Shyam K Sharan

ORCID

Publication Activity (10 Years)

Years Active: 2020-2023
Publications (10 Years): 20

Top Venues

Nature communications

Cancer research

Cell death & disease

Molecular cancer research : MCR

Case Western Reserve University (PHD)

This page only lists publications with an associated author ORCID identifier.

Education History

Case Western Reserve University Aug 15 1988 - Jan 15 1994

United States

PHD :: Genetics

Publications

Ramona N Moro, Uddipta Biswas, Suhas S Kharat, Filip D Duzanic, Prosun Das, Maria Stavrou, Maria C Raso, Raimundo Freire, Arnab Ray Chaudhuri, Shyam K Sharan, Lorenza Penengo
Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15. Nature communications 14 (1) (2023)
Sounak Sahu, Teresa L Sullivan, Alexander Y Mitrophanov, Mélissa Galloux, Darryl Nousome, Eileen Southon, Dylan Caylor, Arun Prakash Mishra, Christine N Evans, Michelle E Clapp, Sandra Sczerba Burkett, Tyler Malys, Raj Chari, Kajal Biswas, Shyam K Sharan
Saturation genome editing of 11 codons and exon 13 of BRCA2 coupled with chemotherapeutic drug response accurately determines pathogenicity of variants. PLoS genetics 19 (9) (2023)
Arun Prakash Mishra, Suzanne A Hartford, Rajani Kant Chittela, Sounak Sahu, Suhas S Kharat, Lucia Alvaro-Aranda, Aida Contreras-Perez, Teresa Sullivan, Betty K Martin, Mary Albaugh, Eileen Southon, Sandra Sczerba Burkett, Baktiar Karim, Aura Carreira, Lino Tessarollo, Shyam K Sharan
Characterization of BRCA2 R3052Q variant in mice supports its functional impact as a low-risk variant. Cell death & disease 14 (11) (2023)
Bing Xia, Kajal Biswas, Tzeh K Foo, Thiago T Gomes, Maximilian Riedel-Topper, Eileen Southon, Zhihua Kang, Yanying Huo, Susan Reid, Stacey Stauffer, Weiyin Zhou, Bin Zhu, Hela Koka, Sally Yepes, Seth A Brodie, Kristine Jones, Aurelie Vogt, Bin Zhu, Brian Carter, Neal D Freedman, Belynda Hicks, Meredith Yeager, Stephen J Chanock, Fergus Couch, Dilys M Parry, Alvaro N Monteiro, Alisa M Goldstein, Marcelo A Carvalho, Shyam K Sharan, Xiaohong R Yang
Rare germline variants in PALB2 and BRCA2 in familial and sporadic chordoma. Human mutation 43 (10) (2022)
Arun Prakash Mishra, Suzanne A Hartford, Sounak Sahu, Kimberly Klarmann, Rajani Kant Chittela, Kajal Biswas, Albert B Jeon, Betty K Martin, Sandra Sczerba Burkett, Eileen Southon, Susan Reid, Mary E Albaugh, Baktiar O Karim, Lino Tessarollo, Jonathan R Keller, Shyam K Sharan
BRCA2-DSS1 interaction is dispensable for RAD51 recruitment at replication-induced and meiotic DNA double strand breaks. Nature communications 13 (1) (2022)
Xiaoping Xu, Kai Ni, Yafeng He, Jianke Ren, Chongkui Sun, Yie Liu, Mirit I Aladjem, Sandra Sczerba Burkett, Richard Finney, Xia Ding, Shyam K Sharan, Kathrin Muegge
The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation. Nature communications 12 (1) (2021)
Arindam Datta, Kajal Biswas, Joshua A Sommers, Haley Thompson, Sanket Awate, Claudia M Nicolae, Tanay Thakar, George-Lucian Moldovan, Robert H Shoemaker, Shyam K Sharan, Robert M Brosh
WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells. Nature communications 12 (1) (2021)
Pankaj Pathak, Yotam Blech-Hermoni, Kalpana Subedi, Jessica Mpamugo, Charissa Obeng-Nyarko, Rachel Ohman, Ilda Molloy, Malcolm M Kates, Jessica Hale, Stacey Stauffer, Shyam K Sharan, Ami Mankodi
Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCα and TSC2-mTOR downregulation. Communications biology 4 (1) (2021)
Rajaa El Meskini, Devon A Atkinson, Alan Kulaga, Abdalla Abdelmaksoud, Michelle Gumprecht, Nathan M Pate, Susana Hayes, Michael Oberst, Ian M Kaplan, Patrick Raber, Terry Van Dyke, Shyam K Sharan, Robert Hollingsworth, Chi-Ping Day, Glenn Merlino, Zoe Weaver Ohler
Distinct Biomarker Profiles and TCR Sequence Diversity Characterize the Response to PD-L1 Blockade in a Mouse Melanoma Model. Molecular cancer research : MCR 19 (8) (2021)
