The Glucagon-like peptide-1 receptor agonist, exendin-4, ameliorated gastrointestinal dysfunction in the Wistar Kyoto rat model of Irritable Bowel Syndrome.

Rebecca O'BrienDervla O'Malley

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2019)

These data suggest that intraperitoneal injection of exendin-4 improves bowel dysfunction in WKY rats without impacting on centrally regulated anxiety-like behaviors. Modulation of enteric neuronal function and tight junction expression appear to underlie the functional benefits of this intervention.

Keyphrases

irritable bowel syndrome
oxidative stress
poor prognosis
randomized controlled trial
blood brain barrier
sleep quality
long non coding rna
binding protein
machine learning
depressive symptoms
artificial intelligence