KDM6A Regulates Immune Response Genes in Multiple Myeloma.
Daphne Dupéré-RicherAlberto RivaSayantan MajiBenjamin G BarwickHeidi Casellas RománAmin SobhGabrielle QuickstadJianping LiUmasankar DeCrissandra PiperMarta KulisTeresa EzpondaJosé Ignacio Martin-SuberoGiovanni TononWeizhou ZhangConstantine S MitsiadesLawrence H BoiseRichard L BennettJonathan D LichtPublished in: bioRxiv : the preprint server for biology (2024)
We show that KDM6A participates in immune recognition of myeloma tumor cells by directly regulating the expression of the master regulators of MHC-I and II, NLRC5 and CIITA. The expression of these regulators can by rescued by the HDAC3 inhibitors in KDM6A-null cell lines.