Roman A Melnyk

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 17

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Science advances

PLoS pathogens

Microbiology spectrum

University of Toronto

University of Toronto (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Toronto Jul 01 2018

Canada

Associate Professor :: Biochemistry

Hospital for Sick Children Sep 01 2017

Canada

Senior Scientist :: Molecular Medicine

University of Toronto Jul 01 2011 - Jun 30 2018

Canada

Assistant Professor :: Biochemistry

Hospital for Sick Children Mar 01 2011 - Aug 31 2017

Canada

Scientist :: Molecular Structure & Function

Merck Frosst Centre for Therapeutic Research Sep 01 2006 - Dec 31 2010

Canada

Senior Scientist :: Biology

Education History

University of Toronto Sep 01 1998 - Dec 31 2003

Canada

PHD :: Biochemistry

Publications

Shivneet K Gill, Seiji N Sugiman-Marangos, Greg L Beilhartz, Elizabeth Mei, Mikko Taipale, Roman A Melnyk
An enhanced intracellular delivery platform based on a distant diphtheria toxin homolog that evades pre-existing antitoxin antibodies. EMBO molecular medicine (2024)
Erum Razvi, Benjamin R DiFrancesco, Gregory A Wasney, Zachary A Morrison, John Tam, Anick Auger, Perrin Baker, Noor Alnabelseya, Jacquelyn D Rich, Piyanka Sivarajah, Gregory B Whitfield, Joe Jonathan Harrison, Roman A Melnyk, Mark Nitz, P Lynne Howell
Small Molecule Inhibition of an Exopolysaccharide Modification Enzyme is a Viable Strategy To Block Pseudomonas aeruginosa Pel Biofilm Formation. Microbiology spectrum (2023)
Simoun Icho, Jennifer S Ward, John Tam, Larry K Kociolek, Casey M Theriot, Roman A Melnyk
Intestinal bile acids provide a surmountable barrier against C. difficile TcdB-induced disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Simoun Icho, Jennifer S Ward, John Tam, Larry K Kociolek, Casey M Theriot, Roman A Melnyk
Intestinal bile acids provide a surmountable barrier against C. difficile TcdB-induced disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Simoun Icho, Jennifer S Ward, John Tam, Larry K Kociolek, Casey M Theriot, Roman A Melnyk
Intestinal bile acids provide a surmountable barrier against C. difficile TcdB-induced disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Simoun Icho, Jennifer S Ward, John Tam, Larry K Kociolek, Casey M Theriot, Roman A Melnyk
Intestinal bile acids provide a surmountable barrier against C. difficile TcdB-induced disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Simoun Icho, Jennifer S Ward, John Tam, Larry K Kociolek, Casey M Theriot, Roman A Melnyk
Intestinal bile acids provide a surmountable barrier against C. difficile TcdB-induced disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Simoun Icho, Jennifer S Ward, John Tam, Larry K Kociolek, Casey M Theriot, Roman A Melnyk
Intestinal bile acids provide a surmountable barrier against C. difficile TcdB-induced disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Simoun Icho, Edurne Rujas, Krithika Muthuraman, John Tam, Huazhu Liang, Shelby Landreth, Mingmin Liao, Darryl Falzarano, Jean-Philippe Julien, Roman A Melnyk
Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into Cells. Antimicrobial agents and chemotherapy 66 (7) (2022)
Seiji N Sugiman-Marangos, Shivneet K Gill, Michael J Mansfield, Kathleen E Orrell, Andrew Charles Doxey, Roman A Melnyk
Structures of distant diphtheria toxin homologs reveal functional determinants of an evolutionarily conserved toxin scaffold. Communications biology 5 (1) (2022)
Colleen M Pike, John Tam, Roman A Melnyk, Casey M Theriot
Tauroursodeoxycholic Acid Inhibits Clostridioides difficile Toxin-Induced Apoptosis. Infection and immunity 90 (8) (2022)
Amy E Arnold, Laura J Smith, Greg L Beilhartz, Laura C Bahlmann, Emma Jameson, Roman A Melnyk, Molly S Shoichet
Attenuated diphtheria toxin mediates siRNA delivery. Science advances 6 (18) (2020)
Kathleen E Orrell, Michael J Mansfield, Andrew Charles Doxey, Roman A Melnyk
The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus. Nature communications 11 (1) (2020)
Vania Vidimar, Greg L Beilhartz, Minyoung Park, Marco Biancucci, Matthew B Kieffer, David R Gius, Roman A Melnyk, Karla J F Satchell
An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth. Proceedings of the National Academy of Sciences of the United States of America 117 (29) (2020)
Seiji N Sugiman-Marangos, Greg L Beilhartz, Xiaochu Zhao, Dongxia Zhou, Rong Hua, Peter Kijun Kim, James M Rini, Berge A Minassian, Roman A Melnyk
Exploiting the diphtheria toxin internalization receptor enhances delivery of proteins to lysosomes for enzyme replacement therapy. Science advances 6 (50) (2020)
Terry W Bilverstone, Megan Garland, Rory J Cave, Michelle L Kelly, Martina Tholen, Donna M Bouley, Philip Kaye, Nigel Peter Minton, Matthew M Bogyo, Sarah A Kuehne, Roman A Melnyk
The glucosyltransferase activity of C. difficile Toxin B is required for disease pathogenesis. PLoS pathogens 16 (9) (2020)
Minyoung Park, Xiaobai Xu, Weixian Min, Seiji N Sugiman-Marangos, Greg L Beilhartz, Jarret J Adams, Sachdev S Sidhu, Eyal Grunebaum, Roman A Melnyk
Intracellular Delivery of Human Purine Nucleoside Phosphorylase by Engineered Diphtheria Toxin Rescues Function in Target Cells. Molecular pharmaceutics 15 (11) (2018)

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Publication Activity (10 Years)

Top Topics

Top Venues

Roman A Melnyk