Longitudinal Cognitive Changes in Genetic Frontotemporal Dementia Within the GENFI Cohort.
Jackie M PoosAmy MacDougallEsther Van Den BergLize C JiskootJanne M PapmaEmma L van der EndeHarro SeelaarLucy L RussellGeorgia PeakmanRhian S ConveryYolande A L PijnenburgFermin MorenoRaquel Sanchez-ValleBarbara BorroniRobert Jr LaforceMarie-Claire DoréMario MasellisMaria Carmela TartagliaCaroline GraffDaniela GalimbertiJames Benedict RoweElizabeth FingerMatthis SynofzikRik VandenbergheAlexandre de MendonçaPietro TiraboschiIsabel SantanaSimon DucharmeChristopher ButlerAlexander GerhardJohannes LevinAdrian DanekMarkus OttoIsabelle Le BerFlorence PasquierJohn van SwietenJonathan D Rohrernull nullPublished in: Neurology (2022)
We confirmed cognitive decline in the asymptomatic and prodromal stage of genetic FTD. Specifically, tests for attention, executive function, language, and memory showed clear differences between genetic groups and controls at baseline, but the speed of change over time differed depending on genetic group and disease stage. This confirms the value of neuropsychological assessment in tracking clinical onset and progression and could inform clinical trials in selecting sensitive end points for measuring treatment effects as well as characterizing the best time window for starting treatment.