William J Polacheck (William Polacheck)

ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 39

Top Venues

Nature communications

Science advances

Small (Weinheim an der Bergstrasse, Germany)

Advanced healthcare materials

University of North Carolina at Chapel Hill

Massachusetts Institute of Technology (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of North Carolina at Chapel Hill Jul 01 2018

United States

Assistant Professor :: Biomedical Engineering

Harvard University Aug 01 2015

United States

Postdoctoral Fellow :: Wyss Institute for Biologically Inspired Engineering

Brigham and Women's Hospital Jul 01 2015

United States

Research Fellow

Harvard University Nov 01 2014 - Jul 31 2015

United States

Visiting Postdoctoral Fellow :: Wyss Institute for Biologically Inspired Engineering

Boston University Nov 01 2014 - Jul 31 2015

United States

Postdoctoral Associate :: Biomedical Engineering

Education History

Massachusetts Institute of Technology Sep 01 2008 - Aug 30 2014

United States

PHD :: Mechanical Engineering

Cornell University Sep 01 2004 - May 30 2008

United States

BSC :: Biological Engineering

Publications

Mitesh L Rathod, Wen Yih Aw, Stephanie Huang, Jingming Lu, Elizabeth L Doherty, Chloe P Whithworth, Gang Xi, Prabir Roy-Chaudhury, William J Polacheck
Donor-Derived Engineered Microvessels for Cardiovascular Risk Stratification of Patients with Kidney Failure. Small (Weinheim an der Bergstrasse, Germany) (2024)
Elizabeth L Doherty, Grace Krohn, Emily C Warren, Alexandra Patton, Chloe P Whitworth, Mitesh Rathod, Andreea Biehl, Wen Yih Aw, Donald O Freytes, William J Polacheck
Human Cell-Derived Matrix Composite Hydrogels with Diverse Composition for Use in Vasculature-on-chip Models. Advanced healthcare materials 13 (19) (2024)
Gregory Farber, Yanhan Dong, Qiaozi Wang, Mitesh Rathod, Hao Fei Wang, Michelle Dixit, Benjamin Keepers, Yifang Xie, Kendall Butz, William J Polacheck, Jiandong Liu, Li Qian
Direct conversion of cardiac fibroblasts into endothelial-like cells using Sox17 and Erg. Nature communications 15 (1) (2024)
Gregory Farber, Yanhan Dong, Qiaozi Wang, Mitesh Rathod, Hao Fei Wang, Michelle Dixit, Benjamin Keepers, Yifang Xie, Kendall Butz, William J Polacheck, Jiandong Liu, Li Qian
Direct conversion of cardiac fibroblasts into endothelial-like cells using Sox17 and Erg. Nature communications 15 (1) (2024)
Elizabeth L Doherty, Grace Krohn, Emily C Warren, Alexandra Patton, Chloe P Whitworth, Mitesh Rathod, Andreea Biehl, Wen Yih Aw, Donald O Freytes, William J Polacheck
Human Cell-Derived Matrix Composite Hydrogels with Diverse Composition for Use in Vasculature-on-chip Models. Advanced healthcare materials (2024)
Mitesh L Rathod, Wen Yih Aw, Stephanie Huang, Jingming Lu, Elizabeth L Doherty, Chloe P Whithworth, Gang Xi, Prabir Roy-Chaudhury, William J Polacheck
Donor-Derived Engineered Microvessels for Cardiovascular Risk Stratification of Patients with Kidney Failure. Small (Weinheim an der Bergstrasse, Germany) 20 (24) (2024)
Gregory Farber, Yanhan Dong, Qiaozi Wang, Mitesh Rathod, Hao Fei Wang, Michelle Dixit, Benjamin Keepers, Yifang Xie, Kendall Butz, William J Polacheck, Jiandong Liu, Li Qian
Direct conversion of cardiac fibroblasts into endothelial-like cells using Sox17 and Erg. Nature communications 15 (1) (2024)
Mitesh L Rathod, Wen Yih Aw, Stephanie Huang, Jingming Lu, Elizabeth L Doherty, Chloe P Whithworth, Gang Xi, Prabir Roy-Chaudhury, William J Polacheck
Donor-Derived Engineered Microvessels for Cardiovascular Risk Stratification of Patients with Kidney Failure. Small (Weinheim an der Bergstrasse, Germany) (2024)
Nidhi Mote, Sarah Kubik, William J Polacheck, Brendon M Baker, Britta Trappmann
A nanoporous hydrogel-based model to study chemokine gradient-driven angiogenesis under luminal flow. Lab on a chip (2024)
Gregory Farber, Yanhan Dong, Qiaozi Wang, Mitesh Rathod, Hao Fei Wang, Michelle Dixit, Benjamin Keepers, Yifang Xie, Kendall Butz, William J Polacheck, Jiandong Liu, Li Qian
Direct conversion of cardiac fibroblasts into endothelial-like cells using Sox17 and Erg. Nature communications 15 (1) (2024)
