NRAS Q61R mutation drives elevated angiopoietin-2 expression in human endothelial cells and a genetic mouse model.
Patricia PasturaC Griffin McDanielSara AlharbiDermot FoxBethany ColemanParul RaiDenise M AdamsTimothy D Le CrasPublished in: Pediatric blood & cancer (2024)
drives elevated Ang-2 through MAP kinase and mTOR-dependent signaling pathways.
Keyphrases
- endothelial cells
- mouse model
- poor prognosis
- signaling pathway
- high glucose
- vascular endothelial growth factor
- angiotensin ii
- genome wide
- cell proliferation
- pi k akt
- binding protein
- copy number
- tyrosine kinase
- protein kinase
- epithelial mesenchymal transition
- pluripotent stem cells
- gene expression
- oxidative stress
- dna methylation
- wild type