Thorsten Mielke

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 41

Top Venues

Nature communications

The EMBO journal

Nature cell biology

PLoS pathogens

Max Planck Institute for Molecular Genetics

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Max Planck Institute for Molecular Genetics Jan 01 2004

Germany

Group Leader :: Microscopy and cryo-electron microscopy service group

Publications

Vera A van der Weijden, Maximilian Stötzel, Dhanur P Iyer, Beatrix Fauler, Elzbieta Gralinska, Mohammed Shahraz, David Meierhofer, Martin Vingron, Steffen Rulands, Theodore Alexandrov, Thorsten Mielke, Aydan Bulut-Karslioğlu
FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy. Nature cell biology 26 (2) (2024)
Timo Flügel, Magdalena Schacherl, Anett Unbehaun, Birgit Schroeer, Marylena Dabrowski, Jörg Bürger, Thorsten Mielke, Thiemo Sprink, Christoph A Diebolder, Yollete V Guillén Schlippe, Christian M T Spahn
Transient disome complex formation in native polysomes during ongoing protein synthesis captured by cryo-EM. Nature communications 15 (1) (2024)
Vera A van der Weijden, Maximilian Stötzel, Dhanur P Iyer, Beatrix Fauler, Elzbieta Gralinska, Mohammed Shahraz, David Meierhofer, Martin Vingron, Steffen Rulands, Theodore Alexandrov, Thorsten Mielke, Aydan Bulut-Karslioğlu
FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy. Nature cell biology (2024)
Vera A van der Weijden, Maximilian Stötzel, Dhanur P Iyer, Beatrix Fauler, Elzbieta Gralinska, Mohammed Shahraz, David Meierhofer, Martin Vingron, Steffen Rulands, Theodore Alexandrov, Thorsten Mielke, Aydan Bulut-Karslioğlu
FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy. Nature cell biology 26 (2) (2024)
Vera A van der Weijden, Maximilian Stötzel, Dhanur P Iyer, Beatrix Fauler, Elzbieta Gralinska, Mohammed Shahraz, David Meierhofer, Martin Vingron, Steffen Rulands, Theodore Alexandrov, Thorsten Mielke, Aydan Bulut-Karslioğlu
FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy. Nature cell biology 26 (2) (2024)
Vera A van der Weijden, Maximilian Stötzel, Dhanur P Iyer, Beatrix Fauler, Elzbieta Gralinska, Mohammed Shahraz, David Meierhofer, Martin Vingron, Steffen Rulands, Theodore Alexandrov, Thorsten Mielke, Aydan Bulut-Karslioğlu
FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy. Nature cell biology 26 (2) (2024)
Timo Flügel, Magdalena Schacherl, Anett Unbehaun, Birgit Schroeer, Marylena Dabrowski, Jörg Bürger, Thorsten Mielke, Thiemo Sprink, Christoph A Diebolder, Yollete V Guillén Schlippe, Christian M T Spahn
Transient disome complex formation in native polysomes during ongoing protein synthesis captured by cryo-EM. Nature communications 15 (1) (2024)
Vera A van der Weijden, Maximilian Stötzel, Dhanur P Iyer, Beatrix Fauler, Elzbieta Gralinska, Mohammed Shahraz, David Meierhofer, Martin Vingron, Steffen Rulands, Theodore Alexandrov, Thorsten Mielke, Aydan Bulut-Karslioğlu
FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy. Nature cell biology 26 (2) (2024)
Timo Flügel, Magdalena Schacherl, Anett Unbehaun, Birgit Schroeer, Marylena Dabrowski, Jörg Bürger, Thorsten Mielke, Thiemo Sprink, Christoph A Diebolder, Yollete V Guillén Schlippe, Christian M T Spahn
Transient disome complex formation in native polysomes during ongoing protein synthesis captured by cryo-EM. Nature communications 15 (1) (2024)
Bo Qin, Simon M Lauer, Annika Balke, Carlos H Vieira-Vieira, Jörg Bürger, Thorsten Mielke, Matthias Selbach, Patrick Scheerer, Christian M T Spahn, Rainer Nikolay