Mitesh L Rathod, Wen Yih Aw, Stephanie Huang, Jingming Lu, Elizabeth L Doherty, Chloe P Whithworth, Gang Xi, Prabir Roy-Chaudhury, William J Polacheck
Donor-Derived Engineered Microvessels for Cardiovascular Risk Stratification of Patients with Kidney Failure. Small (Weinheim an der Bergstrasse, Germany) 20 (24) (2024)
Wen Yih Aw, Aanya Sawhney, Mitesh L Rathod, Chloe P Whitworth, Elizabeth L Doherty, Ethan Madden, Jingming Lu, Kaden Westphal, Ryan Stack, William J Polacheck
Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations. bioRxiv : the preprint server for biology (2024)
Elizabeth L Doherty, Grace Krohn, Emily C Warren, Alexandra Patton, Chloe P Whitworth, Mitesh Rathod, Andreea Biehl, Wen Yih Aw, Donald O Freytes, William J Polacheck
Human Cell-derived Matrix Composite Hydrogels with Diverse Composition for Use in Vasculature-on-chip Models. Advanced healthcare materials (2024)
Mitesh L Rathod, Wen Yih Aw, Stephanie Huang, Jingming Lu, Elizabeth L Doherty, Chloe P Whithworth, Gang Xi, Prabir Roy-Chaudhury, William J Polacheck
Donor-Derived Engineered Microvessels for Cardiovascular Risk Stratification of Patients with Kidney Failure. Small (Weinheim an der Bergstrasse, Germany) 20 (24) (2024)
Elizabeth L Doherty, Grace Krohn, Emily C Warren, Alexandra Patton, Chloe P Whitworth, Mitesh Rathod, Andreea Biehl, Wen Yih Aw, Donald O Freytes, William J Polacheck
Human Cell-Derived Matrix Composite Hydrogels with Diverse Composition for Use in Vasculature-on-chip Models. Advanced healthcare materials 13 (19) (2024)
Elizabeth L Doherty, Grace Krohn, Emily C Warren, Alexandra Patton, Chloe P Whitworth, Mitesh Rathod, Andreea Biehl, Wen Yih Aw, Donald O Freytes, William J Polacheck
Human Cell-Derived Matrix Composite Hydrogels with Diverse Composition for Use in Vasculature-on-chip Models. Advanced healthcare materials 13 (19) (2024)
Chloe P Whitworth, William J Polacheck
Vascular organs-on-chip made with patient-derived endothelial cells: technologies to transform drug discovery and disease modeling. Expert opinion on drug discovery 19 (3) (2023)
Chloe P Whitworth, William J Polacheck
Vascular organs-on-chip made with patient-derived endothelial cells: technologies to transform drug discovery and disease modeling. Expert opinion on drug discovery 19 (3) (2023)
Wen Yih Aw, Crescentia Cho, Hao Wang, Anne Hope Cooper, Elizabeth L Doherty, David J Rocco, Stephanie A Huang, Sarah Kubik, Chloe P Whitworth, Ryan Armstrong, Anthony J Hickey, Boyce E Griffith, Matthew L Kutys, Julie Blatt, William J Polacheck
Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation. Science advances 9 (7) (2023)
Chloe P Whitworth, William J Polacheck
Vascular organs-on-chip made with patient-derived endothelial cells: technologies to transform drug discovery and disease modeling. Expert opinion on drug discovery 19 (3) (2023)
Wen Yih Aw, Crescentia Cho, Hao Wang, Anne Hope Cooper, Elizabeth L Doherty, David J Rocco, Stephanie A Huang, Sarah Kubik, Chloe P Whitworth, Ryan Armstrong, Anthony J Hickey, Boyce E Griffith, Matthew L Kutys, Julie Blatt, William J Polacheck
Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation. Science advances 9 (7) (2023)
Chloe P Whitworth, William J Polacheck
Vascular organs-on-chip made with patient-derived endothelial cells: technologies to transform drug discovery and disease modeling. Expert opinion on drug discovery (2023)
Hao Wang, Jingming Lu, Mitesh L Rathod, Wen Yih Aw, Stephanie A Huang, William J Polacheck
A facile fluid pressure system reveals differential cellular response to interstitial pressure gradients and flow. Biomicrofluidics 17 (5) (2023)
Wen Yih Aw, Crescentia Cho, Hao Wang, Anne Hope Cooper, Elizabeth L Doherty, David J Rocco, Stephanie A Huang, Sarah Kubik, Chloe P Whitworth, Ryan Armstrong, Anthony J Hickey, Boyce E Griffith, Matthew L Kutys, Julie Blatt, William J Polacheck
Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation. Science advances 9 (7) (2023)