Kajal Biswas, Martin Couillard, Luca Cavallone, Sandra Sczerba Burkett, Stacey Stauffer, Betty K Martin, Eileen Southon, Susan Reid, Teri M Plona, Ryan N Baugher, Stephanie D Mellott, Kristen M Pike, Mary E Albaugh, Chelsea Maedler-Kron, Nancy Hamel, Lino Tessarollo, Victoria Marcus, William D Foulkes, Shyam K Sharan
A novel mouse model of PMS2 founder mutation that causes mismatch repair defect due to aberrant splicing. Cell death & disease 12 (9) (2021)
Arun Prakash Mishra, Sounak Sahu, Shyam K Sharan
Coiled-Coil Domain: Uncoiling Tumor Suppression by BRCA1. Cancer research 81 (24) (2021)
Kajal Biswas, Shyam K Sharan
RAD52 S346X variant reduces breast cancer risk in BRCA2 mutation carriers. Molecular oncology 14 (6) (2020)
Nirmala Dushyanthi Sirisena, Kajal Biswas, Teresa Sullivan, Stacey Stauffer, Linda Cleveland, Eileen Southon, Vajira H W Dissanayake, Shyam K Sharan
Functional evaluation of five BRCA2 unclassified variants identified in a Sri Lankan cohort with inherited cancer syndromes using a mouse embryonic stem cell-based assay. Breast cancer research : BCR 22 (1) (2020)
Eva Perez-Guijarro, Howard H Yang, Romina E Araya, Rajaa El Meskini, Helen T Michael, Suman Kumar Vodnala, Kerrie L Marie, Cari Smith, Sung Chin, Khiem C Lam, Andres Thorkelsson, Anthony J Iacovelli, Alan Kulaga, Anyen Fon, Aleksandra M Michalowski, Willy Hugo, Roger S Lo, Nicholas P Restifo, Shyam K Sharan, Terry Van Dyke, Romina S Goldszmid, Zoe Weaver Ohler, Maxwell Ping Lee, Chi-Ping Day, Glenn Merlino
Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy. Nature medicine 26 (5) (2020)
Alvaro N A Monteiro, Peter Bouwman, Arne N Kousholt, Diana M Eccles, Gael A Millot, Jean-Yves Masson, Marjanka K Schmidt, Shyam K Sharan, Ralph Scully, Lisa Wiesmuller, Fergus J Couch, Maaike P G Vreeswijk
Variants of uncertain clinical significance in hereditary breast and ovarian cancer genes: best practices in functional analysis for clinical annotation. Journal of medical genetics 57 (8) (2020)
Suhas S Kharat, Xia Ding, Divya Swaminathan, Akshey Suresh, Manish Singh, Satheesh K Sengodan, Sandra Sczerba Burkett, Hanna Marks, Chinmayi Pamala, Yafeng He, Stephen D Fox, Eugen C Buehler, Kathrin Muegge, Scott E Martin, Shyam K Sharan
Degradation of 5hmC-marked stalled replication forks by APE1 causes genomic instability. Science signaling 13 (645) (2020)
Stacey Stauffer, Kajal Biswas, Shyam K Sharan
Bypass of premature stop codons and generation of functional BRCA2 by exon skipping. Journal of human genetics 65 (9) (2020)
Kajal Biswas, Gary B Lipton, Stacey Stauffer, Teresa Sullivan, Linda Cleveland, Eileen Southon, Susan Reid, Valentin Magidson, Edwin S Iversen, Shyam K Sharan
A computational model for classification of BRCA2 variants using mouse embryonic stem cell-based functional assays. NPJ genomic medicine 5 (1) (2020)
Suhas S Kharat, Shyam K Sharan
Exploring role of 5hmC as potential marker of chemoresistance. Molecular & cellular oncology 7 (6) (2020)
Hélène Tubeuf, Sandrine M Caputo, Teresa Sullivan, Julie Rondeaux, Sophie Krieger, Virginie Caux-Moncoutier, Julie Hauchard, Gaia Castelain, Alice Fiévet, Laëtitia Meulemans, Françoise Révillion, Mélanie Léoné, Nadia Boutry-Kryza, Capucine Delnatte, Marine Guillaud-Bataille, Linda Cleveland, Susan Reid, Eileen Southon, Omar Soukarieh, Aurélie Drouet, Daniela Di Giacomo, Myriam Vezain, Françoise Bonnet-Dorion, Violaine Bourdon, Hélène Larbre, Danièle Muller, Pascal Pujol, Fátima Vaz, Séverine Audebert-Bellanger, Chrystelle Colas, Laurence Venat Bouvet, Angela R Solano, Dominique Stoppat-Lyonnet, Claude Houdayer, Thierry Frebourg, Pascaline Gaildrat, Shyam K Sharan, Alexandra Martins
Calibration of Pathogenicity Due to Variant-Induced Leaky Splicing Defects by Using BRCA2 Exon 3 as a Model System. Cancer research 80 (17) (2020)

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Publication Activity (10 Years)

Top Topics

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Shyam K Sharan