochemistry 56 (5) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Rafael G da Silva