Transcriptomic Correlates of Tumor Cell PD-L1 Expression and Response to Nivolumab Monotherapy in Metastatic Clear Cell Renal Cell Carcinoma.
Thomas DenizeYue HouJean-Christophe PignonEmily WaltonDestiny J WestGordon J FreemanDavid A BraunCatherine J WuSaurabh GuptaRobert J MotzerMichael B AtkinsDavid McDermottToni K ChoueiriSachet A ShuklaSabina SignorettiPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Both TC-extrinsic (immune-related) and TC-intrinsic (cell proliferation-related) mechanisms are likely intertwined in the regulation of TC PD-L1 expression in ccRCC. The quantitation of these transcriptional programs may better predict benefit from anti-PD-1-based therapy compared with TC PD-L1 expression alone in ccRCC.
Keyphrases
- cell proliferation
- single cell
- squamous cell carcinoma
- small cell lung cancer
- cell therapy
- ms ms
- gene expression
- transcription factor
- stem cells
- clinical trial
- open label
- liquid chromatography tandem mass spectrometry
- oxidative stress
- mesenchymal stem cells
- high resolution
- high performance liquid chromatography
- study protocol
- bone marrow