Distinct plasma lipids predict axonal injury and multiple sclerosis activity.
Vinícius Andreoli SchoepsPavan BhargavaAkash VirupakshaiahDimitrios Christos LadakisCarson MoseleyJanet ChongGregory AaenJennifer S GravesLeslie BensonMark P GormanMary RenselAaron W AbramsSoe MarTimothy E LotzeTanuja ChitinisAmy WaldmanLauren B KruppMoses RodriguezJan-Mendelt TillemaJohn RoseTeri SchreinerFerhan QureshiSkyler PetersonLisa F BarcellosT Charles CasperJohn NewmanKamil BorkowskiEmmanuelle Waubantnull nullPublished in: Journal of neurology, neurosurgery, and psychiatry (2024)
There are two categories of lipids associated with MS processes. First, structural lipids strongly associated with NfL levels may result from cell lysis secondary to acute inflammation. In contrast, PUFAs, especially ω-3, had a protective effect on subsequent disease activity.
Keyphrases
- disease activity
- multiple sclerosis
- rheumatoid arthritis
- systemic lupus erythematosus
- rheumatoid arthritis patients
- ankylosing spondylitis
- fatty acid
- liver failure
- juvenile idiopathic arthritis
- magnetic resonance
- spinal cord injury
- single cell
- mass spectrometry
- white matter
- cell therapy
- respiratory failure
- computed tomography
- intensive care unit
- mesenchymal stem cells
- contrast enhanced
- extracorporeal membrane oxygenation