Cryo-EM captures early ribosome assembly in action. Nature communications 14 (1) (2023)
Bo Qin, Simon M Lauer, Annika Balke, Carlos H Vieira-Vieira, Jörg Bürger, Thorsten Mielke, Matthias Selbach, Patrick Scheerer, Christian M T Spahn, Rainer Nikolay
Cryo-EM captures early ribosome assembly in action. Nature communications 14 (1) (2023)
Bo Qin, Simon M Lauer, Annika Balke, Carlos H Vieira-Vieira, Jörg Bürger, Thorsten Mielke, Matthias Selbach, Patrick Scheerer, Christian M T Spahn, Rainer Nikolay
Cryo-EM captures early ribosome assembly in action. Nature communications 14 (1) (2023)
Vu Thuy Khanh Le-Trilling, Sofia Banchenko, Darius Paydar, Pia Madeleine Leipe, Lukas Binting, Simon M Lauer, Andrea Graziadei, Robin L Klingen, Christine Gotthold, Jörg Bürger, Thilo Bracht, Barbara Sitek, Robert Jan Lebbink, Anna Malyshkina, Thorsten Mielke, Juri Rappsilber, Christian Mt Spahn, Sebastian Voigt, Mirko Trilling, David Schwefel
Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor. The EMBO journal (2023)
Vu Thuy Khanh Le-Trilling, Sofia Banchenko, Darius Paydar, Pia Madeleine Leipe, Lukas Binting, Simon M Lauer, Andrea Graziadei, Robin L Klingen, Christine Gotthold, Jörg Bürger, Thilo Bracht, Barbara Sitek, Robert Jan Lebbink, Anna Malyshkina, Thorsten Mielke, Juri Rappsilber, Christian Mt Spahn, Sebastian Voigt, Mirko Trilling, David Schwefel
Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor. The EMBO journal 42 (5) (2023)
Bo Qin, Simon M Lauer, Annika Balke, Carlos H Vieira-Vieira, Jörg Bürger, Thorsten Mielke, Matthias Selbach, Patrick Scheerer, Christian M T Spahn, Rainer Nikolay
Cryo-EM captures early ribosome assembly in action. Nature communications 14 (1) (2023)
Vu Thuy Khanh Le-Trilling, Sofia Banchenko, Darius Paydar, Pia Madeleine Leipe, Lukas Binting, Simon M Lauer, Andrea Graziadei, Robin L Klingen, Christine Gotthold, Jörg Bürger, Thilo Bracht, Barbara Sitek, Robert Jan Lebbink, Anna Malyshkina, Thorsten Mielke, Juri Rappsilber, Christian Mt Spahn, Sebastian Voigt, Mirko Trilling, David Schwefel
Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor. The EMBO journal 42 (5) (2023)
Vu Thuy Khanh Le-Trilling, Sofia Banchenko, Darius Paydar, Pia Madeleine Leipe, Lukas Binting, Simon M Lauer, Andrea Graziadei, Robin L Klingen, Christine Gotthold, Jörg Bürger, Thilo Bracht, Barbara Sitek, Robert Jan Lebbink, Anna Malyshkina, Thorsten Mielke, Juri Rappsilber, Christian Mt Spahn, Sebastian Voigt, Mirko Trilling, David Schwefel
Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor. The EMBO journal 42 (5) (2023)
Vu Thuy Khanh Le-Trilling, Sofia Banchenko, Darius Paydar, Pia Madeleine Leipe, Lukas Binting, Simon M Lauer, Andrea Graziadei, Robin L Klingen, Christine Gotthold, Jörg Bürger, Thilo Bracht, Barbara Sitek, Robert Jan Lebbink, Anna Malyshkina, Thorsten Mielke, Juri Rappsilber, Christian Mt Spahn, Sebastian Voigt, Mirko Trilling, David Schwefel
Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor. The EMBO journal 42 (5) (2023)
Vu Thuy Khanh Le-Trilling, Sofia Banchenko, Darius Paydar, Pia Madeleine Leipe, Lukas Binting, Simon M Lauer, Andrea Graziadei, Robin L Klingen, Christine Gotthold, Jörg Bürger, Thilo Bracht, Barbara Sitek, Robert Jan Lebbink, Anna Malyshkina, Thorsten Mielke, Juri Rappsilber, Christian Mt Spahn, Sebastian Voigt, Mirko Trilling, David Schwefel
Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor. The EMBO journal 42 (5) (2023)
