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KDM6A Regulates Immune Response Genes in Multiple Myeloma.

Daphne Dupéré-RicherAlberto RivaSayantan MajiBenjamin G BarwickHeidi Casellas RománAmin SobhGabrielle QuickstadJianping LiUmasankar DeCrissandra PiperMarta KulisTeresa EzpondaJosé Ignacio Martin-SuberoGiovanni TononWeizhou ZhangConstantine S MitsiadesLawrence H BoiseRichard L BennettJonathan D Licht
Published in: bioRxiv : the preprint server for biology (2024)
We show that KDM6A participates in immune recognition of myeloma tumor cells by directly regulating the expression of the master regulators of MHC-I and II, NLRC5 and CIITA. The expression of these regulators can by rescued by the HDAC3 inhibitors in KDM6A-null cell lines.
Keyphrases
  • multiple myeloma
  • poor prognosis
  • immune response
  • transcription factor
  • binding protein
  • genome wide
  • long non coding rna
  • toll like receptor