Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer's disease.

Dongfang JiangHongmei LiuTingting LiSong ZhaoKeyan YangFuwen YaoBo ZhouHaiping FengSijia WangJiaqi ShenJinglan TangYu-Xin ZhangYun WangCaixia GuoTie-Shan Tang

Published in: Translational neurodegeneration (2024)

CPE may regulate adult hippocampal neurogenesis via the CPE-BDNF-TrkB signaling pathway. This study supports the prospect of developing miRNA agomirs targeting CPE as biopharmaceuticals to counteract aging- and disease-related neurological decline in human brains.

Keyphrases

cerebral ischemia
signaling pathway
endothelial cells
poor prognosis
traumatic brain injury
pi k akt
neural stem cells
blood brain barrier
brain injury
working memory
cancer therapy
oxidative stress
binding protein
cell proliferation
current status
pluripotent stem cells