Julia Smirnova, Justus Loerke, Gunnar Kleinau, Andrea Schmidt, Jörg Bürger, Etienne H Meyer, Thorsten Mielke, Patrick Scheerer, Ralph Bock, Christian M T Spahn, Reimo Zoschke
Structure of the actively translating plant 80S ribosome at 2.2 Å resolution. Nature plants (2023)
Bo Qin, Simon M Lauer, Annika Balke, Carlos H Vieira-Vieira, Jörg Bürger, Thorsten Mielke, Matthias Selbach, Patrick Scheerer, Christian M T Spahn, Rainer Nikolay
Cryo-EM captures early ribosome assembly in action. Nature communications 14 (1) (2023)
Bo Qin, Simon M Lauer, Annika Balke, Carlos H Vieira-Vieira, Jörg Bürger, Thorsten Mielke, Matthias Selbach, Patrick Scheerer, Christian M T Spahn, Rainer Nikolay
Cryo-EM captures early ribosome assembly in action. Nature communications 14 (1) (2023)
Bo Qin, Simon M Lauer, Annika Balke, Carlos H Vieira-Vieira, Jörg Bürger, Thorsten Mielke, Matthias Selbach, Patrick Scheerer, Christian M T Spahn, Rainer Nikolay
Cryo-EM captures early ribosome assembly in action. Nature communications 14 (1) (2023)
Tarek Hilal, Benjamin Y Killam, Milica Grozdanović, Malgorzata Dobosz-Bartoszek, Justus Loerke, Jörg Bürger, Thorsten Mielke, Paul R Copeland, Miljan Simonović, Christian M T Spahn
Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon. Science (New York, N.Y.) 376 (6599) (2022)
Dermot Harnett, Mateusz C Ambrozkiewicz, Ulrike Zinnall, Alexandra Rusanova, Ekaterina Borisova, Amelie N Drescher, Marta Couce-Iglesias, Gabriel Villamil, Rike Dannenberg, Koshi Imami, Agnieszka Münster-Wandowski, Beatrix Fauler, Thorsten Mielke, Matthias Selbach, Markus Landthaler, Christian M T Spahn, Victor Tarabykin, Uwe Ohler, Matthew L Kraushar
A critical period of translational control during brain development at codon resolution. Nature structural & molecular biology (2022)
Nicolas A Heyder, Gunnar Kleinau, David Speck, Andrea Schmidt, Sarah Paisdzior, Michal Szczepek, Brian Bauer, Anja Koch, Monique Gallandi, Dennis Kwiatkowski, Jörg Bürger, Thorsten Mielke, Annette G Beck-Sickinger, Peter W Hildebrand, Christian M T Spahn, Daniel Hilger, Magdalena Schacherl, Heike Biebermann, Tarek Hilal, Peter Kühnen, Brian K Kobilka, Patrick Scheerer
Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-α-MSH and setmelanotide. Cell research 31 (11) (2021)
Atefeh Pooryasin, Marta Maglione, Marco Schubert, Tanja Matkovic-Rachid, Sayed-Mohammad Hasheminasab, Ulrike Pech, André Fiala, Thorsten Mielke, Stephan J Sigrist
Unc13A and Unc13B contribute to the decoding of distinct sensory information in Drosophila. Nature communications 12 (1) (2021)
Chuck Haggerty, Helene Kretzmer, Christina Riemenschneider, Abhishek Sampath Kumar, Alexandra L Mattei, Nina Bailly, Judith Gottfreund, Pay Giesselmann, Raha Weigert, Björn Brändl, Pascal Giehr, René Buschow, Christina Galonska, Ferdinand von Meyenn, Melissa B Pappalardi, Michael T McCabe, Lars Wittler, Claudia Giesecke-Thiel, Thorsten Mielke, David Meierhofer, Bernd Timmermann, Franz-Josef Müller, Jörn Walter, Alexander Meissner
Dnmt1 has de novo activity targeted to transposable elements. Nature structural & molecular biology 28 (7) (2021)
Audrey Labarde, Lina Jakutyte, Cyrille Billaudeau, Beatrix Fauler, Maria López-Sanz, Prishila Ponien, Eric Jacquet, Thorsten Mielke, Silvia Ayora, Rut Carballido-López, Paulo Tavares
Temporal compartmentalization of viral infection in bacterial cells. Proceedings of the National Academy of Sciences of the United States of America 118 (28) (2021)
