FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer.
Oluwademilade O DairoLia DePaula OliveiraEthan D SchafferThiago VidottoAdrianna A A MendesJiayun LuSophie Vo HuynhJessica L HicksAdam G SowalskyAngelo M DeMarzoCorrine E JoshuBrian HanrattyKaren S SfanosWilliam B IsaacsMichael C HaffnerTamara L LotanPublished in: Cancer research communications (2024)
Here, we leverage multiple independent primary and metastatic prostate cancer cohorts to demonstrate that FASN gene body methylation is highly inversely correlated with FASN gene and protein expression. This finding may shed light on epigenetic mechanisms of FASN regulation in prostate cancer and provides a potentially useful biomarker for selecting patients in future trials of FASN inhibitors.
Keyphrases
- prostate cancer
- genome wide
- copy number
- radical prostatectomy
- dna methylation
- fatty acid
- end stage renal disease
- genome wide identification
- ejection fraction
- squamous cell carcinoma
- gene expression
- newly diagnosed
- chronic kidney disease
- small cell lung cancer
- poor prognosis
- prognostic factors
- genome wide analysis
- long non coding rna
- transcription factor
- binding protein
- patient reported