Wen Yih Aw, Crescentia Cho, Hao Wang, Anne Hope Cooper, Elizabeth L Doherty, David J Rocco, Stephanie A Huang, Sarah Kubik, Chloe P Whitworth, Ryan Armstrong, Anthony J Hickey, Boyce E Griffith, Matthew L Kutys, Julie Blatt, William J Polacheck
Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation. Science advances 9 (7) (2023)
Esak Lee, Siu-Lung Chan, Yang Lee, William J Polacheck, Sukyoung Kwak, Aiyun Wen, Duc-Huy T Nguyen, Matthew L Kutys, Stella Alimperti, Anna M Kolarzyk, Tae Joon Kwak, Jeroen Eyckmans, Diane R Bielenberg, Hong Chen, Christopher S Chen
A 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex. Proceedings of the National Academy of Sciences of the United States of America 120 (41) (2023)
Wen Yih Aw, Crescentia Cho, Hao Wang, Anne Hope Cooper, Elizabeth L Doherty, David J Rocco, Stephanie A Huang, Sarah Kubik, Chloe P Whitworth, Ryan Armstrong, Anthony J Hickey, Boyce E Griffith, Matthew L Kutys, Julie Blatt, William J Polacheck
Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation. Science advances 9 (7) (2023)
Gi-Hun Lee, Stephanie A Huang, Wen Yih Aw, Mitesh L Rathod, Crescentia Cho, Frances S Ligler, William J Polacheck
Multilayer microfluidic platform for the study of luminal, transmural, and interstitial flow. Biofabrication 14 (2) (2022)
Sandra Pérez-Rodríguez, Stephanie A Huang, Carlos Borau, José Manuel García Aznar, William J Polacheck
Microfluidic model of monocyte extravasation reveals the role of hemodynamics and subendothelial matrix mechanics in regulating endothelial integrity. Biomicrofluidics 15 (5) (2021)
Jifeng Liu, Hongyan Long, Dagmar Zeuschner, Andreas F B Räder, William J Polacheck, Horst Kessler, Lydia M Sorokin, Britta Trappmann
Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting. Nature communications 12 (1) (2021)
Brittany P Rickard, Christina Conrad, Aaron J Sorrin, Mustafa Kemal Ruhi, Jocelyn C Reader, Stephanie A Huang, Walfre Franco, Giuliano Scarcelli, William J Polacheck, Dana M Roque, Marcela G Del Carmen, Huang-Chiao Huang, Utkan Demirci, Imran Rizvi
Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response. Cancers 13 (17) (2021)
William Y Wang, Daphne Lin, Evan H Jarman, William J Polacheck, Brendon M Baker
Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation. Lab on a chip 20 (6) (2021)
Aaron J Sorrin, Mustafa Kemal Ruhi, Nathaniel A Ferlic, Vida Karimnia, William J Polacheck, Jonathan P Celli, Huang-Chiao Huang, Imran Rizvi
Photodynamic Therapy and the Biophysics of the Tumor Microenvironment. Photochemistry and photobiology 96 (2) (2020)
Matthew L Kutys, William J Polacheck, Michaela K Welch, Keith A Gagnon, Thijs Koorman, Sudong Kim, Linqing Li, Andrea I McClatchey, Christopher S Chen
Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform. Nature communications 11 (1) (2020)
William J Polacheck, Matthew L Kutys, Juliann B Tefft, Christopher S Chen
Microfabricated blood vessels for modeling the vascular transport barrier. Nature protocols 14 (5) (2019)
William J Polacheck, Christopher S Chen
Measuring cell-generated forces: a guide to the available tools. Nature methods 13 (5) (2017)
Stella Alimperti, Teodelinda Mirabella, Varnica Bajaj, William J Polacheck, Dana M Pirone, Jeremy Duffield, Jeroen Eyckmans, Richard K Assoian, Christopher S Chen
Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, and N-cadherin balance in mural cell-endothelial cell-regulated barrier function. Proceedings of the National Academy of Sciences of the United States of America 114 (33) (2017)
Britta Trappmann, Brendon M Baker, William J Polacheck, Colin K Choi, Jason A Burdick, Christopher S Chen
Matrix degradability controls multicellularity of 3D cell migration. Nature communications 8 (1) (2017)
Giuliano Scarcelli, William J Polacheck, Hadi T Nia, Kripa Patel, Alan J Grodzinsky, Roger D Kamm, Seok Hyun Yun
Noncontact three-dimensional mapping of intracellular hydromechanical properties by Brillouin microscopy. Nature methods 12 (12) (2015)

William J Polacheck.css-eqlu8i{font-size:small;padding-left:4px;} (William Polacheck)

Publication Activity (10 Years)

Top Topics

Top Venues

William J Polacheck (William Polacheck)