Sofia Banchenko, Ferdinand Krupp, Christine Gotthold, Jörg Bürger, Andrea Graziadei, Francis J O'Reilly, Ludwig R Sinn, Olga Ruda, Juri Rappsilber, Christian M T Spahn, Thorsten Mielke, Ian A Taylor, David Schwefel
Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses. PLoS pathogens 17 (8) (2021)
Michele Lunelli, Antje Kamprad, Jörg Bürger, Thorsten Mielke, Christian M T Spahn, Michael Kolbe
Cryo-EM structure of the Shigella type III needle complex. PLoS pathogens 16 (2) (2020)
Yi Xiao, Anja Rabien, René Buschow, Vyacheslav Amtislavskiy, Jonas Busch, Ergin Kilic, Sonia L Villegas, Bernd Timmermann, Moritz Schütte, Thorsten Mielke, Marie-Laure Yaspo, Klaus Jung, David Meierhofer
Endocytosis-Mediated Replenishment of Amino Acids Favors Cancer Cell Proliferation and Survival in Chromophobe Renal Cell Carcinoma. Cancer research 80 (24) (2020)
Christin Radon, Gerd Mittelstädt, Benjamin R Duffus, Jörg Bürger, Tobias Hartmann, Thorsten Mielke, Christian Teutloff, Silke Leimkühler, Petra Wendler
Cryo-EM structures reveal intricate Fe-S cluster arrangement and charging in Rhodobacter capsulatus formate dehydrogenase. Nature communications 11 (1) (2020)
Nelly Said, Tarek Hilal, Nicholas D Sunday, Ajay Khatri, Jörg Bürger, Thorsten Mielke, Georgiy A Belogurov, Bernhard Loll, Ranjan Sen, Irina Artsimovitch, Markus C Wahl
Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase ρ. Science (New York, N.Y.) 371 (6524) (2020)
Athanasios Ignatiou, Sandrine Brasilès, Mehdi El Sadek Fadel, Jörg Bürger, Thorsten Mielke, Maya Topf, Paulo Tavares, Elena V Orlova
Structural transitions during the scaffolding-driven assembly of a viral capsid. Nature communications 10 (1) (2019)
Raphael Brandt, Thomas Sell, Mareen Lüthen, Florian Uhlitz, Bertram Klinger, Pamela Riemer, Claudia Giesecke-Thiel, Silvia Schulze, Ismail Amr El-Shimy, Desiree Kunkel, Beatrix Fauler, Thorsten Mielke, Norbert Mages, Bernhard G Herrmann, Christine Sers, Nils Blüthgen, Markus Morkel
Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium. Nature communications 10 (1) (2019)
Malgorzata Nowaczyk-Cieszewska, Dorota Zyla-Uklejewicz, Mateusz Noszka, Pawel Jaworski, Thorsten Mielke, Anna Magdalena Zawilak-Pawlik
The role of Helicobacter pylori DnaA domain I in orisome assembly on a bipartite origin of chromosome replication. Molecular microbiology 113 (2) (2019)
Bilal M Qureshi, Andrea Schmidt, Elmar Behrmann, Jörg Bürger, Thorsten Mielke, Christian M T Spahn, Martin Heck, Patrick Scheerer
Mechanistic insights into the role of prenyl-binding protein PrBP/δ in membrane dissociation of phosphodiesterase 6. Nature communications 9 (1) (2018)
Peggy Matz, Wasco Wruck, Beatrix Fauler, Diran Herebian, Thorsten Mielke, James Adjaye
Footprint-free human fetal foreskin derived iPSCs: A tool for modeling hepatogenesis associated gene regulatory networks. Scientific reports 7 (1) (2017)
Tarek Hilal, Hiroshi Yamamoto, Justus Loerke, Jörg Bürger, Thorsten Mielke, Christian M T Spahn
Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution. Nature communications 7 (2016)
Anup Arumughan, Yvette Roske, Carolin Barth, Laura Lleras Forero, Kenny Bravo-Rodriguez, Alexandra Redel, Simona Kostova, Erik McShane, Robert Opitz, Katja Faelber, Kirstin Rau, Thorsten Mielke, Oliver Daumke, Matthias Selbach, Elsa Sanchez-Garcia, Oliver Rocks, Daniela Panáková, Udo Heinemann, Erich E Wanker
Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers. Nature communications 7 (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Thorsten Mielke