Circular RNA; a new biomarker for breast cancer: A systematic review.
Shima JahaniElahe NazeriKeivan Majidzadeh-AMona JahaniRezvan EsmaeiliPublished in: Journal of cellular physiology (2020)
Circular RNAs (circRNAs) were recently discovered as a looped subset of competing endogenous RNAs, with an ability to regulate gene expression by microRNA sponging. There are several studies on their potential roles in cancer development, such as colorectal cancer and basal cell carcinoma. However, there is still a significant gap in the knowledge about circRNA functions in breast cancer (BC) progression. The current study systematically reviewed circRNA biogenesis and their potential roles as a novel biomarker in BC on published studies of the MEDLINE®/PubMed, Cochrane®, and Scopus® databases. The obtained results showed a general dysregulation of circRNAs expression in BC cells with a cell-type and stage-specific manner. The potential connection between circRNAs and BC cell proliferation, apoptosis, metastasis, and chemotherapy sensitivity and resistance were discussed.
Keyphrases
- gene expression
- cell proliferation
- cell cycle arrest
- induced apoptosis
- basal cell carcinoma
- healthcare
- dna methylation
- endoplasmic reticulum stress
- oxidative stress
- cell death
- poor prognosis
- papillary thyroid
- squamous cell carcinoma
- pi k akt
- randomized controlled trial
- signaling pathway
- young adults
- big data
- case control
- systematic review
- squamous cell
- artificial intelligence
- lymph node metastasis
- meta analyses