Thomas E Smithgall

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 12

Top Topics

Crystal Structure

Acute Lymphoblastic Leukemia

Tyrosine Kinase

Top Venues

Science signaling

ACS chemical biology

ACS infectious diseases

This page only lists publications with an associated author ORCID identifier.

Publications

Lori A Emert-Sedlak, Colin M Tice, Haibin Shi, John J Alvarado, Sherry T Shu, Allen B Reitz, Thomas E Smithgall
PROTAC-mediated Degradation of HIV-1 Nef Efficiently Restores Cell-surface CD4 and MHC-I Expression and Blocks HIV-1 Replication. bioRxiv : the preprint server for biology (2023)
Lori A Emert-Sedlak, Haibin Shi, Colin M Tice, Li Chen, John J Alvarado, Sherry T Shu, Shoucheng Du, Catherine E Thomas, Jay E Wrobel, Allen B Reitz, Thomas E Smithgall
Antiretroviral Drug Discovery Targeting the HIV-1 Nef Virulence Factor. Viruses 14 (9) (2022)
Manish Aryal, David Yin-Wei Lin, Kiera Regan, Shoucheng Du, Haibin Shi, John J Alvarado, Tatiana V Ilina, Amy H Andreotti, Thomas E Smithgall
The HIV-1 protein Nef activates the Tec family kinase Btk by stabilizing an intermolecular SH3-SH2 domain interaction. Science signaling 15 (752) (2022)
Lori A Emert-Sedlak, Omar Moukha-Chafiq, Haibin Shi, Shoucheng Du, John J Alvarado, Vibha Pathak, Samuel G Tanner, Robert N Hunter, Miranda Nebane, Li Chen, Tatiana V Ilina, Rieko Ishima, Sixue Zhang, Yury V Kuzmichev, Elizabeth R Wonderlich, Susan M Schader, Corinne Elizabeth Augelli-Szafran, Roger G Ptak, Thomas E Smithgall
Inhibitors of HIV-1 Nef-Mediated Activation of the Myeloid Src-Family Kinase Hck Block HIV-1 Replication in Macrophages and Disrupt MHC-I Downregulation. ACS infectious diseases 8 (1) (2022)
Georgiana Crainiciuc, Miguel Palomino-Segura, Miguel Molina-Moreno, Jon Sicilia, David G Aragones, Jackson Liang Yao Li, Rodrigo Madurga de Lacalle, José María Adrover, Alejandra Aroca-Crevillén, Sandra Martin-Salamanca, Alfonso Serrano Del Valle, Sandra D Castillo, Heidi C E Welch, Oliver Soehnlein, Mariona Graupera, Fátima Sánchez-Cabo, Alexander Zarbock, Thomas E Smithgall, Mauro Di Pilato, Thorsten R Mempel, Pierre-Louis Tharaux, Santiago Fernandez Gonzalez, Angel Ayuso-Sacido, Lai Guan Ng, Gabriel F Calvo, Iván González-Díaz, Fernando Díaz-de-María, Andrés Hidalgo
Behavioural immune landscapes of inflammation. Nature 601 (7893) (2022)
Ravi K Patel, Yash K Patel, Thomas E Smithgall
In Vitro Evolution Reveals a Single Mutation as Sole Source of Src-Family Kinase C-Helix-out Inhibitor Resistance. ACS chemical biology 15 (8) (2020)
Haibin Shi, Colin M Tice, Lori Emert-Sedlak, Li Chen, Wing Fai Li, Marianne Carlsen, Jay E Wrobel, Allen B Reitz, Thomas E Smithgall
Tight-Binding Hydroxypyrazole HIV-1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-Mediated MHC-I Downregulation. ACS infectious diseases 6 (2) (2019)
Ravi K Patel, Mark C Weir, Kexin Shen, Daniel Snyder, Vaughn S Cooper, Thomas E Smithgall
Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance. PloS one 14 (12) (2019)
Mousheng Wu, John J Alvarado, Corinne E Augelli-Szafran, Roger G Ptak, Thomas E Smithgall
A single β-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding. PloS one 13 (2) (2018)
Kexin Shen, Jamie A Moroco, Ravi K Patel, Haibin Shi, John R Engen, Heather R Dorman, Thomas E Smithgall
The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation. Science signaling 11 (553) (2018)
Mark C Weir, Sherry T Shu, Ravi K Patel, Sabine Hellwig, Li Chen, Li Tan, Nathanael S Gray, Thomas E Smithgall
Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo. ACS chemical biology 13 (6) (2018)
Mark C Weir, Sabine Hellwig, Li Tan, Yao Liu, Nathanael S Gray, Thomas E Smithgall
Dual inhibition of Fes and Flt3 tyrosine kinases potently inhibits Flt3-ITD+ AML cell growth. PloS one 12 (7) (2017)